{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T17:58:01Z","timestamp":1793642281823,"version":"4.5.1"},"reference-count":57,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Zhejiang Natural Science Foundation","doi-asserted-by":"crossref","award":["LY15H020001"],"award-info":[{"award-number":["LY15H020001"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100008990","name":"Science Technology Department of Zhejiang Province","doi-asserted-by":"publisher","award":["2017C37130"],"award-info":[{"award-number":["2017C37130"]}],"id":[{"id":"10.13039\/501100008990","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014996","name":"Health and Family Planning Commission of Zhejiang Province","doi-asserted-by":"crossref","award":["2016ZDB010"],"award-info":[{"award-number":["2016ZDB010"]}],"id":[{"id":"10.13039\/501100014996","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100014996","name":"Health and Family Planning Commission of Zhejiang Province","doi-asserted-by":"crossref","award":["2017Z10"],"award-info":[{"award-number":["2017Z10"]}],"id":[{"id":"10.13039\/501100014996","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Hangzhou Health Science and Technology Project"},{"DOI":"10.13039\/501100003786","name":"Hangzhou Science and Technology Bureau Project","doi-asserted-by":"publisher","award":["20160533B63"],"award-info":[{"award-number":["20160533B63"]}],"id":[{"id":"10.13039\/501100003786","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","clinicaltherapeutics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Therapeutics"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.clinthera.2019.08.008","type":"journal-article","created":{"date-parts":[[2019,9,20]],"date-time":"2019-09-20T23:43:16Z","timestamp":1569022996000},"page":"2137-2152.e12","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"title":["Effects of the Antianginal Drugs Ranolazine, Nicorandil, and Ivabradine on Coronary Microvascular Function in Patients With Nonobstructive Coronary Artery Disease: A Meta-analysis of Randomized Controlled Trials"],"prefix":"10.1016","volume":"41","author":[{"given":"Houyong","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqun","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojiang","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianwu","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tielong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyu","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clinthera.2019.08.008_bib1","doi-asserted-by":"crossref","first-page":"2625","DOI":"10.1016\/j.jacc.2018.09.042","article-title":"Coronary microvascular disease pathogenic mechanisms and therapeutic options: JACC State-of-the-Art Review","volume":"72","author":"Taqueti","year":"2018","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.clinthera.2019.08.008_bib2","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1001\/archinternmed.2009.50","article-title":"Adverse cardiovascular outcomes in women with nonobstructive coronary artery disease: a report from the women's ischemia syndrome evaluation study and the st james women take heart Project","volume":"169","author":"Gulati","year":"2009","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.clinthera.2019.08.008_bib3","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1093\/eurheartj\/ehr331","article-title":"Stable angina pectoris with no obstructive coronary artery disease is associated with increased risks of major adverse cardiovascular events","volume":"33","author":"Jespersen","year":"2012","journal-title":"Eur Heart J"},{"key":"10.1016\/j.clinthera.2019.08.008_bib4","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1161\/CIRCULATIONAHA.105.609990","article-title":"The economic burden of angina in women with suspected ischemic heart disease: results from the national Institutes of health\u2013national heart, Lung, and blood institute\u2013sponsored women's ischemia syndrome evaluation","volume":"114","author":"Shaw","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.clinthera.2019.08.008_bib5","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1093\/eurheartj\/ehl040","article-title":"Persistent chest pain predicts cardiovascular events in women without obstructive coronary artery disease: results from the NIH-NHLBI-sponsored Women's Ischaemia Syndrome Evaluation (WISE) study","volume":"27","author":"Johnson","year":"2006","journal-title":"Eur Heart J"},{"key":"10.1016\/j.clinthera.2019.08.008_bib6","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1186\/s12875-015-0287-9","article-title":"Chest pain syndromes are associated with high rates of recidivism and costs in young United States Veterans","volume":"16","author":"Safdar","year":"2015","journal-title":"Bmc Fam Pract"},{"key":"10.1016\/j.clinthera.2019.08.008_bib7","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1056\/NEJMra061889","article-title":"Coronary microvascular dysfunction","volume":"356","author":"Camici","year":"2007","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.clinthera.2019.08.008_bib8","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1093\/eurheartj\/eht513","article-title":"Coronary microvascular dysfunction: an update","volume":"35","author":"Crea","year":"2014","journal-title":"Eur Heart J"},{"key":"10.1016\/j.clinthera.2019.08.008_bib9","article-title":"Ranolazine in symptomatic diabetic patients without obstructive coronary artery disease: impact on microvascular and diastolic function","volume":"6","author":"Shah","year":"2017","journal-title":"J\u00a0Am Heart Assoc"},{"key":"10.1016\/j.clinthera.2019.08.008_bib10","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.jcmg.2011.03.007","article-title":"Ranolazine improves angina in women with evidence of myocardial ischemia but no obstructive coronary artery disease","volume":"4","author":"Mehta","year":"2011","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.clinthera.2019.08.008_bib11","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.4244\/EIJV9I9A178","article-title":"Nicorandil prevents microvascular dysfunction resulting from PCI in patients with stable angina pectoris: a randomised study","volume":"9","author":"Hirohata","year":"2014","journal-title":"Eurointervention"},{"key":"10.1016\/j.clinthera.2019.08.008_bib12","first-page":"D11747","article-title":"Ranolazine for stable angina pectoris","volume":"2","author":"Salazar","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.clinthera.2019.08.008_bib13","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1016\/j.jacc.2017.08.038","article-title":"The clinical use of ivabradine","volume":"70","author":"Koruth","year":"2017","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.clinthera.2019.08.008_bib14","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.2165\/11592300-000000000-00000","article-title":"Use of nicorandil in cardiovascular disease and its optimization","volume":"71","author":"Horinaka","year":"2011","journal-title":"Drugs"},{"key":"10.1016\/j.clinthera.2019.08.008_bib15","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1093\/eurheartj\/ehv647","article-title":"A\u00a0randomized, placebo-controlled trial of late Na current inhibition (ranolazine) in coronary microvascular dysfunction (CMD): impact on angina and myocardial perfusion reserve","volume":"37","author":"Bairey","year":"2016","journal-title":"Eur Heart J"},{"key":"10.1016\/j.clinthera.2019.08.008_bib16","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.amjcard.2013.02.045","article-title":"Effects of ivabradine and ranolazine in patients with microvascular angina pectoris","volume":"112","author":"Villano","year":"2013","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.clinthera.2019.08.008_bib17","doi-asserted-by":"crossref","first-page":"b2535","DOI":"10.1136\/bmj.b2535","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"339","author":"Moher","year":"2009","journal-title":"BMJ"},{"key":"10.1016\/j.clinthera.2019.08.008_bib18","doi-asserted-by":"crossref","first-page":"S39","DOI":"10.1161\/CIRCOUTCOMES.114.001613","article-title":"Characteristics and outcomes of women veterans undergoing cardiac catheterization in the Veterans Affairs Healthcare System: insights from the VA CART Program","volume":"8","author":"Davis","year":"2015","journal-title":"Circ Cardiovasc Qual Outcomes"},{"key":"10.1016\/j.clinthera.2019.08.008_bib19","doi-asserted-by":"crossref","first-page":"e14165","DOI":"10.1097\/MD.0000000000014165","article-title":"Effects of mitochondrial ATP-sensitive potassium channel activation (nicorandil) in patients with angina pectoris undergoing elective percutaneous coronary interventions: a meta-analysis of randomized controlled trials","volume":"98","author":"Zhu","year":"2019","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.clinthera.2019.08.008_bib20","series-title":"Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (Updated March 2011): The Cochrane Collaboration","article-title":"Chapter 8: assessing risk of bias in included studies","author":"Higgins","year":"2011"},{"key":"10.1016\/j.clinthera.2019.08.008_bib21","series-title":"Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (Updated March 2011): The Cochrane Collaboration","article-title":"Chapter 9: analysing data and undertaking meta-analyses","author":"Higgins","year":"2011"},{"key":"10.1016\/j.clinthera.2019.08.008_bib22","series-title":"Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (Updated March 2011): The Cochrane Collaboration","article-title":"Chapter 5: defining the review question and developing criteria for including studies","author":"Higgins","year":"2011"},{"key":"10.1016\/j.clinthera.2019.08.008_bib23","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.ijcard.2017.08.068","article-title":"International standardization of diagnostic criteria for microvascular angina","volume":"250","author":"Ong","year":"2018","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.clinthera.2019.08.008_bib24","first-page":"6545","article-title":"Microvascular ischemia in patients with successful percutaneous coronary intervention: effects of ranolazine and isosorbide-5-mononitrate","volume":"22","author":"Golino","year":"2018","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"10.1016\/j.clinthera.2019.08.008_bib25","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.clinthera.2016.12.002","article-title":"Ranolazine and microvascular angina by PET in the emergency department: results from a pilot randomized controlled trial","volume":"39","author":"Safdar","year":"2017","journal-title":"Clin Ther"},{"key":"10.1016\/j.clinthera.2019.08.008_bib26","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s10557-013-6456-y","article-title":"Beneficial effects of intracoronary nicorandil on microvascular dysfunction after primary percutaneous coronary intervention: demonstration of its superiority to nitroglycerin in a cross-over study","volume":"27","author":"Ito","year":"2013","journal-title":"Cardiovasc Drugs Ther"},{"key":"10.1016\/j.clinthera.2019.08.008_bib27","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1111\/echo.12674","article-title":"Effects of ranolazine on noninvasive coronary flow reserve in patients with myocardial ischemia but without obstructive coronary artery disease","volume":"32","author":"Tagliamonte","year":"2015","journal-title":"Echocardiography"},{"key":"10.1016\/j.clinthera.2019.08.008_bib28","first-page":"C14","article-title":"Effect of ranolazine in patients with chest pain and normal coronaries\u2014a hospital based study","volume":"11","author":"Saha","year":"2017","journal-title":"J\u00a0Clin Diagn Res"},{"key":"10.1016\/j.clinthera.2019.08.008_bib29","doi-asserted-by":"crossref","DOI":"10.1111\/anec.12503","article-title":"Marked exercise-induced T-wave heterogeneity in symptomatic diabetic patients with nonflow-limiting coronary artery stenosis","volume":"23","author":"Stocco","year":"2018","journal-title":"Ann Noninvasive Electrocardiol"},{"key":"10.1016\/j.clinthera.2019.08.008_bib30","doi-asserted-by":"crossref","DOI":"10.1111\/anec.12480","article-title":"Ranolazine reduces repolarization heterogeneity in symptomatic patients with diabetes and non-flow-limiting coronary artery stenosis","volume":"23","author":"Evaristo","year":"2018","journal-title":"Ann Noninvasive Electrocardiol"},{"key":"10.1016\/j.clinthera.2019.08.008_bib31","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.carrev.2017.04.012","article-title":"Impact of ranolazine on coronary microvascular dysfunction (MICRO) study","volume":"18","author":"Ahmed","year":"2017","journal-title":"Cardiovasc Revasc Med"},{"key":"10.1016\/j.clinthera.2019.08.008_bib32","first-page":"287","article-title":"Ranolazine in treatment of stable angina in woman with atrial fibrillation and intermittent left bundle branch block\u2014a case report","volume":"41","author":"Yuriivna","year":"2016","journal-title":"Pol Merkur Lekarski"},{"key":"10.1016\/j.clinthera.2019.08.008_bib33","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.jccase.2015.08.009","article-title":"A\u00a0case of Werner's syndrome with cardiac syndrome X and heart failure with preserved ejection fraction","volume":"12","author":"Yamamoto","year":"2015","journal-title":"J\u00a0Cardiol Cases"},{"key":"10.1016\/j.clinthera.2019.08.008_bib34","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1007\/s12325-015-0237-x","article-title":"Ivabradine and bisoprolol on Doppler-derived coronary flow velocity reserve in patients with stable coronary artery disease: beyond the heart rate","volume":"32","author":"Tagliamonte","year":"2015","journal-title":"Adv Ther"},{"key":"10.1016\/j.clinthera.2019.08.008_bib35","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s12947-015-0020-9","article-title":"The effects of nicorandil on microvascular function in patients with ST segment elevation myocardial infarction undergoing primary PCI","volume":"13","author":"Kostic","year":"2015","journal-title":"Cardiovasc Ultrasound"},{"key":"10.1016\/j.clinthera.2019.08.008_bib36","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.atherosclerosis.2010.11.035","article-title":"Ivabradine improves coronary flow reserve in patients with stable coronary artery disease","volume":"215","author":"Skalidis","year":"2011","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.clinthera.2019.08.008_bib37","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1253\/circj.CJ-09-0943","article-title":"High index of microcirculatory resistance level after successful primary percutaneous coronary intervention can be improved by intracoronary administration of nicorandil","volume":"74","author":"Ito","year":"2010","journal-title":"Circ J"},{"key":"10.1016\/j.clinthera.2019.08.008_bib38","first-page":"392","article-title":"Myocardial perfusion during transient slow-flow in the patient with old vein graft intervention: assessment by serial measurement of pressure-derived fractional flow reserve and thermodilution-derived coronary flow reserve","volume":"60","author":"Matsuo","year":"2003","journal-title":"Catheter Cardiovasc Interv"},{"key":"10.1016\/j.clinthera.2019.08.008_bib39","doi-asserted-by":"crossref","first-page":"216","DOI":"10.2169\/internalmedicine.41.216","article-title":"Microvascular angina accompanied by epicardial coronary artery spasm","volume":"41","author":"Horimoto","year":"2002","journal-title":"Intern Med"},{"key":"10.1016\/j.clinthera.2019.08.008_bib40","first-page":"175","article-title":"[Coronary flow after successful angioplasty in patients with acute myocardial infarction: comparison between coronary flow reserve by nicorandil and papaverine]","volume":"35","author":"Izumi","year":"2000","journal-title":"J\u00a0Cardiol"},{"key":"10.1016\/j.clinthera.2019.08.008_bib41","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/BF03257245","article-title":"Estimation of coronary flow reserve by intracoronary administration of nicorandil: comparison with intracoronary administration of papaverine","volume":"13","author":"Inoue","year":"1998","journal-title":"Heart Vessels"},{"key":"10.1016\/j.clinthera.2019.08.008_bib42","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1007\/BF00879868","article-title":"Effect of nicorandil on abnormal coronary flow reserve assessed by exercise 201Tl scintigraphy in patients with angina pectoris and nearly normal coronary arteriograms","volume":"9","author":"Yamabe","year":"1995","journal-title":"Cardiovasc Drugs Ther"},{"key":"10.1016\/j.clinthera.2019.08.008_bib43","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.ijcard.2018.11.086","article-title":"Microvascular angina: are all women created equal?","volume":"276","author":"Zuchi","year":"2019","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.clinthera.2019.08.008_bib44","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1055\/s-0043-104469","article-title":"[Optimal diagnostics and therapy for microvascular angina pectoris]","volume":"142","author":"Ong","year":"2017","journal-title":"Dtsch Med Wochenschr"},{"key":"10.1016\/j.clinthera.2019.08.008_bib45","first-page":"68","article-title":"[A new insight on anti-ischemic action of ivabradine in patients with stable angina]","volume":"57","author":"Kobalava","year":"2017","journal-title":"Kardiologiia"},{"key":"10.1016\/j.clinthera.2019.08.008_bib46","first-page":"832","article-title":"Efficiency of ranolazine in the patient with microvascular angina, atrial fibrillation and migraine","volume":"69","author":"Osovska","year":"2016","journal-title":"Wiad Lek"},{"key":"10.1016\/j.clinthera.2019.08.008_bib47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijcard.2016.04.001","article-title":"Ivabradine in chronic stable angina: effects by and beyond heart rate reduction","volume":"215","author":"Camici","year":"2016","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.clinthera.2019.08.008_bib48","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jccase.2015.04.002","article-title":"Takotsubo cardiomyopathy in two patients with microvascular angina","volume":"12","author":"Takahashi","year":"2015","journal-title":"J\u00a0Cardiol Cases"},{"key":"10.1016\/j.clinthera.2019.08.008_bib49","first-page":"343027","article-title":"Resolution of angina pectoris and improvement of the coronary flow reserve after ranolazine treatment in a woman with isolated impaired coronary microcirculation","volume":"2013","author":"Santoro","year":"2013","journal-title":"Case Rep Cardiol"},{"key":"10.1016\/j.clinthera.2019.08.008_bib50","first-page":"158","article-title":"Recurrent angina after coronary angioplasty: mechanisms, diagnostic and therapeutic options","volume":"1","author":"Izzo","year":"2012","journal-title":"Eur Heart J Acute Cardiovasc Care"},{"key":"10.1016\/j.clinthera.2019.08.008_bib51","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.ijcard.2018.09.081","article-title":"Late sodium channel blockade improves angina and myocardial perfusion in patients with severe coronary microvascular dysfunction: women's Ischemia Syndrome Evaluation-Coronary Vascular Dysfunction ancillary study","volume":"276","author":"Rambarat","year":"2019","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.clinthera.2019.08.008_bib52","doi-asserted-by":"crossref","first-page":"e255","DOI":"10.2196\/resprot.8057","article-title":"Daily activity measured with wearable technology as a novel measurement of treatment effect in patients with coronary microvascular dysfunction: substudy of a randomized controlled crossover trial","volume":"6","author":"Birkeland","year":"2017","journal-title":"Jmir Res Protoc"},{"key":"10.1016\/j.clinthera.2019.08.008_bib53","doi-asserted-by":"crossref","first-page":"2771","DOI":"10.1093\/eurheartj\/ehs246","article-title":"Coronary microvascular dysfunction in the clinical setting: from mystery to reality","volume":"33","author":"Herrmann","year":"2012","journal-title":"Eur Heart J"},{"key":"10.1016\/j.clinthera.2019.08.008_bib54","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1253\/circj.CJ-14-1060","article-title":"Coronary flow reserve estimated by positron emission tomography to diagnose significant coronary artery disease and predict cardiac events","volume":"79","author":"Naya","year":"2015","journal-title":"Circ J"},{"key":"10.1016\/j.clinthera.2019.08.008_bib55","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/j.jacc.2017.12.046","article-title":"Diagnosis of microvascular angina using cardiac magnetic resonance","volume":"71","author":"Liu","year":"2018","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.clinthera.2019.08.008_bib56","first-page":"10","article-title":"Invasive assessment of the coronary microvasculature: the index of microcirculatory resistance","author":"Fearon","year":"2017","journal-title":"Circ Cardiovasc Interv"},{"key":"10.1016\/j.clinthera.2019.08.008_bib57","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.amjcard.2017.09.012","article-title":"Doppler versus thermodilution-derived coronary microvascular resistance to predict coronary microvascular dysfunction in patients with acute myocardial infarction or stable angina pectoris","volume":"121","author":"Williams","year":"2018","journal-title":"Am J Cardiol"}],"container-title":["Clinical Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149291819304023?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149291819304023?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T08:51:41Z","timestamp":1758963101000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0149291819304023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":57,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["S0149291819304023"],"URL":"https:\/\/doi.org\/10.1016\/j.clinthera.2019.08.008","relation":{},"ISSN":["0149-2918"],"issn-type":[{"value":"0149-2918","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of the Antianginal Drugs Ranolazine, Nicorandil, and Ivabradine on Coronary Microvascular Function in Patients With Nonobstructive Coronary Artery Disease: A Meta-analysis of Randomized Controlled Trials","name":"articletitle","label":"Article Title"},{"value":"Clinical Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clinthera.2019.08.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}