{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T02:44:03Z","timestamp":1780368243183,"version":"3.54.1"},"reference-count":22,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,4,18]],"date-time":"2020-04-18T00:00:00Z","timestamp":1587168000000},"content-version":"am","delay-in-days":383,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI-32247"],"award-info":[{"award-number":["AI-32247"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI-54478"],"award-info":[{"award-number":["AI-54478"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NS-075653"],"award-info":[{"award-number":["NS-075653"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","clinicaltherapeutics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Therapeutics"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1016\/j.clinthera.2018.12.016","type":"journal-article","created":{"date-parts":[[2019,2,19]],"date-time":"2019-02-19T21:34:51Z","timestamp":1550612091000},"page":"612-618","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":74,"title":["Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome and Fibromyalgia: Definitions, Similarities, and Differences"],"prefix":"10.1016","volume":"41","author":[{"given":"Benjamin H.","family":"Natelson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clinthera.2018.12.016_bib1","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1001\/archinte.159.18.2129","article-title":"A\u00a0community-based study of chronic fatigue syndrome","volume":"159","author":"Jason","year":"1999","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.clinthera.2018.12.016_bib2","first-page":"1570","article-title":"The London fibromyalgia epidemiology study: the prevalence of fibromyalgia syndrome in London, Ontario","volume":"26","author":"White","year":"1999","journal-title":"J\u00a0Rheumatol"},{"key":"10.1016\/j.clinthera.2018.12.016_bib3","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1046\/j.1365-2281.1999.00154.x","article-title":"Cardiovascular response during head-up tilt in chronic fatigue syndrome","volume":"19","author":"LaManca","year":"1999","journal-title":"Clin Physiol"},{"key":"10.1016\/j.clinthera.2018.12.016_bib4","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1002\/art.1780330203","article-title":"The American College of Rheumatology 1990 criteria for the classification of fibromyalgia: report of the Multicenter Criteria Committee","volume":"33","author":"Wolfe","year":"1990","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.clinthera.2018.12.016_bib5","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1002\/acr.20140","article-title":"The American College of Rheumatology preliminary diagnostic criteria for fibromyalgia and measurement of symptom severity","volume":"62","author":"Wolfe","year":"2010","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"10.1016\/j.clinthera.2018.12.016_bib6","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1097\/SCS.0b013e31824cd81a","article-title":"Signs and symptoms of temporomandibular dysfunction in fibromyalgic patients","volume":"23","author":"Fraga","year":"2012","journal-title":"J\u00a0Craniofac Surg"},{"key":"10.1016\/j.clinthera.2018.12.016_bib7","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1097\/01.PSY.0000033125.08272.A9","article-title":"Comorbid illness in the chronic fatigue syndrome: a test of the single syndrome hypothesis","volume":"62","author":"Ciccone","year":"2003","journal-title":"Psychosom Med"},{"key":"10.1016\/j.clinthera.2018.12.016_bib8","doi-asserted-by":"crossref","first-page":"910","DOI":"10.7326\/0003-4819-130-11-199906010-00016","article-title":"Functional somatic syndromes","volume":"130","author":"Barsky","year":"1999","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.clinthera.2018.12.016_bib9","first-page":"47","article-title":"Comparing two fibromyalgia diagnostic criteria in a cohort of chronic fatigue syndrome patients","volume":"19","author":"Kaseeska","year":"2011","journal-title":"Bull IACFS\/ME"},{"key":"10.1016\/j.clinthera.2018.12.016_bib10","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0304-3959(98)00134-1","article-title":"Chronic fatigue syndrome differs from fibromyalgia: no evidence for elevated substance P levels in cerebrospinal fluid of patients with chronic fatigue syndrome","volume":"78","author":"Eveng\u00e5rd","year":"1998","journal-title":"Pain"},{"key":"10.1016\/j.clinthera.2018.12.016_bib11","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1124\/jpet.115.230060","article-title":"Neuropeptides CRH, SP, HK-1, and inflammatory cytokines IL-6 and TNF are increased in serum of patients with fibromyalgia syndrome, implicating mast cells","volume":"356","author":"Tsilioni","year":"2016","journal-title":"J\u00a0Pharmacol Exp Ther"},{"key":"10.1016\/j.clinthera.2018.12.016_bib12","first-page":"195","article-title":"Low-grade chronic inflammation mediated by mast cells in fibromyalgia: role of IL-37","volume":"32","author":"Mastrangelo","year":"2018","journal-title":"J\u00a0Biol Regulat Homeost Agents"},{"key":"10.1016\/j.clinthera.2018.12.016_bib13","first-page":"3","article-title":"Is chronic fatigue syndrome the same illness as fibromyalgia: evaluating the \u2018single syndrome\u2019 hypothesis","volume":"106","author":"Abbi","year":"2013","journal-title":"Q\u00a0J Med"},{"key":"10.1016\/j.clinthera.2018.12.016_bib14","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1249\/01.mss.0000179921.48404.ef","article-title":"Exercise and cognitive performance in chronic fatigue syndrome","volume":"37","author":"Cook","year":"2005","journal-title":"Med Sci Sports Exerc"},{"key":"10.1016\/j.clinthera.2018.12.016_bib15","first-page":"6","article-title":"Sex differences in plasma prolactin response to tryptophan in Chronic Fatigue Syndrome patients with and without comorbid fibromyalgia","volume":"3","author":"Weaver","year":"2010","journal-title":"J\u00a0Womens Health (Larchmt)"},{"key":"10.1016\/j.clinthera.2018.12.016_bib16","article-title":"Responses to exercise differ for chronic fatigue syndrome patients with fibromyalgia","author":"Cook","year":"2012","journal-title":"MedSciSports Exerc"},{"key":"10.1016\/j.clinthera.2018.12.016_bib17","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1017\/S0033291703008894","article-title":"Post-traumatic stress disorder among patients with chronic pain and chronic fatigue","volume":"34","author":"Roy-Byrne","year":"2004","journal-title":"Psychol Med"},{"key":"10.1016\/j.clinthera.2018.12.016_bib18","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/s12883-015-0308-2","article-title":"Chronic fatigue syndrome and fibromyalgia in diagnosed sleep disorders: a further test of the \u2018unitary\u2019 hypothesis","volume":"15","author":"Pejovic","year":"2015","journal-title":"BMC Neurol"},{"key":"10.1016\/j.clinthera.2018.12.016_bib19","first-page":"1551","article-title":"Sleep-stage dynamics in patients with chronic fatigue syndrome with or without fibromyalgia","volume":"34","author":"Kishi","year":"2011","journal-title":"Sleep"},{"key":"10.1016\/j.clinthera.2018.12.016_bib20","doi-asserted-by":"crossref","first-page":"R1980","DOI":"10.1152\/ajpregu.00925.2007","article-title":"Dynamics of sleep stage transitions in healthy humans and patients with chronic fatigue syndrome","volume":"294","author":"Kishi","year":"2008","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.clinthera.2018.12.016_bib21","doi-asserted-by":"crossref","first-page":"R461","DOI":"10.1016\/j.cub.2011.05.012","article-title":"Rocking synchronizes brain waves during a short nap","volume":"21","author":"Bayer","year":"2011","journal-title":"Curr Biol"},{"key":"10.1016\/j.clinthera.2018.12.016_bib22","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0017287","article-title":"Distinct cerebrospinal fluid proteomes differentiate post-treatment lyme disease from chronic fatigue syndrome","volume":"6","author":"Schutzer","year":"2011","journal-title":"PLoS One"}],"container-title":["Clinical Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149291819300037?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149291819300037?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T19:21:48Z","timestamp":1777490508000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0149291819300037"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["S0149291819300037"],"URL":"https:\/\/doi.org\/10.1016\/j.clinthera.2018.12.016","relation":{},"ISSN":["0149-2918"],"issn-type":[{"value":"0149-2918","type":"print"}],"subject":[],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome and Fibromyalgia: Definitions, Similarities, and Differences","name":"articletitle","label":"Article Title"},{"value":"Clinical Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clinthera.2018.12.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}