{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T15:17:43Z","timestamp":1790867863015,"version":"4.1.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100009164","name":"Moffitt Cancer Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009164","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","clinical-lymphoma-myeloma-leukemia.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Lymphoma Myeloma and Leukemia"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1016\/j.clml.2022.12.008","type":"journal-article","created":{"date-parts":[[2022,12,18]],"date-time":"2022-12-18T01:18:58Z","timestamp":1671326338000},"page":"e150-e163","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Clinical Response to Upfront Targeted Tyrosine Kinase Inhibitors among Patients with Myeloid\/Lymphoid Neoplasms with Eosinophilia and Tyrosine Kinase Gene Fusion"],"prefix":"10.1016","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1942-1780","authenticated-orcid":false,"given":"Yumeng","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanyi M.","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6132-6336","authenticated-orcid":false,"given":"Endi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marietya I.S.","family":"Lauw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Somedeb","family":"Ball","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn","family":"Moscinski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2872-1961","authenticated-orcid":false,"given":"Onyee","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seongseok","family":"Yun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Sallman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lubomir","family":"Sokol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bijal","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7651-2406","authenticated-orcid":false,"given":"Todd","family":"Knepper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffery","family":"Lancet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rami","family":"Komrokji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Padron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Kuykendall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clml.2022.12.008_bib0001","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1093\/ajcp\/aqaa208","article-title":"Myeloid\/lymphoid neoplasms associated with eosinophilia and rearrangements of PDGFRA, PDGFRB, or FGFR1 or with PCM1-JAK2","volume":"155","author":"Pozdnyakova","year":"2021","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.clml.2022.12.008_bib0002","doi-asserted-by":"crossref","unstructured":"Reiter A, Gotlib J. Myeloid neoplasms with eosinophilia. Blood. 2017 Feb 9;129(6):704-714. doi: 10.1182\/blood-2016-10-695973. Epub 2016 Dec 27. PMID: 28028030.","DOI":"10.1182\/blood-2016-10-695973"},{"key":"10.1016\/j.clml.2022.12.008_bib0003","unstructured":"Swerdlow SH. WHO Classification of tumours of haematologic and lymphoid tissues : precursor lymphoid neoplasms. 2008 2008:168-178."},{"key":"10.1016\/j.clml.2022.12.008_bib0004","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.1182\/blood-2016-03-643544","article-title":"The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia","volume":"127","author":"Arber","year":"2016","journal-title":"Blood"},{"key":"10.1016\/j.clml.2022.12.008_bib0005","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1038\/s41375-022-01613-1","article-title":"The 5th edition of the World Health Organization classification of haematolymphoid tumours: myeloid and histiocytic\/dendritic neoplasms","volume":"36","author":"Khoury","year":"2022","journal-title":"Leukemia"},{"key":"10.1016\/j.clml.2022.12.008_bib0006","doi-asserted-by":"crossref","DOI":"10.1182\/blood.2022015850","article-title":"International Consensus Classification of Myeloid Neoplasms and Acute Leukemia: integrating morphological, clinical, and genomic data","author":"Arber","year":"2022","journal-title":"Blood"},{"key":"10.1016\/j.clml.2022.12.008_bib0007","first-page":"614","article-title":"Myeloid\/lymphoid neoplasms with eosinophilia\/basophilia and ETV6-ABL1 fusion: cell-of-origin and response to tyrosine kinase inhibition","volume":"106","author":"Yao","year":"2021","journal-title":"Haematologica"},{"key":"10.1016\/j.clml.2022.12.008_bib0008","doi-asserted-by":"crossref","DOI":"10.1016\/j.leukres.2020.106460","article-title":"Myeloid\/lymphoid neoplasms with eosinophilia and FLT3 rearrangement","volume":"99","author":"Shao","year":"2020","journal-title":"Leuk Res"},{"key":"10.1016\/j.clml.2022.12.008_bib0009","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1080\/16078454.2020.1854493","article-title":"Myeloid\/lymphoid neoplasm with CEP110-FGFR1 fusion: an analysis of 16 cases show common features and poor prognosis","volume":"26","author":"Chen","year":"2021","journal-title":"Hematology"},{"key":"10.1016\/j.clml.2022.12.008_bib0010","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1056\/NEJMcpc2004977","article-title":"Case 25-2020: a 47-year-old woman with a lung mass","volume":"383","author":"Sharma","year":"2020","journal-title":"N Engl J Med"},{"key":"10.1016\/j.clml.2022.12.008_bib0011","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.6004\/jnccn.2020.0042","article-title":"Myeloid\/lymphoid neoplasms with eosinophilia and TK fusion genes, Version 3.2021, NCCN Clinical Practice Guidelines in Oncology","volume":"18","author":"Gerds","year":"2020","journal-title":"J Natl Compr Canc Netw"},{"key":"10.1016\/j.clml.2022.12.008_bib0012","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1002\/ajh.25945","article-title":"Epidemiology, clinical picture and long-term outcomes of FIP1L1-PDGFRA-positive myeloid neoplasm with eosinophilia: data from 151 patients","volume":"95","author":"Rohmer","year":"2020","journal-title":"Am J Hematol"},{"key":"10.1016\/j.clml.2022.12.008_bib0013","doi-asserted-by":"crossref","first-page":"e486","DOI":"10.1097\/HS9.0000000000000486","article-title":"Sustained complete molecular remission with imatinib monotherapy in a child presenting with blast phase FIP1L1-PDGFRA-associated myeloid neoplasm with eosinophilia","volume":"4","author":"Jain","year":"2020","journal-title":"Hemasphere"},{"key":"10.1016\/j.clml.2022.12.008_bib0014","unstructured":"J McGowan-Jordan, A Simons, and M Schmid: An International System for Human Cytogenetic Nomenclature (2016): Recommendations of the International Standing Committee on Human Cytogenetic Nomenclature. Karger; 2016. Switzerland. ISBN: 9783318058574."},{"key":"10.1016\/j.clml.2022.12.008_bib0015","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1038\/s41375-020-0776-2","article-title":"European LeukemiaNet 2020 recommendations for treating chronic myeloid leukemia","volume":"34","author":"Hochhaus","year":"2020","journal-title":"Leukemia"},{"key":"10.1016\/j.clml.2022.12.008_bib0016","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1182\/blood-2009-07-235358","article-title":"Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet","volume":"115","author":"Dohner","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.clml.2022.12.008_bib0017","doi-asserted-by":"crossref","first-page":"e577","DOI":"10.1038\/bcj.2017.53","article-title":"Acute lymphoblastic leukemia: a comprehensive review and 2017 update","volume":"7","author":"Terwilliger","year":"2017","journal-title":"Blood Cancer J"},{"issue":"2","key":"10.1016\/j.clml.2022.12.008_bib0018","doi-asserted-by":"crossref","first-page":"e17","DOI":"10.4081\/hr.2011.e17","article-title":"Chronic eosinophilic leukemia with FIP1L1-PDGFRA transcripts after occupational and therapeutic exposure to radiation","volume":"3","author":"Balatzenko","year":"2011","journal-title":"Hematol Rep"},{"key":"10.1016\/j.clml.2022.12.008_bib0019","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.1182\/blood-2011-03-343426","article-title":"Response of ETV6-FLT3-positive myeloid\/lymphoid neoplasm with eosinophilia to inhibitors of FMS-like tyrosine kinase 3","volume":"118","author":"Walz","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.clml.2022.12.008_bib0020","article-title":"A 26-year-old female with systemic mastocytosis with associated myeloid neoplasm with eosinophilia and abnormalities of PDGFRB, t(4;5)(q21;q33)","volume":"2016","author":"Brown","year":"2016","journal-title":"Case Rep Hematol"},{"key":"10.1016\/j.clml.2022.12.008_bib0021","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1111\/j.1365-2710.2009.01130.x","article-title":"A case of myeloid neoplasm associated with eosinophilia and KIAA1509-PDGFRbeta responsive to combination treatment with imatinib mesylate and prednisolone","volume":"35","author":"Wang","year":"2010","journal-title":"J Clin Pharm Ther"},{"key":"10.1016\/j.clml.2022.12.008_bib0022","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.cancergen.2017.03.004","article-title":"Novel t(5;11)(q32;q13.4) with NUMA1-PDGFRB fusion in a myeloid neoplasm with eosinophilia with response to imatinib mesylate","volume":"212-213","author":"Zou","year":"2017","journal-title":"Cancer Genet"},{"key":"10.1016\/j.clml.2022.12.008_bib0023","doi-asserted-by":"crossref","first-page":"e990","DOI":"10.1016\/j.clml.2020.08.016","article-title":"A case of a very young child with t lymphoblastic lymphoma with eosinophilia and PDGFRB translocation: a rare form of myeloid\/lymphoid neoplasm associated with eosinophilia and rearrangements of PDGFRA, PDGFRB or FGFR1","volume":"20","author":"Grimes","year":"2020","journal-title":"Clin Lymphoma Myeloma Leuk"},{"key":"10.1016\/j.clml.2022.12.008_bib0024","doi-asserted-by":"crossref","first-page":"e148","DOI":"10.3324\/haematol.2014.105452","article-title":"PDGFRB-rearranged T-lymphoblastic leukemia\/lymphoma occurring with myeloid neoplasms: the missing link supporting a stem cell origin","volume":"99","author":"Ondrejka","year":"2014","journal-title":"Haematologica"},{"key":"10.1016\/j.clml.2022.12.008_bib0025","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.cell.2009.05.002","article-title":"The tortoise and the hair: slow-cycling cells in the stem cell race","volume":"137","author":"Fuchs","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.clml.2022.12.008_bib0026","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/nbt.1607","article-title":"Induction of cell cycle entry eliminates human leukemia stem cells in a mouse model of AML","volume":"28","author":"Saito","year":"2010","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.clml.2022.12.008_bib0027","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.3389\/fimmu.2020.01280","article-title":"Cancer stem cells-origins and biomarkers: perspectives for targeted personalized therapies","volume":"11","author":"Walcher","year":"2020","journal-title":"Front Immunol"},{"key":"10.1016\/j.clml.2022.12.008_bib0028","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1038\/leu.2016.73","article-title":"Predictors of survival in WHO-defined hypereosinophilic syndrome and idiopathic hypereosinophilia and the role of next-generation sequencing","volume":"30","author":"Pardanani","year":"2016","journal-title":"Leukemia"},{"key":"10.1016\/j.clml.2022.12.008_bib0029","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1038\/modpathol.2016.75","article-title":"Targeted next-generation sequencing identifies a subset of idiopathic hypereosinophilic syndrome with features similar to chronic eosinophilic leukemia, not otherwise specified","volume":"29","author":"Wang","year":"2016","journal-title":"Mod Pathol"}],"container-title":["Clinical Lymphoma Myeloma and Leukemia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2152265022017736?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2152265022017736?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T00:41:42Z","timestamp":1761871302000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2152265022017736"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["S2152265022017736"],"URL":"https:\/\/doi.org\/10.1016\/j.clml.2022.12.008","relation":{},"ISSN":["2152-2650"],"issn-type":[{"value":"2152-2650","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinical Response to Upfront Targeted Tyrosine Kinase Inhibitors among Patients with Myeloid\/Lymphoid Neoplasms with Eosinophilia and Tyrosine Kinase Gene Fusion","name":"articletitle","label":"Article Title"},{"value":"Clinical Lymphoma Myeloma and Leukemia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clml.2022.12.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}