{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T16:47:26Z","timestamp":1793810846836,"version":"4.6.1"},"reference-count":37,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","clinicaltherapeutics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Therapeutics"],"published-print":{"date-parts":[[2022,5]]},"DOI":"10.1016\/j.clinthera.2022.03.005","type":"journal-article","created":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:46:08Z","timestamp":1648773968000},"page":"736-743.e3","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Correlation Between Crohn's Disease Activity and Serum Selenium Concentration"],"prefix":"10.1016","volume":"44","author":[{"given":"Wu","family":"Yan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Meihao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Zihan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huang","family":"Lingjie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Haotian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cao","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8640-4780","authenticated-orcid":false,"given":"Sun","family":"Lianli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clinthera.2022.03.005_bib0001","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/S2468-1253(18)30159-6","article-title":"Differential diagnosis of inflammatory bowel disease: imitations and complications","volume":"3","author":"Gecse","year":"2018","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"10.1016\/j.clinthera.2022.03.005_bib0002","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s12325-019-01151-w","article-title":"Fatigue in inflammatory bowel diseases: etiologies and management","volume":"37","author":"Nocerino","year":"2020","journal-title":"Adv Ther"},{"key":"10.1016\/j.clinthera.2022.03.005_bib0003","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.autrev.2019.03.002","article-title":"Induction and maintenance treatment of inflammatory bowel disease: a comprehensive review","volume":"18","author":"Jeong","year":"2019","journal-title":"Autoimmun Rev"},{"issue":"Suppl 1","key":"10.1016\/j.clinthera.2022.03.005_bib0004","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1159\/000507782","article-title":"Emerging treatment options in inflammatory bowel disease: janus kinases, stem cells, and more","volume":"101","author":"Misselwitz","year":"2020","journal-title":"Digestion"},{"key":"10.1016\/j.clinthera.2022.03.005_bib0005","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1093\/ecco-jcc\/jjw168","article-title":"European Evidence-based Consensus on the Diagnosis and Management of Crohn's Disease 2016","volume":"11","author":"Gomollon","year":"2017","journal-title":"J Crohns Colitis"},{"key":"10.1016\/j.clinthera.2022.03.005_bib0006","doi-asserted-by":"crossref","first-page":"4014","DOI":"10.3748\/wjg.v24.i35.4014","article-title":"Endoscopy in inflammatory bowel disease: role in diagnosis, management, and treatment","volume":"24","author":"Spiceland","year":"2018","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.clinthera.2022.03.005_bib0007","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.crohns.2013.02.005","article-title":"Optimising monitoring in the management of Crohn's disease: a physician's perspective","volume":"7","author":"Papay","year":"2013","journal-title":"J Crohns Colitis"},{"key":"10.1016\/j.clinthera.2022.03.005_bib0008","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.disamonth.2017.07.001","article-title":"A comprehensive review and update on Crohn's disease","volume":"64","author":"Gajendran","year":"2018","journal-title":"Dis Mon"},{"key":"10.1016\/j.clinthera.2022.03.005_bib0009","doi-asserted-by":"crossref","first-page":"11246","DOI":"10.3748\/wjg.v21.i40.11246","article-title":"Disease monitoring in inflammatory bowel disease","volume":"21","author":"Chang","year":"2015","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.clinthera.2022.03.005_bib0010","first-page":"770","article-title":"Current noninvasive modalities in Crohn's disease monitoring","volume":"34","author":"Mitselos","year":"2021","journal-title":"Ann Gastroenterol"},{"key":"10.1016\/j.clinthera.2022.03.005_bib0011","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1097\/01.MIB.0000442681.85545.31","article-title":"Clinical utility of fecal biomarkers for the diagnosis and management of inflammatory bowel disease","volume":"20","author":"Kopylov","year":"2014","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.clinthera.2022.03.005_bib0012","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1093\/jcag\/gwaa009","article-title":"Fecal calprotectin, CRP and leucocytes in IBD patients: comparison of biomarkers with biopsy results","volume":"4","author":"Kyle","year":"2021","journal-title":"J Can Assoc Gastroenterol"},{"key":"10.1016\/j.clinthera.2022.03.005_bib0013","doi-asserted-by":"crossref","first-page":"245","DOI":"10.17219\/acem\/67222","article-title":"Selenium\u2014a fascinating antioxidant of protective properties","volume":"27","author":"Kielczykowska","year":"2018","journal-title":"Adv Clin Exp Med"},{"key":"10.1016\/j.clinthera.2022.03.005_bib0014","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.3390\/nu10091203","article-title":"Selenium, selenoproteins, and immunity","volume":"10","author":"Avery","year":"2018","journal-title":"Nutrients"},{"key":"10.1016\/j.clinthera.2022.03.005_bib0015","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1007\/s10787-020-00690-x","article-title":"Selenium and selenoproteins: its role in regulation of inflammation","volume":"28","author":"Hariharan","year":"2020","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.clinthera.2022.03.005_bib0016","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.3390\/nu4091247","article-title":"Selenium, selenoprotein genes and Crohn's disease in a case-control population from Auckland, New Zealand","volume":"4","author":"Gentschew","year":"2012","journal-title":"Nutrients"},{"key":"10.1016\/j.clinthera.2022.03.005_bib0017","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/1813047","article-title":"New insights into the role of trace elements in IBD","volume":"2018","author":"Gilca-Blanariu","year":"2018","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.clinthera.2022.03.005_bib0018","doi-asserted-by":"crossref","first-page":"363","DOI":"10.5009\/gnl16333","article-title":"Risk factors for vitamin D, zinc, and selenium deficiencies in Korean patients with inflammatory bowel disease","volume":"11","author":"Han","year":"2017","journal-title":"Gut Liver"},{"key":"10.1016\/j.clinthera.2022.03.005_bib0019","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1016\/j.immuni.2021.07.004","article-title":"Multiomics analyses reveal a critical role of selenium in controlling T cell differentiation in Crohn's disease","volume":"54","author":"Huang","year":"2021","journal-title":"Immunity"},{"key":"10.1016\/j.clinthera.2022.03.005_bib0020","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/2894169","article-title":"The influence of nutrients on inflammatory bowel diseases","volume":"2020","author":"Jarmakiewicz-Czaja","year":"2020","journal-title":"J Nutr Metab"},{"key":"10.1016\/j.clinthera.2022.03.005_bib0021","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2020.12.059","article-title":"Colonic epithelial-derived selenoprotein P is the source for antioxidant-mediated protection in colitis-associated cancer","volume":"160","author":"Short","year":"2021","journal-title":"Gastroenterology"},{"key":"10.1016\/j.clinthera.2022.03.005_bib0022","doi-asserted-by":"crossref","first-page":"3253","DOI":"10.1007\/s12011-020-02478-0","article-title":"A spatial ecological study on serum selenium and Keshan disease in Heilongjiang Province","volume":"199","author":"Liu","year":"2021","journal-title":"China. Biol Trace Elem Res"},{"key":"10.1016\/j.clinthera.2022.03.005_bib0023","first-page":"116","article-title":"The serum concentrations of zinc, copper and selenium in children with inflammatory bowel disease","volume":"48","author":"Ojuawo","year":"2002","journal-title":"Cent Afr J Med"},{"key":"10.1016\/j.clinthera.2022.03.005_bib0024","doi-asserted-by":"crossref","first-page":"780","DOI":"10.3390\/nu8120780","article-title":"Ulcerative colitis and Crohn's disease are associated with decreased serum selenium concentrations and increased cardiovascular risk","volume":"8","author":"Castro","year":"2016","journal-title":"Nutrients"},{"key":"10.1016\/j.clinthera.2022.03.005_bib0025","doi-asserted-by":"crossref","first-page":"183","DOI":"10.4103\/1319-3767.182455","article-title":"Implementation of the simple endoscopic activity score in Crohn's disease","volume":"22","author":"Koutroumpakis","year":"2016","journal-title":"Saudi J Gastroenterol"},{"key":"10.1016\/j.clinthera.2022.03.005_bib0026","first-page":"D10642","article-title":"Endoscopic scoring indices for evaluation of disease activity in Crohn's disease","author":"Khanna","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.clinthera.2022.03.005_bib0027","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.cgh.2010.01.001","article-title":"Correlation between the Crohn's disease activity and Harvey-Bradshaw indices in assessing Crohn's disease severity","volume":"8","author":"Vermeire","year":"2010","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.clinthera.2022.03.005_bib0028","first-page":"543","article-title":"Development of the Harvey-Bradshaw Index-pro (HBI-PRO) score to assess endoscopic disease activity in Crohn's disease","volume":"11","author":"Zittan","year":"2017","journal-title":"J Crohns Colitis"},{"key":"10.1016\/j.clinthera.2022.03.005_bib0029","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.clnu.2020.05.010","article-title":"A prospective analysis of micronutrient status in quiescent inflammatory bowel disease","volume":"40","author":"MacMaster","year":"2021","journal-title":"Clin Nutr"},{"key":"10.1016\/j.clinthera.2022.03.005_bib0030","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1093\/ajcn\/74.2.259","article-title":"Lipid peroxidation and plasma antioxidant micronutrients in Crohn's disease","volume":"74","author":"Wendland","year":"2001","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.clinthera.2022.03.005_bib0031","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1053\/j.gastro.2015.07.003","article-title":"Biomarkers of inflammation in inflammatory bowel disease","volume":"149","author":"Sands","year":"2015","journal-title":"Gastroenterology"},{"key":"10.1016\/j.clinthera.2022.03.005_bib0032","first-page":"334","article-title":"Could platelet indices be new biomarkers for inflammatory bowel diseases?","volume":"17","author":"Ozturk","year":"2013","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"10.1016\/j.clinthera.2022.03.005_bib0033","doi-asserted-by":"crossref","first-page":"3190","DOI":"10.1007\/s12011-020-02444-w","article-title":"Zinc and selenium in inflammatory bowel disease: trace elements with key roles?","volume":"199","author":"Vaghari-Tabari","year":"2021","journal-title":"Biol Trace Elem Res"},{"issue":"1-2","key":"10.1016\/j.clinthera.2022.03.005_bib0034","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.mrfmmm.2010.02.006","article-title":"Investigating micronutrients and epigenetic mechanisms in relation to inflammatory bowel disease","volume":"690","author":"Barnett","year":"2010","journal-title":"Mutat Res"},{"key":"10.1016\/j.clinthera.2022.03.005_bib0035","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.ejim.2010.04.012","article-title":"Nutritional status in patients with active inflammatory bowel disease: prevalence of malnutrition and methods for routine nutritional assessment","volume":"21","author":"Mijac","year":"2010","journal-title":"Eur J Intern Med"},{"key":"10.1016\/j.clinthera.2022.03.005_bib0036","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1177\/000313481708301123","article-title":"Hypoalbuminemia and clinical outcomes: what is the mechanism behind the relationship?","volume":"83","author":"Kim","year":"2017","journal-title":"Am Surg"},{"key":"10.1016\/j.clinthera.2022.03.005_bib0037","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1262\/jrd.11-049K","article-title":"Effects of antioxidant supplementation on duodenal Se-Met absorption in ethanol-exposed rat offspring in vivo","volume":"57","author":"Nogales","year":"2011","journal-title":"J Reprod Dev"}],"container-title":["Clinical Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S014929182200087X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S014929182200087X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T08:57:21Z","timestamp":1758963441000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S014929182200087X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":37,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["S014929182200087X"],"URL":"https:\/\/doi.org\/10.1016\/j.clinthera.2022.03.005","relation":{},"ISSN":["0149-2918"],"issn-type":[{"value":"0149-2918","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Correlation Between Crohn's Disease Activity and Serum Selenium Concentration","name":"articletitle","label":"Article Title"},{"value":"Clinical Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clinthera.2022.03.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}