{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:42:56Z","timestamp":1762868576744,"version":"build-2065373602"},"reference-count":31,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","clinical-lymphoma-myeloma-leukemia.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Lymphoma Myeloma and Leukemia"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1016\/j.clml.2021.06.026","type":"journal-article","created":{"date-parts":[[2021,7,18]],"date-time":"2021-07-18T17:33:04Z","timestamp":1626629584000},"page":"e876-e885","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Long-Term Outcome of Philadelphia Chromosome Positive Leukemia From Eastern Indian Subcontinent: An Experience in the Era of Tyrosine Kinase Inhibitor (TKI) Therapy"],"prefix":"10.1016","volume":"21","author":[{"given":"Samya","family":"Dey","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debmalya","family":"Bhattacharyya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Partha Pratim","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Somsubhra","family":"Nath","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.clml.2021.06.026_bib0030","unstructured":"World Health Organization International Agency for Research on Cancer (IARC). GLOBOCAN 2012: estimated cancer incidence, mortality and prevalence worldwide in 2012. [homepage on the internet]; 2012 [cited 2016 Apr 23]. Available from: http:\/\/globocan.iarc.fr\/Pages\/fact_sheets_cancer.aspx."},{"year":"2008","series-title":"Textbook of Cancer Epidemiology","author":"Adami","key":"10.1016\/j.clml.2021.06.026_bib0001"},{"key":"10.1016\/j.clml.2021.06.026_bib0002","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1038\/sj.leu.2401592","article-title":"Standardized RT-PCR analysis of fusion gene transcripts from chromosome aberrations in acute leukemia for detection of minimal residual disease. Report of the BIOMED-1 concerted action: investigation of minimal residual disease in acute leukemia","volume":"13","author":"van Dongen","year":"1999","journal-title":"Leukemia"},{"key":"10.1016\/j.clml.2021.06.026_bib0003","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1056\/NEJM198810133191506","article-title":"The molecular genetics of Philadelphia chromosome-positive leukemias","volume":"319","author":"Kurzrock","year":"1988","journal-title":"N Engl J Med"},{"key":"10.1016\/j.clml.2021.06.026_bib0004","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21165776","article-title":"Philadelphia chromosome-positive leukemia in the lymphoid lineage-similarities and differences with the myeloid lineage and specific vulnerabilities","volume":"21","author":"Komorowski","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.clml.2021.06.026_bib0005","doi-asserted-by":"crossref","first-page":"e484","DOI":"10.1097\/HS9.0000000000000484","article-title":"Philadelphia chromosome-positive acute myeloid leukemia with e1a3 BCR-ABL1 fusion transcript","volume":"4","author":"Sheets","year":"2020","journal-title":"Hemasphere"},{"key":"10.1016\/j.clml.2021.06.026_bib0006","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/s13045-018-0624-2","article-title":"Past, present, and future of Bcr-Abl inhibitors: from chemical development to clinical efficacy","volume":"11","author":"Rossari","year":"2018","journal-title":"J Hematol Oncol"},{"key":"10.1016\/j.clml.2021.06.026_bib0007","doi-asserted-by":"crossref","first-page":"205","DOI":"10.3109\/08880019609030819","article-title":"Prognostic variables and survival in pediatric acute lymphoblastic leukemias: cancer Institute experience","volume":"13","author":"Shanta","year":"1996","journal-title":"Pediatr Hematol Oncol"},{"key":"10.1016\/j.clml.2021.06.026_bib0008","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.ccell.2020.03.006","article-title":"Response and resistance to BCR-ABL1-targeted therapies","volume":"37","author":"Braun","year":"2020","journal-title":"Cancer Cell"},{"key":"10.1016\/j.clml.2021.06.026_bib0009","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1002\/ajh.20682","article-title":"Molecular profiling of chronic myeloid leukemia in eastern India","volume":"81","author":"Mondal","year":"2006","journal-title":"Am J Hematol"},{"key":"10.1016\/j.clml.2021.06.026_bib0010","doi-asserted-by":"crossref","first-page":"260","DOI":"10.4103\/2278-330X.119891","article-title":"Chronic myeloid leukemia in children and adolescents: a single center experience from Eastern India","volume":"2","author":"Raut","year":"2013","journal-title":"South Asian J Cancer"},{"key":"10.1016\/j.clml.2021.06.026_bib0011","doi-asserted-by":"crossref","first-page":"175","DOI":"10.4103\/0971-5851.123721","article-title":"Report of chronic myeloid leukemia in chronic phase from Eastern India, Institute of Hematology and Transfusion Medicine, Kolkata, 2001-2009","volume":"34","author":"Ray","year":"2013","journal-title":"Indian J Med Paediatr Oncol"},{"key":"10.1016\/j.clml.2021.06.026_bib0012","doi-asserted-by":"crossref","first-page":"162","DOI":"10.4103\/2278-330X.187593","article-title":"Summary of the published Indian data on chronic myeloid leukemia","volume":"5","author":"Singhal","year":"2016","journal-title":"South Asian J Cancer"},{"key":"10.1016\/j.clml.2021.06.026_bib0013","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1385\/MO:19:3:141","article-title":"Lympho-hemopoietic malignancies in India","volume":"19","author":"Bhutani","year":"2002","journal-title":"Med Oncol"},{"key":"10.1016\/j.clml.2021.06.026_bib0014","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s13045-019-0729-2","article-title":"Treatment and monitoring of Philadelphia chromosome-positive leukemia patients: recent advances and remaining challenges","volume":"12","author":"Soverini","year":"2019","journal-title":"J Hematol Oncol"},{"key":"10.1016\/j.clml.2021.06.026_bib0015","first-page":"33","article-title":"Acute lymphoblastic leukemia, the Indian scenario","volume":"5","author":"Guru","year":"2018","journal-title":"MOJ Cell Sci Rep"},{"key":"10.1016\/j.clml.2021.06.026_bib0016","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/s11912-012-0247-7","article-title":"Philadelphia-positive acute lymphoblastic leukemia: current treatment options","volume":"14","author":"Liu-Dumlao","year":"2012","journal-title":"Curr Oncol Rep"},{"key":"10.1016\/j.clml.2021.06.026_bib0017","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s12288-011-0096-9","article-title":"BCR-ABL translocation in pediatric acute lymphoblastic leukemia in southern India","volume":"28","author":"Sugapriya","year":"2012","journal-title":"Indian J Hematol Blood Transfus"},{"key":"10.1016\/j.clml.2021.06.026_bib0018","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1200\/JGO.2015.002667","article-title":"Chronic myeloid leukemia in India","volume":"3","author":"Ganesan","year":"2017","journal-title":"J Glob Oncol"},{"key":"10.1016\/j.clml.2021.06.026_bib0019","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s12288-018-1009-y","article-title":"Chronic myeloid leukemia: long-term outcome data in the imatinib era","volume":"35","author":"Ganesan","year":"2019","journal-title":"Indian J Hematol Blood Transfus"},{"key":"10.1016\/j.clml.2021.06.026_bib0020","doi-asserted-by":"crossref","first-page":"328","DOI":"10.4103\/ijmpo.ijmpo_115_17","article-title":"The role of mutation testing in patients with chronic myeloid leukemia in chronic phase after imatinib failure and their outcomes after treatment modification: single-institutional experience over 13 years","volume":"38","author":"Chaitanya","year":"2017","journal-title":"Indian Journal of Medical Paediatric Oncology"},{"key":"10.1016\/j.clml.2021.06.026_bib0021","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1002\/pds.1046","article-title":"Management of chronic myeloid leukemia in France: a multicentered cross-sectional study on 538 patients","volume":"14","author":"Tardieu","year":"2005","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"10.1016\/j.clml.2021.06.026_bib0022","doi-asserted-by":"crossref","first-page":"e468","DOI":"10.1097\/HS9.0000000000000468","article-title":"Chronic myeloid leukemia in 2020","volume":"4","author":"Hehlmann","year":"2020","journal-title":"Hemasphere"},{"key":"10.1016\/j.clml.2021.06.026_bib0023","doi-asserted-by":"crossref","first-page":"e437","DOI":"10.1016\/j.clml.2020.02.015","article-title":"Real-world experience of imatinib in pediatric chronic phase chronic myeloid leukemia: a single-center experience from India","volume":"20","author":"Ganguly","year":"2020","journal-title":"Clin Lymphoma Myeloma Leuk"},{"key":"10.1016\/j.clml.2021.06.026_bib0024","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/S0031-3955(16)36509-9","article-title":"Chronic leukemias of childhood","volume":"35","author":"Altman","year":"1988","journal-title":"Pediatr Clin North Am"},{"key":"10.1016\/j.clml.2021.06.026_bib0031","unstructured":"Cancer Stat Facts: Leukemia \u2014 Acute Lymphocytic Leukemia (ALL), 2020. [Accessed 07 August 2021]."},{"key":"10.1016\/j.clml.2021.06.026_bib0025","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1002\/cncr.24066","article-title":"Efficacy of imatinib dose escalation in patients with chronic myeloid leukemia in chronic phase","volume":"115","author":"Kantarjian","year":"2009","journal-title":"Cancer"},{"key":"10.1016\/j.clml.2021.06.026_bib0026","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1182\/blood-2015-06-648667","article-title":"Pediatric chronic myeloid leukemia is a unique disease that requires a different approach","volume":"127","author":"Hijiya","year":"2016","journal-title":"Blood"},{"key":"10.1016\/j.clml.2021.06.026_bib0027","doi-asserted-by":"crossref","first-page":"2398","DOI":"10.1038\/leu.2017.253","article-title":"Assessment of imatinib as first-line treatment of chronic myeloid leukemia: 10-year survival results of the randomized CML study IV and impact of non-CML determinants","volume":"31","author":"Hehlmann","year":"2017","journal-title":"Leukemia"},{"key":"10.1016\/j.clml.2021.06.026_bib0028","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1056\/NEJMoa1609324","article-title":"Long-term outcomes of imatinib treatment for chronic myeloid leukemia","volume":"376","author":"Hochhaus","year":"2017","journal-title":"N Engl J Med"},{"key":"10.1016\/j.clml.2021.06.026_bib0029","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1016\/S0140-6736(19)33018-1","article-title":"Acute lymphoblastic leukaemia","volume":"395","author":"Malard","year":"2020","journal-title":"Lancet"}],"container-title":["Clinical Lymphoma Myeloma and Leukemia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2152265021002779?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2152265021002779?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T00:38:53Z","timestamp":1761871133000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2152265021002779"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":31,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["S2152265021002779"],"URL":"https:\/\/doi.org\/10.1016\/j.clml.2021.06.026","relation":{},"ISSN":["2152-2650"],"issn-type":[{"type":"print","value":"2152-2650"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Long-Term Outcome of Philadelphia Chromosome Positive Leukemia From Eastern Indian Subcontinent: An Experience in the Era of Tyrosine Kinase Inhibitor (TKI) Therapy","name":"articletitle","label":"Article Title"},{"value":"Clinical Lymphoma Myeloma and Leukemia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clml.2021.06.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}