{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:41:40Z","timestamp":1780965700943,"version":"3.54.1"},"reference-count":40,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","theclinics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinics in Laboratory Medicine"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.cll.2025.10.003","type":"journal-article","created":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T20:22:29Z","timestamp":1767126149000},"page":"65-76","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Pathogen-Reduce Cryoprecipitate"],"prefix":"10.1016","volume":"46","author":[{"given":"Jay P.","family":"Hudgins","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cll.2025.10.003_bib1","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1111\/j.1423-0410.2010.01426.x","article-title":"Hepatitis B, hepatitis C and HIV transfusion-transmitted infections in the 21st century","volume":"100","author":"Dwyre","year":"2011","journal-title":"Vox Sang"},{"key":"10.1016\/j.cll.2025.10.003_bib2","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1046\/j.1365-2516.1999.00317.x","article-title":"De Bosch Haemophilia therapy: assessing the cumulative risk of HIV exposure by cryoprecipitate","volume":"5","author":"Evatt","year":"1999","journal-title":"Haemophilia"},{"issue":"4","key":"10.1016\/j.cll.2025.10.003_bib3","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/j.jhep.2009.05.020","article-title":"Transfusion-transmitted hepatitis B virus infection","volume":"51","author":"Candotti","year":"2009","journal-title":"J Hepatol"},{"key":"10.1016\/j.cll.2025.10.003_bib4","unstructured":"Acker J, Razatos A and Marks D. Whole blood and apheresis collection of blood components intended for transfusion, Technical manual, 202, 21st edition, AABB; Bethesda (MD), 137\u2013167."},{"issue":"Suppl 2","key":"10.1016\/j.cll.2025.10.003_bib5","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1111\/trf.14168","article-title":"Supplemental findings from the national blood collection and utilization surveys, 2013 and 2015","volume":"57 Suppl 2","author":"Sapiano","year":"2017","journal-title":"Transfusion"},{"issue":"9","key":"10.1016\/j.cll.2025.10.003_bib6","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.1111\/trf.13644","article-title":"Declining blood collection and utilization in the United States","volume":"56","author":"Chung","year":"2016","journal-title":"Transfusion"},{"issue":"Suppl 2","key":"10.1016\/j.cll.2025.10.003_bib7","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1111\/trf.14165","article-title":"Continued decline in blood collection and transfusion in the united States-2015","volume":"57 Suppl 2","author":"Ellingson","year":"2017","journal-title":"Transfusion"},{"key":"10.1016\/j.cll.2025.10.003_bib8","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1111\/trf.15604","article-title":"Slowing decline in blood collection and transfusion in the United States \u2013 2017","volume":"60","author":"Jones","year":"2020","journal-title":"Transfusion"},{"key":"10.1016\/j.cll.2025.10.003_bib9","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1111\/trf.16449","article-title":"Has the trend of declining blood transfusions in the United States ended? Findings of the 2019 National Blood Collection and Utilization Survey","volume":"61","author":"Jones","year":"2021","journal-title":"Transfusion"},{"issue":"S4","key":"10.1016\/j.cll.2025.10.003_bib10","doi-asserted-by":"crossref","first-page":"S8","DOI":"10.1111\/trf.17360","article-title":"Continued stabilization of blood collections and transfusions in the United States: findings from the 2021 National Blood Collection and Utilization Survey","volume":"63","author":"Free","year":"2023","journal-title":"Transfusion"},{"key":"10.1016\/j.cll.2025.10.003_bib11","doi-asserted-by":"crossref","DOI":"10.1111\/trf.18187","article-title":"Have we reached a new baseline for blood collection and transfusion in the United States? National Blood Collection and Utilization Survey, 2023","author":"McDavid","year":"2025","journal-title":"Transfusion"},{"key":"10.1016\/j.cll.2025.10.003_bib12","unstructured":"United States, Office of Federal Register: Code of federal regulations, title 21, parts 600 to 799 food and drug. Washington: Office of the Federal Register, National Archives and Records Administration. 2025."},{"key":"10.1016\/j.cll.2025.10.003_bib13","series-title":"AABB Standards for blood banks and transfusion services","year":"2024"},{"key":"10.1016\/j.cll.2025.10.003_bib14","unstructured":"Intercept blood system for plasma. On FDA website, Available at: https:\/\/www.fda.gov\/vaccines-blood-biologics\/approved-blood-products\/intercept-blood-system-plasma, 2020."},{"key":"10.1016\/j.cll.2025.10.003_bib15","unstructured":"Regulatory Update: Circular of infromation updated for cyroprecipitated AHF manufactured from PF24. On: AABB website, Available at: https:\/\/www.aabb.org\/news-resources\/news\/article\/2023\/07\/25\/regulatory-update-circular-of-information-updated-for-cryoprecipitated-ahf-manufactured-from-pf24 (Accessed 28 April 2025)."},{"key":"10.1016\/j.cll.2025.10.003_bib16","unstructured":"Summary of safety and effectiveness data \u2013 intercept blood systems for plasma. On FDA website, Available at: https:\/\/wayback.archive-it.org\/7993\/20190208123701\/https:\/\/www.fda.gov\/downloads\/BiologicsBloodVaccines\/BloodBloodProducts\/ApprovedProducts\/PremarketApprovalsPMAs\/UCM429264.pdf (Accessed 28 April 2025)."},{"key":"10.1016\/j.cll.2025.10.003_bib17","unstructured":"Bacterial risk control strategies for blood collection establishments and transfusion services to enhance the safety and availability of platelets for transfusion guidance for industry on: FDA website, Available at: https:\/\/www.fda.gov\/regulatory-information\/search-fda-guidance-documents\/bacterial-risk-control-strategies-blood-collection-establishments-and-transfusion-services-enhance (Accessed 28 April 2025)."},{"key":"10.1016\/j.cll.2025.10.003_bib18","unstructured":"INTERCEPT blood system for platelets \u2013Approval letter. On: FDA Website, Available at: https:\/\/www.fda.gov\/vaccines-blood-biologics\/approved-blood-products\/intercept-blood-system-platelets (Accessed 28 April 2025)."},{"issue":"1","key":"10.1016\/j.cll.2025.10.003_bib19","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1159\/000323552","article-title":"The use of solvent\/detergent treatment in pathogen reduction of plasma","volume":"38","author":"Hellstern","year":"2011","journal-title":"Transfus Med Hemother"},{"key":"10.1016\/j.cll.2025.10.003_bib20","unstructured":"Summary basis for regulatory action \u2013 octoplas. On: FDA website, Available at: https:\/\/wayback.archive-it.org\/7993\/20170723031347\/https:\/\/www.fda.gov\/downloads\/BiologicsBloodVaccines\/BloodBloodProducts\/ApprovedProducts\/LicensedProductsBLAs\/UCM339994.pdf (Accessed 28 April 2025)."},{"key":"10.1016\/j.cll.2025.10.003_bib21","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1111\/j.1423-0410.2010.01374.x","article-title":"A comparison of methods of pathogen inactivation of FFP","volume":"100","author":"Rock","year":"2011","journal-title":"Vox Sang"},{"key":"10.1016\/j.cll.2025.10.003_bib22","article-title":"Application of riboflavin photochemical properties in hydrogel synthesis","author":"Ionita","year":"2020","journal-title":"IntechOpen"},{"issue":"19","key":"10.1016\/j.cll.2025.10.003_bib23","article-title":"Free radicals and their impact on health and antioxidant defenses: a review","volume":"11","author":"Chandimali","year":"2025","journal-title":"Cell Death Discov"},{"key":"10.1016\/j.cll.2025.10.003_bib24","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1111\/j.1423-0410.2000.tb00065.x","article-title":"The use of riboflavin for the inactivation of pathogens in blood products","volume":"78","author":"Goodrich","year":"2000","journal-title":"Vox Sang"},{"issue":"1","key":"10.1016\/j.cll.2025.10.003_bib25","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.transci.2006.01.007","article-title":"The mirasol PRT system for pathogen reduction of platelets and plasma: an overview of current status and future trends","volume":"35","author":"Goodrich","year":"2006","journal-title":"Transfus Apher Sci"},{"issue":"1","key":"10.1016\/j.cll.2025.10.003_bib26","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1159\/000323786","article-title":"Main properties of THERAFLEX MB-Plasma system for pathogen reduction","volume":"38","author":"Seghatchain","year":"2011","journal-title":"Transfus Med Hemother"},{"key":"10.1016\/j.cll.2025.10.003_bib27","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.freeradbiomed.2020.04.015","article-title":"The photodynamic and direct actions of methylene blue on mitochondrial energy metabolism: a balance of the useful and harmful effects of this photosensitizer","volume":"153","author":"Makiyama-Klosowski","year":"2020","journal-title":"Free Radic Biol Med"},{"issue":"3","key":"10.1016\/j.cll.2025.10.003_bib28","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1111\/trf.17720","article-title":"Results of clinical effectiveness of conventional versus Mirasol-treated apheresis platelets in patients with hypoproliferative thrombocytopenia (MiPLATE) trial","volume":"64","author":"Koepsell","year":"2024","journal-title":"Transfusion"},{"issue":"1","key":"10.1016\/j.cll.2025.10.003_bib29","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1186\/s13063-022-06137-8","article-title":"The mirasol evaluation of reduction in infections trial (MERIT): study protocol for a randomized controlled clinical trial","volume":"23","author":"Kasirye","year":"2022","journal-title":"Trials"},{"issue":"5","key":"10.1016\/j.cll.2025.10.003_bib30","first-page":"443","article-title":"Characteristics of thawed pooled cryoprecipitate stored at refrigerated temperature for 24 hours","volume":"16","author":"Soundar","year":"2018","journal-title":"Blood Transfus"},{"issue":"5","key":"10.1016\/j.cll.2025.10.003_bib31","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1111\/trf.14550","article-title":"Hemostatic profile and safety of pooled cryoprecipitate up to 120 hours after thawing","volume":"58","author":"Lokhandwala","year":"2018","journal-title":"Transfusion"},{"issue":"S2","key":"10.1016\/j.cll.2025.10.003_bib32","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1111\/trf.15180","article-title":"Hemostatic characteristics of thawed, pooled cryoprecipitate stored for 35\u2009days at refrigerated and room temperatures","volume":"59","author":"Fenderson","year":"2019","journal-title":"Transfusion"},{"issue":"11","key":"10.1016\/j.cll.2025.10.003_bib33","doi-asserted-by":"crossref","first-page":"3549","DOI":"10.1111\/trf.15472","article-title":"Bacterial safety of extended room temperature storage of thawed cryoprecipitate","volume":"59","author":"Wagner","year":"2019","journal-title":"Transfusion"},{"issue":"7","key":"10.1016\/j.cll.2025.10.003_bib34","doi-asserted-by":"crossref","first-page":"805","DOI":"10.3390\/pathogens11070805","article-title":"Preparation and storage of cryoprecipitate derived from amotosalen and UVA-treated apheresis plasma and assessment of in vitro quality parameters","volume":"11","author":"Kovacic Krizanic","year":"2022","journal-title":"Pathogens"},{"key":"10.1016\/j.cll.2025.10.003_bib35","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1111\/trf.16376","article-title":"Effects of pathogen reduction technology and storage duration on the ability of cryoprecipitate to rescue induced coagulopathies in vitro","volume":"61","author":"Thomas","year":"2021","journal-title":"Transfusion"},{"issue":"5","key":"10.1016\/j.cll.2025.10.003_bib36","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1111\/trf.15157","article-title":"Efficacy of a new pathogen-reduced cryoprecipitate stored 5 days after thawing to correct dilutional coagulopathy in vitro","volume":"59","author":"Cushing","year":"2019","journal-title":"Transfusion"},{"issue":"8","key":"10.1016\/j.cll.2025.10.003_bib37","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1111\/trf.17940","article-title":"How do I implement pathogen reduced cryoprecipitated fibrinogen complex in a tertiary Hospital\u2019s blood Bank","volume":"64","author":"Aidikoff","year":"2024","journal-title":"Transfusion"},{"key":"10.1016\/j.cll.2025.10.003_bib38","first-page":"aqae073","article-title":"Implementation and early outcomes with pathogen reduced cryoprecipitated fibrinogen complex","author":"Sethapati","year":"2024","journal-title":"Am J Clin Pathol"},{"issue":"3","key":"10.1016\/j.cll.2025.10.003_bib39","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s10916-021-01719-6","article-title":"Perioperative cryoprecipitate waste reduction","volume":"45","author":"Burk","year":"2021","journal-title":"J Med Syst"},{"issue":"3","key":"10.1016\/j.cll.2025.10.003_bib40","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1093\/ajcp\/aqaa042","article-title":"Cryoprecipitate utilization patterns observed with a required prospective approval process vs electronic dosing guidance","volume":"154","author":"Kruse","year":"2020","journal-title":"Am J Clin Pathol"}],"container-title":["Clinics in Laboratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0272271225000836?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0272271225000836?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T19:21:57Z","timestamp":1771874517000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0272271225000836"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["S0272271225000836"],"URL":"https:\/\/doi.org\/10.1016\/j.cll.2025.10.003","relation":{},"ISSN":["0272-2712"],"issn-type":[{"value":"0272-2712","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pathogen-Reduce Cryoprecipitate","name":"articletitle","label":"Article Title"},{"value":"Clinics in Laboratory Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cll.2025.10.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}