{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T02:53:14Z","timestamp":1792896794116,"version":"4.5.0"},"reference-count":20,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T00:00:00Z","timestamp":1757030400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008349","name":"Boehringer Ingelheim GmbH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MC_UU_00017\/3"],"award-info":[{"award-number":["MC_UU_00017\/3"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","clinicaltherapeutics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Therapeutics"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.clinthera.2025.09.005","type":"journal-article","created":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T00:08:44Z","timestamp":1759622924000},"page":"1091-1096","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Empagliflozin Reduces Risk of Hospitalization in Patients With Chronic Kidney Disease in the EMPA-KIDNEY Trial"],"prefix":"10.1016","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-2135-2061","authenticated-orcid":false,"given":"Anastasia","family":"Uster","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nihar","family":"Desai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sankar D.","family":"Navaneethan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Egon","family":"Pfarr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Rita","family":"Mazo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clinthera.2025.09.005_bib0001","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1016\/S0140-6736(10)60674-5","article-title":"Association of estimated glomerular filtration rate and albuminuria with all-cause and cardiovascular mortality in general population cohorts: a collaborative meta-analysis","volume":"375","author":"K","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.clinthera.2025.09.005_bib0002","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.atherosclerosis.2021.09.007","article-title":"Chronic kidney disease measures for cardiovascular risk prediction","volume":"335","author":"Mok","year":"2021","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.clinthera.2025.09.005_bib0003","doi-asserted-by":"crossref","first-page":"e243","DOI":"10.3399\/bjgp20X714125","article-title":"Comorbidity in chronic kidney disease: a large cross-sectional study of prevalence in Scottish primary care","volume":"71","author":"MacRae","year":"2021","journal-title":"Br J Gen Pract"},{"key":"10.1016\/j.clinthera.2025.09.005_bib0004","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1186\/s12882-015-0189-z","article-title":"The burden of comorbidity in people with chronic kidney disease stage 3: a cohort study","volume":"16","author":"Fraser","year":"2015","journal-title":"BMC Nephrol"},{"key":"10.1016\/j.clinthera.2025.09.005_bib0005","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1159\/000178816","article-title":"Chronic kidney disease and US healthcare resource utilization in a nationally representative sample","volume":"29","author":"Alexander","year":"2009","journal-title":"Am J Nephrol"},{"key":"10.1016\/j.clinthera.2025.09.005_bib0006","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1111\/jgs.14662","article-title":"Association of multimorbidity with mortality and healthcare utilization in chronic kidney disease","volume":"65","author":"Bowling","year":"2017","journal-title":"J Am Geriatr Soc"},{"key":"10.1016\/j.clinthera.2025.09.005_bib0007","doi-asserted-by":"crossref","first-page":"2124","DOI":"10.1093\/ckj\/sfac168","article-title":"Healthcare resource utilisation and related costs of patients with CKD from the UK: a report from the DISCOVER CKD retrospective cohort","volume":"15","author":"Pollock","year":"2022","journal-title":"Clin Kidney J"},{"key":"10.1016\/j.clinthera.2025.09.005_bib0008","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1003470","article-title":"Hospitalizations among adults with chronic kidney disease in the United States: a cohort study","volume":"17","author":"Schrauben","year":"2020","journal-title":"PLoS Med"},{"key":"10.1016\/j.clinthera.2025.09.005_bib0009","doi-asserted-by":"crossref","first-page":"409","DOI":"10.2215\/CJN.05070511","article-title":"Risks of subsequent hospitalization and death in patients with kidney disease","volume":"7","author":"Daratha","year":"2012","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.clinthera.2025.09.005_bib0010","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1056\/NEJMoa2107038","article-title":"Empagliflozin in heart failure with a preserved ejection fraction","volume":"385","author":"Anker","year":"2021","journal-title":"N Engl J Med"},{"key":"10.1016\/j.clinthera.2025.09.005_bib0011","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1056\/NEJMoa2022190","article-title":"Cardiovascular and renal outcomes with empagliflozin in heart failure","volume":"383","author":"Packer","year":"2020","journal-title":"N Engl J Med"},{"key":"10.1016\/j.clinthera.2025.09.005_bib0012","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1056\/NEJMoa2206286","article-title":"Dapagliflozin in heart failure with mildly reduced or preserved ejection fraction","volume":"387","author":"Solomon","year":"2022","journal-title":"N Engl J Med"},{"key":"10.1016\/j.clinthera.2025.09.005_bib0013","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1056\/NEJMoa1911303","article-title":"Dapagliflozin in patients with heart failure and reduced ejection fraction","volume":"381","author":"McMurray","year":"2019","journal-title":"N Engl J Med"},{"key":"10.1016\/j.clinthera.2025.09.005_bib0014","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1056\/NEJMoa2204233","article-title":"Empagliflozin in patients with chronic kidney disease","volume":"388","author":"The EMPA-Kidney Collaborative Group","year":"2023","journal-title":"N Engl J Med"},{"key":"10.1016\/j.clinthera.2025.09.005_bib0015","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1056\/NEJMoa2024816","article-title":"Dapagliflozin in patients with chronic kidney disease","volume":"383","author":"Heerspink","year":"2020","journal-title":"N Engl J Med"},{"key":"10.1016\/j.clinthera.2025.09.005_bib0016","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1002\/sim.6853","article-title":"Analysis of recurrent events with an associated informative dropout time: application of the joint frailty model","volume":"35","author":"Rogers","year":"2016","journal-title":"Stat Med"},{"key":"10.1016\/j.clinthera.2025.09.005_bib0017","doi-asserted-by":"crossref","first-page":"59","DOI":"10.7326\/M22-2115","article-title":"Effects of dapagliflozin on hospitalizations in patients with chronic kidney disease: a post hoc analysis of DAPA-CKD","volume":"176","author":"Schechter","year":"2023","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.clinthera.2025.09.005_bib0018","doi-asserted-by":"crossref","first-page":"3627","DOI":"10.1093\/eurheartj\/ehad195","article-title":"2023 Focused Update of the 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure","volume":"44","author":"McDonagh","year":"2023","journal-title":"Eur Heart J"},{"key":"10.1016\/j.clinthera.2025.09.005_bib0019","doi-asserted-by":"crossref","first-page":"e263","DOI":"10.1016\/j.jacc.2021.12.012","article-title":"2022 AHA\/ACC\/HFSA Guideline for the Management of Heart Failure: a report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"79","author":"Heidenreich","year":"2022","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.clinthera.2025.09.005_bib0020","doi-asserted-by":"crossref","first-page":"S117","DOI":"10.1016\/j.kint.2023.10.018","article-title":"Kidney Disease: Improving Global Outcomes CKDWG. KDIGO 2024 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease","volume":"105","year":"2024","journal-title":"Kidney Int"}],"container-title":["Clinical Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149291825003157?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149291825003157?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T04:10:03Z","timestamp":1772856603000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0149291825003157"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":20,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["S0149291825003157"],"URL":"https:\/\/doi.org\/10.1016\/j.clinthera.2025.09.005","relation":{},"ISSN":["0149-2918"],"issn-type":[{"value":"0149-2918","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Empagliflozin Reduces Risk of Hospitalization in Patients With Chronic Kidney Disease in the EMPA-KIDNEY Trial","name":"articletitle","label":"Article Title"},{"value":"Clinical Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clinthera.2025.09.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}