{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T07:02:59Z","timestamp":1763017379056,"version":"build-2065373602"},"reference-count":41,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","clinical-lymphoma-myeloma-leukemia.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Lymphoma Myeloma and Leukemia"],"published-print":{"date-parts":[[2014,8]]},"DOI":"10.1016\/j.clml.2014.02.001","type":"journal-article","created":{"date-parts":[[2014,2,15]],"date-time":"2014-02-15T13:33:09Z","timestamp":1392471189000},"page":"291-296","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["The Choice of Multiple Myeloma Induction Therapy Affects the Frequency and Severity of Oral Mucositis After Melphalan-Based Autologous Stem Cell Transplantation"],"prefix":"10.1016","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9734-5616","authenticated-orcid":false,"given":"Shaun","family":"Fleming","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon J.","family":"Harrison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piers","family":"Blombery","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trish","family":"Joyce","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kerrie","family":"Stokes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John F.","family":"Seymour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. Miles","family":"Prince","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Ritchie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.clml.2014.02.001_bib1","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/bmt.2008.299","article-title":"The Prospective Oral Mucositis Audit: relationship of severe oral mucositis with clinical and medical resource use outcomes in patients receiving high-dose melphalan or BEAM-conditioning CT and autologous SCT","volume":"43","author":"McCann","year":"2008","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.clml.2014.02.001_bib2","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/sj.bmt.1705471","article-title":"Oral mucositis in myeloma patients undergoing melphalan-based autologous stem cell transplantation: incidence, risk factors and a severity predictive model","volume":"38","author":"Grazziutti","year":"2006","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.clml.2014.02.001_bib3","doi-asserted-by":"crossref","first-page":"278","DOI":"10.3109\/07357909909040598","article-title":"Risk factors for chemotherapy-induced oral mucositis: dental appliances, oral hygiene, previous oral lesions, and history of smoking","volume":"17","author":"Dodd","year":"1999","journal-title":"Cancer Invest"},{"key":"10.1016\/j.clml.2014.02.001_bib4","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1200\/JCO.2001.19.8.2201","article-title":"Oral mucositis and the clinical and economic outcomes of hematopoietic stem cell transplantation","volume":"19","author":"Sonis","year":"2001","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.clml.2014.02.001_bib5","first-page":"33","article-title":"Patient reports of complications of bone marrow transplantation","volume":"8","author":"Bellm","year":"2000","journal-title":"Support Care Cancer"},{"key":"10.1016\/j.clml.2014.02.001_bib6","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/sj.thj.6200349","article-title":"Outpatient-based peripheral blood stem cell transplantation for patients with multiple myeloma","volume":"5","author":"Ferrara","year":"2004","journal-title":"Hematol J"},{"key":"10.1016\/j.clml.2014.02.001_bib7","doi-asserted-by":"crossref","first-page":"34","DOI":"10.37464\/2006.234.1921","article-title":"Hospital in the home (HITH) care following autologous stem cell transplantation for lymphoma and multiple myeloma","volume":"23","author":"Johnson","year":"2006","journal-title":"Aust J Adv Nurs"},{"key":"10.1016\/j.clml.2014.02.001_bib8","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1056\/NEJM199607113350204","article-title":"A\u00a0prospective, randomized trial of autologous bone marrow transplantation and chemotherapy in multiple myeloma. Intergroupe Fran\u00e7ais du My\u00e9lome","volume":"335","author":"Attal","year":"1996","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.clml.2014.02.001_bib9","doi-asserted-by":"crossref","first-page":"3077","DOI":"10.1182\/blood.V85.11.3077.bloodjournal85113077","article-title":"Autologous stem cell transplantation after first remission induction treatment in multiple myeloma: a report of the French Registry on autologous transplantation in multiple myeloma","volume":"85","author":"Harousseau","year":"1995","journal-title":"Blood"},{"key":"10.1016\/j.clml.2014.02.001_bib10","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1056\/NEJMoa022340","article-title":"High-dose chemotherapy with hematopoietic stem-cell rescue for multiple myeloma","volume":"348","author":"Child","year":"2003","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.clml.2014.02.001_bib11","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/S0140-6736(89)91549-3","article-title":"Infusion of vincristine and doxorubicin with oral dexamethasone as first-line therapy for multiple myeloma","volume":"334","author":"Samson","year":"1989","journal-title":"Lancet"},{"key":"10.1016\/j.clml.2014.02.001_bib12","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1038\/bjc.1995.65","article-title":"VAD chemotherapy as remission induction for multiple myeloma","volume":"71","author":"Anderson","year":"1995","journal-title":"Br J Cancer"},{"key":"10.1016\/j.clml.2014.02.001_bib13","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1182\/blood-2005-02-0522","article-title":"Superiority of thalidomide and dexamethasone over vincristine-doxorubicindexamethasone (VAD) as primary therapy in preparation for autologous transplantation for multiple myeloma","volume":"106","author":"Cavo","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.clml.2014.02.001_bib14","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1111\/j.1365-2141.2005.05519.x","article-title":"PAD combination therapy (PS-341\/bortezomib, doxorubicin and dexamethasone) for previously untreated patients with multiple myeloma","volume":"129","author":"Oakervee","year":"2005","journal-title":"Br J Haematol"},{"key":"10.1016\/j.clml.2014.02.001_bib15","first-page":"1498","article-title":"Bortezomib plus dexamethasone as induction treatment prior to autologous stem cell transplantation in patients with newly diagnosed multiple myeloma: results of an IFM phase II study","volume":"91","author":"Harousseau","year":"2006","journal-title":"Haematologica"},{"key":"10.1016\/j.clml.2014.02.001_bib16","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1111\/j.1365-2141.2005.05540.x","article-title":"Bortezomib therapy alone and in combination with dexamethasone for previously untreated symptomatic multiple myeloma","volume":"129","author":"Jagannath","year":"2005","journal-title":"Br J Haematol"},{"key":"10.1016\/j.clml.2014.02.001_bib17","doi-asserted-by":"crossref","first-page":"4630","DOI":"10.1200\/JCO.2010.28.3945","article-title":"Bortezomib plus dexamethasone induction improves outcome of patients with t(4;14) myeloma but not outcome of patients with del(17p)","volume":"28","author":"Avet-Loiseau","year":"2010","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.clml.2014.02.001_bib18","first-page":"826","article-title":"First-line therapy with thalidomide and dexamethasone in preparation for autologous stem cell transplantation for multiple myeloma","volume":"89","author":"Cavo","year":"2004","journal-title":"Haematologica"},{"key":"10.1016\/j.clml.2014.02.001_bib19","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1002\/cncr.26422","article-title":"Early versus delayed autologous transplantation after immunomodulatory agents-based induction therapy in patients with newly diagnosed multiple myeloma","volume":"118","author":"Kumar","year":"2012","journal-title":"Cancer"},{"key":"10.1016\/j.clml.2014.02.001_bib20","unstructured":"National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in\u00a0Oncology: Multiple Myeloma version 2. Available at: http:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/myeloma.pdf. Accessed: March 8, 2013."},{"key":"10.1016\/j.clml.2014.02.001_bib21","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.4161\/cbt.7.7.6207","article-title":"Serum levels of NF-\u03baB and pro-inflammatory cytokines following administration of mucotoxic drugs","volume":"7","author":"Logan","year":"2008","journal-title":"Cancer Biol Ther"},{"key":"10.1016\/j.clml.2014.02.001_bib22","doi-asserted-by":"crossref","first-page":"3412","DOI":"10.1200\/JCO.2005.04.242","article-title":"International staging system for multiple myeloma","volume":"23","author":"Greipp","year":"2005","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.clml.2014.02.001_bib23","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/S1053-4296(03)00031-6","article-title":"CTCAE v3.0: development of a comprehensive grading system for the adverse effects of cancer treatment","volume":"13","author":"Trotti","year":"2003","journal-title":"Semin Radiat Oncol"},{"key":"10.1016\/j.clml.2014.02.001_bib24","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1038\/sj.leu.2404284","article-title":"International uniform response criteria for multiple myeloma","volume":"20","author":"Durie","year":"2006","journal-title":"Leukemia"},{"issue":"suppl 7","key":"10.1016\/j.clml.2014.02.001_bib25","doi-asserted-by":"crossref","first-page":"vii141","DOI":"10.1093\/annonc\/mdn462","article-title":"Mucositis in the treatment of haematological malignancies","volume":"19","author":"Niscola","year":"2008","journal-title":"Ann Oncol"},{"key":"10.1016\/j.clml.2014.02.001_bib26","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1046\/j.1365-2141.2001.03171.x","article-title":"Cyclosporin A combined with vincristine, doxorubicin and dexamethasone (VAD) compared with VAD alone in\u00a0patients with advanced refractory multiple myeloma: an EORTC-HOVON randomized phase III study (06914)","volume":"115","author":"Sonneveld","year":"2001","journal-title":"Br J Haematol"},{"issue":"suppl 9","key":"10.1016\/j.clml.2014.02.001_bib27","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1002\/cncr.20162","article-title":"Perspectives on cancer therapy-induced mucosal injury: pathogenesis, measurement, epidemiology, and consequences for patients","volume":"100","author":"Sonis","year":"2004","journal-title":"Cancer"},{"key":"10.1016\/j.clml.2014.02.001_bib28","doi-asserted-by":"crossref","first-page":"222","DOI":"10.3324\/haematol.10232","article-title":"Mucositis in patients with hematologic malignancies: an overview","volume":"92","author":"Niscola","year":"2007","journal-title":"Haematologica"},{"key":"10.1016\/j.clml.2014.02.001_bib29","first-page":"95","article-title":"Role of the cyclooxygenase pathway in chemotherapy-induced oral mucositis: a pilot study","volume":"18","author":"Lalla","year":"2009","journal-title":"Support Care Cancer"},{"key":"10.1016\/j.clml.2014.02.001_bib30","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1038\/bmt.2009.335","article-title":"Genetic polymorphisms associated with outcome in multiple myeloma patients receiving high-dose melphalan","volume":"45","author":"Dumontet","year":"2010","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.clml.2014.02.001_bib31","first-page":"327","article-title":"Systematic review of oral cryotherapy for management of oral mucositis caused by cancer therapy","volume":"21","author":"Peterson","year":"2013","journal-title":"Support Care Cancer"},{"key":"10.1016\/j.clml.2014.02.001_bib32","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/S0360-3016(97)00076-X","article-title":"Low energy Helium-Neon laser in the prevention of oral mucositis in patients undergoing bone marrow transplant: results of a double blind randomized trial","volume":"38","author":"Cowen","year":"1997","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.clml.2014.02.001_bib33","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/bmt.2008.168","article-title":"Keratinocyte growth factor is effective in the prevention of intestinal mucositis in patients with hematological malignancies treated with high-dose chemotherapy and autologous hematopoietic SCT: a video-capsule endoscopy study","volume":"42","author":"Tsirigotis","year":"2008","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.clml.2014.02.001_bib34","doi-asserted-by":"crossref","first-page":"1898","DOI":"10.1093\/annonc\/mdq059","article-title":"A\u00a03-day short course of palifermin before HDT reduces toxicity and need for supportive care after autologous blood stem-cell transplantation in patients with multiple myeloma","volume":"21","author":"Kobbe","year":"2010","journal-title":"Ann Oncol"},{"key":"10.1016\/j.clml.2014.02.001_bib35","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1038\/bmt.2012.257","article-title":"In a high-dose melphalan setting, palifermin compared with placebo had no effect on oral mucositis or related patient's burden","volume":"48","author":"Blijlevens","year":"2013","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.clml.2014.02.001_bib36","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/j.bbmt.2007.03.004","article-title":"Economic impact of palifermin on the costs of hospitalization for autologous hematopoietic stem cell transplant: analysis of phase 3 trial results","volume":"13","author":"Elting","year":"2007","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.clml.2014.02.001_bib37","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1182\/blood-2013-02-483073","article-title":"Bortezomib induction, reduced-intensity transplantation and lenalidomide consolidation-maintenance for myeloma: updated results","volume":"122","author":"Gay","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.clml.2014.02.001_bib38","doi-asserted-by":"crossref","first-page":"2062","DOI":"10.1038\/leu.2013.143","article-title":"Long-term outcome with lenalidomide and dexamethasone therapy for newly diagnosed multiple myeloma","volume":"27","author":"Srivastava","year":"2013","journal-title":"Leukemia"},{"key":"10.1016\/j.clml.2014.02.001_bib39","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1111\/j.1365-2141.2012.09188.x","article-title":"Improved response with post-ASCT consolidation by low dose thalidomide, cyclophosphamide and dexamethasone as first line treatment for multiple myeloma","volume":"158","author":"Rabin","year":"2012","journal-title":"Br J Haematol"},{"key":"10.1016\/j.clml.2014.02.001_bib40","first-page":"491","article-title":"Oral mucositis and outcomes of allogeneic hematopoietic stem-cell transplantation in patients with hematologic malignancies","volume":"15","author":"Vera-Llonch","year":"2007","journal-title":"Support Care Cancer"},{"key":"10.1016\/j.clml.2014.02.001_bib41","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.bbmt.2012.12.006","article-title":"Safety and cost-effectiveness of outpatient autologous stem cell transplantation in patients with multiple myeloma","volume":"19","author":"Holbro","year":"2013","journal-title":"Biol Blood Marrow Transplant"}],"container-title":["Clinical Lymphoma Myeloma and Leukemia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2152265014000433?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2152265014000433?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T00:25:19Z","timestamp":1761870319000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2152265014000433"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8]]},"references-count":41,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["S2152265014000433"],"URL":"https:\/\/doi.org\/10.1016\/j.clml.2014.02.001","relation":{},"ISSN":["2152-2650"],"issn-type":[{"type":"print","value":"2152-2650"}],"subject":[],"published":{"date-parts":[[2014,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Choice of Multiple Myeloma Induction Therapy Affects the Frequency and Severity of Oral Mucositis After Melphalan-Based Autologous Stem Cell Transplantation","name":"articletitle","label":"Article Title"},{"value":"Clinical Lymphoma Myeloma and Leukemia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clml.2014.02.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}