{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T23:19:07Z","timestamp":1770506347791,"version":"3.49.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2014,3,1]],"date-time":"2014-03-01T00:00:00Z","timestamp":1393632000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinics in Laboratory Medicine"],"published-print":{"date-parts":[[2014,3]]},"DOI":"10.1016\/j.cll.2013.11.010","type":"journal-article","created":{"date-parts":[[2014,2,5]],"date-time":"2014-02-05T20:51:35Z","timestamp":1391633495000},"page":"157-166","source":"Crossref","is-referenced-by-count":9,"title":["Biomarkers for Cholesterol Absorption and Synthesis in Hyperlipidemic Patients"],"prefix":"10.1016","volume":"34","author":[{"given":"Alan H.B.","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cll.2013.11.010_bib1","doi-asserted-by":"crossref","first-page":"3143","DOI":"10.1161\/circ.106.25.3143","article-title":"Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Final Report","volume":"106","author":"Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.cll.2013.11.010_bib2","series-title":"Biochemistry of lipids, lipoproteins and membranes","first-page":"409","article-title":"Cholesterol biosynthesis","author":"Liscum","year":"2002"},{"key":"10.1016\/j.cll.2013.11.010_bib3","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/S0022-2275(20)38603-X","article-title":"Correlation between serum levels of some cholesterol precursors and activity of HMG-CoA reducatase in human liver","volume":"27","author":"Bjorkhem","year":"1987","journal-title":"J\u00a0Lipid Res"},{"issue":"3","key":"10.1016\/j.cll.2013.11.010_bib4","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S1665-2681(19)32136-2","article-title":"New concepts of mechanisms of intestinal cholesterol absorption","volume":"2","author":"Wang","year":"2003","journal-title":"Ann Hepatol"},{"key":"10.1016\/j.cll.2013.11.010_bib5","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1002\/humu.1206","article-title":"Mutations in ATP-cassette binding protein G5 (ABCG5) and G8 (ABCG8) causing sitosterolemia","volume":"18","author":"Hubacek","year":"2001","journal-title":"Hum Mutat"},{"key":"10.1016\/j.cll.2013.11.010_bib6","doi-asserted-by":"crossref","first-page":"922","DOI":"10.2174\/138161211795428795","article-title":"Plant sterols and stanols in the treatment of dysplipidemia: new insights into targets and mechanisms related to cardiovascular risk","volume":"17","author":"Baumgartner","year":"2011","journal-title":"Curr Pharm Des"},{"issue":"Suppl","key":"10.1016\/j.cll.2013.11.010_bib7","doi-asserted-by":"crossref","first-page":"E6","DOI":"10.1016\/S1520-765X(01)90106-3","article-title":"Ezetimibe: a selective inhibitor of cholesterol absorption","volume":"3","author":"Catapano","year":"2001","journal-title":"Eur Heart J"},{"key":"10.1016\/j.cll.2013.11.010_bib8","doi-asserted-by":"crossref","first-page":"e58833","DOI":"10.1371\/journal.pone.0058833","article-title":"Cholesterol biosynthesis and homeostatsis in regulation of the cell cycle","volume":"8","author":"Singh","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.cll.2013.11.010_bib9","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1194\/jlr.M600439-JLR200","article-title":"The molecular mechanisms underlying the reduction of LDL apoB-100 by ezetimibe plus simvastatin","volume":"48","author":"Telford","year":"2007","journal-title":"J\u00a0Lipid Res"},{"key":"10.1016\/j.cll.2013.11.010_bib10","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1007\/s11745-000-0616-9","article-title":"Deuterium uptake and plasma cholesterol precursor levels correspond as methods for measurement of endogenous cholesterol synthesis in hypercholesterolemic women","volume":"35","author":"Matthan","year":"2000","journal-title":"Lipids"},{"key":"10.1016\/j.cll.2013.11.010_bib11","unstructured":"Wu AH, Ruan W, Todd J, et\u00a0al. Biological variation of \u03b2-sitosterol, campesterol, and lathosterol as cholesterol absorption and synthesis biomarkers. Clin Chim Acta, in press."},{"key":"10.1016\/j.cll.2013.11.010_bib12","doi-asserted-by":"crossref","first-page":"e005066","DOI":"10.1161\/JAHA.112.005066","article-title":"Sex-specific differences in the predictive value of cholesterol homeostatic markers and 10-year cardiovascular disease event rate in Framingham Offspring Study participants","volume":"2","author":"Matthan","year":"2013","journal-title":"J\u00a0Am Heart Assoc"},{"key":"10.1016\/j.cll.2013.11.010_bib13","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1194\/jlr.P900039-JLR200","article-title":"Alterations in cholesterol absorption\/synthesis markers characterize Framingham Offspring Study participants with CHD","volume":"50","author":"Matthan","year":"2009","journal-title":"J\u00a0Lipid Res"},{"key":"10.1016\/j.cll.2013.11.010_bib14","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1194\/jlr.M900032-JLR200","article-title":"Cholesterol absorption and synthesis markers in individuals with and without a CHD event during pravastatin therapy: insights from the PROSPER Trial","volume":"51","author":"Matthan","year":"2010","journal-title":"J\u00a0Lipid Res"},{"key":"10.1016\/j.cll.2013.11.010_bib15","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1161\/ATVBAHA.109.196550","article-title":"Familial combined hyperlipidemia is associated with alterations in the cholesterol synthesis pathway","volume":"30","author":"Van Himbergen","year":"2010","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.cll.2013.11.010_bib16","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/S0022-2275(20)41411-7","article-title":"Sitosterolemia","volume":"33","author":"Salen","year":"1992","journal-title":"J\u00a0Lipid Res"},{"key":"10.1016\/j.cll.2013.11.010_bib17","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1016\/S0735-1097(00)00527-1","article-title":"Independent association of serum squalene and noncholesterol sterols with coronary artery disease in postmenopausal women","volume":"35","author":"Rajaratnam","year":"2000","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.cll.2013.11.010_bib18","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1161\/01.CIR.0000034044.95911.DC","article-title":"Inhibition of intestinal cholesterol absorption by ezetimibe humans","volume":"106","author":"Sudhop","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.cll.2013.11.010_bib19","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1194\/jlr.M600371-JLR200","article-title":"Plasma levels of plant steros and the risk of coronary artery disease: the prospective EPIC-Norfolk Population Study","volume":"48","author":"Pinedo","year":"2007","journal-title":"J\u00a0Lipid Res"},{"key":"10.1016\/j.cll.2013.11.010_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1161\/01.ATV.0000149140.00499.92","article-title":"Plant sterol levels are not associated with atherosclerosis in mice and men","volume":"24","author":"Wilund","year":"2004","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.cll.2013.11.010_bib21","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1503\/cmaj.070675","article-title":"The efficacy and safety of intensive statin therapy: a meta-analysis of randomized trials","volume":"178","author":"Josan","year":"2008","journal-title":"CMAJ"},{"key":"10.1016\/j.cll.2013.11.010_bib22","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1056\/NEJM199007263230403","article-title":"Influence of pravastatin, a specific inhibitor of HMG-CoA reductase, on hepatic metabolism of cholesterol","volume":"323","author":"Reihner","year":"1990","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.cll.2013.11.010_bib23","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1016\/j.lfs.2012.03.038","article-title":"Cholesterol metabolism differs after statin therapy according to the type of hyperlipidemia","volume":"90","author":"Lupattelli","year":"2012","journal-title":"Life Sci"},{"key":"10.1016\/j.cll.2013.11.010_bib24","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1194\/jlr.P800042-JLR200","article-title":"Comparison of the effects of maximal dose atorvastatin and rosuvastatin therapy on cholesterol synthesis and absorption markers","volume":"50","author":"van Himbergen","year":"2009","journal-title":"J\u00a0Lipid Res"},{"key":"10.1016\/j.cll.2013.11.010_bib25","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1194\/jlr.M011080","article-title":"Atorvastatin increases intestinal expression of NPC1L1 in hyperlipidemic men","volume":"52","author":"Tremblay","year":"2011","journal-title":"J\u00a0Lipid Res"},{"key":"10.1016\/j.cll.2013.11.010_bib26","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1111\/j.1742-1241.2008.01841.x","article-title":"Long-term efficacy and safety of ezetimibe 10 mg in patients with homozygous sitosterolemia: a 2-year, open lapel extension study","volume":"62","author":"Lutjohann","year":"2008","journal-title":"Int J Clin Pract"},{"key":"10.1016\/j.cll.2013.11.010_bib27","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1161\/01.CIR.0000116766.31036.03","article-title":"Ezetimibe effectively reduces plasma plant sterols in patients with sitosterolemia","volume":"108","author":"Salen","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.cll.2013.11.010_bib28","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.atherosclerosis.2012.09.001","article-title":"Effects of ezetimibe added to statin therapy on markers of cholesterol absorption and synthesis and LDL-C lowering in hyperlipidemic patients","volume":"225","author":"Thongtang","year":"2012","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.cll.2013.11.010_bib29","doi-asserted-by":"crossref","first-page":"86","DOI":"10.2152\/jmi.58.86","article-title":"Efficacy of ezetimibe as monotherapy or combination therapy in hyperchoelsterolemic patients with and without diabetes","volume":"58","author":"Kishimoto","year":"2011","journal-title":"J\u00a0Med Invest"}],"container-title":["Clinics in Laboratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0272271213000991?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0272271213000991?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T16:59:43Z","timestamp":1648227583000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0272271213000991"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["S0272271213000991"],"URL":"https:\/\/doi.org\/10.1016\/j.cll.2013.11.010","relation":{},"ISSN":["0272-2712"],"issn-type":[{"value":"0272-2712","type":"print"}],"subject":[],"published":{"date-parts":[[2014,3]]}}}