{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T12:16:59Z","timestamp":1780316219001,"version":"3.54.1"},"reference-count":25,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","clinicaltherapeutics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Therapeutics"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.clinthera.2018.08.011","type":"journal-article","created":{"date-parts":[[2018,9,20]],"date-time":"2018-09-20T00:39:10Z","timestamp":1537403950000},"page":"1659-1667.e1","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Maternal BMI, Mid-pregnancy Fatty Acid Concentrations, and Perinatal Outcomes"],"prefix":"10.1016","volume":"40","author":[{"given":"Annie","family":"Penfield-Cyr","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Monthe-Dreze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcela C.","family":"Smid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarbattama","family":"Sen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clinthera.2018.08.011_bib0001","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/S0140-6736(11)60813-1","article-title":"The global obesity pandemic: shaped by global drivers and local environments","volume":"378","author":"Swinburn","year":"2011","journal-title":"Lancet"},{"key":"10.1016\/j.clinthera.2018.08.011_bib0002","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1001\/jamainternmed.2015.2405","article-title":"Prevalence of overweight and obesity in the United States, 2007 to 2012","volume":"175","author":"Yang","year":"2015","journal-title":"JAMA Intern Med"},{"key":"10.1016\/j.clinthera.2018.08.011_bib0003","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/418975","article-title":"Maternal obesity, inflammation, and developmental programming","volume":"2014","author":"Segovia","year":"2014","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.clinthera.2018.08.011_bib0004","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1111\/j.1471-0528.2006.00989.x","article-title":"The short- and long-term implications of maternal obesity on the mother and her offspring","volume":"113","author":"Catalano","year":"2006","journal-title":"BJOG"},{"key":"10.1016\/j.clinthera.2018.08.011_bib0005","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/S0753-3322(02)00253-6","article-title":"The importance of the ratio of omega-6\/omega-3 essential fatty acids","volume":"56","author":"Simopoulos","year":"2002","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.clinthera.2018.08.011_bib0006","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1159\/000073790","article-title":"The importance of omega-6\/omega-3 fatty acid ratio in cell function. The gene transfer of omega-3 fatty acid desaturase","volume":"92","author":"Kang","year":"2003","journal-title":"World Rev Nutr Diet"},{"key":"10.1016\/j.clinthera.2018.08.011_bib0007","doi-asserted-by":"crossref","first-page":"292S","DOI":"10.3945\/an.114.006940","article-title":"The science of fatty acids and inflammation","volume":"6","author":"Fritsche","year":"2015","journal-title":"Adv Nutr"},{"key":"10.1016\/j.clinthera.2018.08.011_bib0008","doi-asserted-by":"crossref","first-page":"128","DOI":"10.3390\/nu8030128","article-title":"An increase in the omega-6\/omega-3 fatty acid ratio increases the risk for obesity","volume":"8","author":"Simopoulos","year":"2016","journal-title":"Nutrients"},{"key":"10.1016\/j.clinthera.2018.08.011_bib0009","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.plefa.2009.02.007","article-title":"Associations of maternal prenatal dietary intake of n-3 and n-6 fatty acids with maternal and umbilical cord blood levels","volume":"80","author":"Donahue","year":"2009","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"key":"10.1016\/j.clinthera.2018.08.011_bib0010","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1210\/jc.2012-2482","article-title":"Maternal plasma polyunsaturated fatty acid status in late pregnancy is associated with offspring body composition in childhood","volume":"98","author":"Moon","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.clinthera.2018.08.011_bib0011","doi-asserted-by":"crossref","first-page":"e67791","DOI":"10.1371\/journal.pone.0067791","article-title":"Transgenic increase in n-3\/n-6 fatty acid ratio reduces maternal obesity-associated inflammation and limits adverse developmental programming in mice","volume":"8","author":"Heerwagen","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.clinthera.2018.08.011_bib0012","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.plefa.2011.04.027","article-title":"The effect of maternal omega-3 long-chain polyunsaturated fatty acid (n-3 LCPUFA) supplementation during pregnancy and\/or lactation on body fat mass in the offspring: a systematic review of animal studies","volume":"85","author":"Muhlhausler","year":"2011","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"key":"10.1016\/j.clinthera.2018.08.011_bib0013","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0147359","article-title":"Maternal fatty acids and their association with birth outcome: a prospective study","volume":"11","author":"Meher","year":"2016","journal-title":"PLos One"},{"key":"10.1016\/j.clinthera.2018.08.011_bib0014","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.3945\/ajcn.115.112847","article-title":"Maternal plasma PUFA concentrations during pregnancy and childhood adiposity: the Generation R study","volume":"103","author":"Vidakovic","year":"2016","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.clinthera.2018.08.011_bib0015","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/jp.2013.153","article-title":"Obesity during pregnancy alters maternal oxidant balance and micronutrient status","volume":"34","author":"Sen","year":"2014","journal-title":"J Perinatol"},{"key":"10.1016\/j.clinthera.2018.08.011_bib0016","doi-asserted-by":"crossref","unstructured":"Monthe-Dreze C, Penfield-Cyr A, Smid M, Sen S. Maternal pre-pregnancy obesity attenuates response to omega-3 fatty acid supplementation during pregnancy. Abstract presented at Society for Reproductive Investigation, Orlando, FL, March 2017 and New England Perinatal Scientific Meeting, Newport, RI, March 2018; manuscript under review.","DOI":"10.3390\/nu10121908"},{"key":"10.1016\/j.clinthera.2018.08.011_bib0017","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1097\/AOG.0b013e3181cbd60e","article-title":"Omega-3 fatty acid supplementation to prevent recurrent preterm birth: a randomized control trial","volume":"115","author":"Harper","year":"2010","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.clinthera.2018.08.011_bib0018","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/S0002-9378(97)70620-3","article-title":"Maternal and perinatal long-chain fatty acids: possible roles in preterm birth","volume":"176","author":"Reece","year":"1997","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.clinthera.2018.08.011_bib0019","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0021-9258(18)64849-5","article-title":"A simple method for the isolation and purification of total lipids from animal tissues","volume":"226","author":"Folch","year":"1957","journal-title":"J Biol Chem"},{"key":"10.1016\/j.clinthera.2018.08.011_bib0020","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/1471-2431-13-59","article-title":"A systematic review and meta-analysis to revise the Fenton growth chart for preterm infants","volume":"13","author":"Fenton","year":"2013","journal-title":"BMC Pediatr"},{"key":"10.1016\/j.clinthera.2018.08.011_bib0021","article-title":"Maternal plasma n-3 and n-6 polyunsaturated fatty acids during pregnancy and features of fetal health: fetal growth velocity, birth weight and duration of pregnancy","author":"Grootendorst-van Mil","year":"2017","journal-title":"Clin Nutr."},{"key":"10.1016\/j.clinthera.2018.08.011_bib0022","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0148752","article-title":"Polyunsaturated fatty acid (PUFA) status in pregnancy women: associations with sleep quality, inflammation, and length of gestation","volume":"11","author":"Christian","year":"2016","journal-title":"PLoS One"},{"issue":"Suppl 1","key":"10.1016\/j.clinthera.2018.08.011_bib0023","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/j.1753-4887.2009.00172.x","article-title":"Mediterranean food pattern and the primary prevention of chronic disease: recent developments","author":"Martinez-Gonzalez","year":"2009","journal-title":"Nutr Rev."},{"key":"10.1016\/j.clinthera.2018.08.011_bib0024","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1002\/1438-9312(200210)104:9\/10<698::AID-EJLT698>3.0.CO;2-A","article-title":"Mediterranean diet, olive oil and health","volume":"104","author":"Wahrburg","year":"2002","journal-title":"Eur J Lipid Sci Technol"},{"key":"10.1016\/j.clinthera.2018.08.011_bib0025","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1093\/ajcn\/47.5.828","article-title":"Fetal growth and fetal lung phospholipid content in rats fed safflower oil, menhaden oil, or hydrogenated coconut oil","volume":"47","author":"Clarke","year":"2008","journal-title":"Am J Clin Nutr"}],"container-title":["Clinical Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149291818303746?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149291818303746?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T23:59:00Z","timestamp":1662076740000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0149291818303746"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":25,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["S0149291818303746"],"URL":"https:\/\/doi.org\/10.1016\/j.clinthera.2018.08.011","relation":{},"ISSN":["0149-2918"],"issn-type":[{"value":"0149-2918","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Maternal BMI, Mid-pregnancy Fatty Acid Concentrations, and Perinatal Outcomes","name":"articletitle","label":"Article Title"},{"value":"Clinical Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clinthera.2018.08.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}