{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T04:08:44Z","timestamp":1791950924428,"version":"4.3.4"},"reference-count":47,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","theclinics.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinics in Laboratory Medicine"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1016\/j.cll.2023.04.003","type":"journal-article","created":{"date-parts":[[2023,6,4]],"date-time":"2023-06-04T10:54:31Z","timestamp":1685876071000},"page":"323-332","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["The Immunophenotypic Profile of Healthy Human Bone Marrow"],"prefix":"10.1016","volume":"43","author":[{"given":"Joshua E.","family":"Lewis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher B.","family":"Hergott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cll.2023.04.003_bib1","series-title":"Rodak\u2019s hematology-e-book: clinical principles and applications","author":"Keohane","year":"2019"},{"issue":"8","key":"10.1016\/j.cll.2023.04.003_bib2","doi-asserted-by":"crossref","first-page":"3941","DOI":"10.1182\/blood-2007-11-120535","article-title":"Flow cytometric immunophenotyping for hematologic neoplasms","volume":"111","author":"Craig","year":"2008","journal-title":"Blood"},{"issue":"12","key":"10.1016\/j.cll.2023.04.003_bib3","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a008250","article-title":"Hematopoiesis","volume":"4","author":"Rieger","year":"2012","journal-title":"Cold Spring Harb Perspect Biol"},{"issue":"6","key":"10.1016\/j.cll.2023.04.003_bib4","first-page":"640","article-title":"Hematopoietic stem cell: self-renewal versus differentiation","volume":"2","author":"Seita","year":"2010","journal-title":"Wiley Interdisciplinary Reviews"},{"issue":"10","key":"10.1016\/j.cll.2023.04.003_bib5","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1038\/mt.2011.184","article-title":"Bridge over troubled stem cells","volume":"19","author":"Challen","year":"2011","journal-title":"Mol Ther"},{"issue":"4","key":"10.1016\/j.cll.2023.04.003_bib6","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/j.celrep.2019.06.084","article-title":"Integrin-\u03b13 is a functional marker of ex\u00a0vivo expanded human long-term hematopoietic stem cells","volume":"28","author":"Tomellini","year":"2019","journal-title":"Cell Rep"},{"issue":"11","key":"10.1016\/j.cll.2023.04.003_bib7","doi-asserted-by":"crossref","first-page":"7358","DOI":"10.4049\/jimmunol.180.11.7358","article-title":"Human Flt3 is expressed at the hematopoietic stem cell and the granulocyte\/macrophage progenitor stages to maintain cell survival","volume":"180","author":"Kikushige","year":"2008","journal-title":"J\u00a0Immunol"},{"issue":"6039","key":"10.1016\/j.cll.2023.04.003_bib8","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1126\/science.1201219","article-title":"Isolation of single human hematopoietic stem cells capable of long-term multilineage engraftment","volume":"333","author":"Notta","year":"2011","journal-title":"Science"},{"issue":"5","key":"10.1016\/j.cll.2023.04.003_bib9","doi-asserted-by":"crossref","first-page":"e0197823","DOI":"10.1371\/journal.pone.0197823","article-title":"Phenotypic characterization of aberrant stem and progenitor cell populations in myelodysplastic syndromes","volume":"13","author":"Ostendorf","year":"2018","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.cll.2023.04.003_bib10","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1182\/blood-2014-02-555318","article-title":"A\u00a0hyperactive Mpl-based cell growth switch drives macrophage-associated erythropoiesis through an erythroid-megakaryocytic precursor","volume":"125","author":"Belay","year":"2015","journal-title":"Blood"},{"issue":"15","key":"10.1016\/j.cll.2023.04.003_bib11","doi-asserted-by":"crossref","first-page":"2343","DOI":"10.1182\/blood-2013-09-529537","article-title":"Preclinical targeting of human acute myeloid leukemia and myeloablation using chimeric antigen receptor-modified T\u00a0cells","volume":"123","author":"Gill","year":"2014","journal-title":"Blood"},{"issue":"6","key":"10.1016\/j.cll.2023.04.003_bib12","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1016\/j.stemcr.2014.09.016","article-title":"Multipotent hematopoietic progenitors divide asymmetrically to create progenitors of the lymphomyeloid and erythromyeloid lineages","volume":"3","author":"G\u00f6rgens","year":"2014","journal-title":"Stem Cell Rep"},{"issue":"7","key":"10.1016\/j.cll.2023.04.003_bib13","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/ni.1889","article-title":"Revised map of the human progenitor hierarchy shows the origin of macrophages and dendritic cells in early lymphoid development","volume":"11","author":"Doulatov","year":"2010","journal-title":"Nat Immunol"},{"issue":"2","key":"10.1016\/j.cll.2023.04.003_bib14","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/bjh.13938","article-title":"Advances in understanding erythropoiesis: evolving perspectives","volume":"173","author":"Nandakumar","year":"2016","journal-title":"Br J Haematol"},{"issue":"2","key":"10.1016\/j.cll.2023.04.003_bib15","doi-asserted-by":"crossref","first-page":"177","DOI":"10.14218\/JCTH.2019.00031","article-title":"Erythroid lineage cells in the liver: novel immune regulators and beyond","volume":"8","author":"Yang","year":"2020","journal-title":"J\u00a0Clin Transl Hepatol"},{"issue":"S1","key":"10.1016\/j.cll.2023.04.003_bib16","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1111\/voxs.12155","article-title":"Megakaryopoiesis and ex\u00a0vivo differentiation of stem cells into megakaryocytes and platelets","volume":"10","author":"Pineault","year":"2015","journal-title":"ISBT Sci Ser"},{"issue":"5","key":"10.1016\/j.cll.2023.04.003_bib17","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.exphem.2014.02.002","article-title":"Biomanufacture of human platelets for transfusion: rationale and approaches","volume":"42","author":"Lee","year":"2014","journal-title":"Expl Hematol"},{"key":"10.1016\/j.cll.2023.04.003_bib18","series-title":"Stem cells in regenerative medicine","first-page":"109","article-title":"Ex vivo megakaryocyte expansion and platelet production from human cord blood stem cells","author":"Cortin","year":"2009"},{"issue":"9","key":"10.1016\/j.cll.2023.04.003_bib19","doi-asserted-by":"crossref","first-page":"e0138200","DOI":"10.1371\/journal.pone.0138200","article-title":"Immunophenotypic profiling of erythroid progenitor-derived extracellular vesicles in diamond-blackfan anaemia: a new diagnostic strategy","volume":"10","author":"Macr\u00ec","year":"2015","journal-title":"PLoS One"},{"issue":"18","key":"10.1016\/j.cll.2023.04.003_bib20","doi-asserted-by":"crossref","first-page":"9808","DOI":"10.3390\/ijms22189808","article-title":"Industrially compatible transfusable iPSC-derived RBCs: progress, challenges and prospective solutions","volume":"22","author":"Lim","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10.1016\/j.cll.2023.04.003_bib21","first-page":"1","article-title":"Immunophenotypic differentiation patterns of normal hematopoiesis in human bone marrow: reference patterns for age-related changes and disease-induced shifts","volume":"60","author":"Van Lochem","year":"2004","journal-title":"Cytometry Part B: Clinical Cytometry: The Journal of the International Society for Analytical Cytology"},{"key":"10.1016\/j.cll.2023.04.003_bib22","series-title":"Biology of myelomonocytic cells","article-title":"Phenotypic markers and functional regulators of myelomonocytic cells","author":"Marti","year":"2017"},{"key":"10.1016\/j.cll.2023.04.003_bib23","series-title":"A biomathematical analysis of immunophenotypic characteristics in patients with acute myeloblastic leukemia","author":"Plesa","year":"2006"},{"issue":"11","key":"10.1016\/j.cll.2023.04.003_bib24","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.1038\/sj.leu.2400847","article-title":"Flow cytometry CD45 gating for immunophenotyping of acute myeloid leukemia","volume":"11","author":"Lacombe","year":"1997","journal-title":"Leukemia"},{"key":"10.1016\/j.cll.2023.04.003_bib25","series-title":"Atlas of hematopathology: morphology, immunophenotype, cytogenetics, and molecular approaches","author":"Naeim","year":"2012"},{"key":"10.1016\/j.cll.2023.04.003_bib26","series-title":"Molecular genetic pathology","first-page":"155","article-title":"Clinical flow cytometry","author":"Czader","year":"2008"},{"key":"10.1016\/j.cll.2023.04.003_bib27","series-title":"Practical flow cytometry in haematology diagnosis","author":"Leach","year":"2013"},{"issue":"3","key":"10.1016\/j.cll.2023.04.003_bib28","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1038\/leu.2012.217","article-title":"The proportion of CD34+ CD38low or neg myeloblasts, but not side population frequency, predicts initial response to induction therapy in patients with newly diagnosed acute myeloid leukemia","volume":"27","author":"Roshal","year":"2013","journal-title":"Leukemia"},{"issue":"4","key":"10.1016\/j.cll.2023.04.003_bib29","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1084\/jem.158.4.1092","article-title":"Immune interferon induces the receptor for monomeric IgG1 on human monocytic and myeloid cells","volume":"158","author":"Perussia","year":"1983","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.cll.2023.04.003_bib30","doi-asserted-by":"crossref","unstructured":"Repp R, Valerius T, Sendler A, et\u00a0al. Neutrophils express the high affinity receptor for IgG (Fc gamma RI, CD64) after in\u00a0vivo application of recombinant human granulocyte colony-stimulating factor. 1991.","DOI":"10.1182\/blood.V78.4.885.bloodjournal784885"},{"issue":"3","key":"10.1016\/j.cll.2023.04.003_bib31","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1002\/cyto.b.21219","article-title":"Introduction to the diagnosis and classification of monocytic-lineage leukemias by flow cytometry","volume":"92","author":"Matarraz","year":"2017","journal-title":"Cytometry B Clin Cytometry"},{"issue":"23","key":"10.1016\/j.cll.2023.04.003_bib32","doi-asserted-by":"crossref","first-page":"3618","DOI":"10.1182\/blood-2015-01-620781","article-title":"Characteristic repartition of monocyte subsets as a diagnostic signature of chronic myelomonocytic leukemia","volume":"125","author":"Selimoglu-Buet","year":"2015","journal-title":"Blood"},{"key":"10.1016\/j.cll.2023.04.003_bib33","doi-asserted-by":"crossref","first-page":"602963","DOI":"10.3389\/fimmu.2021.602963","article-title":"Neutrophils: need for standardized nomenclature","volume":"12","author":"McKenna","year":"2021","journal-title":"Front Immunol"},{"issue":"1","key":"10.1016\/j.cll.2023.04.003_bib34","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1002\/cyto.b.10008","article-title":"CD87 as a marker for terminal granulocytic maturation: assessment of its expression during granulopoiesis","volume":"51","author":"Elghetany","year":"2003","journal-title":"Cytometry Part B: Clinical Cytometry: The Journal of the International Society for Analytical Cytology"},{"issue":"10","key":"10.1016\/j.cll.2023.04.003_bib35","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1182\/blood-2016-04-713206","article-title":"Mature CD10+ and immature CD10\u2212 neutrophils present in G-CSF\u2013treated donors display opposite effects on T\u00a0cells","volume":"129","author":"Marini","year":"2017","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.cll.2023.04.003_bib36","doi-asserted-by":"crossref","first-page":"858","DOI":"10.4049\/jimmunol.178.2.858","article-title":"Bone marrow-derived hemopoietic precursors commit to the T\u00a0cell lineage only after arrival in the thymic microenvironment","volume":"178","author":"Heinzel","year":"2007","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.cll.2023.04.003_bib37","series-title":"Lymphoid hematopoiesis and lymphocytes differentiation and maturation, In: Isvoranu G., Lymphocyte updates-cancer, autoimmunity and infection","author":"Marti","year":"2017"},{"issue":"S1","key":"10.1016\/j.cll.2023.04.003_bib38","first-page":"S47","article-title":"Human peripheral blood B-cell compartments: a crossroad in B-cell traffic","volume":"78","author":"Perez-Andres","year":"2010","journal-title":"Cytometry B Clin Cytometry"},{"key":"10.1016\/j.cll.2023.04.003_bib39","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.omto.2018.10.006","article-title":"Preclinical development of bivalent chimeric antigen receptors targeting both CD19 and CD22","volume":"11","author":"Qin","year":"2018","journal-title":"Molecular Therapy-Oncolytics"},{"issue":"11","key":"10.1016\/j.cll.2023.04.003_bib40","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1016\/j.leukres.2013.07.024","article-title":"Hematogones: an overview","volume":"37","author":"Chantepie","year":"2013","journal-title":"Leuk Res"},{"issue":"8","key":"10.1016\/j.cll.2023.04.003_bib41","first-page":"2498","article-title":"Immunophenotypic analysis of hematogones (B-lymphocyte precursors) in 662 consecutive bone marrow specimens by 4-color flow cytometry","volume":"98","author":"McKenna","year":"2001","journal-title":"Blood, The Journal of the American Society of Hematology"},{"issue":"6","key":"10.1016\/j.cll.2023.04.003_bib42","first-page":"501","article-title":"Normal maturation sequence of immunoglobulin light and heavy chains in hematogone stages 1, 2 and 3 in acute leukemia after treatment","volume":"55","author":"Babusikova","year":"2008","journal-title":"Neoplasma"},{"issue":"3","key":"10.1016\/j.cll.2023.04.003_bib43","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.it.2022.01.003","article-title":"Unraveling B cell trajectories at single cell resolution","volume":"43","author":"Morgan","year":"2022","journal-title":"Trends Immunol"},{"issue":"23","key":"10.1016\/j.cll.2023.04.003_bib44","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.124928","article-title":"Human bone marrow assessment by single-cell RNA sequencing, mass cytometry, and flow cytometry","volume":"3","author":"Oetjen","year":"2018","journal-title":"JCI insight"},{"issue":"1","key":"10.1016\/j.cll.2023.04.003_bib45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-021-27232-5","article-title":"Single-cell analysis identifies dynamic gene expression networks that govern B cell development and transformation","volume":"12","author":"Lee","year":"2021","journal-title":"Nat Commun"},{"issue":"23","key":"10.1016\/j.cll.2023.04.003_bib46","doi-asserted-by":"crossref","first-page":"12868","DOI":"10.1073\/pnas.1915085117","article-title":"Putative regulators for the continuum of erythroid differentiation revealed by single-cell transcriptome of human BM and UCB cells","volume":"117","author":"Huang","year":"2020","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1","key":"10.1016\/j.cll.2023.04.003_bib47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12859-022-04817-5","article-title":"Detection of cell markers from single cell RNA-seq with sc2marker","volume":"23","author":"Li","year":"2022","journal-title":"BMC Bioinf"}],"container-title":["Clinics in Laboratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0272271223000410?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0272271223000410?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T10:08:36Z","timestamp":1715594916000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0272271223000410"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":47,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["S0272271223000410"],"URL":"https:\/\/doi.org\/10.1016\/j.cll.2023.04.003","relation":{},"ISSN":["0272-2712"],"issn-type":[{"value":"0272-2712","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Immunophenotypic Profile of Healthy Human Bone Marrow","name":"articletitle","label":"Article Title"},{"value":"Clinics in Laboratory Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cll.2023.04.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}