{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T10:53:53Z","timestamp":1794048833781,"version":"4.8.0"},"reference-count":26,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicaltherapeutics.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Therapeutics"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1016\/j.clinthera.2024.01.009","type":"journal-article","created":{"date-parts":[[2024,2,24]],"date-time":"2024-02-24T20:11:40Z","timestamp":1708805500000},"page":"338-344","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Comparison of Empiric Antibiotic Treatment Regimens for Hospitalized, Non-severe Community-acquired Pneumonia: A Retrospective, Multicenter Cohort Study"],"prefix":"10.1016","volume":"46","author":[{"given":"Sidney D.","family":"Reeves","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron P.","family":"Hartmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda C.","family":"Tedder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul A.","family":"Juang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikaela","family":"Hofer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0671-0751","authenticated-orcid":false,"given":"Marin H.","family":"Kollef","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott T.","family":"Micek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6007-359X","authenticated-orcid":false,"given":"Kevin D.","family":"Betthauser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clinthera.2024.01.009_bib0001","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1164\/rccm.201501-0140OC","article-title":"Ten-year mortality after community-acquired pneumonia: a prospective cohort","volume":"192","author":"Eurich","year":"2015","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.clinthera.2024.01.009_bib0002","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1056\/NEJMra1312885","article-title":"Community-acquired pneumonia","volume":"371","author":"Musher","year":"2014","journal-title":"N Engl J Med"},{"key":"10.1016\/j.clinthera.2024.01.009_bib0003","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1080\/00325481.2015.1074030","article-title":"Community-acquired pneumonia: an overview","volume":"127","author":"Mandell","year":"2015","journal-title":"Postgrad Med"},{"key":"10.1016\/j.clinthera.2024.01.009_bib0004","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.emc.2018.07.001","article-title":"Community-acquired pneumonia","volume":"36","author":"Rider","year":"2018","journal-title":"Emerg Med Clin North Am"},{"key":"10.1016\/j.clinthera.2024.01.009_bib0005","doi-asserted-by":"crossref","first-page":"E45","DOI":"10.1164\/rccm.201908-1581ST","article-title":"Diagnosis and treatment of adults with community-acquired pneumonia: an official Clinical Practice Guideline of the American Thoracic Society and Infectious Diseases Society of America","volume":"200","author":"Metlay","year":"2019","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.clinthera.2024.01.009_bib0006","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1093\/cid\/cis414","article-title":"Macrolide-based regimens and mortality in hospitalized patients with community-acquired pneumonia: a systematic review and meta-analysis","volume":"55","author":"Asadi","year":"2012","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.clinthera.2024.01.009_bib0007","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1097\/CCM.0b013e3182a66b9b","article-title":"Macrolides and mortality in critically ill patients with community-acquired pneumonia","volume":"42","author":"Sligl","year":"2014","journal-title":"Crit Care Med"},{"key":"10.1016\/j.clinthera.2024.01.009_bib0008","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1016\/j.ajem.2018.01.079","article-title":"Ceftriaxone combination therapy versus respiratory fluoroquinolone monotherapy for community-acquired pneumonia: a meta-analysis","volume":"36","author":"Zhang","year":"2018","journal-title":"AmJ Emergency Medicine"},{"key":"10.1016\/j.clinthera.2024.01.009_bib0009","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1111\/j.1365-2710.2009.01073.x","article-title":"Doxycycline vs. Levofloxacin in the Treatment of Community-Acquired Pneumonia","volume":"35","author":"Mokabberi","year":"2009","journal-title":"J Clin Pharm Ther"},{"key":"10.1016\/j.clinthera.2024.01.009_bib0010","article-title":"Respiratory fluoroquinolones monotherapy vs. \u03b2-lactams with or without macrolides for hospitalized community-acquired pneumonia patients: a meta-analysis","volume":"10","author":"Liu","year":"2019","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.clinthera.2024.01.009_bib0011","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/jhm.8","article-title":"Effectiveness of ceftriaxone plus doxycycline in the treatment of patients hospitalized with community-acquired pneumonia","volume":"1","author":"Flanders","year":"2006","journal-title":"J Hosp Med"},{"key":"10.1016\/j.clinthera.2024.01.009_bib0012","doi-asserted-by":"crossref","first-page":"E71","DOI":"10.1111\/j.1469-0691.2011.03759.x","article-title":"Doxycycline vs. macrolides in combination therapy for treatment of community-acquired pneumonia","volume":"18","author":"Teh","year":"2012","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.clinthera.2024.01.009_bib0013","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.chest.2023.08.008","article-title":"Comparative effectiveness of first-line and alternative antibiotic regimens in hospitalized patients with non-severe community-acquired pneumonia: a multicenter retrospective cohort study","volume":"165","author":"Bai","year":"2024","journal-title":"Chest"},{"key":"10.1016\/j.clinthera.2024.01.009_bib0014","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1093\/cid\/ciab863","article-title":"Effectiveness of beta-lactam plus doxycycline for patients hospitalized with community-acquired pneumonia","volume":"75","author":"Uddin","year":"2022","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.clinthera.2024.01.009_bib0015","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1093\/cid\/ciac615","article-title":"Efficacy of doxycycline for mild-to-moderate community-acquired pneumonia in adults: a systematic review and meta-analysis of randomized controlled trials","volume":"76","author":"Choi","year":"2023","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.clinthera.2024.01.009_bib0016","doi-asserted-by":"crossref","first-page":"e258","DOI":"10.1097\/CCM.0000000000004809","article-title":"Racial disparities in readmissions following initial hospitalization for sepsis","volume":"49","author":"Lizza","year":"2021","journal-title":"Crit Care Med"},{"key":"10.1016\/j.clinthera.2024.01.009_bib0017","first-page":"188","article-title":"Charlson comorbidity index: ICD-9 update and ICD-10 translation","volume":"12","author":"Glasheen","year":"2019","journal-title":"Am Health Drug Benefits"},{"issue":"1","key":"10.1016\/j.clinthera.2024.01.009_bib0018","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1186\/s12879-017-2495-5","article-title":"Clinical failure with and without empiric atypical bacteria coverage in hospitalized adults with community-acquired pneumonia: a systematic review and meta-analysis","volume":"17","author":"Eljaaly","year":"2017","journal-title":"BMC Infect Dis"},{"key":"10.1016\/j.clinthera.2024.01.009_bib0019","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1183\/09031936.00098411","article-title":"Treatment failure in pneumonia: impact of antibiotic treatment and cost analysis","volume":"39","author":"Ott","year":"2012","journal-title":"Eur Respir J"},{"key":"10.1016\/j.clinthera.2024.01.009_bib0020","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/j.rmed.2014.02.007","article-title":"Predictors and impact of time to clinical stability in community-acquired pneumococcal pneumonia","volume":"108","author":"Takada","year":"2014","journal-title":"Respir Med"},{"key":"10.1016\/j.clinthera.2024.01.009_bib0021","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1378\/chest.06-1995","article-title":"Treatment failure in community-acquired pneumonia","volume":"132","author":"Menendez","year":"2007","journal-title":"Chest"},{"issue":"22","key":"10.1016\/j.clinthera.2024.01.009_bib0022","doi-asserted-by":"crossref","first-page":"443","DOI":"10.21037\/atm.2017.06.54","article-title":"Predictors of treatment failure and clinical stability in patients with community acquired pneumonia","volume":"5","author":"Morley","year":"2017","journal-title":"Ann Transl Med"},{"issue":"8","key":"10.1016\/j.clinthera.2024.01.009_bib0023","doi-asserted-by":"crossref","first-page":"ofad413","DOI":"10.1093\/ofid\/ofad413","article-title":"Comparison of different antibiotics and the risk for community-associated Clostridioides difficile infection: a case-control study","volume":"10","author":"Miller","year":"2023","journal-title":"Open Forum Infect Dis"},{"key":"10.1016\/j.clinthera.2024.01.009_bib0024","article-title":"Impact of doxycycline on Clostridioides difficile infection in patients hospitalized with community-acquired pneumonia","author":"O'Leary","year":"2023","journal-title":"Am J Infect Control"},{"key":"10.1016\/j.clinthera.2024.01.009_bib0025","doi-asserted-by":"crossref","first-page":"3","DOI":"10.2174\/1871525717666190402121958","article-title":"Fluoroquinolones and the risk of aortic aneurysm or aortic dissection: a systematic review and meta-analysis","volume":"17","author":"Rawla","year":"2019","journal-title":"Cardiovasc Hematol Agents Med Chem"},{"key":"10.1016\/j.clinthera.2024.01.009_bib0026","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.7150\/ijms.34141","article-title":"Study of the FDA adverse event reporting system","volume":"16","author":"Teng","year":"2019","journal-title":"Int J Med Sci"}],"container-title":["Clinical Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149291824000201?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149291824000201?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T12:56:35Z","timestamp":1716296195000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0149291824000201"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":26,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["S0149291824000201"],"URL":"https:\/\/doi.org\/10.1016\/j.clinthera.2024.01.009","relation":{},"ISSN":["0149-2918"],"issn-type":[{"value":"0149-2918","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparison of Empiric Antibiotic Treatment Regimens for Hospitalized, Non-severe Community-acquired Pneumonia: A Retrospective, Multicenter Cohort Study","name":"articletitle","label":"Article Title"},{"value":"Clinical Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clinthera.2024.01.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}