{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:51:38Z","timestamp":1790682698057,"version":"4.1.0"},"reference-count":66,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","clinicaltherapeutics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Therapeutics"],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1016\/j.clinthera.2019.04.018","type":"journal-article","created":{"date-parts":[[2019,6,10]],"date-time":"2019-06-10T03:59:04Z","timestamp":1560139144000},"page":"1246-1255","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":58,"title":["Extra-articular Manifestations and Comorbidity in Rheumatoid Arthritis: Potential Impact of Pre\u2013Rheumatoid Arthritis Prevention"],"prefix":"10.1016","volume":"41","author":[{"given":"Jon T.","family":"Giles","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clinthera.2019.04.018_bib1","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1080\/03009740310004621","article-title":"Epidemiology of extra-articular manifestations in rheumatoid arthritis","volume":"33","author":"Turesson","year":"2004","journal-title":"Scand J Rheumatol"},{"key":"10.1016\/j.clinthera.2019.04.018_bib2","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.autrev.2011.09.001","article-title":"Extra-articular manifestations of rheumatoid arthritis: an update","volume":"11","author":"Prete","year":"2011","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.clinthera.2019.04.018_bib3","doi-asserted-by":"crossref","first-page":"983","DOI":"10.3899\/jrheum.101133","article-title":"Incidence of extraarticular rheumatoid arthritis in Olmsted County, Minnesota, in 1995-2007 versus 1985-1994: a population-based study","volume":"38","author":"Myasoedova","year":"2011","journal-title":"J\u00a0Rheumatol"},{"key":"10.1016\/j.clinthera.2019.04.018_bib4","doi-asserted-by":"crossref","first-page":"981","DOI":"10.3899\/jrheum.161103","article-title":"Severe extraarticular manifestations in a community-based cohort of patients with rheumatoid arthritis: risk factors and incidence in relation to treatment with tumor necrosis factor inhibitors","volume":"44","author":"Theander","year":"2017","journal-title":"J\u00a0Rheumatol"},{"key":"10.1016\/j.clinthera.2019.04.018_bib5","doi-asserted-by":"crossref","first-page":"406927","DOI":"10.1155\/2013\/406927","article-title":"Asymptomatic preclinical rheumatoid arthritis-associated interstitial lung disease","volume":"2013","author":"Chen","year":"2013","journal-title":"Clin Dev Immunol"},{"key":"10.1016\/j.clinthera.2019.04.018_bib6","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1097\/WNO.0b013e318183ca13","article-title":"Optic neuritis as the first manifestation of rheumatoid arthritis","volume":"28","author":"Chen","year":"2008","journal-title":"J\u00a0Neuroophthalmol"},{"key":"10.1016\/j.clinthera.2019.04.018_bib7","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.2169\/internalmedicine.49.3609","article-title":"Organizing pneumonia with a positive result for anti-CCP antibodies as the first clinical presentation of rheumatoid arthritis","volume":"49","author":"Komiya","year":"2010","journal-title":"Intern Med"},{"key":"10.1016\/j.clinthera.2019.04.018_bib8","first-page":"40","article-title":"Pulmonary vasculitis as the first manifestation of rheumatoid arthritis","volume":"8","author":"Tourin","year":"2013","journal-title":"Respir Med Case Rep"},{"key":"10.1016\/j.clinthera.2019.04.018_bib9","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.semarthrit.2008.08.003","article-title":"Systemic nonarticular manifestations of rheumatoid arthritis: focus on inflammatory mechanisms","volume":"39","author":"Moreland","year":"2009","journal-title":"Semin Arthritis Rheum"},{"key":"10.1016\/j.clinthera.2019.04.018_bib10","first-page":"62","article-title":"Occurrence of extraarticular disease manifestations is associated with excess mortality in a community based cohort of patients with rheumatoid arthritis","volume":"29","author":"Turesson","year":"2002","journal-title":"J\u00a0Rheumatol"},{"key":"10.1016\/j.clinthera.2019.04.018_bib11","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1136\/ard.2006.052506","article-title":"Severe extra-articular disease manifestations are associated with an increased risk of first ever cardiovascular events in patients with rheumatoid arthritis","volume":"66","author":"Turesson","year":"2007","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.clinthera.2019.04.018_bib12","doi-asserted-by":"crossref","first-page":"2750","DOI":"10.1002\/art.11439","article-title":"Direct medical costs and their predictors in patients with rheumatoid arthritis: a three-year study of 7,527 patients","volume":"48","author":"Michaud","year":"2003","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.clinthera.2019.04.018_bib13","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1093\/rheumatology\/39.1.28","article-title":"Economic burden of rheumatoid arthritis: a systematic review","volume":"39","author":"Cooper","year":"2000","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.clinthera.2019.04.018_bib14","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s11926-017-0667-3","article-title":"Rheumatoid vasculitis: a diminishing yet devastating menace","volume":"19","author":"Kishore","year":"2017","journal-title":"Curr Rheumatol Rep"},{"key":"10.1016\/j.clinthera.2019.04.018_bib15","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1002\/art.38210","article-title":"Glucocorticoid dose thresholds associated with all-cause and cardiovascular mortality in rheumatoid arthritis","volume":"66","author":"del Rincon","year":"2014","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.clinthera.2019.04.018_bib16","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1002\/art.23721","article-title":"American College of Rheumatology 2008 recommendations for the use of nonbiologic and biologic disease-modifying antirheumatic drugs in rheumatoid arthritis","volume":"59","author":"Saag","year":"2008","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.clinthera.2019.04.018_bib17","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.autrev.2004.09.004","article-title":"TNF-alpha, rheumatoid arthritis, and heart failure: a rheumatological dilemma","volume":"4","author":"Sarzi-Puttini","year":"2005","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.clinthera.2019.04.018_bib18","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2014-005615","article-title":"Potential risk of TNF inhibitors on the progression of interstitial lung disease in patients with rheumatoid arthritis","volume":"4","author":"Nakashita","year":"2014","journal-title":"BMJ Open"},{"key":"10.1016\/j.clinthera.2019.04.018_bib19","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1002\/art.24092","article-title":"Risk of cardiovascular mortality in patients with rheumatoid arthritis: a meta-analysis of observational studies","volume":"59","author":"Avina-Zubieta","year":"2008","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.clinthera.2019.04.018_bib20","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1136\/annrheumdis-2011-200726","article-title":"Risk of incident cardiovascular events in patients with rheumatoid arthritis: a meta-analysis of observational studies","volume":"71","author":"Avina-Zubieta","year":"2012","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.clinthera.2019.04.018_bib21","first-page":"S35","article-title":"Mortality in rheumatoid arthritis: 2008 update","volume":"26","author":"Sokka","year":"2008","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.clinthera.2019.04.018_bib22","doi-asserted-by":"crossref","first-page":"743","DOI":"10.3899\/jrheum.080670","article-title":"Hidden cost of rheumatoid arthritis (RA): estimating cost of comorbid cardiovascular disease and depression among patients with RA","volume":"36","author":"Joyce","year":"2009","journal-title":"J\u00a0Rheumatol"},{"key":"10.1016\/j.clinthera.2019.04.018_bib23","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1160\/TH-17-03-0162","article-title":"Derivation and validation of a novel bleeding risk score for elderly patients with venous thromboembolism on extended anticoagulation","volume":"117","author":"Seiler","year":"2017","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.clinthera.2019.04.018_bib24","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1002\/art.38894","article-title":"Lipid profile changes in patients with chronic inflammatory arthritis treated with biologic agents and tofacitinib in randomized clinical trials: a systematic review and meta-analysis","volume":"67","author":"Souto","year":"2015","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.clinthera.2019.04.018_bib25","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1136\/annrheumdis-2014-206624","article-title":"The effects of tumour necrosis factor inhibitors, methotrexate, non-steroidal anti-inflammatory drugs and corticosteroids on cardiovascular events in rheumatoid arthritis, psoriasis and psoriatic arthritis: a systematic review and meta-analysis","volume":"74","author":"Roubille","year":"2015","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.clinthera.2019.04.018_bib26","article-title":"Comparative cardiovascular risk of abatacept and tumor necrosis factor inhibitors in patients with rheumatoid arthritis with and without diabetes mellitus: a multidatabase cohort study","volume":"7","author":"Kang","year":"2018","journal-title":"J\u00a0Am Heart Assoc"},{"key":"10.1016\/j.clinthera.2019.04.018_bib27","doi-asserted-by":"crossref","first-page":"2905","DOI":"10.1002\/art.22809","volume":"56","author":"Dixon","year":"2007","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.clinthera.2019.04.018_bib28","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1002\/art.20853","article-title":"Increased unrecognized coronary heart disease and sudden deaths in rheumatoid arthritis: a population-based cohort study","volume":"52","author":"Maradit-Kremers","year":"2005","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.clinthera.2019.04.018_bib29","doi-asserted-by":"crossref","first-page":"2741","DOI":"10.1002\/art.11223","article-title":"Antibodies against cyclic citrullinated peptide and IGA rheumatoid factor predict the development of rheumatoid arthritis","volume":"48","author":"Rantapaa-Dahlqvist","year":"2003","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.clinthera.2019.04.018_bib30","doi-asserted-by":"crossref","DOI":"10.1371\/annotation\/2e462817-ab93-4d78-95a4-1d8b9d172971","article-title":"Autoantibody epitope spreading in the pre-clinical phase predicts progression to rheumatoid arthritis","volume":"7","author":"Sokolove","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.clinthera.2019.04.018_bib31","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1136\/ard.2009.122374","article-title":"Total cholesterol and LDL levels decrease before rheumatoid arthritis","volume":"69","author":"Myasoedova","year":"2010","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.clinthera.2019.04.018_bib32","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1002\/acr.22930","article-title":"Association of rheumatoid factors with subclinical and clinical atherosclerosis in African American women: the Multiethnic Study of Atherosclerosis","volume":"69","author":"Majka","year":"2017","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"10.1016\/j.clinthera.2019.04.018_bib33","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1136\/annrheumdis-2016-211066","article-title":"Acute coronary syndrome in new-onset rheumatoid arthritis: a population-based nationwide cohort study of time trends in risks and excess risks","volume":"76","author":"Holmqvist","year":"2017","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.clinthera.2019.04.018_bib34","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.semarthrit.2006.08.006","article-title":"Incidence and prevalence of rheumatoid arthritis, based on the 1987 american college of rheumatology criteria: a systematic review","volume":"36","author":"Alamanos","year":"2006","journal-title":"Semin Arthritis Rheum"},{"key":"10.1016\/j.clinthera.2019.04.018_bib35","doi-asserted-by":"crossref","first-page":"495","DOI":"10.2147\/CEOR.S89331","article-title":"Patient-level costs of major cardiovascular conditions: a review of the international literature","volume":"8","author":"Nicholson","year":"2016","journal-title":"Clinicoecon Outcomes Res"},{"key":"10.1016\/j.clinthera.2019.04.018_bib36","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.rdc.2014.12.004","article-title":"Lung disease in rheumatoid arthritis","volume":"41","author":"Yunt","year":"2015","journal-title":"Rheum Dis Clin North Am"},{"key":"10.1016\/j.clinthera.2019.04.018_bib37","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1002\/art.27405","article-title":"Incidence and mortality of interstitial lung disease in rheumatoid arthritis: a population-based study","volume":"62","author":"Bongartz","year":"2010","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.clinthera.2019.04.018_bib38","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1186\/s12890-016-0269-2","article-title":"Variable course of disease of rheumatoid arthritis-associated usual interstitial pneumonia compared to other subtypes","volume":"16","author":"Nurmi","year":"2016","journal-title":"BMC Pulm Med"},{"key":"10.1016\/j.clinthera.2019.04.018_bib39","doi-asserted-by":"crossref","first-page":"360","DOI":"10.3899\/jrheum.171315","article-title":"Rheumatoid arthritis-interstitial lung disease in the United States: prevalence, incidence, and healthcare costs and mortality","volume":"46","author":"Raimundo","year":"2019","journal-title":"J\u00a0Rheumatol"},{"key":"10.1016\/j.clinthera.2019.04.018_bib40","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/j.rmed.2014.03.015","article-title":"The burden of idiopathic pulmonary fibrosis: an unmet public health need","volume":"108","author":"Lee","year":"2014","journal-title":"Respir Med"},{"key":"10.1016\/j.clinthera.2019.04.018_bib41","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1111\/resp.12989","article-title":"Health-related quality of life in idiopathic pulmonary fibrosis: data from the Australian IPF registry","volume":"22","author":"Glaspole","year":"2017","journal-title":"Respirology"},{"key":"10.1016\/j.clinthera.2019.04.018_bib42","first-page":"1","article-title":"2015 American College of Rheumatology guideline for the treatment of rheumatoid arthritis","volume":"68","author":"Singh","year":"2016","journal-title":"Arthritis Rheumat"},{"key":"10.1016\/j.clinthera.2019.04.018_bib43","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1186\/s13075-015-0835-7","article-title":"Incidence and complications of interstitial lung disease in users of tocilizumab, rituximab, abatacept and anti-tumor necrosis factor alpha agents, a retrospective cohort study","volume":"17","author":"Curtis","year":"2015","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.clinthera.2019.04.018_bib44","doi-asserted-by":"crossref","first-page":"613","DOI":"10.2165\/11537460-000000000-00000","article-title":"Mycophenolate mofetil in the treatment of adults with advanced rheumatoid arthritis: three 24-week, randomized, double-blind, placebo- or ciclosporin-controlled trials","volume":"30","author":"Schiff","year":"2010","journal-title":"Clin Drug Invest"},{"key":"10.1016\/j.clinthera.2019.04.018_bib45","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0153024","article-title":"Smoking and subclinical ILD in RA versus the multi-ethnic study of atherosclerosis","volume":"11","author":"Johnson","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.clinthera.2019.04.018_bib46","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1136\/annrheumdis-2012-203160","article-title":"Association of fine specificity and repertoire expansion of anticitrullinated peptide antibodies with rheumatoid arthritis associated interstitial lung disease","volume":"73","author":"Giles","year":"2014","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.clinthera.2019.04.018_bib47","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1136\/annrheumdis-2017-211138","article-title":"A\u00a0population-based cohort study of rheumatoid arthritis-associated interstitial lung disease: comorbidity and mortality","volume":"76","author":"Hyldgaard","year":"2017","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.clinthera.2019.04.018_bib48","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1016\/j.rmed.2012.03.006","article-title":"Lung disease with anti-CCP antibodies but not rheumatoid arthritis or connective tissue disease","volume":"106","author":"Fischer","year":"2012","journal-title":"Respir Med"},{"key":"10.1016\/j.clinthera.2019.04.018_bib49","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.maturitas.2016.11.006","article-title":"Inflammation and sarcopenia: a systematic review and meta-analysis","volume":"96","author":"Bano","year":"2017","journal-title":"Maturitas"},{"key":"10.1016\/j.clinthera.2019.04.018_bib50","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1002\/art.23719","article-title":"Abnormal body composition phenotypes in older rheumatoid arthritis patients: association with disease characteristics and pharmacotherapies","volume":"59","author":"Giles","year":"2008","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.clinthera.2019.04.018_bib51","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1093\/rheumatology\/kep165","article-title":"Early rheumatoid arthritis and body composition","volume":"48","author":"Book","year":"2009","journal-title":"Rheumatology (Oxford, England)"},{"key":"10.1016\/j.clinthera.2019.04.018_bib52","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1111\/apt.13058","article-title":"Infliximab reverses inflammatory muscle wasting (sarcopenia) in Crohn's disease","volume":"41","author":"Subramaniam","year":"2015","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.clinthera.2019.04.018_bib53","doi-asserted-by":"crossref","first-page":"2438","DOI":"10.1002\/art.34464","article-title":"Muscle density in rheumatoid arthritis: associations with disease features and functional outcomes","volume":"64","author":"Kramer","year":"2012","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.clinthera.2019.04.018_bib54","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1111\/j.1532-5415.2004.52261.x","article-title":"Determinants of lower-body muscle power in early postmenopausal women","volume":"52","author":"Sipila","year":"2004","journal-title":"J\u00a0Am Geriatr Soc"},{"key":"10.1016\/j.clinthera.2019.04.018_bib55","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1007\/s12603-016-0843-6","article-title":"Prospective associations of low muscle mass and function with 10-year falls risk, incident fracture and mortality in community-dwelling older adults","volume":"21","author":"Balogun","year":"2017","journal-title":"J\u00a0Nutr Health Aging"},{"key":"10.1016\/j.clinthera.2019.04.018_bib56","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.jamda.2018.10.016","article-title":"Sarcopenia definitions and their associations with mortality in older Australian women","volume":"20","author":"Sim","year":"2019","journal-title":"J\u00a0Am Med Dir Assoc"},{"key":"10.1016\/j.clinthera.2019.04.018_bib57","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1001\/archinte.165.14.1624","article-title":"Paradoxical effect of body mass index on survival in rheumatoid arthritis: role of comorbidity and systemic inflammation","volume":"165","author":"Escalante","year":"2005","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.clinthera.2019.04.018_bib58","doi-asserted-by":"crossref","first-page":"3450","DOI":"10.1002\/art.20612","article-title":"Prognostic importance of low body mass index in relation to cardiovascular mortality in rheumatoid arthritis","volume":"50","author":"Kremers","year":"2004","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.clinthera.2019.04.018_bib59","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1136\/ard.2005.044677","article-title":"Prevalence and predictors of disability in valued life activities among individuals with rheumatoid arthritis","volume":"65","author":"Katz","year":"2006","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.clinthera.2019.04.018_bib60","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1016\/j.clinthera.2010.07.006","article-title":"Relationship between rheumatoid arthritis disease severity, health-related utility, and resource use in Australian patients: a cross-sectional, multicenter study","volume":"32","author":"Standfield","year":"2010","journal-title":"Clin Ther"},{"key":"10.1016\/j.clinthera.2019.04.018_bib61","series-title":"Inflation Calculator","year":"2019"},{"key":"10.1016\/j.clinthera.2019.04.018_bib62","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1097\/00006842-200201000-00008","article-title":"Depression in rheumatoid arthritis: a systematic review of the literature with meta-analysis","volume":"64","author":"Dickens","year":"2002","journal-title":"Psychosom Med"},{"key":"10.1016\/j.clinthera.2019.04.018_bib63","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.jpsychores.2017.07.015","article-title":"Increased incidence of psychiatric disorders in immune-mediated inflammatory disease","volume":"101","author":"Marrie","year":"2017","journal-title":"J\u00a0Psychosom Res"},{"key":"10.1016\/j.clinthera.2019.04.018_bib64","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.genhosppsych.2018.06.001","article-title":"Psychiatric comorbidity increases mortality in immune-mediated inflammatory diseases","volume":"53","author":"Marrie","year":"2018","journal-title":"Gen Hosp Psychiatry"},{"key":"10.1016\/j.clinthera.2019.04.018_bib65","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.genhosppsych.2018.01.003","article-title":"Physical comorbidities increase the risk of psychiatric comorbidity in immune-mediated inflammatory disease","volume":"51","author":"Marrie","year":"2018","journal-title":"Gen Hosp Psychiatry"},{"key":"10.1016\/j.clinthera.2019.04.018_bib66","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1038\/nm.3589","article-title":"Chronic variable stress activates hematopoietic stem cells","volume":"20","author":"Heidt","year":"2014","journal-title":"Nat Med"}],"container-title":["Clinical Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149291819301821?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149291819301821?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,7,5]],"date-time":"2019-07-05T21:13:30Z","timestamp":1562361210000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0149291819301821"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":66,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["S0149291819301821"],"URL":"https:\/\/doi.org\/10.1016\/j.clinthera.2019.04.018","relation":{},"ISSN":["0149-2918"],"issn-type":[{"value":"0149-2918","type":"print"}],"subject":[],"published":{"date-parts":[[2019,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Extra-articular Manifestations and Comorbidity in Rheumatoid Arthritis: Potential Impact of Pre\u2013Rheumatoid Arthritis Prevention","name":"articletitle","label":"Article Title"},{"value":"Clinical Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clinthera.2019.04.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}