{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T12:34:02Z","timestamp":1770813242951,"version":"3.50.1"},"reference-count":29,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","clinicaltherapeutics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Therapeutics"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1016\/j.clinthera.2018.02.012","type":"journal-article","created":{"date-parts":[[2018,3,16]],"date-time":"2018-03-16T17:44:55Z","timestamp":1521222295000},"page":"574-586.e4","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["Immunotherapy With the SQ Tree SLIT-tablet in Adults and Adolescents With Allergic Rhinoconjunctivitis"],"prefix":"10.1016","volume":"40","author":[{"given":"Mika J.","family":"M\u00e4kel\u00e4","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u00e4r","family":"Gyllfors","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erkka","family":"Valovirta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria A.","family":"Steffensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pernille M.","family":"Gr\u00f8nager","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Savolainen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lone","family":"Winther","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.clinthera.2018.02.012_bib1","doi-asserted-by":"crossref","first-page":"S147","DOI":"10.1067\/mai.2001.118891","article-title":"Allergic rhinitis and its impact on asthma","volume":"108","author":"Bousquet","year":"2001","journal-title":"J Allergy Clin Immunol"},{"issue":"Suppl 86","key":"10.1016\/j.clinthera.2018.02.012_bib2","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/j.1398-9995.2007.01620.x","article-title":"Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen)","volume":"63","author":"Bousquet","year":"2008","journal-title":"Allergy"},{"key":"10.1016\/j.clinthera.2018.02.012_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000151243","article-title":"The principle of homologous groups in regulatory affairs of allergen products\u2014a proposal","volume":"148","author":"Lorenz","year":"2008","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.clinthera.2018.02.012_bib4","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1111\/all.12696","article-title":"Tree pollen allergens\u2014an update from a molecular perspective","volume":"70","author":"Asam","year":"2015","journal-title":"Allergy"},{"key":"10.1016\/j.clinthera.2018.02.012_bib5","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1159\/000082332","article-title":"Transition from a botanical to a molecular classification in tree pollen allergy: implications for diagnosis and therapy","volume":"135","author":"Mothes","year":"2004","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.clinthera.2018.02.012_bib6","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1097\/ACI.0b013e32833973fb","article-title":"Food allergy and oral allergy or pollen-food syndrome","volume":"10","author":"Katelaris","year":"2010","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"10.1016\/j.clinthera.2018.02.012_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/ACI.0b013e3282f3f42f","article-title":"The voice of the patients: allergic rhinitis is not a trivial disease","volume":"8","author":"Valovirta","year":"2008","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"10.1016\/j.clinthera.2018.02.012_bib8","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/S0091-6749(98)70271-4","article-title":"Allergen immunotherapy: therapeutic vaccines for allergic diseases. A WHO position paper","volume":"102","author":"Bousquet","year":"1998","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.clinthera.2018.02.012_bib9","first-page":"224","article-title":"Hymenoptera venom immunotherapy and field stings","volume":"16","author":"Lang","year":"2006","journal-title":"J Investig Allergol Clin Immunol"},{"key":"10.1016\/j.clinthera.2018.02.012_bib10","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1111\/j.1398-9995.2010.02451.x","article-title":"SQ-standardised house dust mite immunotherapy as an immunomodulatory treatment in asthma patients","volume":"66","author":"Blumberga","year":"2011","journal-title":"Allergy"},{"key":"10.1016\/j.clinthera.2018.02.012_bib11","first-page":"827","article-title":"Allergen-specific immunotherapy in birch- and grass-pollen-allergic rhinitis. II","volume":"55","author":"Winther","year":"2000","journal-title":"Side-effects. Allergy"},{"key":"10.1016\/j.clinthera.2018.02.012_bib12","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1034\/j.1398-9995.2000.00367.x","article-title":"Allergen-specific immunotherapy in birch- and grass-pollen-allergic rhinitis. I. Efficacy estimated by a model reducing the bias of annual differences in pollen counts","volume":"55","author":"Winther","year":"2000","journal-title":"Allergy"},{"key":"10.1016\/j.clinthera.2018.02.012_bib13","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.jaci.2015.06.036","article-title":"Effective treatment of house dust mite-induced allergic rhinitis with 2 doses of the SQ HDM SLIT-tablet: results from a randomized double-blind, placebo-controlled phase III trial","volume":"137","author":"Demoly","year":"2016","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.clinthera.2018.02.012_bib14","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.jaci.2011.12.973","article-title":"SQ-standardized sublingual grass immunotherapy: confirmation of disease modification 2 years after 3 years of treatment in a randomized trial","volume":"129","author":"Durham","year":"2012","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.clinthera.2018.02.012_bib15","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/S0091-6749(98)70273-8","article-title":"Recombinant birch pollen allergens (rBet v 1 and rBet v 2) contain most of the IgE epitopes present in birch, alder, hornbeam, hazel, and oak pollen: a quantitative IgE inhibition study with sera from different populations","volume":"102","author":"Niederberger","year":"1998","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.clinthera.2018.02.012_bib16","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1111\/j.1365-2222.2011.03866.x","article-title":"Bet v 1-like pollen allergens of multiple Fagales species can sensitize atopic individuals","volume":"41","author":"Hauser","year":"2011","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.clinthera.2018.02.012_bib17","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1007\/s11882-014-0473-1","article-title":"Immune mechanisms of sublingual immunotherapy","volume":"14","author":"Jay","year":"2014","journal-title":"Curr Allergy Asthma Rep"},{"key":"10.1016\/j.clinthera.2018.02.012_bib18","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/2045-7022-2-2","article-title":"Mechanisms of allergen-specific immunotherapy","volume":"2","author":"Fujita","year":"2012","journal-title":"Clin Transl Allergy"},{"key":"10.1016\/j.clinthera.2018.02.012_bib19","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.jaci.2013.09.043","article-title":"Grass tablet sublingual immunotherapy downregulates the TH2 cytokine response followed by regulatory T-cell generation","volume":"133","author":"Suarez-Fueyo","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.clinthera.2018.02.012_bib21","unstructured":"ICH. ICH Harmonised Tripartite Guideline Topic E6 (R1): Guideline for Good Clinical Practice. 1996."},{"key":"10.1016\/j.clinthera.2018.02.012_bib22","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/S0091-6749(99)70380-5","article-title":"Validation of the standardized version of the Rhinoconjunctivitis Quality of Life Questionnaire","volume":"104","author":"Juniper","year":"1999","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.clinthera.2018.02.012_bib23","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.3390\/ijerph6061706","article-title":"Analysis of airborne betula pollen in Finland; a 31-year perspective","volume":"6","author":"Yli-Panula","year":"2009","journal-title":"Int J Environ Res Public Health"},{"key":"10.1016\/j.clinthera.2018.02.012_bib24","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1111\/all.12373","article-title":"Magnitude of efficacy measurements in grass allergy immunotherapy trials is highly dependent on pollen exposure","volume":"69","author":"Durham","year":"2014","journal-title":"Allergy"},{"key":"10.1016\/j.clinthera.2018.02.012_bib25","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1111\/j.1398-9995.2011.02669.x","article-title":"European Academy of Allergy and Clinical Immunology task force report on 'dose-response relationship in allergen-specific immunotherapy'","volume":"66","author":"Calderon","year":"2011","journal-title":"Allergy"},{"key":"10.1016\/j.clinthera.2018.02.012_bib26","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s13601-015-0088-1","article-title":"Choosing the optimal dose in sublingual immunotherapy: rationale for the 300 index of reactivity dose","volume":"5","author":"Demoly","year":"2015","journal-title":"Clin Transl Allergy"},{"key":"10.1016\/j.clinthera.2018.02.012_bib27","doi-asserted-by":"crossref","first-page":"403","DOI":"10.2332\/allergolint.13-RAI-0650","article-title":"Allergen immunotherapy and tolerance","volume":"62","author":"Matsuoka","year":"2013","journal-title":"Allergol Int"},{"key":"10.1016\/j.clinthera.2018.02.012_bib28","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.1016\/j.clinthera.2017.08.003","article-title":"Tolerability of the SQ Tree SCIT tablet in adults","volume":"39","author":"Birk","year":"2017","journal-title":"Clin Ther"},{"key":"10.1016\/j.clinthera.2018.02.012_bib29","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/j.jaci.2005.12.1358","article-title":"Sublingual immunotherapy with once-daily grass allergen tablets: a randomized controlled trial in seasonal allergic rhinoconjunctivitis","volume":"117","author":"Durham","year":"2006","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.clinthera.2018.02.012_bib30","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.jaci.2014.03.019","article-title":"Standardized quality (SQ) house dust mite sublingual immunotherapy tablet (ALK) reduces inhaled corticosteroid use while maintaining asthma control: a randomized, double-blind, placebo-controlled trial","volume":"134","author":"Mosbech","year":"2014","journal-title":"J Allergy Clin Immunol"}],"container-title":["Clinical Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149291818300626?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149291818300626?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,17]],"date-time":"2019-01-17T06:42:32Z","timestamp":1547707352000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0149291818300626"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4]]},"references-count":29,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["S0149291818300626"],"URL":"https:\/\/doi.org\/10.1016\/j.clinthera.2018.02.012","relation":{},"ISSN":["0149-2918"],"issn-type":[{"value":"0149-2918","type":"print"}],"subject":[],"published":{"date-parts":[[2018,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Immunotherapy With the SQ Tree SLIT-tablet in Adults and Adolescents With Allergic Rhinoconjunctivitis","name":"articletitle","label":"Article Title"},{"value":"Clinical Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clinthera.2018.02.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}