{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T02:07:29Z","timestamp":1793066849973,"version":"4.5.0"},"reference-count":19,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","clinical-lung-cancer.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Lung Cancer"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.cllc.2025.07.001","type":"journal-article","created":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T12:28:10Z","timestamp":1751545690000},"page":"e560-e565","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Lymphovascular Invasion is a Predictor of Postoperative Recurrence or Death in Stage I Non-small-cell Lung Cancer (NSCLC)"],"prefix":"10.1016","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5162-1638","authenticated-orcid":false,"given":"Margaret","family":"Locke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wint Yan","family":"Aung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Esposito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nagashree","family":"Seetharamu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.cllc.2025.07.001_bib0001","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.jtho.2015.09.009","article-title":"The IASLC lung cancer staging project: proposals for revision of the TNM stage groupings in the forthcoming (Eighth) edition of the TNM Classification for Lung Cancer","volume":"11","author":"Goldstraw","year":"2016","journal-title":"J Thorac Oncol"},{"issue":"4","key":"10.1016\/j.cllc.2025.07.001_bib0002","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1016\/j.athoracsur.2014.11.052","article-title":"Visceral pleural invasion remains a size-independent prognostic factor in stage I non-small cell lung cancer","volume":"99","author":"Huang","year":"2015","journal-title":"Ann Thorac Surg"},{"issue":"39","key":"10.1016\/j.cllc.2025.07.001_bib0003","doi-asserted-by":"crossref","first-page":"66576","DOI":"10.18632\/oncotarget.16476","article-title":"Visceral pleural invasion predict a poor survival among lung adenocarcinoma patients with tumor size \u2264 3cm","volume":"8","author":"Chen","year":"2017","journal-title":"Oncotarget"},{"issue":"6","key":"10.1016\/j.cllc.2025.07.001_bib0004","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1378\/chest.14-0204","article-title":"Prognostic significance of visceral pleural involvement in early-stage lung cancer","volume":"146","author":"Lakha","year":"2014","journal-title":"Chest"},{"issue":"1","key":"10.1016\/j.cllc.2025.07.001_bib0005","doi-asserted-by":"crossref","first-page":"e109","DOI":"10.1016\/j.cllc.2017.06.001","article-title":"Prognostic effect of lymphovascular invasion on TNM staging in stage I non-small-cell lung cancer","volume":"19","author":"Noma","year":"2018","journal-title":"Clin Lung Cancer"},{"issue":"17","key":"10.1016\/j.cllc.2025.07.001_bib0006","doi-asserted-by":"crossref","first-page":"2413","DOI":"10.1111\/1759-7714.14530","article-title":"Lymphovascular invasion: a non-sized T descriptor for stage IA non-small cell lung cancer","volume":"13","author":"Cai","year":"2022","journal-title":"Thorac Cancer"},{"issue":"3","key":"10.1016\/j.cllc.2025.07.001_bib0007","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/j.athoracsur.2013.11.002","article-title":"Lymphovascular invasion as a prognostic indicator in stage I non-small cell lung cancer: a systematic review and meta-analysis","volume":"97","author":"Mollberg","year":"2014","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.cllc.2025.07.001_bib0008","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.lungcan.2020.04.033","article-title":"Comparison of prognostic impact of lymphovascular invasion in stage IA non-small cell lung cancer after lobectomy versus sublobar resection: a propensity score-matched analysis","volume":"146","author":"Yun","year":"2020","journal-title":"Lung Cancer"},{"key":"10.1016\/j.cllc.2025.07.001_bib0009","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.lungcan.2022.11.007","article-title":"Spread through air spaces is a powerful prognostic predictor in patients with completely resected pathological stage I lung adenocarcinoma","volume":"174","author":"Shimomura","year":"2022","journal-title":"Lung Cancer"},{"issue":"3","key":"10.1016\/j.cllc.2025.07.001_bib0010","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1038\/s41379-020-00709-2","article-title":"Tumor spread through air spaces (STAS): prognostic significance of grading in non-small cell lung cancer","volume":"34","author":"Han","year":"2021","journal-title":"Mod Pathol"},{"issue":"3","key":"10.1016\/j.cllc.2025.07.001_bib0011","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.cllc.2021.10.004","article-title":"Meta-analysis of lobectomy and sublobar resection for stage I non-small cell lung cancer with spread through air spaces","volume":"23","author":"Li","year":"2022","journal-title":"Clin Lung Cancer"},{"issue":"3","key":"10.1016\/j.cllc.2025.07.001_bib0012","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1007\/s12253-017-0274-7","article-title":"Clinicopathological significance of micropapillary pattern in lung adenocarcinoma","volume":"24","author":"Pyo","year":"2018","journal-title":"Pathol Oncol Res"},{"key":"10.1016\/j.cllc.2025.07.001_bib0013","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.lungcan.2018.09.024","article-title":"Proposal on incorporating lymphovascular invasion as a T-descriptor for stage I lung cancer","volume":"125","author":"Wang","year":"2018","journal-title":"Lung Cancer"},{"issue":"4","key":"10.1016\/j.cllc.2025.07.001_bib0014","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.21037\/jtd.2018.03.184","article-title":"Efficacy of adjuvant chemotherapy for completely resected stage IB non-small cell lung cancer: a retrospective study","volume":"10","author":"Park","year":"2018","journal-title":"J Thorac Dis"},{"issue":"9","key":"10.1016\/j.cllc.2025.07.001_bib0015","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1007\/s00432-020-03276-w","article-title":"Effects of adjuvant chemotherapy on survival of patients with stage IB non-small cell lung cancer with visceral pleural invasion","volume":"146","author":"Xie","year":"2020","journal-title":"J Cancer Res Clin Oncol"},{"issue":"1","key":"10.1016\/j.cllc.2025.07.001_bib0016","doi-asserted-by":"crossref","first-page":"ezab498","DOI":"10.1093\/ejcts\/ezab498","article-title":"Adjuvant chemotherapy for visceral pleural invasion in 3-4-cm non-small-cell lung cancer improves survival","volume":"62","author":"Wightman","year":"2022","journal-title":"Eur J Cardiothorac Surg"},{"issue":"5","key":"10.1016\/j.cllc.2025.07.001_bib0017","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.1016\/j.jtcvs.2018.06.034","article-title":"Adjuvant chemotherapy may improve prognosis after resection of stage I lung cancer with lymphovascular invasion","volume":"156","author":"Wang","year":"2018","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"1","key":"10.1016\/j.cllc.2025.07.001_bib0018","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1186\/s12885-020-07691-7","article-title":"A single-arm, phase 2 study of adjuvant chemotherapy with oral tegafur-uracil for pathologically lymphovascular invasion positive stage IA non-small cell lung cancer: LOGIK0602 study","volume":"20","author":"Tsuchiya","year":"2020","journal-title":"BMC Cancer"},{"issue":"5","key":"10.1016\/j.cllc.2025.07.001_bib0019","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1016\/j.athoracsur.2021.04.108","article-title":"Adjuvant chemotherapy for high-risk pathologic stage I non-small cell lung cancer","volume":"113","author":"Tsutani","year":"2022","journal-title":"Ann Thorac Surg"}],"container-title":["Clinical Lung Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525730425001457?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525730425001457?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T15:04:05Z","timestamp":1778943845000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525730425001457"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":19,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["S1525730425001457"],"URL":"https:\/\/doi.org\/10.1016\/j.cllc.2025.07.001","relation":{},"ISSN":["1525-7304"],"issn-type":[{"value":"1525-7304","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lymphovascular Invasion is a Predictor of Postoperative Recurrence or Death in Stage I Non-small-cell Lung Cancer (NSCLC)","name":"articletitle","label":"Article Title"},{"value":"Clinical Lung Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cllc.2025.07.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}