{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:30:37Z","timestamp":1790706637096,"version":"4.1.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","clinical-lymphoma-myeloma-leukemia.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Lymphoma Myeloma and Leukemia"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.clml.2020.08.025","type":"journal-article","created":{"date-parts":[[2020,9,18]],"date-time":"2020-09-18T04:19:35Z","timestamp":1600402775000},"page":"e39-e47","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"title":["Acute Complications and Survival Analysis of Childhood Acute Lymphoblastic Leukemia: A 15-year Experience"],"prefix":"10.1016","volume":"21","author":[{"given":"Ay\u015fe P\u0131nar","family":"\u00d6zt\u00fcrk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ba\u015fak","family":"Ko\u00e7","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00fclent","family":"Z\u00fclfikar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clml.2020.08.025_bib1","series-title":"Cancer Incidence and Survival Among Children and Adolescents: United States SEER Program 1975-1995. NIH Publication No. 99-4649","first-page":"99","author":"Ries","year":"1999"},{"key":"10.1016\/j.clml.2020.08.025_bib2","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1200\/JCO.2011.37.8018","article-title":"Improved survival for children and adolescents with acute lymphoblastic leukemia between 1990 and 2005: a report from the Children\u2019s Oncology Group","volume":"30","author":"Hunger","year":"2012","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.clml.2020.08.025_bib3","doi-asserted-by":"crossref","first-page":"130","DOI":"10.3109\/08880018.2011.629859","article-title":"ALL-BFM 95 treatment in Turkish children with acute lymphoblastic leukemia\u2014experience of a single center","volume":"29","author":"Kocak","year":"2012","journal-title":"Pediatr Hematol Oncol"},{"key":"10.1016\/j.clml.2020.08.025_bib4","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1007\/s00277-014-2106-0","article-title":"The long-term results of childhood acute lymphoblastic leukemia at two centers from Turkey: 15 years of experience with the ALL-BFM 95 protocol","volume":"93","author":"Gunes","year":"2014","journal-title":"Ann Hematol"},{"key":"10.1016\/j.clml.2020.08.025_bib5","first-page":"5","article-title":"Cocukluk cag\u0131 kanserlerinin epidemiyolojisi","volume":"20","author":"Kutluk","year":"2007","journal-title":"Klinik Gelis"},{"key":"10.1016\/j.clml.2020.08.025_bib6","series-title":"Childhood Leukemias","first-page":"660","article-title":"Acute complications","author":"Howard","year":"2013"},{"key":"10.1016\/j.clml.2020.08.025_bib7","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1038\/sj.leu.2401960","article-title":"Long-term results of three randomized trials (58831, 58832, 58881) in childhood acute lymphoblastic leukemia: a CLCG-EORTC report. Children\u2019s Leukemia Cooperative Group","volume":"14","author":"Vilmer","year":"2000","journal-title":"Leukemia"},{"key":"10.1016\/j.clml.2020.08.025_bib8","doi-asserted-by":"crossref","first-page":"2196","DOI":"10.1038\/sj.leu.2401963","article-title":"Long-term results of the Italian Association of Pediatric Hematology and Oncology (AIEOP) acute lymphoblastic leukemia studies, 1982-1995","volume":"14","author":"Conter","year":"2000","journal-title":"Leukemia"},{"key":"10.1016\/j.clml.2020.08.025_bib9","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1038\/leu.2009.12","article-title":"Induction death and treatment-related mortality in first remission of children with acute lymphoblastic leukemia: a population-based analysis of the Austrian Berlin-Frankfurt-Munster study group","volume":"23","author":"Prucker","year":"2009","journal-title":"Leukemia"},{"key":"10.1016\/j.clml.2020.08.025_bib10","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1111\/j.1365-2141.1976.tb03563.x","article-title":"Proposals for the classification of the acute leukaemias. French-American-British (FAB) Co-operative Group","volume":"33","author":"Bennett","year":"1976","journal-title":"Br J Haematol"},{"key":"10.1016\/j.clml.2020.08.025_bib11","first-page":"1211","article-title":"Prognostic implications of blast cell morphology in childhood acute lymphoblastic leukemia: a report from the Children\u2019s Cancer Study Group","volume":"69","author":"Miller","year":"1985","journal-title":"Cancer Treat Rep"},{"key":"10.1016\/j.clml.2020.08.025_bib12","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.1038\/leu.2008.251","article-title":"Factors influencing survival after relapse from acute lymphoblastic leukemia: a Children\u2019s Oncology Group study","volume":"22","author":"Nguyen","year":"2008","journal-title":"Leukemia"},{"key":"10.1016\/j.clml.2020.08.025_bib13","doi-asserted-by":"crossref","first-page":"2730","DOI":"10.1056\/NEJMoa0900386","article-title":"Treating childhood acute lymphoblastic leukemia without cranial irradiation","volume":"360","author":"Pui","year":"2009","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.clml.2020.08.025_bib14","series-title":"Childhood acute lymphoblastic leukemia: how to cure the very high risk?","first-page":"2","author":"Pui","year":"2019"},{"key":"10.1016\/j.clml.2020.08.025_bib15","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1200\/JCO.2013.48.6522","article-title":"Intensive chemotherapy for childhood acute lymphoblastic leukemia: results of the randomized intercontinental trial ALL IC-BFM 2002","volume":"32","author":"Stary","year":"2014","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.clml.2020.08.025_bib16","doi-asserted-by":"crossref","first-page":"2807","DOI":"10.1182\/blood-2012-02-265884","article-title":"How I treat relapsed childhood acute lymphoblastic leukemia","volume":"120","author":"Locatelli","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.clml.2020.08.025_bib17","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.leukres.2014.03.016","article-title":"A\u00a017-year experience with ALL-BFM protocol in acute lymphoblastic leukemia: prognostic predictors and interruptions during protocol","volume":"38","author":"Koka","year":"2014","journal-title":"Leuk Res"},{"key":"10.1016\/j.clml.2020.08.025_bib18","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1111\/bjh.12442","article-title":"Predicting relapse risk in childhood acute lymphoblastic leukaemia","volume":"162","author":"Teachey","year":"2013","journal-title":"Br J Haematol"},{"key":"10.1016\/j.clml.2020.08.025_bib19","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1200\/JCO.2017.74.0449","article-title":"Genotype-specific minimal residual disease interpretation improves stratification in pediatric acute lymphoblastic leukemia","volume":"36","author":"O\u2019Connor","year":"2018","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.clml.2020.08.025_bib20","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1182\/asheducation-2017.1.251","article-title":"Crisis management in the treatment of childhood acute lymphoblastic leukemia: putting right what can go wrong (emergency complications of disease and treatment)","volume":"2017","author":"Hough","year":"2017","journal-title":"Hematology Am Soc Hematol Educ Program"},{"key":"10.1016\/j.clml.2020.08.025_bib21","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S1470-2045(12)70600-9","article-title":"Treatment reduction for children and young adults with low-risk acute lymphoblastic leukaemia defined by minimal residual disease (UKALL 2003): a randomised controlled trial","volume":"14","author":"Vora","year":"2013","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.clml.2020.08.025_bib22","first-page":"100","article-title":"Infections in leukemic children","volume":"31","author":"Haidas","year":"1984","journal-title":"Ann Clin Pediatr Univ Atheniensis"},{"key":"10.1016\/j.clml.2020.08.025_bib23","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1093\/annonc\/mdw557","article-title":"Infection-related complications during treatment for childhood acute lymphoblastic leukemia","volume":"28","author":"Inaba","year":"2017","journal-title":"Ann Oncol"},{"key":"10.1016\/j.clml.2020.08.025_bib24","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1182\/blood-2014-03-560847","article-title":"Infection-related mortality in children with acute lymphoblastic leukemia: an analysis of infectious deaths on UKALL2003","volume":"124","author":"O\u2019Connor","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.clml.2020.08.025_bib25","first-page":"277","article-title":"Infections in a pediatric patient cohort with acute lymphoblastic leukemia during the entire course of treatment","volume":"14","author":"Katsimpardi","year":"2006","journal-title":"Support Care Cancer"},{"key":"10.1016\/j.clml.2020.08.025_bib26","doi-asserted-by":"crossref","first-page":"2216","DOI":"10.1182\/blood-2006-04-015511","article-title":"Thrombotic complications in childhood acute lymphoblastic leukemia: a meta-analysis of 17 prospective studies comprising 1752 pediatric patients","volume":"108","author":"Caruso","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.clml.2020.08.025_bib27","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1200\/JCO.1998.16.5.1712","article-title":"Acute neurotoxicity in children with B-precursor acute lymphoid leukemia: an association with intermediate-dose intravenous methotrexate and intrathecal triple therapy\u2014a Pediatric Oncology Group study","volume":"16","author":"Mahoney","year":"1998","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.clml.2020.08.025_bib28","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S0268-960X(02)00042-5","article-title":"Endocrine complications in pediatric patients with acute lymphoblastic leukemia","volume":"16","author":"Howard","year":"2002","journal-title":"Blood Rev"},{"key":"10.1016\/j.clml.2020.08.025_bib29","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.pedneo.2015.01.008","article-title":"Risk factors for hyperglycemia during chemotherapy for acute lymphoblastic leukemia among Taiwanese children","volume":"56","author":"Tsai","year":"2015","journal-title":"Pediatr Neonatol"},{"key":"10.1016\/j.clml.2020.08.025_bib30","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1002\/pbc.20320","article-title":"Transient hyperglycemia in Hispanic children with acute lymphoblastic leukemia","volume":"45","author":"Baillargeon","year":"2005","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.clml.2020.08.025_bib31","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1002\/pbc.21505","article-title":"Diabetic ketoacidosis during therapy for pediatric acute lymphoblastic leukemia","volume":"50","author":"Roberson","year":"2008","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.clml.2020.08.025_bib32","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1067\/mpd.2001.111273","article-title":"Fasting hypoglycemia is common during maintenance therapy for childhood acute lymphoblastic leukemia","volume":"138","author":"Halonen","year":"2001","journal-title":"J\u00a0Pediatr"},{"key":"10.1016\/j.clml.2020.08.025_bib33","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1002\/mpo.10097","article-title":"Symptomatic hypoglycemia in children receiving oral purine analogues for treatment of childhood acute lymphoblastic leukemia","volume":"39","author":"Ziino","year":"2002","journal-title":"Med Pediatr Oncol"},{"key":"10.1016\/j.clml.2020.08.025_bib34","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.beha.2008.12.001","article-title":"Epidemiology of cancer-related venous thromboembolism","volume":"22","author":"Wun","year":"2009","journal-title":"Best Pract Res Clin Haematol"},{"key":"10.1016\/j.clml.2020.08.025_bib35","doi-asserted-by":"crossref","first-page":"653","DOI":"10.4187\/respcare.00947","article-title":"Superior vena cava syndrome in thoracic malignancies","volume":"56","author":"Lepper","year":"2011","journal-title":"Respir Care"},{"key":"10.1016\/j.clml.2020.08.025_bib36","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1111\/j.1365-2141.2010.08446.x","article-title":"Personal practice: how we manage the risk of bleeding and thrombosis in children and young adults with acute lymphoblastic leukaemia","volume":"152","author":"Astwood","year":"2011","journal-title":"Br J Haematol"},{"key":"10.1016\/j.clml.2020.08.025_bib37","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.thromres.2003.10.013","article-title":"Thrombosis in children with acute lymphoblastic leukemia: part I. Epidemiology of thrombosis in children with acute lymphoblastic leukemia","volume":"111","author":"Athale","year":"2003","journal-title":"Thromb Res"},{"key":"10.1016\/j.clml.2020.08.025_bib38","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1111\/j.1365-2141.2010.08524.x","article-title":"The frequency and management of asparaginase-related thrombosis in paediatric and adult patients with acute lymphoblastic leukaemia treated on Dana-Farber Cancer Institute consortium protocols","volume":"152","author":"Grace","year":"2011","journal-title":"Br J Haematol"},{"key":"10.1016\/j.clml.2020.08.025_bib39","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1038\/sj.leu.2405032","article-title":"High incidence of avascular necrosis in adolescents with acute lymphoblastic leukaemia: a UKALL XII analysis","volume":"22","author":"Patel","year":"2008","journal-title":"Leukemia"},{"key":"10.1016\/j.clml.2020.08.025_bib40","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/S1470-2045(12)70274-7","article-title":"Effect of alternate-week versus continuous dexamethasone scheduling on the risk of osteonecrosis in paediatric patients with acute lymphoblastic leukaemia: results from the CCG-1961 randomised cohort trial","volume":"13","author":"Mattano","year":"2012","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.clml.2020.08.025_bib41","doi-asserted-by":"crossref","first-page":"4205","DOI":"10.1002\/cncr.29641","article-title":"Allergic reactions and antiasparaginase antibodies in children with high-risk acute lymphoblastic leukemia: a Children\u2019s Oncology Group report","volume":"121","author":"Ko","year":"2015","journal-title":"Cancer"},{"key":"10.1016\/j.clml.2020.08.025_bib42","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1200\/JCO.2003.03.009","article-title":"Intensification of therapy for children with lower-risk acute lymphoblastic leukemia: long-term follow-up of patients treated on Children\u2019s Cancer Group trial 1881","volume":"21","author":"Hutchinson","year":"2003","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.clml.2020.08.025_bib43","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1200\/JCO.2013.53.0808","article-title":"Methotrexate-induced neurotoxicity and leukoencephalopathy in childhood acute lymphoblastic leukemia","volume":"32","author":"Bhojwani","year":"2014","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.clml.2020.08.025_bib44","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1111\/bjh.12733","article-title":"Asparaginase-associated pancreatitis in children with acute lymphoblastic leukaemia in the NOPHO ALL2008 protocol","volume":"165","author":"Raja","year":"2014","journal-title":"Br J Haematol"},{"key":"10.1016\/j.clml.2020.08.025_bib45","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1111\/bjh.12016","article-title":"Asparaginase-associated pancreatitis in children","volume":"159","author":"Raja","year":"2012","journal-title":"Br J Haematol"},{"key":"10.1016\/j.clml.2020.08.025_bib46","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1097\/MPH.0b013e3181b87035","article-title":"Acute pancreatitis in children with acute lymphoblastic leukemia after chemotherapy","volume":"31","author":"Treepongkaruna","year":"2009","journal-title":"J\u00a0Pediatr Hematol Oncol"}],"container-title":["Clinical Lymphoma Myeloma and Leukemia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2152265020305152?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2152265020305152?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T00:35:13Z","timestamp":1761870913000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2152265020305152"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":46,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["S2152265020305152"],"URL":"https:\/\/doi.org\/10.1016\/j.clml.2020.08.025","relation":{},"ISSN":["2152-2650"],"issn-type":[{"value":"2152-2650","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Acute Complications and Survival Analysis of Childhood Acute Lymphoblastic Leukemia: A 15-year Experience","name":"articletitle","label":"Article Title"},{"value":"Clinical Lymphoma Myeloma and Leukemia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clml.2020.08.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}