{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T19:31:44Z","timestamp":1783625504227,"version":"3.55.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","theclinics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinics in Laboratory Medicine"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1016\/j.cll.2021.04.010","type":"journal-article","created":{"date-parts":[[2021,7,22]],"date-time":"2021-07-22T22:11:50Z","timestamp":1626991910000},"page":"529-540","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Pediatric Myeloproliferative Neoplasms"],"prefix":"10.1016","volume":"41","author":[{"given":"Farah","family":"El-Sharkawy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Margolskee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.cll.2021.04.010_bib1","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1182\/blood.V6.4.372.372","article-title":"Editorial some speculations on the myeloproliferative syndromes","volume":"6","author":"Dameshek","year":"1951","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.cll.2021.04.010_bib2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/sj.leu.2404946","article-title":"The history of myeloproliferative disorders: before and after dameshek","volume":"22","author":"Tefferi","year":"2008","journal-title":"Leukemia"},{"issue":"5405","key":"10.1016\/j.cll.2021.04.010_bib3","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/243290a0","article-title":"A\u00a0new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining","volume":"243","author":"Rowley","year":"1973","journal-title":"Nature"},{"issue":"6020","key":"10.1016\/j.cll.2021.04.010_bib4","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1038\/315550a0","article-title":"Fused transcript of ABL and BCR genes in chronic myelogenous leukaemia","volume":"315","author":"Shtivelman","year":"1985","journal-title":"Nature"},{"issue":"17","key":"10.1016\/j.cll.2021.04.010_bib5","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1056\/NEJMoa051113","article-title":"A\u00a0gain-of-function mutation of JAK2 in myeloproliferative disorders","volume":"352","author":"Kralovics","year":"2005","journal-title":"N\u00a0Engl J Med"},{"issue":"3","key":"10.1016\/j.cll.2021.04.010_bib6","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1182\/blood-2015-07-661835","article-title":"Whole-exome sequencing identifies novel MPL and JAK2 mutations in triple-negative myeloproliferative neoplasms","volume":"127","author":"Milosevic Feenstra","year":"2016","journal-title":"Blood"},{"issue":"25","key":"10.1016\/j.cll.2021.04.010_bib7","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.1056\/NEJMoa1312542","article-title":"Somatic CALR Mutations in myeloproliferative neoplasms with nonmutated JAK2","volume":"369","author":"Nangalia","year":"2013","journal-title":"N\u00a0Engl J Med"},{"issue":"3","key":"10.1016\/j.cll.2021.04.010_bib8","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1046\/j.1365-2141.2000.02239-7.x","article-title":"Incidence of essential thrombocythaemia in children","volume":"110","author":"Hasle","year":"2000","journal-title":"Br J Haematol"},{"issue":"8","key":"10.1016\/j.cll.2021.04.010_bib9","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.3324\/haematol.2018.200832","article-title":"Characteristics and outcomes of patients with essential thrombocythemia or polycythemia vera diagnosed before 20 years of age: a systematic review","volume":"104","author":"Ianotto","year":"2019","journal-title":"Haematologica"},{"issue":"22","key":"10.1016\/j.cll.2021.04.010_bib10","doi-asserted-by":"crossref","first-page":"3040","DOI":"10.1182\/blood-2017-01-761767","article-title":"Bone marrow histology for the diagnosis of essential thrombocythemia in children: a multicenter Italian study","volume":"129","author":"Putti","year":"2017","journal-title":"Blood"},{"issue":"4","key":"10.1016\/j.cll.2021.04.010_bib11","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1111\/bjh.13329","article-title":"Are all cases of paediatric essential thrombocythaemia really myeloproliferative neoplasms? Analysis of a large cohort","volume":"169","author":"Randi","year":"2015","journal-title":"Br J Haematol"},{"key":"10.1016\/j.cll.2021.04.010_bib12","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1182\/blood.V26.3.243.243","article-title":"Polycythemia vera: age relationship and survival","volume":"26","author":"Osgood","year":"1965","journal-title":"Blood"},{"issue":"8","key":"10.1016\/j.cll.2021.04.010_bib13","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1007\/s00277-009-0758-y","article-title":"Clinical and hematological presentation of children and adolescents with polycythemia vera","volume":"88","author":"Cario","year":"2009","journal-title":"Ann Hematol"},{"issue":"1","key":"10.1016\/j.cll.2021.04.010_bib14","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/bjh.15386","article-title":"Difficulty distinguishing essential thrombocythaemia from polycythaemia vera in children with JAK2 V617F-positive myeloproliferative neoplasms","volume":"185","author":"Kucine","year":"2019","journal-title":"Br J Haematol"},{"issue":"9","key":"10.1016\/j.cll.2021.04.010_bib15","doi-asserted-by":"crossref","first-page":"3384","DOI":"10.1182\/blood-2007-06-094276","article-title":"The revised WHO diagnostic criteria for Ph-negative myeloproliferative diseases are not appropriate for the diagnostic screening of childhood polycythemia vera and essential thrombocythemia","volume":"110","author":"Teofili","year":"2007","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.cll.2021.04.010_bib16","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1002\/ajh.23585","article-title":"Masked polycythemia vera (mPV): results of an international study","volume":"89","author":"Barbui","year":"2014","journal-title":"Am J Hematol"},{"issue":"7","key":"10.1016\/j.cll.2021.04.010_bib17","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.3324\/haematol.12260","article-title":"A\u00a0study of 36 unrelated cases with pure erythrocytosis revealed three new mutations in the erythropoietin receptor gene","volume":"93","author":"Al-Sheikh","year":"2008","journal-title":"Haematologica"},{"issue":"5","key":"10.1016\/j.cll.2021.04.010_bib18","doi-asserted-by":"crossref","first-page":"674","DOI":"10.3324\/haematol.10787","article-title":"Molecular genetic analyses in familial and sporadic congenital primary erythrocytosis","volume":"92","author":"Rives","year":"2007","journal-title":"Haematologica"},{"issue":"1","key":"10.1016\/j.cll.2021.04.010_bib19","doi-asserted-by":"crossref","first-page":"7","DOI":"10.4081\/hr.2018.7221","article-title":"Congenital methemoglobinemia misdiagnosed as polycythemia vera: case report and review of literature","volume":"10","author":"Soliman","year":"2018","journal-title":"Hematol Rep"},{"issue":"19","key":"10.1016\/j.cll.2021.04.010_bib20","doi-asserted-by":"crossref","first-page":"3918","DOI":"10.1182\/blood-2012-11-469296","article-title":"Novel homozygous VHL mutation in exon 2 is associated with congenital polycythemia but not with cancer","volume":"121","author":"Lanikova","year":"2013","journal-title":"Blood"},{"issue":"6","key":"10.1016\/j.cll.2021.04.010_bib21","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1182\/blood-2007-04-084434","article-title":"A\u00a0novel erythrocytosis-associated PHD2 mutation suggests the location of a HIF binding groove","volume":"110","author":"Percy","year":"2007","journal-title":"Blood"},{"issue":"10","key":"10.1016\/j.cll.2021.04.010_bib22","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1182\/blood-2011-08-371328","article-title":"Thrombocythemia and polycythemia in patients younger than 20 years at diagnosis: clinical and biologic features, treatment, and long-term outcome","volume":"119","author":"Giona","year":"2012","journal-title":"Blood"},{"issue":"Supplement_1","key":"10.1016\/j.cll.2021.04.010_bib23","doi-asserted-by":"crossref","first-page":"4194","DOI":"10.1182\/blood-2019-124023","article-title":"Use of pegylated interferon in six pediatric patients with myeloproliferative neoplasms","volume":"134","author":"Kucine","year":"2019","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.cll.2021.04.010_bib24","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s12308-015-0256-1","article-title":"Myeloproliferative neoplasms in children","volume":"8","author":"Hofmann","year":"2015","journal-title":"J\u00a0Hematopathol"},{"issue":"12","key":"10.1016\/j.cll.2021.04.010_bib25","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.1002\/pbc.25211","article-title":"CALR mutation screening in pediatric primary myelofibrosis","volume":"61","author":"An","year":"2014","journal-title":"Pediatr Blood Cancer"},{"issue":"5","key":"10.1016\/j.cll.2021.04.010_bib26","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1002\/ajh.23140","article-title":"Clinical, histopathologic, and genetic features of pediatric primary myelofibrosis-an entity different from adults","volume":"87","author":"Delario","year":"2012","journal-title":"Am J Hematol"},{"issue":"8","key":"10.1016\/j.cll.2021.04.010_bib27","first-page":"1128","article-title":"European consensus on grading bone marrow fibrosis and assessment of cellularity","volume":"90","author":"Thiele","year":"2005","journal-title":"Haematologica"},{"issue":"5","key":"10.1016\/j.cll.2021.04.010_bib28","doi-asserted-by":"crossref","first-page":"e28232","DOI":"10.1002\/pbc.28232","article-title":"Pediatric myelofibrosis: WHO 2024 update on myeloproliferative neoplasms calling?","volume":"67","author":"Mishra","year":"2020","journal-title":"Pediatr Blood Cancer"},{"issue":"2","key":"10.1016\/j.cll.2021.04.010_bib29","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1097\/MPH.0000000000000452","article-title":"Secondary bone marrow fibrosis in children and young adults: an institutional experience","volume":"38","author":"Soundar","year":"2016","journal-title":"J\u00a0Pediatr Hematol Oncol"},{"issue":"4","key":"10.1016\/j.cll.2021.04.010_bib30","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1007\/s10875-020-00778-7","article-title":"Infantile myelofibrosis and myeloproliferation with CDC42 dysfunction","volume":"40","author":"Verboon","year":"2020","journal-title":"J\u00a0Clin Immunol"},{"issue":"1","key":"10.1016\/j.cll.2021.04.010_bib31","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1056\/NEJMoa1301296","article-title":"A\u00a0congenital neutrophil defect syndrome associated with mutations in VPS45","volume":"369","author":"Vilboux","year":"2013","journal-title":"N\u00a0Engl J Med"},{"issue":"2","key":"10.1016\/j.cll.2021.04.010_bib32","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/BF01630378","article-title":"The minute chromosome (Ph1) in chronic granulocytic leukemia","volume":"8","author":"Nowell","year":"1962","journal-title":"Blut"},{"key":"10.1016\/j.cll.2021.04.010_bib33","series-title":"WHO classification of tumours of haematopoietic and lymphoid tissues","author":"Swerdlow","year":"2017"},{"issue":"4","key":"10.1016\/j.cll.2021.04.010_bib34","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1182\/blood-2015-06-648667","article-title":"Pediatric chronic myeloid leukemia is a unique disease that requires a different approach","volume":"127","author":"Hijiya","year":"2016","journal-title":"Blood"},{"issue":"10","key":"10.1016\/j.cll.2021.04.010_bib35","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.6004\/jnccn.2020.0047","article-title":"Chronic myeloid leukemia, version 2.2021","volume":"18","author":"Deininger","year":"2020","journal-title":"J\u00a0Natl Compr Canc Netw"},{"issue":"1","key":"10.1016\/j.cll.2021.04.010_bib36","doi-asserted-by":"crossref","first-page":"110","DOI":"10.4103\/jcrt.JCRT_833_15","article-title":"Pediatric chronic myeloid leukemia: a single-center experience","volume":"16","author":"Madabhavi","year":"2020","journal-title":"J\u00a0Cancer Res Ther"},{"issue":"21","key":"10.1016\/j.cll.2021.04.010_bib37","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1182\/blood.V124.21.521.521","article-title":"The experience of the international registry for chronic myeloid leukemia (CML) in children and adolescents (I-CML-Ped Study): pronostic consideration","volume":"124","author":"Millot","year":"2014","journal-title":"Blood"},{"issue":"9","key":"10.1016\/j.cll.2021.04.010_bib38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/pbc.27827","article-title":"Management of chronic myeloid leukemia in children and adolescents: recommendations from the children\u2019s oncology group CML working group","volume":"66","author":"Athale","year":"2019","journal-title":"Pediatr Blood Cancer"},{"issue":"3","key":"10.1016\/j.cll.2021.04.010_bib39","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.beha.2009.07.006","article-title":"The blast phase of chronic myeloid leukaemia","volume":"22","author":"Silver","year":"2009","journal-title":"Best Pract Res Clin Haematol"},{"issue":"23","key":"10.1016\/j.cll.2021.04.010_bib40","doi-asserted-by":"crossref","first-page":"2789","DOI":"10.1182\/blood.V126.23.2789.2789","article-title":"Description and management of accelerated phase and blast crisis in 21\u00a0cml pediatric patients","volume":"126","author":"Meyran","year":"2015","journal-title":"Blood"},{"key":"10.1016\/j.cll.2021.04.010_bib41","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.ejca.2019.03.020","article-title":"Favourable outcome of de novo advanced phases of childhood chronic myeloid leukaemia","volume":"115","author":"Millot","year":"2019","journal-title":"Eur J Cancer"},{"issue":"7","key":"10.1016\/j.cll.2021.04.010_bib42","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1007\/s00431-018-3155-5","article-title":"Leukemoid reaction in the pediatric population: etiologies, outcome, and implications","volume":"177","author":"Hoofien","year":"2018","journal-title":"Eur J Pediatr"},{"issue":"11","key":"10.1016\/j.cll.2021.04.010_bib43","doi-asserted-by":"crossref","first-page":"e177","DOI":"10.1093\/cid\/cit562","article-title":"Leukemoid reaction: spectrum and prognosis of 173 adult patients","volume":"57","author":"Potasman","year":"2013","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.cll.2021.04.010_bib44","series-title":"Rodak\u2019s hematology","first-page":"445","article-title":"Nonmalignant leukocyte disorders","author":"Marionneaux","year":"2020"},{"issue":"7","key":"10.1016\/j.cll.2021.04.010_bib45","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1038\/leu.2008.162","article-title":"Juvenile myelomonocytic leukemia and chronic myelomonocytic leukemia","volume":"22","author":"Emanuel","year":"2008","journal-title":"Leukemia"},{"issue":"1","key":"10.1016\/j.cll.2021.04.010_bib46","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1542\/peds.2004-2473","article-title":"Clinical and biological features at diagnosis in 40 children with chronic myeloid leukemia","volume":"116","author":"Millot","year":"2005","journal-title":"Pediatrics"},{"issue":"11","key":"10.1016\/j.cll.2021.04.010_bib47","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1002\/gcc.21989","article-title":"Genomic BCR-ABL1 breakpoints in pediatric chronic myeloid leukemia","volume":"51","author":"Krumbholz","year":"2012","journal-title":"Genes Chromosomes Cancer"},{"issue":"9","key":"10.1016\/j.cll.2021.04.010_bib48","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.1038\/s41375-018-0157-2","article-title":"Frequent ASXL1 mutations in children and young adults with chronic myeloid leukemia","volume":"32","author":"Ernst","year":"2018","journal-title":"Leukemia"},{"key":"10.1016\/j.cll.2021.04.010_bib49","series-title":"Gregory\u2019s pediatric anesthesia","article-title":"Gregory\u2019s pediatric anesthesia","author":"Gregory","year":"2012"},{"key":"10.1016\/j.cll.2021.04.010_bib50","doi-asserted-by":"crossref","first-page":"234","DOI":"10.3389\/fendo.2017.00234","article-title":"Genetic Alterations of the Thrombepoietic\/MPL\/JAK2 Axis Impacting Megakaryopoiesis","volume":"8","author":"Plo","year":"2017","journal-title":"Front Endocrinol (Lausanne)"}],"container-title":["Clinics in Laboratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0272271221000287?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0272271221000287?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T23:58:53Z","timestamp":1759449533000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0272271221000287"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":50,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["S0272271221000287"],"URL":"https:\/\/doi.org\/10.1016\/j.cll.2021.04.010","relation":{},"ISSN":["0272-2712"],"issn-type":[{"value":"0272-2712","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pediatric Myeloproliferative Neoplasms","name":"articletitle","label":"Article Title"},{"value":"Clinics in Laboratory Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cll.2021.04.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}