{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T10:34:46Z","timestamp":1782902086286,"version":"3.54.5"},"reference-count":25,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100005089","name":"Beijing Municipal Natural Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005089","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013076","name":"National Major Science and Technology Projects of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013076","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","clinicaltherapeutics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Therapeutics"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1016\/j.clinthera.2019.05.002","type":"journal-article","created":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T16:10:24Z","timestamp":1559405424000},"page":"1614-1620","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Propafenone-associated Gross Hematuria: A Case Report and Review of the Literature"],"prefix":"10.1016","volume":"41","author":[{"given":"Shuqing","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhui","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zining","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yimin","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clinthera.2019.05.002_bib1","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1684\/ejd.2009.0673","article-title":"Neutropenia and cutaneous lesions secondary to propafenone","volume":"19","author":"Couto","year":"2009","journal-title":"Eur J Dermatol"},{"key":"10.1016\/j.clinthera.2019.05.002_bib2","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1056\/NEJM199002223220806","volume":"322","author":"Funckbrentano","year":"1990","journal-title":"Propafenone N Engl J Med"},{"key":"10.1016\/j.clinthera.2019.05.002_bib3","unstructured":"Highlights of prescribing information PYTHMOL. https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2018\/019151s015lbl.pdf. Accessed 28 Jan 2019."},{"key":"10.1016\/j.clinthera.2019.05.002_bib4","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/S0002-9149(84)80287-8","article-title":"Propafenone: noninvasive evaluation of therapy","volume":"54","author":"Podrid","year":"1984","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.clinthera.2019.05.002_bib5","first-page":"580","article-title":"Safety of long term propafenone therapy Fur cardiac arrhythmia: expedience with 774 patients","volume":"1","author":"Ravid","year":"1987","journal-title":"J\u00a0Electrophysiol"},{"key":"10.1016\/j.clinthera.2019.05.002_bib6","first-page":"619","article-title":"Propafenone overdose: cardiac arrest and full recovery","volume":"17","author":"Wo\u017cakowska Kap\u0142on","year":"2010","journal-title":"Cardiol J"},{"key":"10.1016\/j.clinthera.2019.05.002_bib7","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s13181-010-0037-2","article-title":"Propafenone poisoning\u2014a case report with plasma propafenone concentrations","volume":"6","author":"Ovaska","year":"2010","journal-title":"J\u00a0Med Toxicol"},{"key":"10.1016\/j.clinthera.2019.05.002_bib8","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1177\/106002809502900606","article-title":"Probable propafenone-induced transient global amnesia","volume":"29","author":"Jones","year":"1995","journal-title":"Ann Pharmacother"},{"key":"10.1016\/j.clinthera.2019.05.002_bib9","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1684\/ejd.2009.0673","article-title":"Neutropenia and cutaneous lesions secondary to propafenone","volume":"19","author":"Couto","year":"2009","journal-title":"Eur J Dermatol"},{"key":"10.1016\/j.clinthera.2019.05.002_bib10","first-page":"217","article-title":"Hemolytic reaction resulting from propafenone administration [in Chinese]","volume":"30","author":"Zeng","year":"1991","journal-title":"Chin J Intern Med"},{"key":"10.1016\/j.clinthera.2019.05.002_bib11","first-page":"467","article-title":"One case with hemoglobinuria caused by intravenous injection of propafenone [in Chinese]","volume":"9","author":"Li","year":"1994","journal-title":"Chin Circ J"},{"key":"10.1016\/j.clinthera.2019.05.002_bib12","first-page":"217","article-title":"One case with hemoglobinuria caused by intravenous injection of rytmonorm [in Chinese]","volume":"16","author":"Yang","year":"1995","journal-title":"[chinese J Hematol"},{"key":"10.1016\/j.clinthera.2019.05.002_bib13","first-page":"17","article-title":"One case with hemolysis caused by intravenous injection of propafenone [in Chinese]","volume":"9","author":"Liang","year":"2000","journal-title":"Chin J Pharmacoepidemiol"},{"key":"10.1016\/j.clinthera.2019.05.002_bib14","first-page":"254","article-title":"One case of propafenone induced hemoglobinuria [in Chinese]","volume":"9","author":"Yan","year":"2000","journal-title":"Chin J Clin Pharm"},{"key":"10.1016\/j.clinthera.2019.05.002_bib15","article-title":"One case of rytmonorm induced hemoglobinuria [in Chinese]","volume":"17","author":"Wang","year":"2001","journal-title":"Chin Commun Doctors"},{"key":"10.1016\/j.clinthera.2019.05.002_bib16","first-page":"19","article-title":"One case with hemolysis caused by intravenous injection of rytonorm [in Chinese]","volume":"43","author":"Yang","year":"2003","journal-title":"Shandong Med J"},{"key":"10.1016\/j.clinthera.2019.05.002_bib17","first-page":"259","article-title":"Hematuria following high-dose propafenone therapy","volume":"5","author":"Xu","year":"2003","journal-title":"Adverse Drug React J"},{"key":"10.1016\/j.clinthera.2019.05.002_bib18","article-title":"Arrhythmia treatment of prapafenone causing gross hematuria: a case report [in Chinese]","volume":"22","author":"Liu","year":"2007","journal-title":"Clin Focus"},{"key":"10.1016\/j.clinthera.2019.05.002_bib19","first-page":"441","article-title":"Hematuria caused by intravenous injection of propafenone: 4 case reports [in Chinese]","volume":"8","author":"Chen","year":"2006","journal-title":"Chin J Med Guide"},{"key":"10.1016\/j.clinthera.2019.05.002_bib20","first-page":"127","article-title":"Two cases of rytmonorm induced hemoglobinuria [in Chinese]","volume":"5","author":"Qu","year":"2008","journal-title":"Mod Health (Med Innovation Res)"},{"key":"10.1016\/j.clinthera.2019.05.002_bib21","first-page":"100","article-title":"Two cases of rytmonorm induced gross hematuria [in Chinese]","volume":"9","author":"Yang","year":"2011","journal-title":"Chin Med Mod Distance Educ China"},{"key":"10.1016\/j.clinthera.2019.05.002_bib22","first-page":"91","article-title":"Analysis of intravenous injection of propafenone caused hematuria from 20 cases [in Chinese]","volume":"6","author":"Tang","year":"2012","journal-title":"Chin J Mod Drug Appl"},{"key":"10.1016\/j.clinthera.2019.05.002_bib23","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/clpt.1981.154","article-title":"A\u00a0method for estimating the probability of adverse drug reactions","volume":"30","author":"Naranjo","year":"1981","journal-title":"Clin Pharmacol Ther"},{"key":"10.1016\/j.clinthera.2019.05.002_bib24","unstructured":"https:\/\/www.medicines.org.uk\/emc\/product\/1733\/smpc. Accessed April 26, 2019."},{"key":"10.1016\/j.clinthera.2019.05.002_bib25","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s00210-005-1025-y","article-title":"Characterisation of (R\/S)-propafenone and its metabolites as substrates and inhibitors of P-glycoprotein","volume":"371","author":"Bachmakov","year":"2005","journal-title":"Naunyn-schmiedeberg\u2019s Arch Pharm"}],"container-title":["Clinical Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149291819302474?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149291819302474?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T08:51:41Z","timestamp":1758963101000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0149291819302474"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":25,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["S0149291819302474"],"URL":"https:\/\/doi.org\/10.1016\/j.clinthera.2019.05.002","relation":{},"ISSN":["0149-2918"],"issn-type":[{"value":"0149-2918","type":"print"}],"subject":[],"published":{"date-parts":[[2019,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Propafenone-associated Gross Hematuria: A Case Report and Review of the Literature","name":"articletitle","label":"Article Title"},{"value":"Clinical Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clinthera.2019.05.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}