{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T05:40:21Z","timestamp":1784698821771,"version":"3.55.0"},"reference-count":85,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100006315","name":"Dutch Arthritis Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006315","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","clinicaltherapeutics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Therapeutics"],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1016\/j.clinthera.2019.04.017","type":"journal-article","created":{"date-parts":[[2019,6,9]],"date-time":"2019-06-09T23:59:06Z","timestamp":1560124746000},"page":"1286-1298","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"title":["Predicting Rheumatoid Arthritis in At-risk Individuals"],"prefix":"10.1016","volume":"41","author":[{"given":"Laurette","family":"van Boheemen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirkjan","family":"van Schaardenburg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.clinthera.2019.04.017_bib1","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1016\/j.clinthera.2019.04.028","article-title":"The natural history of rheumatoid arthritis","volume":"41","author":"Deane","year":"2019","journal-title":"Clin Ther"},{"key":"10.1016\/j.clinthera.2019.04.017_bib2","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.rdc.2014.07.001","article-title":"Preclinical inflammatory rheumatic diseases: an overview and relevant nomenclature","volume":"40","author":"Raza","year":"2014","journal-title":"Rheum Dis Clin North Am"},{"key":"10.1016\/j.clinthera.2019.04.017_bib3","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1002\/art.20018","article-title":"Specific autoantibodies precede the symptoms of rheumatoid arthritis: a study of serial measurements in blood donors","volume":"50","author":"Nielen","year":"2004","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.clinthera.2019.04.017_bib4","doi-asserted-by":"crossref","first-page":"3226","DOI":"10.1002\/art.30537","article-title":"Development of the anti-citrullinated protein antibody repertoire prior to the onset of rheumatoid arthritis","volume":"63","author":"van de Stadt","year":"2011","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.clinthera.2019.04.017_bib5","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1136\/annrheumdis-2013-203565","article-title":"Anti-citrullinated protein antibodies acquire a pro-inflammatory Fc glycosylation phenotype prior to the onset of rheumatoid arthritis","volume":"74","author":"Rombouts","year":"2015","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.clinthera.2019.04.017_bib6","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.1002\/art.20431","article-title":"Increased levels of C-reactive protein in serum from blood donors before the onset of rheumatoid arthritis","volume":"50","author":"Nielen","year":"2004","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.clinthera.2019.04.017_bib7","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1002\/art.30655","article-title":"Macrophage positron emission tomography imaging as a biomarker for preclinical rheumatoid arthritis: findings of a prospective pilot study","volume":"64","author":"Gent","year":"2012","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.clinthera.2019.04.017_bib8","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0140-6736(97)01300-7","article-title":"Randomised comparison of combined step-down prednisolone, methotrexate and sulphasalazine with sulphasalazine alone in early rheumatoid arthritis","volume":"350","author":"Boers","year":"1997","journal-title":"Lancet"},{"key":"10.1016\/j.clinthera.2019.04.017_bib9","doi-asserted-by":"crossref","first-page":"3381","DOI":"10.1002\/art.21405","article-title":"Clinical and radiographic outcomes of four different treatment strategies in patients with early rheumatoid arthritis (the BeSt study): a randomized, controlled trial","volume":"52","author":"Goekoop-Ruiterman","year":"2005","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.clinthera.2019.04.017_bib10","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1093\/oxfordjournals.aje.a112878","article-title":"The epidemiology of rheumatoid arthritis in Rochester, Minnesota: a study of incidence, prevalence, and mortality","volume":"111","author":"Linos","year":"1980","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.clinthera.2019.04.017_bib11","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/nrrheum.2016.52","article-title":"Family history of rheumatoid arthritis: an old concept with new developments","volume":"12","author":"Frisell","year":"2016","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.clinthera.2019.04.017_bib12","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/j.semarthrit.2004.08.003","article-title":"Rheumatoid arthritis in American Indians and Alaska Natives: a review of the literature","volume":"34","author":"Ferucci","year":"2005","journal-title":"Semin Arthritis Rheum"},{"key":"10.1016\/j.clinthera.2019.04.017_bib13","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.berh.2017.08.003","article-title":"Genetic and environmental risk factors for rheumatoid arthritis","volume":"31","author":"Deane","year":"2017","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"10.1016\/j.clinthera.2019.04.017_bib14","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1038\/nrrheum.2014.109","article-title":"PTPN22: the archetypal non-HLA autoimmunity gene","volume":"10","author":"Stanford","year":"2014","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.clinthera.2019.04.017_bib15","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.jaut.2015.07.007","article-title":"Immunogenetics of rheumatoid arthritis: understanding functional implications","volume":"64","author":"Messemaker","year":"2015","journal-title":"J\u00a0Autoimmun"},{"key":"10.1016\/j.clinthera.2019.04.017_bib16","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.ajhg.2010.12.007","article-title":"Genetic basis of autoantibody positive and negative rheumatoid arthritis risk in a multi-ethnic cohort derived from electronic health records","volume":"88","author":"Kurreeman","year":"2011","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.clinthera.2019.04.017_bib17","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.rdc.2014.07.005","article-title":"Genetics, environment, and gene-environment interactions in the development of systemic rheumatic diseases","volume":"40","author":"Sparks","year":"2014","journal-title":"Rheum Dis Clin North Am"},{"key":"10.1016\/j.clinthera.2019.04.017_bib18","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1136\/ard.2008.096487","article-title":"Impact of smoking as a risk factor for developing rheumatoid arthritis: a meta-analysis of observational studies","volume":"69","author":"Sugiyama","year":"2010","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.clinthera.2019.04.017_bib19","doi-asserted-by":"crossref","first-page":"2611","DOI":"10.1002\/art.39228","article-title":"Interactions between amino acid-defined major histocompatibility complex class II variants and smoking in seropositive rheumatoid arthritis","volume":"67","author":"Kim","year":"2015","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.clinthera.2019.04.017_bib20","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1093\/rheumatology\/keu287","article-title":"Strategies to predict rheumatoid arthritis development in at-risk populations","volume":"55","author":"Karlson","year":"2016","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.clinthera.2019.04.017_bib21","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.berh.2015.09.001","article-title":"How does established rheumatoid arthritis develop, and are there possibilities for prevention?","volume":"29","author":"van Beers-Tas","year":"2015","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"10.1016\/j.clinthera.2019.04.017_bib22","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1007\/s00281-017-0624-2","article-title":"Environmental factors and hormones in the development of rheumatoid arthritis","volume":"39","author":"Alpizar-Rodriguez","year":"2017","journal-title":"Semin Immunopathol"},{"key":"10.1016\/j.clinthera.2019.04.017_bib23","doi-asserted-by":"crossref","first-page":"e2859","DOI":"10.1097\/MD.0000000000002859","article-title":"Body mass index and risk of rheumatoid arthritis: a meta-analysis of observational studies","volume":"95","author":"Feng","year":"2016","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.clinthera.2019.04.017_bib24","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/s13075-015-0601-x","article-title":"Body mass index and the risk of rheumatoid arthritis: a systematic review and dose-response meta-analysis","volume":"17","author":"Qin","year":"2015","journal-title":"Arthritis Res Ther"},{"issue":"3","key":"10.1016\/j.clinthera.2019.04.017_bib25","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1093\/rheumatology\/ker299","article-title":"Modifiable risk factors for RA: prevention, better than cure?","volume":"51","author":"Lahiri","year":"2012","journal-title":"Rheumatology (Oxford)"},{"issue":"8","key":"10.1016\/j.clinthera.2019.04.017_bib26","first-page":"1254","article-title":"The role of female hormonal factors in the development of rheumatoid arthritis","volume":"56","author":"Alpizar-Rodriguez","year":"2017","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.clinthera.2019.04.017_bib27","doi-asserted-by":"crossref","first-page":"959","DOI":"10.3945\/ajcn.114.086918","article-title":"Sugar-sweetened soda consumption and risk of developing rheumatoid arthritis in women","volume":"100","author":"Hu","year":"2014","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.clinthera.2019.04.017_bib28","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1186\/s13075-014-0446-8","article-title":"Fish consumption and risk of rheumatoid arthritis: a dose-response meta-analysis","volume":"16","author":"Di Giuseppe","year":"2014","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.clinthera.2019.04.017_bib29","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.3899\/jrheum.150195","article-title":"Breastfeeding and risk of rheumatoid arthritis: a systematic review and metaanalysis","volume":"42","author":"Chen","year":"2015","journal-title":"J\u00a0Rheumatol"},{"key":"10.1016\/j.clinthera.2019.04.017_bib30","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1111\/jog.13370","article-title":"Number of parity and the risk of rheumatoid arthritis in women: a dose-response meta-analysis of observational studies","volume":"43","author":"Ren","year":"2017","journal-title":"J\u00a0Obstet Gynaecol Res"},{"key":"10.1016\/j.clinthera.2019.04.017_bib31","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1111\/1756-185X.12413","article-title":"Absence of protective effect of oral contraceptive use on the development of rheumatoid arthritis: a meta-analysis of observational studies","volume":"17","author":"Chen","year":"2014","journal-title":"Int J Rheum Dis"},{"key":"10.1016\/j.clinthera.2019.04.017_bib32","first-page":"915","article-title":"Meta-analysis of oral contraceptives and rheumatoid arthritis risk in women","volume":"10","author":"Qi","year":"2014","journal-title":"Ther Clin Risk Manag"},{"key":"10.1016\/j.clinthera.2019.04.017_bib33","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1007\/s10067-012-2080-7","article-title":"Association between vitamin D intake and the risk of rheumatoid arthritis: a meta-analysis","volume":"31","author":"Song","year":"2012","journal-title":"Clin Rheumatol"},{"key":"10.1016\/j.clinthera.2019.04.017_bib34","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1093\/aje\/kwf205","article-title":"Antioxidant micronutrients and risk of rheumatoid arthritis in a cohort of older women","volume":"157","author":"Cerhan","year":"2003","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.clinthera.2019.04.017_bib35","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1093\/aje\/kwq089","article-title":"Antioxidant intake and risks of rheumatoid arthritis and systemic lupus erythematosus in women","volume":"172","author":"Costenbader","year":"2010","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.clinthera.2019.04.017_bib36","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1136\/annrheumdis-2016-210431","article-title":"Long-term dietary quality and risk of developing rheumatoid arthritis in women","volume":"76","author":"Hu","year":"2017","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.clinthera.2019.04.017_bib37","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s10067-018-4261-5","article-title":"Inflammatory dietary pattern and risk of developing rheumatoid arthritis in women","volume":"38","author":"Sparks","year":"2019","journal-title":"Clin Rheumatol"},{"key":"10.1016\/j.clinthera.2019.04.017_bib38","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1136\/annrheumdis-2012-202254","article-title":"Smoking and overweight determine the likelihood of developing rheumatoid arthritis","volume":"72","author":"de Hair","year":"2013","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.clinthera.2019.04.017_bib39","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1136\/annrheumdis-2012-202481","article-title":"Using lifestyle factors to identify individuals at higher risk of inflammatory polyarthritis (results from the European Prospective Investigation of Cancer-Norfolk and the Norfolk Arthritis Register--the EPIC-2-NOAR Study)","volume":"73","author":"Lahiri","year":"2014","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.clinthera.2019.04.017_bib40","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0122121","article-title":"Periodontitis and Porphyromonas gingivalis in preclinical stage of arthritis patients","volume":"10","author":"Hashimoto","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.clinthera.2019.04.017_bib41","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.3899\/jrheum.091398","article-title":"A\u00a0prospective study of periodontal disease and risk of rheumatoid arthritis","volume":"37","author":"Arkema","year":"2010","journal-title":"J\u00a0Rheumatol"},{"key":"10.1016\/j.clinthera.2019.04.017_bib42","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1136\/annrheumdis-2013-204594","article-title":"Antibodies against Porphyromonas gingivalis in seropositive arthralgia patients do not predict development of rheumatoid arthritis","volume":"73","author":"de Smit","year":"2014","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.clinthera.2019.04.017_bib43","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0024380","article-title":"Genetic risk score predicting risk of rheumatoid arthritis phenotypes and age of symptom onset","volume":"6","author":"Chibnik","year":"2011","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.clinthera.2019.04.017_bib44","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1186\/s13075-018-1767-9","article-title":"The value of joint ultrasonography in predicting arthritis in seropositive arthralgia patients: a prospective cohort study","volume":"20","author":"van Beers-Tas","year":"2018","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.clinthera.2019.04.017_bib45","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1136\/ard.2009.120170","article-title":"Cumulative association of 22 genetic variants with seropositive rheumatoid arthritis risk","volume":"69","author":"Karlson","year":"2010","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.clinthera.2019.04.017_bib46","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1002\/acr.22005","article-title":"Association of environmental and genetic factors and gene-environment interactions with risk of developing rheumatoid arthritis","volume":"65","author":"Karlson","year":"2013","journal-title":"Arthritis Care Res (Hoboken)."},{"key":"10.1016\/j.clinthera.2019.04.017_bib47","doi-asserted-by":"crossref","DOI":"10.1371\/annotation\/a86ab397-f58c-4144-a241-4957836a728a","article-title":"Predicting the risk of rheumatoid arthritis and its age of onset through modelling genetic risk variants with smoking","volume":"9","author":"Scott","year":"2013","journal-title":"Plos Genet"},{"key":"10.1016\/j.clinthera.2019.04.017_bib48","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1136\/annrheumdis-2013-205009","article-title":"Improved performance of epidemiologic and genetic risk models for rheumatoid arthritis serologic phenotypes using family history","volume":"74","author":"Sparks","year":"2015","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.clinthera.2019.04.017_bib49","doi-asserted-by":"crossref","first-page":"2741","DOI":"10.1002\/art.11223","article-title":"Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis","volume":"48","author":"Rantapaa-Dahlqvist","year":"2003","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.clinthera.2019.04.017_bib50","doi-asserted-by":"crossref","first-page":"R13","DOI":"10.1186\/ar3237","article-title":"Antibodies of IgG, IgA and IgM isotypes against cyclic citrullinated peptide precede the development of rheumatoid arthritis","volume":"13","author":"Kokkonen","year":"2011","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.clinthera.2019.04.017_bib51","doi-asserted-by":"crossref","first-page":"R159","DOI":"10.1186\/ar4342","article-title":"Anti-citrullinated peptide autoantibodies, human leukocyte antigen shared epitope and risk of future rheumatoid arthritis: a nested case-control study","volume":"15","author":"Arkema","year":"2013","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.clinthera.2019.04.017_bib52","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1002\/art.37835","article-title":"Multiplex analyses of antibodies against citrullinated peptides in individuals prior to development of rheumatoid arthritis","volume":"65","author":"Brink","year":"2013","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.clinthera.2019.04.017_bib53","doi-asserted-by":"crossref","DOI":"10.1371\/annotation\/2e462817-ab93-4d78-95a4-1d8b9d172971","article-title":"Autoantibody epitope spreading in the pre-clinical phase predicts progression to rheumatoid arthritis","volume":"7","author":"Sokolove","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.clinthera.2019.04.017_bib54","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.berh.2017.07.005","article-title":"Evolution of autoantibody responses in individuals at risk of rheumatoid arthritis","volume":"31","author":"WJJ","year":"2017","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"10.1016\/j.clinthera.2019.04.017_bib55","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1136\/annrheumdis-2014-205227","article-title":"Predicting the development of clinical arthritis in anti-CCP positive individuals with non-specific musculoskeletal symptoms: a prospective observational cohort study","volume":"74","author":"Rakieh","year":"2015","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.clinthera.2019.04.017_bib56","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1136\/ard.2008.105759","article-title":"Arthritis development in patients with arthralgia is strongly associated with anti-citrullinated protein antibody status: a prospective cohort study","volume":"69","author":"Bos","year":"2010","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.clinthera.2019.04.017_bib57","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1136\/annrheumdis-2017-212763","article-title":"Effects of B-cell directed therapy on the preclinical stage of rheumatoid arthritis: the PRAIRI study","volume":"78","author":"Gerlag","year":"2019","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.clinthera.2019.04.017_bib58","doi-asserted-by":"crossref","first-page":"2837","DOI":"10.1002\/art.39297","article-title":"Autoantibodies in prediction of the development of rheumatoid arthritis among healthy relatives of patients with the disease","volume":"67","author":"Ramos-Remus","year":"2015","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.clinthera.2019.04.017_bib59","doi-asserted-by":"crossref","first-page":"2633","DOI":"10.1002\/art.27570","article-title":"Autoimmunity to peptidyl arginine deiminase type 4 precedes clinical onset of rheumatoid arthritis","volume":"62","author":"Kolfenbach","year":"2010","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.clinthera.2019.04.017_bib60","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1136\/annrheumdis-2013-204154","article-title":"Anti-carbamylated protein (anti-CarP) antibodies precede the onset of rheumatoid arthritis","volume":"73","author":"Shi","year":"2014","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.clinthera.2019.04.017_bib61","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1002\/art.38335","article-title":"Antibodies to IgG4 hinge can be found in rheumatoid arthritis patients during all stages of disease and may exacerbate chronic antibody-mediated inflammation","volume":"66","author":"van de Stadt","year":"2014","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.clinthera.2019.04.017_bib62","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1002\/art.37830","article-title":"Anti-carbamylated protein antibodies are present in arthralgia patients and predict the development of rheumatoid arthritis","volume":"65","author":"Shi","year":"2013","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.clinthera.2019.04.017_bib63","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1002\/art.40562","article-title":"Triple positivity for anti-citrullinated protein autoantibodies, rheumatoid factor, and anti-carbamylated protein antibodies conferring high specificity for rheumatoid arthritis: implications for very early identification of at-risk individuals","volume":"70","author":"Verheul","year":"2018","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.clinthera.2019.04.017_bib64","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1111\/jep.12614","article-title":"Prevalence, diagnostics and management of musculoskeletal disorders in primary health care in Sweden - an investigation of 2000 randomly selected patient records","volume":"23","author":"Wiitavaara","year":"2017","journal-title":"J\u00a0Eval Clin Pract"},{"key":"10.1016\/j.clinthera.2019.04.017_bib65","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1002\/art.38022","article-title":"Relatives without rheumatoid arthritis show reactivity to anti-citrullinated protein\/peptide antibodies that are associated with arthritis-related traits: studies of the etiology of rheumatoid arthritis","volume":"65","author":"Young","year":"2013","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.clinthera.2019.04.017_bib66","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1136\/annrheumdis-2017-211351","article-title":"Dominant B cell receptor clones in peripheral blood predict onset of arthritis in individuals at risk for rheumatoid arthritis","volume":"76","author":"Tak","year":"2017","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.clinthera.2019.04.017_bib67","first-page":"151","article-title":"OP0204 Dominant B cell receptor clones in peripheral blood predict onset of arthritis in individuals at risk for rheumatoid arthritis: a validation cohort","volume":"77","author":"Musters","year":"2018","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.clinthera.2019.04.017_bib68","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1136\/annrheumdis-2012-202127","article-title":"A\u00a0prediction rule for the development of arthritis in seropositive arthralgia patients","volume":"72","author":"van de Stadt","year":"2013","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.clinthera.2019.04.017_bib69","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1093\/rheumatology\/keu159","article-title":"Symptom complexes in patients with seropositive arthralgia and in patients newly diagnosed with rheumatoid arthritis: a qualitative exploration of symptom development","volume":"53","author":"Stack","year":"2014","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.clinthera.2019.04.017_bib70","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1186\/s13075-015-0616-3","article-title":"Reappraisal of the diagnostic and prognostic value of morning stiffness in arthralgia and early arthritis: results from the Groningen EARC, Leiden EARC, ESPOIR, Leiden EAC and REACH","volume":"17","author":"van Nies","year":"2015","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.clinthera.2019.04.017_bib71","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1093\/rheumatology\/kev431","article-title":"Clinical expertise and its accuracy in differentiating arthralgia patients at risk for rheumatoid arthritis from other patients presenting with joint symptoms","volume":"55","author":"van Steenbergen","year":"2016","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.clinthera.2019.04.017_bib72","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1136\/annrheumdis-2016-209846","article-title":"EULAR definition of arthralgia suspicious for progression to rheumatoid arthritis","volume":"76","author":"van Steenbergen","year":"2017","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.clinthera.2019.04.017_bib73","doi-asserted-by":"crossref","DOI":"10.1136\/rmdopen-2017-000641","article-title":"Initial validation and results of the symptoms in persons at risk of rheumatoid arthritis (SPARRA) questionnaire: a EULAR project","volume":"4","author":"van Beers-Tas","year":"2018","journal-title":"RMD Open"},{"key":"10.1016\/j.clinthera.2019.04.017_bib74","doi-asserted-by":"crossref","first-page":"2909","DOI":"10.1002\/art.38757","article-title":"Three-year clinical outcome following baseline magnetic resonance imaging in anti-citrullinated protein antibody-positive arthralgia patients: an exploratory study","volume":"66","author":"Gent","year":"2014","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.clinthera.2019.04.017_bib75","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1136\/annrheumdis-2012-202628","article-title":"MRI of hand and foot joints of patients with anticitrullinated peptide antibody positive arthralgia without clinical arthritis","volume":"72","author":"Krabben","year":"2013","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.clinthera.2019.04.017_bib76","doi-asserted-by":"crossref","first-page":"R92","DOI":"10.1186\/ar4536","article-title":"Subclinical inflammation on MRI of hand and foot of anticitrullinated peptide antibody-negative arthralgia patients at risk for rheumatoid arthritis","volume":"16","author":"van Steenbergen","year":"2014","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.clinthera.2019.04.017_bib77","doi-asserted-by":"crossref","first-page":"2593","DOI":"10.1002\/art.39749","article-title":"Magnetic resonance imaging-detected features of inflammation and erosions in symptom-free persons from the general population","volume":"68","author":"Mangnus","year":"2016","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.clinthera.2019.04.017_bib78","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1136\/annrheumdis-2015-208138","article-title":"Clinical factors, anticitrullinated peptide antibodies and MRI-detected subclinical inflammation in relation to progression from clinically suspect arthralgia to arthritis","volume":"75","author":"van Steenbergen","year":"2016","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.clinthera.2019.04.017_bib79","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1093\/rheumatology\/kex167","article-title":"Evaluation of the diagnostic accuracy of hand and foot MRI for early rheumatoid arthritis","volume":"56","author":"Nieuwenhuis","year":"2017","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.clinthera.2019.04.017_bib80","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.1136\/annrheumdis-2015-208235","article-title":"Ultrasound findings predict progression to inflammatory arthritis in anti-CCP antibody-positive patients without clinical synovitis","volume":"75","author":"Nam","year":"2016","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.clinthera.2019.04.017_bib81","doi-asserted-by":"crossref","first-page":"R98","DOI":"10.1186\/ar3028","article-title":"The value of ultrasonography in predicting arthritis in auto-antibody positive arthralgia patients: a prospective cohort study","volume":"12","author":"van de Stadt","year":"2010","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.clinthera.2019.04.017_bib82","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1136\/annrheumdis-2013-204133","article-title":"A\u00a0weighted genetic risk score using all known susceptibility variants to estimate rheumatoid arthritis risk","volume":"74","author":"Yarwood","year":"2015","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.clinthera.2019.04.017_bib83","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1136\/annrheumdis-2016-209991","article-title":"Presence of anticitrullinated protein antibodies in a large population-based cohort from The Netherlands","volume":"76","author":"van Zanten","year":"2017","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.clinthera.2019.04.017_bib84","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1136\/annrheumdis-2011-200990","article-title":"EULAR recommendations for terminology and research in individuals at risk of rheumatoid arthritis: report from the Study Group for Risk Factors for Rheumatoid Arthritis","volume":"71","author":"Gerlag","year":"2012","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.clinthera.2019.04.017_bib85","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1002\/acr.23411","article-title":"Disclosure of personalized rheumatoid arthritis risk using genetics, biomarkers, and lifestyle factors to motivate health behavior improvements: a randomized controlled trial","volume":"70","author":"Sparks","year":"2018","journal-title":"Arthritis Care Res (Hoboken)"}],"container-title":["Clinical Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S014929181930181X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S014929181930181X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,20]],"date-time":"2019-09-20T10:40:54Z","timestamp":1568976054000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S014929181930181X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":85,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["S014929181930181X"],"URL":"https:\/\/doi.org\/10.1016\/j.clinthera.2019.04.017","relation":{},"ISSN":["0149-2918"],"issn-type":[{"value":"0149-2918","type":"print"}],"subject":[],"published":{"date-parts":[[2019,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Predicting Rheumatoid Arthritis in At-risk Individuals","name":"articletitle","label":"Article Title"},{"value":"Clinical Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clinthera.2019.04.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}