{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T06:04:06Z","timestamp":1773381846299,"version":"3.50.1"},"reference-count":45,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","clinical-lung-cancer.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Lung Cancer"],"published-print":{"date-parts":[[2023,5]]},"DOI":"10.1016\/j.cllc.2023.01.002","type":"journal-article","created":{"date-parts":[[2023,1,21]],"date-time":"2023-01-21T02:20:39Z","timestamp":1674267639000},"page":"269-277","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Upfront and Repeated Stereotactic Radiosurgery in Patients With Brain Metastases From NSCLC"],"prefix":"10.1016","volume":"24","author":[{"given":"Anna S.","family":"Kr\u00e4mer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Adeberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorothea","family":"Kronsteiner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laila","family":"K\u00f6nig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabian","family":"Schunn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farastuk","family":"Bozorgmehr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petros","family":"Christopoulos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanja","family":"Eichkorn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annabella","family":"Schiele","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Hahnemann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Rieken","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00fcrgen","family":"Debus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rami A. El","family":"Shafie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cllc.2023.01.002_bib0001","article-title":"Krebs in Deutschland f\u00fcr 2017\/2018","volume":"13","author":"Erdmann","year":"2021","journal-title":"Krebsregister"},{"key":"10.1016\/j.cllc.2023.01.002_bib0002","doi-asserted-by":"crossref","first-page":"e396","DOI":"10.1016\/S1470-2045(13)70311-5","article-title":"Challenges relating to solid tumour brain metastases in clinical trials, part 1: patient population, response, and progression. A report from the RANO group","volume":"14","author":"Lin","year":"2013","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.cllc.2023.01.002_bib0003","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.lungcan.2004.01.025","article-title":"Multivariate analysis of factors predictive of brain metastases in localised non-small cell lung carcinoma","volume":"45","author":"Bajard","year":"2004","journal-title":"Lung Cancer"},{"key":"10.1016\/j.cllc.2023.01.002_bib0004","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.jtho.2021.08.009","article-title":"Brain metastases in EGFR- and ALK-positive NSCLC: outcomes of central nervous system-penetrant tyrosine kinase inhibitors alone versus in combination with radiation","volume":"17","author":"Thomas","year":"2022","journal-title":"J Thorac Oncol"},{"key":"10.1016\/j.cllc.2023.01.002_bib0005","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S1470-2045(11)70393-X","article-title":"Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial","volume":"13","author":"Rosell","year":"2012","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.cllc.2023.01.002_bib0006","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1056\/NEJMoa1507643","article-title":"Nivolumab versus docetaxel in advanced nonsquamous non-small-cell lung cancer","volume":"373","author":"Borghaei","year":"2015","journal-title":"N Engl J Med"},{"key":"10.1016\/j.cllc.2023.01.002_bib0007","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.ejca.2022.05.011","article-title":"Trends in age- and sex-specific lung cancer mortality in Europe and Northern America: analysis of vital registration data from the WHO Mortality Database between 2000 and 2017","volume":"171","author":"Baum","year":"2022","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.cllc.2023.01.002_bib0008","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S1470-2045(14)70061-0","article-title":"Stereotactic radiosurgery for patients with multiple brain metastases (JLGK0901): a multi-institutional prospective observational study","volume":"15","author":"Yamamoto","year":"2014","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.cllc.2023.01.002_bib0009","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.3171\/jns.2002.97.6.1276","article-title":"Radiosurgery for non-small cell lung carcinoma metastatic to the brain: long-term outcomes and prognostic factors influencing patient survival time and local tumor control","volume":"97","author":"Sheehan","year":"2002","journal-title":"J Neurosurg"},{"key":"10.1016\/j.cllc.2023.01.002_bib0010","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1200\/JCO.2010.30.1655","article-title":"Adjuvant whole-brain radiotherapy versus observation after radiosurgery or surgical resection of one to three cerebral metastases: results of the EORTC 22952-26001 study","volume":"29","author":"Kocher","year":"2011","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.cllc.2023.01.002_bib0011","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1200\/JCO.2011.41.0639","volume":"31","author":"Soffietti","year":"2013","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.cllc.2023.01.002_bib0012","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1016\/S0140-6736(16)30825-X","volume":"388","author":"Mulvenna","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.cllc.2023.01.002_bib0013","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1001\/jama.2016.9839","article-title":"Effect of radiosurgery alone vs radiosurgery with whole brain radiation therapy on cognitive function in patients with 1 to 3 brain metastases: a randomized clinical trial","volume":"316","author":"Brown","year":"2016","journal-title":"JAMA"},{"key":"10.1016\/j.cllc.2023.01.002_bib0014","doi-asserted-by":"crossref","first-page":"2483","DOI":"10.1001\/jama.295.21.2483","article-title":"Stereotactic radiosurgery plus whole-brain radiation therapy vs stereotactic radiosurgery alone for treatment of brain metastases: a randomized controlled trial","volume":"295","author":"Aoyama","year":"2006","journal-title":"JAMA"},{"key":"10.1016\/j.cllc.2023.01.002_bib0015","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/S1470-2045(09)70263-3","article-title":"Neurocognition in patients with brain metastases treated with radiosurgery or radiosurgery plus whole-brain irradiation: a randomised controlled trial","volume":"10","author":"Chang","year":"2009","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.cllc.2023.01.002_bib0016","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/s13014-016-0653-3","article-title":"Hypo-fractionated stereotactic radiotherapy alone using volumetric modulated arc therapy for patients with single, large brain metastases unsuitable for surgical resection","volume":"11","author":"Navarria","year":"2016","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.cllc.2023.01.002_bib0017","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1097\/COC.0b013e31828aadac","article-title":"Fractionated stereotactic radiosurgery for large brain metastases","volume":"38","author":"Wegner","year":"2015","journal-title":"Am J Clin Oncol"},{"key":"10.1016\/j.cllc.2023.01.002_bib0018","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/S0360-3016(96)00619-0","article-title":"Recursive partitioning analysis (RPA) of prognostic factors in three Radiation Therapy Oncology Group (RTOG) brain metastases trials","volume":"37","author":"Gaspar","year":"1997","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.cllc.2023.01.002_bib0019","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.ijrobp.2017.01.201","article-title":"Brain metastasis velocity: a novel prognostic metric predictive of overall survival and freedom from whole-brain radiation therapy after distant brain failure following upfront radiosurgery alone","volume":"98","author":"Farris","year":"2017","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.cllc.2023.01.002_bib0020","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1200\/JCO.2011.38.0527","article-title":"Summary report on the graded prognostic assessment: an accurate and facile diagnosis-specific tool to estimate survival for patients with brain metastases","volume":"30","author":"Sperduto","year":"2012","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.cllc.2023.01.002_bib0021","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1001\/jamaoncol.2016.3834","article-title":"Estimating survival in patients with lung cancer and brain metastases: an update of the graded prognostic assessment for lung cancer using molecular markers (Lung-molGPA)","volume":"3","author":"Sperduto","year":"2017","journal-title":"JAMA Oncol"},{"key":"10.1016\/j.cllc.2023.01.002_bib0022","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1002\/ijc.32133","article-title":"Combined targeted DNA and RNA sequencing of advanced NSCLC in routine molecular diagnostics: Analysis of the first 3,000 Heidelberg cases","volume":"145","author":"Volckmar","year":"2019","journal-title":"Int J Cancer"},{"issue":"1-4 Pt 2","key":"10.1016\/j.cllc.2023.01.002_bib0023","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1159\/000099863","article-title":"The Cyberknife: a frameless robotic system for radiosurgery","volume":"69","author":"Adler","year":"1997","journal-title":"Stereotact Funct Neurosurg"},{"key":"10.1016\/j.cllc.2023.01.002_bib0024","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1016\/j.ijrobp.2009.12.061","article-title":"Randomized double-blind placebo-controlled trial of bevacizumab therapy for radiation necrosis of the central nervous system","volume":"79","author":"Levin","year":"2011","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.cllc.2023.01.002_bib0025","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.6004\/jnccn.2020.0052","article-title":"Central nervous system cancers, version 3.2020, NCCN clinical practice guidelines in oncology","volume":"18","author":"Nabors","year":"2020","journal-title":"J Natl Compr Canc Netw"},{"key":"10.1016\/j.cllc.2023.01.002_bib0026","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1056\/NEJMoa1612674","article-title":"Osimertinib or platinum-pemetrexed in EGFR T790M-positive lung cancer","volume":"376","author":"Mok","year":"2017","journal-title":"N Engl J Med"},{"key":"10.1016\/j.cllc.2023.01.002_bib0027","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.ejca.2017.05.019","article-title":"Efficacy of alectinib in central nervous system metastases in crizotinib-resistant ALK-positive non-small-cell lung cancer: comparison of RECIST 1.1 and RANO-HGG criteria","volume":"82","author":"Gandhi","year":"2017","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.cllc.2023.01.002_bib0028","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1007\/s40263-015-0283-6","article-title":"Oral targeted therapies and central nervous system (CNS) metastases","volume":"29","author":"Gabay","year":"2015","journal-title":"CNS Drugs"},{"key":"10.1016\/j.cllc.2023.01.002_bib0029","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1200\/JCO.2016.69.7144","article-title":"Management of brain metastases in tyrosine kinase inhibitor-na\u00efve epidermal growth factor receptor-mutant non-small-cell lung cancer: a retrospective multi-institutional analysis","volume":"35","author":"Magnuson","year":"2017","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.cllc.2023.01.002_bib0030","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1056\/NEJMoa1704795","article-title":"Alectinib versus Crizotinib in untreated ALK-positive non-small-cell lung cancer","volume":"377","author":"Peters","year":"2017","journal-title":"N Engl J Med"},{"key":"10.1016\/j.cllc.2023.01.002_bib0031","doi-asserted-by":"crossref","DOI":"10.1200\/JCO.2018.78.3118","article-title":"CNS response to osimertinib versus standard epidermal growth factor receptor tyrosine kinase inhibitors in patients with untreated egfr-mutated advanced non-small-cell lung cancer","author":"Reungwetwattana","year":"2018","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.cllc.2023.01.002_bib0032","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.ijrobp.2019.02.051","article-title":"Optimal sequence of local and EGFR-TKI therapy for EGFR-mutant non-small cell lung cancer with brain metastases stratified by number of brain metastases","volume":"104","author":"Miyawaki","year":"2019","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.cllc.2023.01.002_bib0033","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/1748-717X-6-48","article-title":"Stereotactic radiosurgery for brain metastases: analysis of outcome and risk of brain radionecrosis","volume":"6","author":"Minniti","year":"2011","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.cllc.2023.01.002_bib0034","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.ijrobp.2020.08.013","article-title":"Single- and multifraction stereotactic radiosurgery dose\/volume tolerances of the brain","volume":"110","author":"Milano","year":"2021","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.cllc.2023.01.002_bib0035","doi-asserted-by":"crossref","first-page":"50","DOI":"10.2176\/nmc.ra.2014-0188","article-title":"Pathophysiology, diagnosis, and treatment of radiation necrosis in the brain","volume":"55","author":"Miyatake","year":"2015","journal-title":"Neurol Med Chir (Tokyo)"},{"key":"10.1016\/j.cllc.2023.01.002_bib0036","doi-asserted-by":"crossref","first-page":"e567","DOI":"10.1016\/j.ijrobp.2021.07.1531","article-title":"Clinical outcomes of non-small cell lung cancer brain metastases treated with stereotactic radiosurgery and immune checkpoint inhibitors, EGFR tyrosine kinase inhibitors, chemotherapy and immune checkpoint inhibitors, or chemotherapy alone","volume":"111","author":"Dohm","year":"2021","journal-title":"Int J\u00a0Radiat Oncol Biol Phys"},{"key":"10.1016\/j.cllc.2023.01.002_bib0037","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.lungcan.2018.03.013","article-title":"Impacts of EGFR-mutation status and EGFR-TKI on the efficacy of stereotactic radiosurgery for brain metastases from non-small cell lung adenocarcinoma: A retrospective analysis of 133 consecutive patients","volume":"119","author":"Yomo","year":"2018","journal-title":"Lung Cancer"},{"key":"10.1016\/j.cllc.2023.01.002_bib0038","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.854402","article-title":"Improving brain metastases outcomes through therapeutic synergy between stereotactic radiosurgery and targeted cancer therapies","volume":"12","author":"Rubino","year":"2022","journal-title":"Front Oncol"},{"key":"10.1016\/j.cllc.2023.01.002_bib0039","doi-asserted-by":"crossref","first-page":"551","DOI":"10.3389\/fonc.2018.00551","article-title":"Repeated courses of radiosurgery for new brain metastases to defer whole brain radiotherapy: feasibility and outcome with validation of the new prognostic metric brain metastasis velocity","volume":"8","author":"Fritz","year":"2018","journal-title":"Front Oncol"},{"key":"10.1016\/j.cllc.2023.01.002_bib0040","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1093\/neuros\/nyy026","article-title":"Robotic radiosurgery for brain metastases diagnosed with either SPACE or MPRAGE sequence (CYBER-SPACE)-a single-center prospective randomized trial","volume":"84","author":"El Shafie","year":"2019","journal-title":"Neurosurgery"},{"key":"10.1016\/j.cllc.2023.01.002_bib0041","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1016\/j.ijrobp.2011.10.026","article-title":"Treatment of five or more brain metastases with stereotactic radiosurgery","volume":"83","author":"Hunter","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.cllc.2023.01.002_bib0042","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.ijrobp.2018.10.036","article-title":"Validity of a recently proposed prognostic grading index, brain metastasis velocity, for patients with brain metastasis undergoing multiple radiosurgical procedures","volume":"103","author":"Yamamoto","year":"2019","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.cllc.2023.01.002_bib0043","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.radonc.2019.08.011","article-title":"Multi-institutional validation of brain metastasis velocity, a recently defined predictor of outcomes following stereotactic radiosurgery","volume":"142","author":"McTyre","year":"2020","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.cllc.2023.01.002_bib0044","doi-asserted-by":"crossref","first-page":"550","DOI":"10.21037\/tlcr.2017.08.02","article-title":"Beyond ALK and ROS1: RET, NTRK, EGFR and BRAF gene rearrangements in non-small cell lung cancer","volume":"6","author":"Farago","year":"2017","journal-title":"Transl Lung Cancer Res"},{"key":"10.1016\/j.cllc.2023.01.002_bib0045","doi-asserted-by":"crossref","first-page":"e498","DOI":"10.1016\/S1470-2045(15)00007-8","article-title":"Radiation and checkpoint blockade immunotherapy: radiosensitisation and potential mechanisms of synergy","volume":"16","author":"Sharabi","year":"2015","journal-title":"Lancet Oncol"}],"container-title":["Clinical Lung Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525730423000062?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525730423000062?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T19:13:51Z","timestamp":1761506031000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525730423000062"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":45,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["S1525730423000062"],"URL":"https:\/\/doi.org\/10.1016\/j.cllc.2023.01.002","relation":{},"ISSN":["1525-7304"],"issn-type":[{"value":"1525-7304","type":"print"}],"subject":[],"published":{"date-parts":[[2023,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Upfront and Repeated Stereotactic Radiosurgery in Patients With Brain Metastases From NSCLC","name":"articletitle","label":"Article Title"},{"value":"Clinical Lung Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cllc.2023.01.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}