{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T02:48:16Z","timestamp":1792118896307,"version":"4.4.0"},"reference-count":20,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100007114","name":"Ralph W and Grace M Showalter Research Trust Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007114","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["5U01CA209414"],"award-info":[{"award-number":["5U01CA209414"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["5U01CA209414"],"award-info":[{"award-number":["5U01CA209414"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","clinical-lung-cancer.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Lung Cancer"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.cllc.2025.09.007","type":"journal-article","created":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T07:31:07Z","timestamp":1758785467000},"page":"201-209.e3","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effects of Sex on Mortality in Patients With Lung Cancer: A Multiple Mediation Analysis of The Boston Lung Cancer Study"],"prefix":"10.1016","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5394-3323","authenticated-orcid":false,"given":"Adriana Araceli Rodriguez","family":"Alvarez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuming","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David C.","family":"Christiani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.cllc.2025.09.007_bib0001","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1007\/s10900-020-00826-8","article-title":"Examining gender differences in lung cancer screening","volume":"45","author":"Randhawa","year":"2020","journal-title":"J Community Health"},{"key":"10.1016\/j.cllc.2025.09.007_bib0002","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.lungcan.2022.07.015","article-title":"Sex disparities in lung cancer survival rates based on screening status","volume":"171","author":"Rodriguez Alvarez","year":"2022","journal-title":"Lung Cancer"},{"issue":"6","key":"10.1016\/j.cllc.2025.09.007_bib0003","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1053\/j.seminoncol.2009.09.003","article-title":"Population-based trends in lung cancer incidence in women","volume":"36","author":"Egleston","year":"2009","journal-title":"Semin Oncol"},{"issue":"9","key":"10.1016\/j.cllc.2025.09.007_bib0004","doi-asserted-by":"crossref","first-page":"2376","DOI":"10.1002\/ijc.32716","article-title":"Sex-specificity in lung cancer risk","volume":"146","author":"Stapelfeld","year":"2020","journal-title":"Int J Cancer"},{"issue":"4","key":"10.1016\/j.cllc.2025.09.007_bib0005","article-title":"Sex differences in lung cancer treatment and outcomes at a large hybrid academic-community practice","volume":"3","author":"Stabellini","year":"2022","journal-title":"JTO Clin Res Rep"},{"issue":"5","key":"10.1016\/j.cllc.2025.09.007_bib0006","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.jtho.2022.01.016","article-title":"Evaluating prognostic factors for sex differences in lung cancer survival: findings from a large Australian cohort","volume":"17","author":"Yu","year":"2022","journal-title":"J Thorac Oncol"},{"key":"10.1016\/j.cllc.2025.09.007_bib0007","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/j.amsu.2020.11.081","article-title":"Gender disparities in lung cancer survival from an enriched Florida population-based cancer registry","volume":"60","author":"Elkbuli","year":"2020","journal-title":"Ann Med Surg"},{"key":"10.1016\/j.cllc.2025.09.007_bib0008","article-title":"Exploring sex difference in the risk factors and prognosis of inoperable lung cancer","volume":"41","author":"Islam","year":"2024","journal-title":"Cancer Treat Res Commun"},{"issue":"4","key":"10.1016\/j.cllc.2025.09.007_bib0009","doi-asserted-by":"crossref","first-page":"909","DOI":"10.3390\/cancers14040909","article-title":"The impact of estrogens and their receptors on immunity and inflammation during infection","volume":"14","author":"Harding","year":"2022","journal-title":"Cancers (Basel)"},{"issue":"22","key":"10.1016\/j.cllc.2025.09.007_bib0010","first-page":"5801","article-title":"Different susceptibility to smoking-induced DNA damage among male and female lung cancer patients","volume":"54","author":"Ryberg","year":"1994","journal-title":"Cancer Res"},{"issue":"14","key":"10.1016\/j.cllc.2025.09.007_bib0011","first-page":"3317","article-title":"Sex differences in lung CYP1A1 expression and DNA adduct levels among lung cancer patients","volume":"59","author":"Mollerup","year":"1999","journal-title":"Cancer Res"},{"key":"10.1016\/j.cllc.2025.09.007_bib0012","unstructured":"Christiani D. Boston lung cancer survival cohort. 2017. Accessed August 3, 2025. https:\/\/epi.grants.cancer.gov\/cohort-consortium\/members\/blcs.html"},{"issue":"3","key":"10.1016\/j.cllc.2025.09.007_bib0013","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1002\/sim.7977","article-title":"Multiple mediation analysis with survival outcomes: with an application to explore racial disparity in breast cancer survival","volume":"38","author":"Yu","year":"2019","journal-title":"Stat Med"},{"key":"10.1016\/j.cllc.2025.09.007_bib0016","first-page":"1595","article-title":"EGFR mutations as a prognostic and predictive marker in non-small-cell lung cancer","volume":"8","author":"Fang","year":"2014","journal-title":"Drug Des Devel Ther"},{"key":"10.1016\/j.cllc.2025.09.007_bib0017","doi-asserted-by":"crossref","first-page":"153","DOI":"10.2147\/TACG.S531337","article-title":"Differential responses to targeted therapies in non-small cell lung cancer: a comparative analysis of outcomes in patients with single EGFR mutation and concurrent gene alterations","volume":"18","author":"Le","year":"2025","journal-title":"Appl Clin Genet"},{"issue":"7","key":"10.1016\/j.cllc.2025.09.007_bib0018","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.3390\/cancers17071054","article-title":"Sex-related differences in immunotherapy toxicities: insights into dimorphic responses","volume":"17","author":"Canzian","year":"2025","journal-title":"Cancers (Basel)"},{"issue":"1","key":"10.1016\/j.cllc.2025.09.007_bib0019","doi-asserted-by":"crossref","first-page":"3043","DOI":"10.1038\/s41598-024-51804-2","article-title":"Investigation of the potential effects of estrogen receptor modulators on immune checkpoint molecules","volume":"14","author":"Abramenko","year":"2024","journal-title":"Sci Rep"},{"issue":"5","key":"10.1016\/j.cllc.2025.09.007_bib0020","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1097\/01243894-200606000-00011","article-title":"Survival differences by sex for patients with advanced non-small cell lung cancer on Eastern Cooperative Oncology Group trial 1594","volume":"1","author":"Wakelee","year":"2006","journal-title":"J Thorac Oncol"},{"key":"10.1016\/j.cllc.2025.09.007_bib0021","doi-asserted-by":"crossref","DOI":"10.1136\/esmoopen-2020-000796","article-title":"Gender-specific aspects of epidemiology, molecular genetics and outcome: lung cancer","volume":"5","author":"Mederos","year":"2020","journal-title":"ESMO Open"},{"issue":"163","key":"10.1016\/j.cllc.2025.09.007_bib0022","doi-asserted-by":"crossref","DOI":"10.1183\/16000617.0100-2021","article-title":"The evolving landscape of sex-based differences in lung cancer: a distinct disease in women","volume":"31","author":"Ragavan","year":"2022","journal-title":"Eur Respir Rev"}],"container-title":["Clinical Lung Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525730425002335?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525730425002335?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T11:13:39Z","timestamp":1775042019000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525730425002335"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["S1525730425002335"],"URL":"https:\/\/doi.org\/10.1016\/j.cllc.2025.09.007","relation":{},"ISSN":["1525-7304"],"issn-type":[{"value":"1525-7304","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of Sex on Mortality in Patients With Lung Cancer: A Multiple Mediation Analysis of The Boston Lung Cancer Study","name":"articletitle","label":"Article Title"},{"value":"Clinical Lung Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cllc.2025.09.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}