{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T14:06:52Z","timestamp":1775830012875,"version":"3.50.1"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","clinical-lymphoma-myeloma-leukemia.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Lymphoma Myeloma and Leukemia"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1016\/j.clml.2016.02.014","type":"journal-article","created":{"date-parts":[[2016,8,9]],"date-time":"2016-08-09T10:07:13Z","timestamp":1470737233000},"page":"S181-S190.e4","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"S","title":["Increased Levels of Plasma Epstein Barr Virus DNA Identify a Poor-Risk Subset of Patients With Advanced Stage Cutaneous T-Cell Lymphoma"],"prefix":"10.1016","volume":"16","author":[{"given":"Bradley M.","family":"Haverkos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro A.","family":"Gru","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan M.","family":"Geyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anissa K.","family":"Bingman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica A.","family":"Hemminger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anjali","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry K.","family":"Wong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Preeti","family":"Pancholi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aharon G.","family":"Freud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael A.","family":"Caligiuri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert A.","family":"Baiocchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierluigi","family":"Porcu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.clml.2016.02.014_bib1","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1111\/j.1365-2141.2011.08852.x","article-title":"Evolving insights in the pathogenesis and therapy of cutaneous T-cell lymphoma (mycosis fungoides and Sezary syndrome)","volume":"155","author":"Wong","year":"2011","journal-title":"Br J Haematol"},{"key":"10.1016\/j.clml.2016.02.014_bib2","doi-asserted-by":"crossref","first-page":"3288","DOI":"10.1182\/blood-2012-04-423061","article-title":"Transcriptome sequencing in Sezary syndrome identifies Sezary cell and mycosis fungoides-associated lncRNAs and novel transcripts","volume":"120","author":"Lee","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.clml.2016.02.014_bib3","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1182\/blood-2007-03-055749","volume":"110","author":"Olsen","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.clml.2016.02.014_bib4","doi-asserted-by":"crossref","first-page":"4730","DOI":"10.1200\/JCO.2009.27.7665","article-title":"Survival outcomes and prognostic factors in mycosis fungoides\/Sezary syndrome: validation of the revised International Society for Cutaneous Lymphomas\/European Organisation for Research and Treatment of Cancer staging proposal","volume":"28","author":"Agar","year":"2010","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.clml.2016.02.014_bib5","doi-asserted-by":"crossref","first-page":"5051","DOI":"10.1158\/1078-0432.CCR-12-0604","article-title":"Long-term outcomes of 1,263 patients with mycosis fungoides and Sezary syndrome from 1982 to 2009","volume":"18","author":"Talpur","year":"2012","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.clml.2016.02.014_bib6","doi-asserted-by":"crossref","first-page":"5830","DOI":"10.1002\/cncr.27627","article-title":"Time course, clinical pathways, and long-term hazards risk trends of disease progression in patients with classic mycosis fungoides: a multicenter, retrospective follow-up study from the Italian Group of Cutaneous Lymphomas","volume":"118","author":"Quaglino","year":"2012","journal-title":"Cancer"},{"key":"10.1016\/j.clml.2016.02.014_bib7","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1001\/archderm.139.7.857","article-title":"Long-term outcome of 525 patients with mycosis fungoides and Sezary syndrome: clinical prognostic factors and risk for disease progression","volume":"139","author":"Kim","year":"2003","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.clml.2016.02.014_bib8","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1111\/bjd.12763","article-title":"Quantitation of tumour development correlates with prognosis in tumour stage (stage IIB) mycosis fungoides","volume":"170","author":"Boonk","year":"2014","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.clml.2016.02.014_bib9","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1111\/bjd.12909","article-title":"Prognostic factors, prognostic indices and staging in mycosis fungoides and Sezary syndrome: where are we now?","volume":"170","author":"Scarisbrick","year":"2014","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.clml.2016.02.014_bib10","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/S1473-3099(04)01202-2","article-title":"Human cytomegalovirus: clinical aspects, immune regulation, and emerging treatments","volume":"4","author":"Gandhi","year":"2004","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.clml.2016.02.014_bib11","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1126\/science.1252786","article-title":"Virology. Epstein\u2013Barr virus turns 50","volume":"343","author":"Lieberman","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.clml.2016.02.014_bib12","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1016\/j.humpath.2007.05.020","article-title":"Epstein\u2013Barr virus-associated lymphoproliferative disorders","volume":"38","author":"Rezk","year":"2007","journal-title":"Hum Pathol"},{"key":"10.1016\/j.clml.2016.02.014_bib13","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1002\/rmv.582","article-title":"Measuring Epstein\u2013Barr virus (EBV) load: the significance and application for each EBV-associated disease","volume":"18","author":"Kimura","year":"2008","journal-title":"Rev Med Virol"},{"key":"10.1016\/j.clml.2016.02.014_bib14","doi-asserted-by":"crossref","first-page":"3547","DOI":"10.1182\/blood-2012-09-454694","article-title":"Plasma Epstein\u2013Barr virus DNA predicts outcome in advanced Hodgkin lymphoma: correlative analysis from a large North American cooperative group trial","volume":"121","author":"Kanakry","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.clml.2016.02.014_bib15","doi-asserted-by":"crossref","first-page":"5414","DOI":"10.1200\/JCO.2006.07.7982","article-title":"Plasma Epstein\u2013Barr viral deoxyribonucleic acid quantitation complements tumor-node-metastasis staging prognostication in nasopharyngeal carcinoma","volume":"24","author":"Leung","year":"2006","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.clml.2016.02.014_bib16","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1111\/j.1365-2133.1996.tb07613.x","article-title":"Low incidence of Epstein\u2013Barr virus presence in primary cutaneous T-cell lymphoproliferations","volume":"134","author":"Anagnostopoulos","year":"1996","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.clml.2016.02.014_bib17","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1002\/(SICI)1096-9896(199602)178:2<173::AID-PATH428>3.0.CO;2-Y","article-title":"Absence of Epstein\u2013Barr viral encoded RNA (EBER) in primary cutaneous t-cell lymphoma","volume":"178","author":"Angel","year":"1996","journal-title":"J\u00a0Pathol"},{"key":"10.1016\/j.clml.2016.02.014_bib18","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.yexmp.2010.05.001","article-title":"Evidence of multiple infectious agents in mycosis fungoides lesions","volume":"89","author":"Bonin","year":"2010","journal-title":"Exp Mol Pathol"},{"key":"10.1016\/j.clml.2016.02.014_bib19","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1111\/j.1600-0560.1993.tb01266.x","article-title":"Examination of cutaneous T-cell lymphoma for human herpesviruses by using the polymerase chain reaction","volume":"20","author":"Brice","year":"1993","journal-title":"J\u00a0Cutan Pathol"},{"key":"10.1016\/j.clml.2016.02.014_bib20","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1182\/blood.V83.6.1612.1612","article-title":"Presence of Epstein\u2013Barr virus in extranodal T-cell lymphomas: differences in relation to site","volume":"83","author":"de Bruin","year":"1994","journal-title":"Blood"},{"key":"10.1016\/j.clml.2016.02.014_bib21","doi-asserted-by":"crossref","first-page":"355","DOI":"10.2340\/0001555574359360","article-title":"Presence of Epstein\u2013Barr virus in cutaneous lesions of mycosis fungoides and Sezary syndrome","volume":"74","author":"Dreno","year":"1994","journal-title":"Acta Derm Venereol"},{"key":"10.1016\/j.clml.2016.02.014_bib22","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1111\/j.1365-2133.2003.05677.x","article-title":"Prognostic factors in Sezary syndrome: a study of 28 patients","volume":"149","author":"Foulc","year":"2003","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.clml.2016.02.014_bib23","first-page":"203","article-title":"Unlikely role of Epstein\u2013Barr virus in the pathogenesis of primary cutaneous CD30+ anaplastic large cell lymphoma","volume":"11","author":"Hellier","year":"2001","journal-title":"Eur J Dermatol"},{"key":"10.1016\/j.clml.2016.02.014_bib24","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/S0344-0338(11)80423-1","article-title":"Mycosis fungoides: expression of C-myc p62 p53, bcl-2 and PCNA proteins and absence of association with Epstein\u2013Barr virus","volume":"190","author":"Kanavaros","year":"1994","journal-title":"Pathol Res Pract"},{"key":"10.1016\/j.clml.2016.02.014_bib25","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1111\/j.1365-4632.2006.02951.x","article-title":"Epstein\u2013Barr virus in CD30 anaplastic large cell lymphoma involving the skin and lymphomatoid papulosis in South Korea","volume":"45","author":"Kim","year":"2006","journal-title":"Int J Dermatol"},{"key":"10.1016\/j.clml.2016.02.014_bib26","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1046\/j.1365-2133.2000.03657.x","article-title":"Detection of Epstein\u2013Barr virus and human herpesvirus 7 and 8 genomes in primary cutaneous T- and B-cell lymphomas","volume":"143","author":"Nagore","year":"2000","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.clml.2016.02.014_bib27","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1007\/BF03032394","article-title":"Prevalence of mycosis fungoides and its association with EBV and HTLV-1 in Pakistanian patients","volume":"8","author":"Noorali","year":"2002","journal-title":"Pathol Oncol Res"},{"key":"10.1016\/j.clml.2016.02.014_bib28","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1007\/BF00371794","article-title":"Detection of Epstein\u2013Barr virus genome in primary cutaneous T and B cell lymphomas and pseudolymphomas","volume":"286","author":"Peris","year":"1994","journal-title":"Arch Dermatol Res"},{"key":"10.1016\/j.clml.2016.02.014_bib29","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1111\/j.1365-2133.1995.tb02701.x","article-title":"Detection of Epstein\u2013Barr virus in cutaneous and lymph nodal anaplastic large cell lymphomas (Ki-1+)","volume":"133","author":"Peris","year":"1995","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.clml.2016.02.014_bib30","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/0190-9622(93)70231-H","article-title":"Cutaneous manifestations of Epstein\u2013Barr virus-associated T-cell lymphoma","volume":"29","author":"Su","year":"1993","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"10.1016\/j.clml.2016.02.014_bib31","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1182\/blood.V85.2.480.480","article-title":"Lack of the expression of EBNA-2 and LMP-1 in T-cell neoplasms possessing Epstein\u2013Barr virus","volume":"85","author":"Suzushima","year":"1995","journal-title":"Blood"},{"key":"10.1016\/j.clml.2016.02.014_bib32","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1002\/1097-0215(200102)9999:9999<::AID-IJC1172>3.0.CO;2-O","article-title":"Expression of Epstein\u2013Barr virus in cutaneous T-cell lymphoma including mycosis fungoides","volume":"92","author":"Shimakage","year":"2001","journal-title":"Int J Cancer"},{"key":"10.1016\/j.clml.2016.02.014_bib33","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1097\/DAD.0b013e3181d68381","article-title":"Primary cutaneous Epstein\u2013Barr virus-associated T-cell lymphoproliferative disorder-2 cases with unusual, prolonged clinical course","volume":"32","author":"Park","year":"2010","journal-title":"Am J Dermatopathol"},{"key":"10.1016\/j.clml.2016.02.014_bib34","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1097\/00000478-199208000-00009","article-title":"Recurrent cutaneous anaplastic large cell (CD30+) lymphoma associated with Epstein\u2013Barr virus. A case report with 9-year follow-up","volume":"16","author":"Borisch","year":"1992","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.clml.2016.02.014_bib35","first-page":"574","article-title":"Aggressive cutaneous T-cell lymphoma associated with the presence of Epstein\u2013Barr virus. 2 cases","volume":"123","author":"Mouly","year":"1996","journal-title":"Ann Dermatol Venereol"},{"key":"10.1016\/j.clml.2016.02.014_bib36","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1046\/j.1365-2133.1996.99812.x","article-title":"An Epstein\u2013Barr virus-associated lymphoproliferative lesion of the skin presenting as recurrent necrotic papulovesicles of the face","volume":"134","author":"Cho","year":"1996","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.clml.2016.02.014_bib37","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/S0025-6196(11)63231-X","article-title":"Cutaneous lymphoma associated with Epstein\u2013Barr virus infection in 2 patients treated with methotrexate","volume":"76","author":"Tournadre","year":"2001","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.clml.2016.02.014_bib38","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1046\/j.1468-3083.2001.00309.x","article-title":"Examination of mycosis fungoides for the presence of Epstein\u2013Barr virus and human herpesvirus-6 by polymerase chain reaction","volume":"15","author":"Erkek","year":"2001","journal-title":"J\u00a0Eur Acad Dermatol Venereol"},{"issue":"6","key":"10.1016\/j.clml.2016.02.014_bib39","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1038\/jid.2008.396","article-title":"Epstein\u2013Barr virus in cutaneous T-cell lymphomas: evaluation of the viral presence and significance in skin and peripheral blood","volume":"129","author":"Novelli","year":"2009","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.clml.2016.02.014_bib40","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1111\/j.1600-0560.2010.01526.x","article-title":"Non-mycosis fungoides cutaneous T-cell lymphoma: reclassification according to the WHO-EORTC classification","volume":"37","author":"Weaver","year":"2010","journal-title":"J\u00a0Cutan Pathol"},{"key":"10.1016\/j.clml.2016.02.014_bib41","doi-asserted-by":"crossref","first-page":"3768","DOI":"10.1182\/blood-2004-09-3502","article-title":"WHO-EORTC classification for cutaneous lymphomas","volume":"105","author":"Willemze","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.clml.2016.02.014_bib42","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.3324\/haematol.2009.008607","article-title":"Reactivation of DNA viruses in association with histone deacetylase inhibitor therapy: a case series report","volume":"94","author":"Ritchie","year":"2009","journal-title":"Haematologica"},{"key":"10.1016\/j.clml.2016.02.014_bib43","first-page":"CD008078","article-title":"Alemtuzumab for patients with chronic lymphocytic leukaemia","author":"Skoetz","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.clml.2016.02.014_bib44","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.oraloncology.2013.02.006","article-title":"Clinical scenario of EBV DNA follow-up in patients of treated localized nasopharyngeal carcinoma","volume":"49","author":"Hsu","year":"2013","journal-title":"Oral Oncol"},{"key":"10.1016\/j.clml.2016.02.014_bib45","doi-asserted-by":"crossref","first-page":"30317","DOI":"10.18632\/oncotarget.4505","article-title":"Post-treatment plasma EBV-DNA positivity predicts early relapse and poor prognosis for patients with extranodal NK\/T cell lymphoma in the era of asparaginase","volume":"6","author":"Wang","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.clml.2016.02.014_bib46","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1182\/blood-2012-06-435024","article-title":"Clinical implications of plasma Epstein\u2013Barr virus DNA in early-stage extranodal nasal-type NK\/T-cell lymphoma patients receiving primary radiotherapy","volume":"120","author":"Wang","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.clml.2016.02.014_bib47","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1007\/s11899-012-0136-z","article-title":"Epstein-barr virus and the pathogenesis of T and NK lymphoma: a mystery unsolved","volume":"7","author":"George","year":"2012","journal-title":"Curr Hematol Malig Rep"},{"key":"10.1016\/j.clml.2016.02.014_bib48","doi-asserted-by":"crossref","first-page":"4163","DOI":"10.1182\/blood-2006-04-017632","article-title":"Prognostic significance of Epstein\u2013Barr virus in nodal peripheral T-cell lymphoma, unspecified: A Groupe d'Etude des Lymphomes de l'Adulte (GELA) study","volume":"108","author":"Dupuis","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.clml.2016.02.014_bib49","article-title":"Targeting tumor-infiltrating B cells in cutaneous T-cell lymphoma","author":"Theurich","year":"2014","journal-title":"J Clin Oncol"}],"container-title":["Clinical Lymphoma Myeloma and Leukemia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2152265016000690?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2152265016000690?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T00:30:05Z","timestamp":1761870605000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2152265016000690"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8]]},"references-count":49,"alternative-id":["S2152265016000690"],"URL":"https:\/\/doi.org\/10.1016\/j.clml.2016.02.014","relation":{},"ISSN":["2152-2650"],"issn-type":[{"value":"2152-2650","type":"print"}],"subject":[],"published":{"date-parts":[[2016,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Increased Levels of Plasma Epstein Barr Virus DNA Identify a Poor-Risk Subset of Patients With Advanced Stage Cutaneous T-Cell Lymphoma","name":"articletitle","label":"Article Title"},{"value":"Clinical Lymphoma Myeloma and Leukemia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clml.2016.02.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}