{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T18:19:09Z","timestamp":1790533149507,"version":"4.1.0"},"reference-count":10,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","clinicaltherapeutics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Therapeutics"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1016\/j.clinthera.2020.02.003","type":"journal-article","created":{"date-parts":[[2020,3,8]],"date-time":"2020-03-08T23:48:08Z","timestamp":1583711288000},"page":"704-710","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Risk Factors for Acetaminophen-induced Liver Injury: A Single-center Study from Japan"],"prefix":"10.1016","volume":"42","author":[{"given":"Noriaki","family":"Hidaka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichi","family":"Kaji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shingo","family":"Takatori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ichiro","family":"Matsuoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamoru","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clinthera.2020.02.003_bib1","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/clpt.1986.15","article-title":"Ketorolac and acetaminophen for orthopedic postoperative pain","volume":"39","author":"McQuay","year":"1986","journal-title":"Clin Pharmacol Ther"},{"key":"10.1016\/j.clinthera.2020.02.003_bib2","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1111\/j.1365-2125.2006.02723.x","article-title":"Dose\u2013response in direct comparisons of different doses of aspirin, ibuprofen and paracetamol (acetaminophen) in analgesic studies","volume":"63","author":"McQuay","year":"2007","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/j.clinthera.2020.02.003_bib3","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1111\/j.1532-5415.2009.02376.x","article-title":"Pharmacological management of persistent pain in older persons","volume":"57","author":"American Geriatrics Society Panel on Pharmacological Management of Persistent Pain in Older Persons","year":"2009","journal-title":"J\u00a0Am Geriatr Soc"},{"issue":"18","key":"10.1016\/j.clinthera.2020.02.003_bib4","first-page":"476","article-title":"OARSI Recommendations for the management of hip and knee osteoarthritis: part III: changes in evidence following systematic cumulative update of research published through","volume":"2010","author":"Zhang","year":"2009","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.clinthera.2020.02.003_bib5","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/clpt.1981.154","article-title":"A\u00a0method for estimating the probability of adverse drug reactions","volume":"2","author":"Naranjo","year":"1981","journal-title":"Clin Pharmacol Ther"},{"key":"10.1016\/j.clinthera.2020.02.003_bib6","doi-asserted-by":"crossref","first-page":"31","DOI":"10.3999\/jscpt.47.31","article-title":"Analysis of data from special drug use surveillance on elevation of liver function tests in Japanese Patients administered high dose acetaminophen","volume":"47","author":"Kumagai","year":"2016","journal-title":"Jpn J Clin Pharmacol Ther"},{"key":"10.1016\/j.clinthera.2020.02.003_bib7","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1185\/030079906X148346","article-title":"Retrospective analysis of transient elevations in alanine aminotransferase during long-term treatment with acetaminophen in osteoarthritis clinical trials","volume":"22","author":"Kuffner","year":"2006","journal-title":"Curr Med Res Opin"},{"key":"10.1016\/j.clinthera.2020.02.003_bib8","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s00204-014-1432-2","article-title":"Acetaminophen hepatotoxicity: an updated review","volume":"89","author":"Lancaster","year":"2015","journal-title":"Arch Toxicol"},{"key":"10.1016\/j.clinthera.2020.02.003_bib9","doi-asserted-by":"crossref","first-page":"e171","DOI":"10.1111\/liv.12514","article-title":"Acetaminophen-induced liver injury in obesity and nonalcoholic fatty liver disease","volume":"34","author":"Michaut","year":"2014","journal-title":"Liver Int"},{"key":"10.1016\/j.clinthera.2020.02.003_bib10","doi-asserted-by":"crossref","first-page":"e289","DOI":"10.1016\/S1470-2045(19)30296-7","article-title":"Use of the child\u2013pugh score in anticancer drug dosing making: proceed with caution","volume":"20","author":"Palmieri","year":"2019","journal-title":"Lancet Oncol"}],"container-title":["Clinical Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149291820300783?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149291820300783?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T08:51:58Z","timestamp":1758963118000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0149291820300783"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["S0149291820300783"],"URL":"https:\/\/doi.org\/10.1016\/j.clinthera.2020.02.003","relation":{},"ISSN":["0149-2918"],"issn-type":[{"value":"0149-2918","type":"print"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Risk Factors for Acetaminophen-induced Liver Injury: A Single-center Study from Japan","name":"articletitle","label":"Article Title"},{"value":"Clinical Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clinthera.2020.02.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}