{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:51:47Z","timestamp":1791298307299,"version":"4.1.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,8,29]],"date-time":"2018-08-29T00:00:00Z","timestamp":1535500800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","clinicaltherapeutics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Therapeutics"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.clinthera.2018.08.019","type":"journal-article","created":{"date-parts":[[2018,9,21]],"date-time":"2018-09-21T13:41:13Z","timestamp":1537537273000},"page":"1765-1776.e5","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"title":["Analgesic Efficacy of an Acetaminophen\/Ibuprofen Fixed-dose Combination in Moderate to Severe Postoperative Dental Pain: A Randomized, Double-blind, Parallel-group, Placebo-controlled Trial"],"prefix":"10.1016","volume":"40","author":[{"given":"Stephen E.","family":"Daniels","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hartley C.","family":"Atkinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioana","family":"Stanescu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0603-5661","authenticated-orcid":false,"given":"Chris","family":"Frampton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clinthera.2018.08.019_bib0001","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1345\/aph.1A035","article-title":"Hepatotoxicity associated with chronic acetaminophen administration in patients without risk factors","volume":"36","author":"Bolesta","year":"2002","journal-title":"Ann Pharmacother"},{"key":"10.1016\/j.clinthera.2018.08.019_bib0002","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1002\/hep.20293","article-title":"Acetaminophen and the U.S. acute liver failure study group: lowering the risks of hepatic failure","volume":"40","author":"Lee","year":"2004","journal-title":"Hepatology"},{"key":"10.1016\/j.clinthera.2018.08.019_bib0004","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1002\/pds.758","article-title":"An approximate Bayesian risk-analysis for the gastro-intestinal safety of ibuprofen","volume":"11","author":"Wang","year":"2002","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"10.1016\/j.clinthera.2018.08.019_bib0005","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1056\/NEJMp1011512","article-title":"A flood of opioids, a rising tide of deaths","volume":"363","author":"Okie","year":"2010","journal-title":"N Engl J Med"},{"key":"10.1016\/j.clinthera.2018.08.019_bib0006","unstructured":"Washington State Agency Medical Directors\u2019 Group (AMDG). Interagency Guideline on Prescribing Opioids for Pain; 2015."},{"issue":"Supplement 100","key":"10.1016\/j.clinthera.2018.08.019_bib0007","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1177\/014107680710004801s01","article-title":"Ibuprofen: a journey from prescription to over-the-counter use","author":"Moore","year":"2007","journal-title":"J R Soc Med"},{"key":"10.1016\/j.clinthera.2018.08.019_bib0008","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1136\/bmj.312.7046.1563","article-title":"Variability in risk of gastrointestinal complications with individual non-steroidal anti-inflammatory drugs: results of a collaborative meta-analysis","volume":"312","author":"Henry","year":"1996","journal-title":"BMJ"},{"key":"10.1016\/j.clinthera.2018.08.019_bib0009","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1093\/bja\/aep338","article-title":"Combined acetaminophen and ibuprofen for pain relief after oral surgery in adults: a randomized controlled trial","volume":"104","author":"Merry","year":"2010","journal-title":"BJA Br J Anaesth"},{"key":"10.1016\/j.clinthera.2018.08.019_bib0010","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/j.clinthera.2010.06.002","volume":"32","author":"Mehlisch","year":"2010","journal-title":"Clin Ther"},{"key":"10.1016\/j.clinthera.2018.08.019_bib0011","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/j.clinthera.2010.04.022","volume":"32","author":"Mehlisch","year":"2010","journal-title":"Clin Ther"},{"key":"10.1016\/j.clinthera.2018.08.019_bib0012","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD010107.pub2","article-title":"Single dose oral ibuprofen plus paracetamol (acetaminophen) for acute postoperative pain. Cochrane Pain, Palliative and Supportive Care Group, ed","author":"Derry","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.clinthera.2018.08.019_bib0013","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/978-1-60327-323-7_15","article-title":"The value of the dental impaction pain model in drug development","volume":"617","author":"Cooper","year":"2010","journal-title":"Methods Mol Biol Clifton NJ"},{"key":"10.1016\/j.clinthera.2018.08.019_bib0014","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1007\/s00228-015-1827-x","article-title":"Combination paracetamol and ibuprofen for pain relief after oral surgery: a dose ranging study","volume":"71","author":"Atkinson","year":"2015","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1016\/j.clinthera.2018.08.019_bib0015","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/j.pain.2010.12.012","article-title":"A randomised, five-parallel-group, placebo-controlled trial comparing the efficacy and tolerability of analgesic combinations including a novel single-tablet combination of ibuprofen\/paracetamol for postoperative dental pain","volume":"152","author":"Daniels","year":"2011","journal-title":"PAIN"},{"key":"10.1016\/j.clinthera.2018.08.019_bib0016","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.joms.2013.09.029","article-title":"Changes in demographics of patients undergoing third molar surgery in a hospital setting between 1994 and 2012 and the influence of the National Institute for Health and Care Excellence Guidelines","volume":"72","author":"Petrosyan","year":"2014","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.clinthera.2018.08.019_bib0017","first-page":"10","article-title":"The pharmacokinetic profile of a novel fixed-dose combination tablet of ibuprofen and paracetamol","volume":"10","author":"Tanner","year":"2010","journal-title":"BMC Pharmacol Toxicol"},{"key":"10.1016\/j.clinthera.2018.08.019_bib0018","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1111\/j.1526-4637.2010.00983.x","article-title":"Causes and consequences of inadequate management of acute pain","volume":"11","author":"Sinatra","year":"2010","journal-title":"Pain Med"},{"key":"10.1016\/j.clinthera.2018.08.019_bib0019","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1002\/jhrm.21262","article-title":"Multimodal analgesia as an alternative to the risks of opioid monotherapy in surgical pain management","volume":"37","author":"Savarese","year":"2017","journal-title":"J Healthc Risk Manag"},{"key":"10.1016\/j.clinthera.2018.08.019_bib0020","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1111\/j.1524-4725.2011.02022.x","article-title":"A randomized controlled trial comparing acetaminophen, acetaminophen and ibuprofen, and acetaminophen and codeine for postoperative pain relief after Mohs surgery and cutaneous reconstruction","volume":"37","author":"Sniezek","year":"2011","journal-title":"Dermatol Surg"},{"key":"10.1016\/j.clinthera.2018.08.019_bib0021","doi-asserted-by":"crossref","first-page":"3792","DOI":"10.1245\/s10434-012-2447-7","article-title":"A randomized, controlled trial comparing acetaminophen plus ibuprofen versus acetaminophen plus codeine plus caffeine (Tylenol 3) after outpatient breast surgery","volume":"19","author":"Mitchell","year":"2012","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.clinthera.2018.08.019_bib0022","article-title":"Single dose oral analgesics for acute postoperative pain in adults\u2014an overview of Cochrane reviews","volume":"9","author":"Moore","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.clinthera.2018.08.019_bib0023","series-title":"Cochrane Database of Systematic Reviews","article-title":"Adverse events associated with single dose oral analgesics for acute postoperative pain in adults\u2014an overview of Cochrane reviews","author":"Moore","year":"2015"},{"key":"10.1016\/j.clinthera.2018.08.019_bib0024","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1111\/j.1365-2591.2004.00836.x","article-title":"The efficacy of pain control following nonsurgical root canal treatment using ibuprofen or a combination of ibuprofen and acetaminophen in a randomized, double-blind, placebo-controlled study","volume":"37","author":"Menhinick","year":"2004","journal-title":"Int Endod J"},{"key":"10.1016\/j.clinthera.2018.08.019_bib0025","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1136\/ard.2011.154047","article-title":"A randomised controlled trial of ibuprofen, paracetamol or a combination tablet of ibuprofen\/paracetamol in community-derived people with knee pain","volume":"70","author":"Doherty","year":"2011","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.clinthera.2018.08.019_bib0026","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1097\/00003643-200406000-00009","article-title":"Ibuprofen vs. acetaminophen vs. ibuprofen and acetaminophen after arthroscopically assisted anterior cruciate ligament reconstruction","volume":"21","author":"Dahl","year":"2004","journal-title":"Eur J Anaesthesiol"},{"key":"10.1016\/j.clinthera.2018.08.019_bib0027","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1016\/j.joen.2011.08.026","article-title":"Efficacy of ibuprofen and ibuprofen\/acetaminophen on postoperative pain in symptomatic patients with a pulpal diagnosis of necrosis","volume":"37","author":"Wells","year":"2011","journal-title":"J Endod"},{"key":"10.1016\/j.clinthera.2018.08.019_bib0028","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1016\/j.ajem.2013.06.007","article-title":"Ibuprofen vs acetaminophen vs their combination in the relief of musculoskeletal pain in the ED: a randomized, controlled trial","volume":"31","author":"Bondarsky","year":"2013","journal-title":"Am J Emerg Med"},{"key":"10.1016\/j.clinthera.2018.08.019_bib0029","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0192043","article-title":"Oral paracetamol and\/or ibuprofen for treating pain after soft tissue injuries: single centre double-blind, randomised controlled clinical trial. Bekelis K, ed","volume":"13","author":"Hung","year":"2018","journal-title":"PLOS ONE"}],"container-title":["Clinical Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149291818303825?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149291818303825?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,9,2]],"date-time":"2022-09-02T09:15:17Z","timestamp":1662110117000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0149291818303825"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":28,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["S0149291818303825"],"URL":"https:\/\/doi.org\/10.1016\/j.clinthera.2018.08.019","relation":{},"ISSN":["0149-2918"],"issn-type":[{"value":"0149-2918","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Analgesic Efficacy of an Acetaminophen\/Ibuprofen Fixed-dose Combination in Moderate to Severe Postoperative Dental Pain: A Randomized, Double-blind, Parallel-group, Placebo-controlled Trial","name":"articletitle","label":"Article Title"},{"value":"Clinical Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clinthera.2018.08.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 AFT Pharmaceuticals Ltd. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}