{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T00:40:00Z","timestamp":1776991200199,"version":"3.51.4"},"reference-count":19,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","clinical-lung-cancer.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Lung Cancer"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.cllc.2023.07.004","type":"journal-article","created":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T04:35:37Z","timestamp":1690259737000},"page":"733-742","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Effect of Surgical Treatment for N2-Positive c-stage III Non-Small Cell Lung Carcinoma in the \u201cPACIFIC\u201d Era"],"prefix":"10.1016","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8928-9394","authenticated-orcid":false,"given":"Hiroyuki","family":"Adachi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Ito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuya","family":"Isaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kotaro","family":"Murakami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Miura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noritake","family":"Kikunishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoko","family":"Shigeta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruhiro","family":"Saito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisaku","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoyuki","family":"Yokose","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aya","family":"Saito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.cllc.2023.07.004_bib0001","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1002\/ijc.31937","article-title":"Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods","volume":"144","author":"Ferlay","year":"2019","journal-title":"Int J Cancer"},{"issue":"13","key":"10.1016\/j.cllc.2023.07.004_bib0002","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1200\/JCO.2009.26.2543","article-title":"Meta-analysis of concomitant versus sequential radiochemotherapy in locally advanced non-small-cell lung cancer","volume":"28","author":"Aup\u00e9rin","year":"2010","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.cllc.2023.07.004_bib0003","unstructured":"NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines), Non-small cell lung cancer. Version 5.2022. Accessed 17 October, 2022. Avalable at: https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/nscl.pdf."},{"issue":"12","key":"10.1016\/j.cllc.2023.07.004_bib0004","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1200\/JCO.21.01308","article-title":"Five-year survival outcomes from the PACIFIC trial: durvalumab after chemoradiotherapy in stage III non-small-cell lung cancer","volume":"40","author":"Spigel","year":"2022","journal-title":"J Clin Oncol"},{"issue":"5","key":"10.1016\/j.cllc.2023.07.004_bib0005","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1097\/JTO.0b013e3181a0d82e","article-title":"The IASLC lung cancer staging project: a proposal for a new international lymph node map in the forthcoming seventh edition of the TNM classification for lung cancer","volume":"4","author":"Rusch","year":"2009","journal-title":"J Thorac Oncol"},{"issue":"6","key":"10.1016\/j.cllc.2023.07.004_bib0006","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1016\/S0022-5223(99)70246-1","article-title":"Lobe-specific extent of systematic lymph node dissection for non-small cell lung carcinomas according to a retrospective study of metastasis and prognosis","volume":"117","author":"Asamura","year":"1999","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"2","key":"10.1016\/j.cllc.2023.07.004_bib0007","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1510\/icvts.2004.098814","article-title":"The new strategy of selective nodal dissection for lung cancer based on segment-specific patterns of nodal spread","volume":"4","author":"Watanabe","year":"2005","journal-title":"Interact Cardiovasc Thorac Surg"},{"issue":"7","key":"10.1016\/j.cllc.2023.07.004_bib0008","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1634\/theoncologist.2017-0659","article-title":"The eighth edition of TNM staging of lung cancer: reference chart and diagrams","volume":"23","author":"Lababede","year":"2018","journal-title":"Oncologist"},{"key":"10.1016\/j.cllc.2023.07.004_bib0009","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/bmt.2012.244","article-title":"Investigation of the freely available easy-to-use software 'EZR' for medical statistics","volume":"48","author":"Kanda","year":"2013","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.cllc.2023.07.004_bib0010","series-title":"Guidelines for Diagnosis and Treatment of the Lung Cancer\/Malignant Pleural Mesothelioma\/Thymic Tumors 2022","first-page":"80","year":"2010"},{"issue":"3","key":"10.1016\/j.cllc.2023.07.004_bib0011","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.jtho.2019.10.022","article-title":"Asian thoracic oncology research group expert consensus statement on optimal management of stage III NSCLC","volume":"15","author":"Tan","year":"2020","journal-title":"J Thorac Oncol"},{"issue":"2","key":"10.1016\/j.cllc.2023.07.004_bib0012","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.jtho.2018.10.002","article-title":"Demographics, safety and quality, and prognostic information in both the seventh and eighth editions of the TNM classification in 18,973 surgical cases of the Japanese Joint Committee of Lung Cancer Registry Database in 2010","volume":"14","author":"Okami","year":"2019","journal-title":"J Thorac Oncol"},{"issue":"4","key":"10.1016\/j.cllc.2023.07.004_bib0013","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1016\/j.athoracsur.2013.12.047","article-title":"Long-term survival of patients with pN2 lung cancer according to the pattern of lymphatic spread","volume":"97","author":"Legras","year":"2014","journal-title":"Ann Thorac Surg"},{"issue":"1","key":"10.1016\/j.cllc.2023.07.004_bib0014","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1093\/ejcts\/ezt550","article-title":"Time to refine N2 staging? cN2\u03b1 and cN2\u03b2 based on local regional involvement provide a more accurate prognosis in surgically treated IIIA non-small-cell lung cancer than N2 alone or the number of node stations involved","volume":"46","author":"Matsunaga","year":"2014","journal-title":"Eur J Cardiothorac Surg"},{"issue":"18","key":"10.1016\/j.cllc.2023.07.004_bib0015","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1056\/NEJMoa2027071","article-title":"Osimertinib in resected EGFR-mutated non-small-cell lung cancer","volume":"383","author":"Wu","year":"2020","journal-title":"N Engl J Med"},{"issue":"10","key":"10.1016\/j.cllc.2023.07.004_bib0016","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1200\/JCO.22.02186","article-title":"Adjuvant osimertinib for resected EGFR-mutated stage IB-IIIA non-small-cell lung cancer: updated results from the phase III randomized ADAURA trial","volume":"41","author":"Herbst","year":"2023","journal-title":"J Clin Oncol."},{"issue":"10308","key":"10.1016\/j.cllc.2023.07.004_bib0017","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1016\/S0140-6736(21)02098-5","article-title":"Adjuvant atezolizumab after adjuvant chemotherapy in resected stage IB-IIIA non-small-cell lung cancer (IMpower010): a randomised, multicentre, open-label, phase 3 trial","volume":"398","author":"Felip","year":"2021","journal-title":"Lancet"},{"issue":"21","key":"10.1016\/j.cllc.2023.07.004_bib0018","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.1056\/NEJMoa2202170","article-title":"Neoadjuvant nivolumab plus chemotherapy in resectable lung cancer","volume":"386","author":"Forde","year":"2022","journal-title":"N Engl J Med"},{"issue":"25","key":"10.1016\/j.cllc.2023.07.004_bib0019","doi-asserted-by":"crossref","first-page":"41670","DOI":"10.18632\/oncotarget.16471","article-title":"Definitive radiochemotherapy versus surgery within multimodality treatment in stage III non-small cell lung cancer (NSCLC) - a cumulative meta-analysis of the randomized evidence","volume":"8","author":"P\u00f6ttgen","year":"2017","journal-title":"Oncotarget"}],"container-title":["Clinical Lung Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525730423001444?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525730423001444?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T19:15:01Z","timestamp":1761506101000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525730423001444"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":19,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["S1525730423001444"],"URL":"https:\/\/doi.org\/10.1016\/j.cllc.2023.07.004","relation":{},"ISSN":["1525-7304"],"issn-type":[{"value":"1525-7304","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of Surgical Treatment for N2-Positive c-stage III Non-Small Cell Lung Carcinoma in the \u201cPACIFIC\u201d Era","name":"articletitle","label":"Article Title"},{"value":"Clinical Lung Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cllc.2023.07.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}