{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T16:36:31Z","timestamp":1781800591777,"version":"3.54.5"},"reference-count":77,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","theclinics.com","clinicalkey.com.au","clinicalkey.fr","labmed.theclinics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinics in Laboratory Medicine"],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.1016\/j.cll.2016.01.013","type":"journal-article","created":{"date-parts":[[2016,3,8]],"date-time":"2016-03-08T19:06:54Z","timestamp":1457464014000},"page":"319-329","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"title":["Aspirin for the Prevention of Preeclampsia and Intrauterine Growth Restriction"],"prefix":"10.1016","volume":"36","author":[{"given":"Stephanie","family":"Roberge","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony O.","family":"Odibo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Bujold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.cll.2016.01.013_bib1","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1067\/mob.2000.107928","article-title":"Report of the national high blood pressure education program working group on high blood pressure in pregnancy","volume":"183","year":"2000","journal-title":"Am J Obstet Gynecol"},{"issue":"1","key":"10.1016\/j.cll.2016.01.013_bib2","first-page":"80","article-title":"Geographic variation in the incidence of hypertension in pregnancy. World Health Organization International Collaborative Study of hypertensive disorders of pregnancy","volume":"158","year":"1988","journal-title":"Am J Obstet Gynecol"},{"issue":"9237","key":"10.1016\/j.cll.2016.01.013_bib3","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1016\/S0140-6736(00)02800-2","article-title":"Pre-eclampsia","volume":"356","author":"Walker","year":"2000","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.cll.2016.01.013_bib4","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.ajog.2010.08.009","article-title":"The \u201cGreat Obstetrical Syndromes\u201d are associated with disorders of deep placentation","volume":"204","author":"Brosens","year":"2011","journal-title":"Am J Obstet Gynecol"},{"issue":"9741","key":"10.1016\/j.cll.2016.01.013_bib5","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/S0140-6736(10)60279-6","article-title":"Pre-eclampsia","volume":"376","author":"Steegers","year":"2010","journal-title":"Lancet"},{"issue":"6","key":"10.1016\/j.cll.2016.01.013_bib6","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1515\/jpm.2011.098","article-title":"Placental lesions associated with maternal underperfusion are more frequent in early-onset than in late-onset preeclampsia","volume":"39","author":"Ogge","year":"2011","journal-title":"J\u00a0Perinat Med"},{"issue":"1","key":"10.1016\/j.cll.2016.01.013_bib7","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0143-4004(80)80012-9","article-title":"Trophoblastic invasion of human decidua from 8 to 18\u00a0weeks of pregnancy","volume":"1","author":"Pijnenborg","year":"1980","journal-title":"Placenta"},{"issue":"1","key":"10.1016\/j.cll.2016.01.013_bib8","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/0002-9378(80)90387-7","article-title":"The human placental bed: electron microscopic study of trophoblastic invasion of spiral arteries","volume":"137","author":"De Wolf","year":"1980","journal-title":"Am J Obstet Gynecol"},{"issue":"1","key":"10.1016\/j.cll.2016.01.013_bib9","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1080\/14767050500202493","article-title":"Evidence supporting that the excess of the sVEGFR-1 concentration in maternal plasma in preeclampsia has a uterine origin","volume":"18","author":"Bujold","year":"2005","journal-title":"J\u00a0Matern Fetal Neonatal Med"},{"issue":"5","key":"10.1016\/j.cll.2016.01.013_bib10","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/S1701-2163(15)30588-0","article-title":"Diagnosis, evaluation, and management of the hypertensive disorders of pregnancy: executive summary","volume":"36","author":"Magee","year":"2014","journal-title":"J\u00a0Obstet Gynaecol Can"},{"issue":"12","key":"10.1016\/j.cll.2016.01.013_bib11","doi-asserted-by":"crossref","first-page":"2570","DOI":"10.3109\/14767058.2012.715220","article-title":"Calcium supplementation and prevention of preeclampsia: a meta-analysis","volume":"25","author":"Patrelli","year":"2012","journal-title":"J\u00a0Matern Fetal Neonatal Med"},{"issue":"1","key":"10.1016\/j.cll.2016.01.013_bib12","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1111\/j.1538-7836.2011.04553.x","article-title":"Low-molecular-weight heparin added to aspirin in the prevention of recurrent early-onset pre-eclampsia in women with inheritable thrombophilia: the FRUIT-RCT","volume":"10","author":"de Vries","year":"2012","journal-title":"J\u00a0Thromb Haemost"},{"issue":"2 Pt 1","key":"10.1016\/j.cll.2016.01.013_bib13","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1097\/AOG.0b013e3181e9322a","article-title":"Prevention of preeclampsia and intrauterine growth restriction with aspirin started in early pregnancy: a meta-analysis","volume":"116","author":"Bujold","year":"2010","journal-title":"Obstet Gynecol"},{"issue":"9","key":"10.1016\/j.cll.2016.01.013_bib14","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/S1701-2163(16)34300-6","article-title":"Acetylsalicylic acid for the prevention of preeclampsia and intra-uterine growth restriction in women with abnormal uterine artery Doppler: a systematic review and meta-analysis","volume":"31","author":"Bujold","year":"2009","journal-title":"J\u00a0Obstet Gynaecol Can"},{"issue":"7","key":"10.1016\/j.cll.2016.01.013_bib15","first-page":"551","article-title":"Early administration of low-dose aspirin for the prevention of severe and mild preeclampsia: a systematic review and meta-analysis","volume":"29","author":"Roberge","year":"2012","journal-title":"Am J Perinatol"},{"issue":"3","key":"10.1016\/j.cll.2016.01.013_bib16","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1159\/000336662","article-title":"Early administration of low-dose aspirin for the prevention of preterm and term preeclampsia: a systematic review and meta-analysis","volume":"31","author":"Roberge","year":"2012","journal-title":"Fetal Diagn Ther"},{"issue":"1","key":"10.1016\/j.cll.2016.01.013_bib17","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD004227.pub3","article-title":"Antioxidants for preventing pre-eclampsia","author":"Rumbold","year":"2008","journal-title":"Cochrane Database Syst Rev"},{"issue":"4","key":"10.1016\/j.cll.2016.01.013_bib18","article-title":"Progesterone for preventing pre-eclampsia and its complications","author":"Meher","year":"2006","journal-title":"Cochrane Database Syst Rev"},{"issue":"2","key":"10.1016\/j.cll.2016.01.013_bib19","article-title":"Exercise or other physical activity for preventing pre-eclampsia and its complications","author":"Meher","year":"2006","journal-title":"Cochrane Database Syst Rev"},{"issue":"5","key":"10.1016\/j.cll.2016.01.013_bib20","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1002\/uog.12421","article-title":"Prevention of perinatal death and adverse perinatal outcome using low-dose aspirin: a meta-analysis","volume":"41","author":"Roberge","year":"2013","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"1","key":"10.1016\/j.cll.2016.01.013_bib21","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0020-7292(02)80002-9","article-title":"Diagnosis and management of preeclampsia and eclampsia","volume":"77","author":"ACOG Committee on Obstetric Practice","year":"2002","journal-title":"Int J Gynaecol Obstet"},{"issue":"4","key":"10.1016\/j.cll.2016.01.013_bib22","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1067\/S0002-9378(03)00576-3","article-title":"The frequency and severity of placental findings in women with preeclampsia are gestational age dependent","volume":"189","author":"Moldenhauer","year":"2003","journal-title":"Am J Obstet Gynecol"},{"issue":"4","key":"10.1016\/j.cll.2016.01.013_bib23","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1067\/S0002-9378(03)00838-X","article-title":"Failure of physiologic transformation of the spiral arteries in patients with preterm labor and intact membranes","volume":"189","author":"Kim","year":"2003","journal-title":"Am J Obstet Gynecol"},{"issue":"5","key":"10.1016\/j.cll.2016.01.013_bib24","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1067\/mob.2002.127720","article-title":"Failure of physiologic transformation of the spiral arteries in the placental bed in preterm premature rupture of membranes","volume":"187","author":"Kim","year":"2002","journal-title":"Am J Obstet Gynecol"},{"issue":"8079","key":"10.1016\/j.cll.2016.01.013_bib25","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0140-6736(78)91367-3","article-title":"Aspirin for the treatment of recurrent toxaemia","volume":"2","author":"Goodlin","year":"1978","journal-title":"Lancet"},{"issue":"8130","key":"10.1016\/j.cll.2016.01.013_bib26","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1016\/S0140-6736(79)91996-2","article-title":"Effect of aspirin on incidence of pre-eclampsia","volume":"1","author":"Crandon","year":"1979","journal-title":"Lancet"},{"issue":"8154","key":"10.1016\/j.cll.2016.01.013_bib27","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1016\/S0140-6736(79)92334-1","article-title":"Differential inhibition of prostacyclin production and platelet aggregation by aspirin","volume":"2","author":"Masotti","year":"1979","journal-title":"Lancet"},{"issue":"8433","key":"10.1016\/j.cll.2016.01.013_bib28","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/S0140-6736(85)92207-X","article-title":"Prevention of pre-eclampsia by early antiplatelet therapy","volume":"1","author":"Beaufils","year":"1985","journal-title":"Lancet"},{"issue":"9575","key":"10.1016\/j.cll.2016.01.013_bib29","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1016\/S0140-6736(07)60712-0","article-title":"Antiplatelet agents for prevention of pre-eclampsia: a meta-analysis of individual patient data","volume":"369","author":"Askie","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.cll.2016.01.013_bib30","series-title":"The investigation and management of the small-for-gestational-age fetus","first-page":"1","author":"Robson","year":"2014"},{"issue":"8","key":"10.1016\/j.cll.2016.01.013_bib31","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/S1701-2163(15)30865-3","article-title":"Intrauterine growth restriction: screening, diagnosis, and management","volume":"35","author":"Lausman","year":"2013","journal-title":"J\u00a0Obstet Gynaecol Can"},{"issue":"6","key":"10.1016\/j.cll.2016.01.013_bib32","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1503\/cmaj.070430","article-title":"Use of uterine artery Doppler ultrasonography to predict pre-eclampsia and intrauterine growth restriction: a systematic review and bivariable meta-analysis","volume":"178","author":"Cnossen","year":"2008","journal-title":"CMAJ"},{"issue":"2","key":"10.1016\/j.cll.2016.01.013_bib33","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.placenta.2013.11.015","article-title":"Association between first-trimester placental volume and birth weight","volume":"35","author":"Effendi","year":"2014","journal-title":"Placenta"},{"issue":"1","key":"10.1016\/j.cll.2016.01.013_bib34","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1159\/000342109","article-title":"Second-trimester uterine artery Doppler in the prediction of stillbirths","volume":"33","author":"Poon","year":"2013","journal-title":"Fetal Diagn Ther"},{"issue":"2","key":"10.1016\/j.cll.2016.01.013_bib35","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD004659.pub2","article-title":"Antiplatelet agents for preventing pre-eclampsia and its complications","author":"Duley","year":"2007","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.cll.2016.01.013_bib36","doi-asserted-by":"crossref","unstructured":"Roberge S, Carpentier C, Demers S, et\u00a0al. The impact of low-dose aspirin on utero-placental circulation: a systematic review. Ultrasound Obstet Gynecol 2014; 24th World Congress on Ultrasound in Obstetrics and Gynecology. September 14\u201317, 2014. Barcelona, Spain. p. 269.","DOI":"10.1002\/uog.14284"},{"issue":"Suppl 1","key":"10.1016\/j.cll.2016.01.013_bib37","doi-asserted-by":"crossref","first-page":"S18","DOI":"10.1111\/nure.12055","article-title":"Epidemiology of preeclampsia: impact of obesity","volume":"71","author":"Jeyabalan","year":"2013","journal-title":"Nutr Rev"},{"key":"10.1016\/j.cll.2016.01.013_bib38","series-title":"Hypertension in pregnancy: practice guidelines, American College of Obstetrician and Gynecologist","author":"ACOG","year":"2013"},{"issue":"2","key":"10.1016\/j.cll.2016.01.013_bib39","doi-asserted-by":"crossref","first-page":"128","DOI":"10.3109\/01443615.2011.635224","article-title":"Antenatal screening for pre-eclampsia: evaluation of the NICE and pre-eclampsia community guidelines","volume":"32","author":"Verghese","year":"2012","journal-title":"J\u00a0Obstet Gynaecol"},{"issue":"6","key":"10.1016\/j.cll.2016.01.013_bib40","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1097\/AOG.0000000000001115","article-title":"A\u00a0cost-benefit analysis of low-dose aspirin prophylaxis for the prevention of preeclampsia in the United States","volume":"126","author":"Werner","year":"2015","journal-title":"Obstet Gynecol"},{"issue":"4","key":"10.1016\/j.cll.2016.01.013_bib41","doi-asserted-by":"crossref","first-page":"383.e1","DOI":"10.1016\/j.ajog.2010.06.014","article-title":"Screening for preeclampsia using first-trimester serum markers and uterine artery Doppler in nulliparous women","volume":"203","author":"Audibert","year":"2010","journal-title":"Am J Obstet Gynecol"},{"issue":"2","key":"10.1016\/j.cll.2016.01.013_bib42","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1002\/uog.6452","article-title":"Hypertensive disorders in pregnancy: screening by uterine artery Doppler at 11-13\u00a0weeks","volume":"34","author":"Poon","year":"2009","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.cll.2016.01.013_bib43","article-title":"Serum placental growth factor at 12, 22, 32 and 36\u00a0weeks' gestation in screening for preeclampsia","author":"Tsiakkas","year":"2015","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"4","key":"10.1016\/j.cll.2016.01.013_bib44","doi-asserted-by":"crossref","first-page":"530.e1","DOI":"10.1016\/j.ajog.2015.06.044","article-title":"Validation of metabolomic models for prediction of early-onset preeclampsia","volume":"213","author":"Bahado-Singh","year":"2015","journal-title":"Am J Obstet Gynecol"},{"issue":"1","key":"10.1016\/j.cll.2016.01.013_bib45","doi-asserted-by":"crossref","first-page":"62.e1","DOI":"10.1016\/j.ajog.2015.02.018","article-title":"Competing risks model in screening for preeclampsia by maternal characteristics and medical history","volume":"213","author":"Wright","year":"2015","journal-title":"Am J Obstet Gynecol"},{"issue":"2","key":"10.1016\/j.cll.2016.01.013_bib46","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1055\/s-0033-1338172","article-title":"Prediction of recurrent preeclampsia using first-trimester uterine artery Doppler","volume":"31","author":"Demers","year":"2014","journal-title":"Am J Perinatol"},{"issue":"1","key":"10.1016\/j.cll.2016.01.013_bib47","doi-asserted-by":"crossref","first-page":"103.e1","DOI":"10.1016\/j.ajog.2015.08.034","article-title":"Competing risks model in screening for preeclampsia by maternal factors and biomarkers at 11-13\u00a0weeks gestation","volume":"214","author":"O'Gorman","year":"2015","journal-title":"Am J Obstet Gynecol"},{"issue":"4","key":"10.1016\/j.cll.2016.01.013_bib48","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1002\/uog.14819","article-title":"Prediction and prevention of early-onset pre-eclampsia: impact of aspirin after first-trimester screening","volume":"46","author":"Park","year":"2015","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"5 Suppl","key":"10.1016\/j.cll.2016.01.013_bib49","first-page":"52S","article-title":"Neonatal intracranial hemorrhage and maternal use of aspirin","volume":"58","author":"Rumack","year":"1981","journal-title":"Obstet Gynecol"},{"issue":"5","key":"10.1016\/j.cll.2016.01.013_bib50","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1213\/ANE.0b013e31828a4b54","article-title":"Nonsteroidal anti-inflammatory drugs during pregnancy and the initiation of lactation","volume":"116","author":"Bloor","year":"2013","journal-title":"Anesth Anal"},{"issue":"3","key":"10.1016\/j.cll.2016.01.013_bib51","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1517\/14656566.5.3.571","article-title":"Anti-inflammatory pharmacotherapy during pregnancy","volume":"5","author":"Ostensen","year":"2004","journal-title":"Expert Opin Pharmacother"},{"issue":"11","key":"10.1016\/j.cll.2016.01.013_bib52","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1016\/S1701-2163(16)34346-8","article-title":"Low-dose ASA response using the PFA-100 in women with high-risk pregnancy","volume":"31","author":"Caron","year":"2009","journal-title":"J\u00a0Obstet Gynaecol Can"},{"issue":"3","key":"10.1016\/j.cll.2016.01.013_bib53","first-page":"334","article-title":"Aspirin resistance may be associated with adverse pregnancy outcomes","volume":"32","author":"Wojtowicz","year":"2011","journal-title":"Neuro Endocrinol Lett"},{"issue":"9955","key":"10.1016\/j.cll.2016.01.013_bib54","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1016\/S0140-6736(14)60793-5","article-title":"Antepartum dalteparin versus no antepartum dalteparin for the prevention of pregnancy complications in pregnant women with thrombophilia (TIPPS): a multinational open-label randomised trial","volume":"384","author":"Rodger","year":"2014","journal-title":"Lancet"},{"issue":"14","key":"10.1016\/j.cll.2016.01.013_bib55","doi-asserted-by":"crossref","first-page":"3269","DOI":"10.1182\/blood-2011-11-391383","article-title":"Heparin in pregnant women with previous placenta-mediated pregnancy complications: a prospective, randomized, multicenter, controlled clinical trial","volume":"119","author":"Martinelli","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.cll.2016.01.013_bib56","article-title":"Prevention of pre-eclampsia by low-molecular weight heparin in addition to aspirin: a meta-analysis","author":"Roberge","year":"2015","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.cll.2016.01.013_bib57","unstructured":"August P, Helseth G, Edersheim T, et\u00a0al. Sustained relase, low-dose aspirin ameliorates but does not prevent preeclampsia (PE) in a high risk population. In: Proceedings of 9th International Congress, International Society for the Study of Hypertension. Hypertension in Pregnancy. Sydney, Australia, March 15\u201318, 1994. p. 72."},{"key":"10.1016\/j.cll.2016.01.013_bib58","unstructured":"Azar R, Turpin D. Effect of antiplatelet therapy in women at high risk for pregnancy-induced hypertension. In: Proceedings of 7th World Congress of Hypertension in Pregnancy. Perugia, Italy, October, 1990. p. 257."},{"issue":"6","key":"10.1016\/j.cll.2016.01.013_bib59","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1056\/NEJM198908103210604","article-title":"Effect of low-dose aspirin on fetal and maternal generation of thromboxane by platelets in women at risk for pregnancy-induced hypertension","volume":"321","author":"Benigni","year":"1989","journal-title":"N\u00a0Engl J Med"},{"issue":"10","key":"10.1016\/j.cll.2016.01.013_bib60","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1038\/hr.2011.111","article-title":"Prevention of gravidic endothelial hypertension by aspirin treatment administered from the 8th week of gestation","volume":"34","author":"Bakhti","year":"2011","journal-title":"Hypertension Research"},{"issue":"11","key":"10.1016\/j.cll.2016.01.013_bib61","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1056\/NEJM199803123381101","article-title":"Low-dose aspirin to prevent preeclampsia in women at high risk. National Institute of Child Health and Human Development Network of Maternal-Fetal Medicine Units","volume":"338","author":"Caritis","year":"1998","journal-title":"N\u00a0Engl J Med"},{"issue":"5","key":"10.1016\/j.cll.2016.01.013_bib62","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1038\/jp.2014.214","article-title":"Early initiation of low-dose aspirin for reduction in preeclampsia risk in high-risk women: a secondary analysis of the MFMU High-Risk Aspirin Study","volume":"35","author":"Moore","year":"2015","journal-title":"J\u00a0Perinatol"},{"issue":"2","key":"10.1016\/j.cll.2016.01.013_bib63","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/S0301-2115(03)00269-0","article-title":"A\u00a0small randomised trial of low-dose aspirin in women at high risk of pre-eclampsia","volume":"112","author":"Chiaffarino","year":"2004","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"6","key":"10.1016\/j.cll.2016.01.013_bib64","first-page":"507","article-title":"Effect of maternal low dose aspirin on neonatal platelet function","volume":"35","author":"Dasari","year":"1998","journal-title":"Indian Pediatr"},{"issue":"5","key":"10.1016\/j.cll.2016.01.013_bib65","first-page":"826","article-title":"Usefulness of aspirin therapy in high-risk pregnant women with abnormal uterine artery Doppler ultrasound at 14-16\u00a0weeks pregnancy: randomized controlled clinical trial","volume":"46","author":"Ebrashy","year":"2005","journal-title":"Croat Med J"},{"issue":"3 Pt 2","key":"10.1016\/j.cll.2016.01.013_bib66","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1161\/01.HYP.30.3.589","article-title":"Time-dependent effects of low-dose aspirin administration on blood pressure in pregnant women","volume":"30","author":"Hermida","year":"1997","journal-title":"Hypertension"},{"issue":"1\u20132","key":"10.1016\/j.cll.2016.01.013_bib67","doi-asserted-by":"crossref","first-page":"260","DOI":"10.3109\/07420528.2012.717455","article-title":"Chronotherapy with low-dose aspirin for prevention of complications in pregnancy","volume":"30","author":"Ayala","year":"2013","journal-title":"Chronobiol Int"},{"issue":"4 Pt 2","key":"10.1016\/j.cll.2016.01.013_bib68","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1161\/01.HYP.34.4.1016","article-title":"Administration time-dependent effects of aspirin in women at differing risk for preeclampsia","volume":"34","author":"Hermida","year":"1999","journal-title":"Hypertension"},{"issue":"3","key":"10.1016\/j.cll.2016.01.013_bib69","first-page":"265","article-title":"Evaluation of the effect of metformin and aspirin on utero placental circulation of pregnant women with PCOS","volume":"10","author":"Jamal","year":"2012","journal-title":"Iran J Reprod Med"},{"issue":"2","key":"10.1016\/j.cll.2016.01.013_bib70","first-page":"98","article-title":"Effect of aspirin for prevention of preeclampsia in women with abnormal ultrasonic findings in uterine artery","volume":"15","author":"Mesdaghinia","year":"2011","journal-title":"Feyz"},{"key":"10.1016\/j.cll.2016.01.013_bib71","series-title":"Low-dose aspirin in the prevention of pre-eclampsia: current evaluation","year":"1992"},{"issue":"4","key":"10.1016\/j.cll.2016.01.013_bib72","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1002\/uog.14889","article-title":"Early prediction and aspirin for prevention of pre-eclampsia (EPAPP) study: a randomized controlled trial","volume":"46","author":"Odibo","year":"2015","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"8840","key":"10.1016\/j.cll.2016.01.013_bib73","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/0140-6736(93)92672-G","article-title":"Low-dose aspirin and hypertension in pregnancy","volume":"341","author":"Porreco","year":"1993","journal-title":"Lancet"},{"issue":"7","key":"10.1016\/j.cll.2016.01.013_bib74","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1093\/humrep\/12.7.1567","article-title":"Low-dose aspirin in prevention of miscarriage in women with unexplained or autoimmune related recurrent miscarriage: effect on prostacyclin and thromboxane A2 production","volume":"12","author":"Tulppala","year":"1997","journal-title":"Hum Reprod"},{"issue":"2","key":"10.1016\/j.cll.2016.01.013_bib75","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/j.1471-0528.2002.01046.x","article-title":"Low dose acetylsalicylic acid in prevention of pregnancy-induced hypertension and intrauterine growth retardation in women with bilateral uterine artery notches","volume":"109","author":"Vainio","year":"2002","journal-title":"BJOG"},{"issue":"1","key":"10.1016\/j.cll.2016.01.013_bib76","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1111\/j.1471-0528.2012.03493.x","article-title":"Aspirin in the prevention of pre-eclampsia in high-risk women: a randomised placebo-controlled PREDO Trial and a meta-analysis of randomised trials","volume":"120","author":"Villa","year":"2013","journal-title":"BJOG"},{"key":"10.1016\/j.cll.2016.01.013_bib77","first-page":"355","article-title":"Low-dose aspirin prescribed at bed time for the prevention of pre-eclampsia in high-risk pregnant women","volume":"32","author":"Zhao","year":"2012","journal-title":"Reprod Contracept"}],"container-title":["Clinics in Laboratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0272271216300130?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0272271216300130?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,14]],"date-time":"2018-09-14T09:50:47Z","timestamp":1536918647000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0272271216300130"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6]]},"references-count":77,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["S0272271216300130"],"URL":"https:\/\/doi.org\/10.1016\/j.cll.2016.01.013","relation":{},"ISSN":["0272-2712"],"issn-type":[{"value":"0272-2712","type":"print"}],"subject":[],"published":{"date-parts":[[2016,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Aspirin for the Prevention of Preeclampsia and Intrauterine Growth Restriction","name":"articletitle","label":"Article Title"},{"value":"Clinics in Laboratory Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cll.2016.01.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}