{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T17:13:41Z","timestamp":1780506821602,"version":"3.54.1"},"reference-count":23,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,8,24]],"date-time":"2020-08-24T00:00:00Z","timestamp":1598227200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Hanlim Pharmaceuticals Co Ltd"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","clinicaltherapeutics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Therapeutics"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1016\/j.clinthera.2020.08.002","type":"journal-article","created":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T10:44:09Z","timestamp":1599043449000},"page":"2021-2035.e3","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Efficacy and Tolerability of Pitavastatin Versus Pitavastatin\/Fenofibrate in High-risk Korean Patients with Mixed Dyslipidemia: A Multicenter, Randomized, Double-blinded, Parallel, Therapeutic Confirmatory Clinical Trial"],"prefix":"10.1016","volume":"42","author":[{"given":"Sang-Hyun","family":"Ihm","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woo-Baek","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong-Min","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byung-Hee","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki-Dong","family":"Yoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung-Ho","family":"Her","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woo-Hyuk","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In-Ho","family":"Chae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae-Ho","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3186-0770","authenticated-orcid":false,"given":"Ju-Han","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Woon","family":"Jeon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2095-1121","authenticated-orcid":false,"given":"Byung-Ryul","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung-Ho","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang-Don","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7814-0527","authenticated-orcid":false,"given":"Jin-Bae","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong-Taek","family":"Woo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byung-Wan","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung-Ah","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung-Heon","family":"Won","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyo-Soo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae-Myung","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Choon Hee","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8958-7164","authenticated-orcid":false,"given":"Hae-Jin","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0712-7728","authenticated-orcid":false,"given":"Ho-Chan","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki-Bae","family":"Seung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clinthera.2020.08.002_bib1","doi-asserted-by":"crossref","first-page":"2333","DOI":"10.1161\/01.ATV.20.11.2333","article-title":"Treatment of dyslipidemia","volume":"20","author":"Crouse","year":"2000","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.clinthera.2020.08.002_bib2","doi-asserted-by":"crossref","first-page":"2459","DOI":"10.1093\/eurheartj\/ehx144","article-title":"Low-density lipoproteins cause atherosclerotic cardiovascular disease. 1. Evidence from genetic, epidemiologic, and clinical studies. A consensus statement from the European Atherosclerosis Society Consensus Panel","volume":"38","author":"Ference","year":"2017","journal-title":"Eur Heart J"},{"key":"10.1016\/j.clinthera.2020.08.002_bib3","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1056\/NEJM199502233320807","article-title":"Cholesterol reduction in cardiovascular disease\u2014clinical benefits and possible mechanisms","volume":"332","author":"Levine","year":"1995","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.clinthera.2020.08.002_bib4","first-page":"e1046","article-title":"2018 AHA\/ACC\/AACVPR\/AAPA\/ABC\/ACPM\/ADA\/AGS\/APhA\/ASPC\/NLA\/PCNA guideline on the management of blood cholesterol: a report of the American College of Cardiology\/American heart association task force on clinical practice guidelines","volume":"139","year":"2019","journal-title":"Circulation"},{"issue":"9346","key":"10.1016\/j.clinthera.2020.08.002_bib5","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1016\/S0140-6736(02)11600-X","article-title":"Pravastatin in elderly individuals at risk of vascular disease (PROSPER): a randomised controlled trial","volume":"360","author":"Shepherd","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.clinthera.2020.08.002_bib6","doi-asserted-by":"crossref","first-page":"85","DOI":"10.7326\/M17-0681","article-title":"Comparison of five major guidelines for statin use in primary prevention in a contemporary general population","volume":"168","author":"Mortensen","year":"2018","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.clinthera.2020.08.002_bib7","doi-asserted-by":"crossref","first-page":"2556","DOI":"10.1001\/jama.2011.860","article-title":"Risk of incident diabetes with intensive-dose compared with moderate-dose statin therapy: a meta-analysis.","volume":"305","author":"Preiss","year":"2011","journal-title":"JAMA"},{"key":"10.1016\/j.clinthera.2020.08.002_bib8","doi-asserted-by":"crossref","first-page":"373","DOI":"10.2165\/0129784-200808060-00004","article-title":"Statin adverse effects","volume":"8","author":"Golomb","year":"2008","journal-title":"Am J Cardiovasc Drugs"},{"key":"10.1016\/j.clinthera.2020.08.002_bib9","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1517\/14740338.5.5.651","article-title":"Statins and myotoxicity: a therapeutic limitation","volume":"5","author":"Tiwari","year":"2006","journal-title":"Exp Opin Drug Saf"},{"key":"10.1016\/j.clinthera.2020.08.002_bib10","doi-asserted-by":"crossref","first-page":"227","DOI":"10.2165\/11207690-000000000-00000","article-title":"Fenofibrate","volume":"11","author":"Keating","year":"2011","journal-title":"Am J Cardiovasc Drugs."},{"key":"10.1016\/j.clinthera.2020.08.002_bib11","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.1016\/S0149-2918(02)80095-9","article-title":"Fenofibrate in the treatment of dyslipidemia: a review of the data as they relate to the new suprabioavailable tablet formulation","volume":"24","author":"Najib","year":"2002","journal-title":"Clin Ther"},{"key":"10.1016\/j.clinthera.2020.08.002_bib12","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1111\/1755-5922.12148","article-title":"New fixed-dose combinations of fenofibrate\/simvastatin therapy significantly improve the lipid profile of high-risk patients with mixed dyslipidemia versus monotherapies","volume":"33","author":"Foucher","year":"2015","journal-title":"Cardiovasc Ther"},{"key":"10.1016\/j.clinthera.2020.08.002_bib13","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1900\/RDS.2013.10.171","article-title":"Does combination therapy with statins and fibrates prevent cardiovascular disease in diabetic patients with atherogenic mixed dyslipidemia?","volume":"10","author":"Agouridis","year":"2013","journal-title":"Rev Diabet Stud"},{"key":"10.1016\/j.clinthera.2020.08.002_bib14","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1056\/NEJMoa1001282","article-title":"Effects of combination lipid therapy in type 2 diabetes mellitus","volume":"362","author":"Ginsberg","year":"2010","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.clinthera.2020.08.002_bib15","doi-asserted-by":"crossref","first-page":"2486","DOI":"10.1001\/jama.285.19.2486","volume":"285","year":"2001","journal-title":"JAMA"},{"issue":"9716","key":"10.1016\/j.clinthera.2020.08.002_bib16","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/S0140-6736(09)61965-6","article-title":"Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials","volume":"375","author":"Sattar","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.clinthera.2020.08.002_bib17","article-title":"Effect of change in total cholesterol levels on cardiovascular disease among young adults","volume":"7","author":"Jeong","year":"2018","journal-title":"J\u00a0Am Heart Assoc"},{"key":"10.1016\/j.clinthera.2020.08.002_bib18","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1007\/s11886-011-0220-3","article-title":"The role of triglycerides in atherosclerosis","volume":"13","author":"Talayero","year":"2011","journal-title":"Curr Cardiol Rep"},{"key":"10.1016\/j.clinthera.2020.08.002_bib19","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.amjcard.2010.05.005","article-title":"Efficacy and safety of adding fenofibrate 160 mg in high-risk patients with mixed hyperlipidemia not controlled by pravastatin 40 mg monotherapy","volume":"106","author":"Farnier","year":"2010","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.clinthera.2020.08.002_bib20","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1194\/jlr.M700108-JLR200","article-title":"Fenofibrate increases HDL-cholesterol by reducing cholesteryl ester transfer protein expression","volume":"48","author":"Hoogt","year":"2007","journal-title":"J\u00a0Lipid Res"},{"key":"10.1016\/j.clinthera.2020.08.002_bib21","doi-asserted-by":"crossref","first-page":"57","DOI":"10.4137\/JCM.S7863","article-title":"Additional treatment with fenofibrate for patients treated with pitavastatin under ordinary medical practice for hypertriglyceridemia in Japan (APPROACH-J Study)","volume":"2","author":"Wakida","year":"2011","journal-title":"Jpn Clin Med"},{"key":"10.1016\/j.clinthera.2020.08.002_bib22","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1373\/clinchem.2008.118356","article-title":"Apolipoprotein B and cardiovascular disease risk: position statement from the AACC lipoproteins and vascular diseases division working group on best practices","volume":"55","author":"Contois","year":"2009","journal-title":"Clin Chem"},{"key":"10.1016\/j.clinthera.2020.08.002_bib23","doi-asserted-by":"crossref","first-page":"281","DOI":"10.2165\/11630820-000000000-00000","article-title":"Safety of a fixed-dose combination of fenofibrate\/pravastatin 160\u2009mg\/40\u2009mg in patients with mixed hyperlipidaemia","volume":"32","author":"Farnier","year":"2012","journal-title":"Clin Drug Invest"}],"container-title":["Clinical Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149291820303532?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149291820303532?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T08:56:01Z","timestamp":1758963361000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0149291820303532"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":23,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["S0149291820303532"],"URL":"https:\/\/doi.org\/10.1016\/j.clinthera.2020.08.002","relation":{},"ISSN":["0149-2918"],"issn-type":[{"value":"0149-2918","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficacy and Tolerability of Pitavastatin Versus Pitavastatin\/Fenofibrate in High-risk Korean Patients with Mixed Dyslipidemia: A Multicenter, Randomized, Double-blinded, Parallel, Therapeutic Confirmatory Clinical Trial","name":"articletitle","label":"Article Title"},{"value":"Clinical Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clinthera.2020.08.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}