{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T05:45:49Z","timestamp":1792043149902,"version":"4.4.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,8,29]],"date-time":"2018-08-29T00:00:00Z","timestamp":1535500800000},"content-version":"vor","delay-in-days":59,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","clinicaltherapeutics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Therapeutics"],"published-print":{"date-parts":[[2018,7]]},"DOI":"10.1016\/j.clinthera.2018.04.021","type":"journal-article","created":{"date-parts":[[2018,6,24]],"date-time":"2018-06-24T03:29:13Z","timestamp":1529810953000},"page":"1096-1107.e1","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"title":["A Randomized, Multicenter, Double-blind, Phase III Study to Evaluate the Efficacy on Allergic Rhinitis and Safety of a Combination Therapy of Montelukast and Levocetirizine in Patients With Asthma and Allergic Rhinitis"],"prefix":"10.1016","volume":"40","author":[{"given":"Mi-Kyeong","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sook Young","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hae-Sim","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ho Joo","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang-Ha","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Joo","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwang-Ha","family":"Yoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo-Keol","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee-Kyoo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung-Won","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heung-Woo","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Hong","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byoung Whui","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byung-Jae","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoon-Seok","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun-Jung","family":"Jo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang-Yeub","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You Sook","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young-Koo","family":"Jee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong-Myung","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jina","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Choon-Sik","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clinthera.2018.04.021_bib0001","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00130832-200402000-00002","article-title":"Classification and global approaches to treatment","volume":"4","author":"Pawankar","year":"2004","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"10.1016\/j.clinthera.2018.04.021_bib0002","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/j.1398-9995.2004.00526.x","article-title":"Holt S, Beasley R. The global burden of asthma: executive summary of the GINA Dissemination Committee report","volume":"59","author":"Masoli","year":"2004","journal-title":"Allergy"},{"key":"10.1016\/j.clinthera.2018.04.021_bib0003","article-title":"Evaluation and Control of Allergic Rhinitis in Adult Patients with Asthma (CARINA) in Korea","volume":"27","author":"Kim","year":"2007","journal-title":"Korean J Asthma Allergy Clin Immunol"},{"key":"10.1016\/j.clinthera.2018.04.021_bib0004","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1034\/j.1398-9995.2003.00105.x","article-title":"Links between rhinitis and asthma","volume":"58","author":"Bousquet","year":"2003","journal-title":"Allergy"},{"key":"10.1016\/j.clinthera.2018.04.021_bib0005","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/S0091-6749(99)70320-9","article-title":"Allergic rhinobronchitis: the asthma-allergic rhinitis link","volume":"104","author":"Simons","year":"1999","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.clinthera.2018.04.021_bib0006","first-page":"7","article-title":"The nose-lung interaction in allergic rhinitis and asthma: united airways disease","volume":"1","author":"Passalacqua","year":"2001","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"10.1016\/j.clinthera.2018.04.021_bib0007","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1097\/00130832-200406000-00007","article-title":"An update on the asthma-rhinitis link","volume":"4","author":"Passalacqua","year":"2004","journal-title":"Curr Opin Allergy Clin Immunol"},{"issue":"Suppl. 86","key":"10.1016\/j.clinthera.2018.04.021_bib0008","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/j.1398-9995.2007.01620.x","article-title":"Allergic Rhinitis and its Impact on Asthma (ARIA) 2008","volume":"63","author":"Bousquet","year":"2008","journal-title":"Allergy"},{"key":"10.1016\/j.clinthera.2018.04.021_bib0009","doi-asserted-by":"crossref","first-page":"335","DOI":"10.3345\/kjp.2007.50.4.335","article-title":"Allergic rhinitis, sinusitis and asthma: evidence for respiratory system integration","volume":"50","author":"Kim","year":"2007","journal-title":"Korean J Pediatrics"},{"key":"10.1016\/j.clinthera.2018.04.021_bib0010","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1157\/13079841","article-title":"Rhinitis and asthma: one airway, one disease","volume":"41","author":"Serrano","year":"2005","journal-title":"Arch Bronconeumol"},{"key":"10.1016\/j.clinthera.2018.04.021_bib0011","first-page":"13","article-title":"Beyond the nose: the systemic inflammatory effects of allergic rhinitis","volume":"40","author":"Luskin","year":"2004","journal-title":"Hosp Physician"},{"key":"10.1016\/j.clinthera.2018.04.021_bib0012","doi-asserted-by":"crossref","first-page":"93","DOI":"10.2147\/JAA.S81541","article-title":"United airway disease: current perspectives","volume":"11","author":"Giavina-Bianchi","year":"2016","journal-title":"J Asthma Allergy"},{"key":"10.1016\/j.clinthera.2018.04.021_bib0013","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.jaci.2011.09.036","article-title":"Natural course and comorbidities of allergic and nonallergic rhinitis in children","volume":"129","author":"Westman","year":"2012","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.clinthera.2018.04.021_bib0014","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1046\/j.1472-9725.2003.00016.x","article-title":"Cysteinyl leukotrienes as common mediators of asthma and allergic disease","volume":"3","author":"Dahl\u00e9n","year":"2003","journal-title":"Clin Exp Allergy Rev"},{"key":"10.1016\/j.clinthera.2018.04.021_bib0015","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1001\/archinte.158.11.1213","article-title":"Montelukast, a once-daily leukotriene receptor antagonist, in the treatment of chronic asthma: a multicenter, randomized, double-blind trial","volume":"158","author":"Reiss","year":"1998","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.clinthera.2018.04.021_bib0016","first-page":"368","article-title":"A clinical review of montelukast in the treatment of seasonal allergic rhinitis","volume":"38","author":"Goneayu","year":"2003","journal-title":"Formulary"},{"key":"10.1016\/j.clinthera.2018.04.021_bib0017","doi-asserted-by":"crossref","first-page":"327","DOI":"10.2147\/tcrm.2007.3.2.327","article-title":"Montelukast in the management of allergic rhinitis","volume":"3","author":"Logos","year":"2007","journal-title":"Ther Clin Risk Manag"},{"key":"10.1016\/j.clinthera.2018.04.021_bib0018","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/S1081-1206(10)61018-6","article-title":"Randomized, double-blind, placebo-controlled study of montelukast for treating perennial allergic rhinitis","volume":"95","author":"Patel","year":"2005","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.clinthera.2018.04.021_bib0019","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1046\/j.1365-2222.2002.01422.x","article-title":"Montelukast for treating seasonal allergic rhinitis: a randomized, double-blind, placebo-controlled trial performed in the spring","volume":"32","author":"Philip","year":"2002","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.clinthera.2018.04.021_bib0020","first-page":"17","article-title":"Once daily levocetirizine for the treatment of allergic rhinitis and chronic idiopathic urticarial","volume":"2","author":"Nettis","year":"2009","journal-title":"J Asthma Allergy"},{"key":"10.1016\/j.clinthera.2018.04.021_bib0021","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.anai.2009.12.003","article-title":"Efficacy and safety of levocetirizine in improving symptoms and health-related quality of life in US adults with seasonal allergic rhinitis: a randomized, placebo-controlled study","volume":"104","author":"Segall","year":"2010","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.clinthera.2018.04.021_bib0022","doi-asserted-by":"crossref","first-page":"21","DOI":"10.2500\/108854194778816634","article-title":"Long-term risk factors for developing asthma and allergic rhinitis: a 23-year follow-up study of college students","volume":"15","author":"Settipane","year":"1994","journal-title":"Allergy Proc"},{"key":"10.1016\/j.clinthera.2018.04.021_bib0023","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1067\/mai.2000.106040","article-title":"Concomitant montelukast and loratadine as treatment for seasonal allergic rhinitis: a randomized, placebo-controlled clinical trial","volume":"105","author":"Meltzer","year":"2000","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.clinthera.2018.04.021_bib0024","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/S1081-1206(10)61891-1","article-title":"Efficacy and tolerability of montelukast alone or in combination with loratadine in seasonal allergic rhinitis: a multicenter, randomized, double-blind, placebo-controlled trial performed in the fall","volume":"88","author":"Nayak","year":"2002","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.clinthera.2018.04.021_bib0025","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1016\/S1081-1206(10)61098-8","article-title":"Montelukast with desloratadine or levocetirizine for the treatment of persistent allergic rhinitis","volume":"97","author":"Ciebiada","year":"2006","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.clinthera.2018.04.021_bib0026","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4172\/2155-6121.1000103","article-title":"Efficacy of montelukast and levocetirizine as treatment for allergic rhinitis","volume":"1","author":"Gupta","year":"2010","journal-title":"J Aller Ther"},{"key":"10.1016\/j.clinthera.2018.04.021_bib0027","doi-asserted-by":"crossref","first-page":"S201","DOI":"10.1067\/mai.2000.110151","article-title":"Epidemiologic evidence for asthma and rhinitis comorbidity","volume":"106","author":"Leynaert","year":"2000","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.clinthera.2018.04.021_bib0028","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1164\/ajrccm.160.5.9811002","article-title":"Risk factors for early, persistent, and late-onset wheezing in young children","volume":"160","author":"Rusconi","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"issue":"Suppl. 1","key":"10.1016\/j.clinthera.2018.04.021_bib0029","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1186\/1471-2466-6-S1-S3","article-title":"Survey on the impact of comorbid allergic rhinitis in patients with asthma","volume":"6","author":"Valovirta","year":"2006","journal-title":"BMC Plum Med"},{"key":"10.1016\/j.clinthera.2018.04.021_bib0030","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1111\/j.1365-2222.2005.02182.x","article-title":"Effect of a concomitant diagnosis of allergic rhinitis on asthma-related health care use by adults","volume":"35","author":"Price","year":"2005","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.clinthera.2018.04.021_bib0031","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/S0091-6749(99)70464-1","article-title":"Healthcare expenditures for sinusitis in 1996: contributions of asthma, rhinitis, and other airway disorders","volume":"103","author":"Ray","year":"1999","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.clinthera.2018.04.021_bib0032","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1111\/j.1365-2222.2005.02251.x","article-title":"Increased risk of asthma attacks and emergency visits among asthma patients with allergic rhinitis: a subgroup analysis of the improving asthma control trial","volume":"35","author":"Bousquet","year":"2005","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.clinthera.2018.04.021_bib0033","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.jaci.2003.11.034","article-title":"Rhinitis therapy and the prevention of hospital care for asthma: a case-control study","volume":"113","author":"Corren","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.clinthera.2018.04.021_bib0034","unstructured":"Guideline on the clinical investigation of medicinal products for the treatment of asthma, EMA CHMP, 2016."}],"container-title":["Clinical Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149291818302340?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149291818302340?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,8,30]],"date-time":"2018-08-30T03:19:00Z","timestamp":1535599140000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0149291818302340"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7]]},"references-count":34,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["S0149291818302340"],"URL":"https:\/\/doi.org\/10.1016\/j.clinthera.2018.04.021","relation":{},"ISSN":["0149-2918"],"issn-type":[{"value":"0149-2918","type":"print"}],"subject":[],"published":{"date-parts":[[2018,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A Randomized, Multicenter, Double-blind, Phase III Study to Evaluate the Efficacy on Allergic Rhinitis and Safety of a Combination Therapy of Montelukast and Levocetirizine in Patients With Asthma and Allergic Rhinitis","name":"articletitle","label":"Article Title"},{"value":"Clinical Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clinthera.2018.04.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}