{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:52:48Z","timestamp":1787068368635,"version":"build-2736575974"},"reference-count":38,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","clinicaltherapeutics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Therapeutics"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1016\/j.clinthera.2019.02.003","type":"journal-article","created":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T22:15:06Z","timestamp":1551478506000},"page":"582-590.e3","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"title":["Colchicine for Stroke Prevention: A Systematic Review and Meta-analysis"],"prefix":"10.1016","volume":"41","author":[{"given":"Chinmay","family":"Khandkar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaivan","family":"Vaidya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clinthera.2019.02.003_bib1","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1007\/s11926-008-0036-3","article-title":"Colchicine: its mechanism of action and efficacy in crystal-induced inflammation","volume":"10","author":"Nuki","year":"2008","journal-title":"Curr Rheumatol Rep"},{"key":"10.1016\/j.clinthera.2019.02.003_bib2","doi-asserted-by":"crossref","first-page":"2921","DOI":"10.1093\/eurheartj\/ehv318","volume":"36","author":"Adler","year":"2015","journal-title":"Eur Heart J"},{"key":"10.1016\/j.clinthera.2019.02.003_bib3","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.amjmed.2014.12.010","article-title":"Colchicine: old and new","volume":"128","author":"Slobodnick","year":"2015","journal-title":"Am J Med"},{"key":"10.1016\/j.clinthera.2019.02.003_bib4","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1016\/j.jacc.2013.08.726","article-title":"Colchicine and the heart: pushing the envelope","volume":"62","author":"Deftereos","year":"2013","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.clinthera.2019.02.003_bib5","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1093\/eurheartj\/ehu203","article-title":"Anti-inflammatory therapies for cardiovascular disease","volume":"35","author":"Ridker","year":"2014","journal-title":"Eur Heart J"},{"key":"10.1016\/j.clinthera.2019.02.003_bib6","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.clinthera.2018.07.023","article-title":"The role of colchicine in acute coronary syndromes","volume":"41","author":"Vaidya","year":"2019","journal-title":"Clin Ther"},{"key":"10.1016\/j.clinthera.2019.02.003_bib7","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1056\/NEJMoa1707914","article-title":"Antiinflammatory therapy with canakinumab for atherosclerotic disease","volume":"377","author":"Ridker","year":"2017","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.clinthera.2019.02.003_bib8","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1212\/WNL.0000000000001099","article-title":"Optimal combination secondary prevention drug treatment and stroke outcomes","volume":"84","author":"Park","year":"2015","journal-title":"Neurology"},{"key":"10.1016\/j.clinthera.2019.02.003_bib9","doi-asserted-by":"crossref","first-page":"e1000097","DOI":"10.1371\/journal.pmed.1000097","article-title":"The PG: Preferred Reporting Items for Systematic Reviews and Meta-Analyses: the PRISMA statement","volume":"6","author":"Moher","year":"2009","journal-title":"PLOS Med"},{"key":"10.1016\/j.clinthera.2019.02.003_bib10","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.d5928","article-title":"The Cochrane Collaboration's tool for assessing risk of bias in randomised trials","volume":"343","author":"Higgins","year":"2011","journal-title":"BMJ"},{"key":"10.1016\/j.clinthera.2019.02.003_bib11","series-title":"10.4.1 Funnel Plots, Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0","author":"Higgens","year":"2011"},{"key":"10.1016\/j.clinthera.2019.02.003_bib12","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1016\/j.jacc.2013.01.055","article-title":"Colchicine treatment for the prevention of bare-metal stent restenosis in diabetic patients","volume":"61","author":"Deftereos","year":"2013","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.clinthera.2019.02.003_bib13","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1001\/jama.2014.11026","article-title":"Colchicine for prevention of postpericardiotomy syndrome and postoperative atrial fibrillation: the COPPS-2 randomized clinical trial","volume":"312","author":"Imazio","year":"2014","journal-title":"JAMA"},{"key":"10.1016\/j.clinthera.2019.02.003_bib14","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.jacc.2012.10.027","article-title":"Low-dose colchicine for secondary prevention of cardiovascular disease","volume":"61","author":"Nidorf","year":"2013","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.clinthera.2019.02.003_bib15","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1007\/s11239-011-0637-y","article-title":"Effect of colchicine compared with placebo on high sensitivity C-reactive protein in patients with acute coronary syndrome or acute stroke: a pilot randomized controlled trial","volume":"33","author":"Raju","year":"2012","journal-title":"J\u00a0Thromb Thrombolysis"},{"key":"10.1016\/j.clinthera.2019.02.003_bib16","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1136\/annrheumdis-2015-207984","article-title":"The effects of colchicine on risk of cardiovascular events and mortality among patients with gout: a cohort study using electronic medical records linked with Medicare claims","volume":"75","author":"Solomon","year":"2016","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.clinthera.2019.02.003_bib17","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.atherosclerosis.2017.12.027","article-title":"The NLRP3 inflammasome and the emerging role of colchicine to inhibit atherosclerosis-associated inflammation","volume":"269","author":"Martinez","year":"2018","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.clinthera.2019.02.003_bib18","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1042\/CS20160090","article-title":"Colchicine therapy in acute coronary syndrome patients acts on caspase-1 to suppress NLRP3 inflammasome monocyte activation","volume":"130","author":"Robertson","year":"2016","journal-title":"Clin Sci (Lond)"},{"key":"10.1016\/j.clinthera.2019.02.003_bib19","doi-asserted-by":"crossref","first-page":"668","DOI":"10.2174\/1381612824666180116100310","article-title":"The role of colchicine in the prevention of cerebrovascular ischemia","volume":"24","author":"Tsivgoulis","year":"2018","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.clinthera.2019.02.003_bib20","doi-asserted-by":"crossref","first-page":"e002128","DOI":"10.1161\/JAHA.115.002128","article-title":"Colchicine acutely suppresses local cardiac production of inflammatory cytokines in patients with an acute coronary syndrome","volume":"4","author":"Martinez","year":"2015","journal-title":"J\u00a0Am Heart Assoc"},{"key":"10.1016\/j.clinthera.2019.02.003_bib21","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.jcmg.2017.08.013","article-title":"Colchicine therapy and plaque stabilization in patients with acute coronary syndrome: a CT coronary angiography study","volume":"11","author":"Vaidya","year":"2018","journal-title":"JACC Cardiovasc Imag"},{"key":"10.1016\/j.clinthera.2019.02.003_bib22","first-page":"CD011047","article-title":"Colchicine for prevention of cardiovascular events","volume":"1","author":"Hemkens","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.clinthera.2019.02.003_bib23","doi-asserted-by":"crossref","first-page":"2686","DOI":"10.1002\/1529-0131(200111)44:11<2686::AID-ART448>3.0.CO;2-H","article-title":"A\u00a0double-blind trial of colchicine in Behcet's syndrome","volume":"44","author":"Yurdakul","year":"2001","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.clinthera.2019.02.003_bib24","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.jclinepi.2010.04.026","article-title":"GRADE guidelines: 1. Introduction-GRADE evidence profiles and summary of findings tables","volume":"64","author":"Guyatt","year":"2011","journal-title":"J\u00a0Clin Epidemiol"},{"key":"10.1016\/j.clinthera.2019.02.003_bib25","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1056\/NEJMoa040583","article-title":"Intensive versus moderate lipid lowering with statins after acute coronary syndromes","volume":"350","author":"Cannon","year":"2004","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.clinthera.2019.02.003_bib26","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.jacc.2015.11.052","article-title":"Statins for prevention of cardiovascular events in a low-risk population with low ankle brachial index","volume":"67","author":"Ramos","year":"2016","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.clinthera.2019.02.003_bib27","first-page":"379","article-title":"Prevalence of stroke\u2014United States, 2006-2010","volume":"61","author":"Centers for Disease Control and Prevention (CDC)","year":"2012","journal-title":"MMWR Morbid Mortal W"},{"key":"10.1016\/j.clinthera.2019.02.003_bib28","doi-asserted-by":"crossref","first-page":"e020285","DOI":"10.1136\/bmjopen-2017-020285","article-title":"Prevalence of stroke, risk factors, disability and care needs in older adults in Singapore: results from the WiSE study","volume":"28","author":"Teh","year":"2018","journal-title":"BMJ Open"},{"key":"10.1016\/j.clinthera.2019.02.003_bib29","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","article-title":"Measuring inconsistency in meta-analyses","volume":"327","author":"Higgins","year":"2003","journal-title":"BMJ"},{"key":"10.1016\/j.clinthera.2019.02.003_bib30","series-title":"I2 is Subject to the Same Statistical Power Problems as Cochran's Q","author":"Huendo-Medina","year":"2007"},{"key":"10.1016\/j.clinthera.2019.02.003_bib31","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1161\/01.STR.0000181754.38408.4c","article-title":"Associations of inflammatory and hemostatic variables with the risk of recurrent stroke","volume":"36","author":"Woodward","year":"2005","journal-title":"Stroke"},{"key":"10.1016\/j.clinthera.2019.02.003_bib32","doi-asserted-by":"crossref","first-page":"2290","DOI":"10.1161\/CIRCULATIONAHA.111.026153","article-title":"Colchicine reduces postoperative atrial fibrillation: results of the Colchicine for the Prevention of the Postpericardiotomy Syndrome (COPPS) atrial fibrillation substudy","volume":"124","author":"Imazio","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.clinthera.2019.02.003_bib33","doi-asserted-by":"crossref","first-page":"A757","DOI":"10.1016\/j.jval.2014.08.236","article-title":"Association of colchicine with primary and secondary cardiovascular events in peritoneal dialysis patients: a propensity score analysis","volume":"17","author":"Nochaiwong","year":"2014","journal-title":"Value Health"},{"key":"10.1016\/j.clinthera.2019.02.003_bib34","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1186\/s12872-015-0068-3","article-title":"Colchicine in cardiac disease: a systematic review and meta-analysis of randomized controlled trials","volume":"15","author":"Verma","year":"2015","journal-title":"BMC Cardiovas Disor"},{"key":"10.1016\/j.clinthera.2019.02.003_bib35","series-title":"NCT02898610\u2013CONVINCE \u2013(COlchicine for preventioN of Vascular Inflammation in Non-CardioEmbolic Stroke)\u2014A Randomised Clinical Trial of Low-Dose Colchicine for Secondary Prevention after Stroke","year":"2016"},{"key":"10.1016\/j.clinthera.2019.02.003_bib36","article-title":"ACTRN12614000093684\u2014 The LoDoCo2 trial: a randomised controlled trial on the effect of low dose colchicine for secondary prevention of cardiovascular disease in patients with established","author":"Australian and New Zealand Clincal Trials Registry","year":"2014","journal-title":"Stable Coronary Artery Disease"},{"key":"10.1016\/j.clinthera.2019.02.003_bib37","series-title":"NCT01906749\u2013Colchicine for Acute Coronary Syndromes (COACS)","author":"US National Library of Medicine","year":"2013"},{"key":"10.1016\/j.clinthera.2019.02.003_bib38","series-title":"ACTRN12615000861550\u2014The Australian COPS Trial\u2014COlchicine in Patients with Acute Coronary Syndromes","year":"2015"}],"container-title":["Clinical Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149291819300608?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149291819300608?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T23:28:45Z","timestamp":1694647725000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0149291819300608"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":38,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["S0149291819300608"],"URL":"https:\/\/doi.org\/10.1016\/j.clinthera.2019.02.003","relation":{},"ISSN":["0149-2918"],"issn-type":[{"value":"0149-2918","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Colchicine for Stroke Prevention: A Systematic Review and Meta-analysis","name":"articletitle","label":"Article Title"},{"value":"Clinical Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clinthera.2019.02.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Crown Copyright \u00a9 2019 Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}