{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T05:08:59Z","timestamp":1789708139596,"version":"4.0.1"},"reference-count":41,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","clinical-lymphoma-myeloma-leukemia.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Lymphoma Myeloma and Leukemia"],"published-print":{"date-parts":[[2023,4]]},"DOI":"10.1016\/j.clml.2023.01.003","type":"journal-article","created":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T21:05:25Z","timestamp":1673471125000},"page":"291-302","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Whole-Exome Sequencing Revealed the Mutational Profiles of Primary Central Nervous System Lymphoma"],"prefix":"10.1016","volume":"23","author":[{"given":"Rui","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boyuan","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiyang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenying","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abudurexiti","family":"Adilai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianning","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clml.2023.01.003_bib0001","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1093\/jnci\/88.10.675","article-title":"Epidemiology of brain lymphoma among people with or without acquired immunodeficiency syndrome","volume":"88","author":"Cote","year":"1996","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.clml.2023.01.003_bib0002","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1215\/S1522851705000323","article-title":"Temporal trends in incidence of primary brain tumors in the United States, 1985-1999","volume":"8","author":"Hoffman","year":"2006","journal-title":"Neuro Oncol"},{"key":"10.1016\/j.clml.2023.01.003_bib0003","doi-asserted-by":"crossref","first-page":"2410","DOI":"10.1200\/JCO.2017.72.7602","article-title":"Primary CNS lymphoma","volume":"35","author":"Grommes","year":"2017","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.clml.2023.01.003_bib0004","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1093\/ajcp\/110.5.607","article-title":"Primary central nervous system lymphomas in 72 immunocompetent patients: pathologic findings and clinical correlations. Groupe Ouest Est d'etude des Leucenies et Autres Maladies du Sang (GOELAMS)","volume":"110","author":"Camilleri-Broet","year":"1998","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.clml.2023.01.003_bib0005","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1002\/ajh.23551","article-title":"The changing incidence of primary central nervous system lymphoma is driven primarily by the changing incidence in young and middle-aged men and differs from time trends in systemic diffuse large B-cell non-Hodgkin's lymphoma","volume":"88","author":"O'Neill","year":"2013","journal-title":"Am J Hematol"},{"key":"10.1016\/j.clml.2023.01.003_bib0006","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1038\/bjc.2011.357","article-title":"Age, gender, and racial differences in incidence and survival in primary CNS lymphoma","volume":"105","author":"Villano","year":"2011","journal-title":"Br J Cancer"},{"key":"10.1016\/j.clml.2023.01.003_bib0007","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s11060-006-9165-6","article-title":"Relapse of primary central nervous system lymphoma: clinical features, outcome and prognostic factors","volume":"80","author":"Jahnke","year":"2006","journal-title":"J Neurooncol"},{"key":"10.1016\/j.clml.2023.01.003_bib0008","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1093\/neuonc\/now033","article-title":"Primary CNS lymphoma at first relapse\/progression: characteristics, management, and outcome of 256 patients from the French LOC network","volume":"18","author":"Langner-Lemercier","year":"2016","journal-title":"Neuro Oncol"},{"key":"10.1016\/j.clml.2023.01.003_bib0009","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/sj.leu.2403171","article-title":"NF-kappaB\/Rel-mediated regulation of apoptosis in hematologic malignancies and normal hematopoietic progenitors","volume":"18","author":"Turco","year":"2004","journal-title":"Leukemia"},{"key":"10.1016\/j.clml.2023.01.003_bib0010","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1111\/nan.12259","article-title":"Recurrent mutations of CD79B and MYD88 are the hallmark of primary central nervous system lymphomas","volume":"42","author":"Nakamura","year":"2016","journal-title":"Neuropathol Appl Neurobiol"},{"key":"10.1016\/j.clml.2023.01.003_bib0011","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1016\/j.neo.2018.08.012","article-title":"Analysis of genomic alteration in primary central nervous system lymphoma and the expression of some related genes","volume":"20","author":"Zhou","year":"2018","journal-title":"Neoplasia"},{"key":"10.1016\/j.clml.2023.01.003_bib0012","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.3109\/10428194.2014.979413","article-title":"Primary diffuse large B-cell lymphomas of central nervous system exhibit remarkably high prevalence of oncogenic MYD88 and CD79B mutations","volume":"56","author":"Yamada","year":"2015","journal-title":"Leuk Lymphoma"},{"key":"10.1016\/j.clml.2023.01.003_bib0013","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1111\/neup.12405","article-title":"Frequency of MYD88 and CD79B mutations, and MGMT methylation in primary central nervous system diffuse large B-cell lymphoma","volume":"37","author":"Zheng","year":"2017","journal-title":"Neuropathology"},{"key":"10.1016\/j.clml.2023.01.003_bib0014","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1053\/j.seminhematol.2015.01.008","article-title":"B-cell receptor signaling in diffuse large B-cell lymphoma","volume":"52","author":"Young","year":"2015","journal-title":"Semin Hematol"},{"key":"10.1016\/j.clml.2023.01.003_bib0015","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/nature08638","article-title":"Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma","volume":"463","author":"Davis","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.clml.2023.01.003_bib0016","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1038\/leu.2009.120","article-title":"Chromosomal imbalances and partial uniparental disomies in primary central nervous system lymphoma","volume":"23","author":"Schwindt","year":"2009","journal-title":"Leukemia"},{"key":"10.1016\/j.clml.2023.01.003_bib0017","doi-asserted-by":"crossref","first-page":"4245","DOI":"10.1158\/1078-0432.CCR-11-0395","article-title":"Primary central nervous system lymphomas: a validation study of array-based comparative genomic hybridization in formalin-fixed paraffin-embedded tumor specimens","volume":"17","author":"Braggio","year":"2011","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.clml.2023.01.003_bib0018","doi-asserted-by":"crossref","first-page":"5203","DOI":"10.1158\/1078-0432.CCR-12-0845","article-title":"Recurrent mutations of MYD88 and TBL1XR1 in primary central nervous system lymphomas","volume":"18","author":"Gonzalez-Aguilar","year":"2012","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.clml.2023.01.003_bib0019","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/nbt.2514","article-title":"Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples","volume":"31","author":"Cibulskis","year":"2013","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.clml.2023.01.003_bib0020","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1093\/bioinformatics\/bts271","article-title":"Strelka: accurate somatic small-variant calling from sequenced tumor-normal sample pairs","volume":"28","author":"Saunders","year":"2012","journal-title":"Bioinformatics"},{"key":"10.1016\/j.clml.2023.01.003_bib0021","doi-asserted-by":"crossref","first-page":"e164","DOI":"10.1093\/nar\/gkq603","article-title":"ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data","volume":"38","author":"Wang","year":"2010","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.clml.2023.01.003_bib0022","doi-asserted-by":"crossref","first-page":"W316","DOI":"10.1093\/nar\/gkr483","article-title":"KOBAS 2.0: a web server for annotation and identification of enriched pathways and diseases","volume":"39","author":"Xie","year":"2011","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.clml.2023.01.003_bib0023","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nature12477","article-title":"Signatures of mutational processes in human cancer","volume":"500","author":"Alexandrov","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.clml.2023.01.003_bib0024","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.3389\/fimmu.2019.01113","article-title":"Association of LRP1B mutation with tumor mutation burden and outcomes in melanoma and non-small cell lung cancer patients treated with immune check-point blockades","volume":"10","author":"Chen","year":"2019","journal-title":"Front Immunol"},{"key":"10.1016\/j.clml.2023.01.003_bib0025","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.ymgme.2009.10.010","article-title":"PKHD1 sequence variations in 78 children and adults with autosomal recessive polycystic kidney disease and congenital hepatic fibrosis","volume":"99","author":"Gunay-Aygun","year":"2010","journal-title":"Mol Genet Metab"},{"key":"10.1016\/j.clml.2023.01.003_bib0026","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1111\/j.1523-1755.2005.00148.x","article-title":"Clinical consequences of PKHD1 mutations in 164 patients with autosomal-recessive polycystic kidney disease (ARPKD)","volume":"67","author":"Bergmann","year":"2005","journal-title":"Kidney Int"},{"key":"10.1016\/j.clml.2023.01.003_bib0027","article-title":"Whole-genome\/exome sequencing uncovers mutations and copy number variations in primary diffuse large b-cell lymphoma of the central nervous system","volume":"13","author":"Zhu","year":"2022","journal-title":"Front Genet."},{"key":"10.1016\/j.clml.2023.01.003_bib0028","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s00277-018-3498-z","article-title":"MYC, BCL2, and BCL6 rearrangements in primary central nervous system lymphoma of large B cell type","volume":"98","author":"Nosrati","year":"2019","journal-title":"Ann Hematol"},{"key":"10.1016\/j.clml.2023.01.003_bib0029","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1158\/1535-7163.MCT-16-0459","article-title":"Vulnerability of small-cell lung cancer to apoptosis induced by the combination of BET bromodomain proteins and BCL2 inhibitors","volume":"16","author":"Lam","year":"2017","journal-title":"Mol Cancer Ther"},{"key":"10.1016\/j.clml.2023.01.003_bib0030","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.3892\/ijo.2012.1669","article-title":"Function and cancer genomics of FAT family genes (review)","volume":"41","author":"Katoh","year":"2012","journal-title":"Int J Oncol"},{"key":"10.1016\/j.clml.2023.01.003_bib0031","doi-asserted-by":"crossref","first-page":"6034","DOI":"10.3892\/mmr.2017.7319","article-title":"Interferon regulatory factor 4 (IRF4) is overexpressed in human non\u2011small cell lung cancer (NSCLC) and activates the Notch signaling pathway","volume":"16","author":"Qian","year":"2017","journal-title":"Mol Med Rep"},{"key":"10.1016\/j.clml.2023.01.003_bib0032","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1111\/1759-7714.12613","article-title":"ALK-rearrangement in non-small-cell lung cancer (NSCLC)","volume":"9","author":"Du","year":"2018","journal-title":"Thorac Cancer"},{"key":"10.1016\/j.clml.2023.01.003_bib0033","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1111\/bjh.15674","article-title":"MYD88 p.(L265P) detection on cell-free DNA in liquid biopsies of patients with primary central nervous system lymphoma","volume":"185","author":"Hiemcke-Jiwa","year":"2019","journal-title":"Br J Haematol"},{"key":"10.1016\/j.clml.2023.01.003_bib0034","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/s41525-019-0107-6","article-title":"Spontaneous mutations in the single TTN gene represent high tumor mutation burden","volume":"5","author":"Oh","year":"2020","journal-title":"NPJ Genom Med"},{"key":"10.1016\/j.clml.2023.01.003_bib0035","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.lungcan.2019.04.025","article-title":"Somatic mutation of LRP1B is associated with tumor mutational burden in patients with lung cancer","volume":"132","author":"Lan","year":"2019","journal-title":"Lung Cancer"},{"key":"10.1016\/j.clml.2023.01.003_bib0036","doi-asserted-by":"crossref","first-page":"577","DOI":"10.7150\/jca.28905","article-title":"LRP1B polymorphisms are associated with multiple myeloma risk in a Chinese Han population","volume":"10","author":"Li","year":"2019","journal-title":"J Cancer"},{"key":"10.1016\/j.clml.2023.01.003_bib0037","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.jns.2015.09.345","article-title":"LRP1B deletion is associated with poor outcome for glioblastoma patients","volume":"358","author":"Tabouret","year":"2015","journal-title":"J Neurol Sci"},{"key":"10.1016\/j.clml.2023.01.003_bib0038","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1097\/01.ASN.0000039578.55705.6E","article-title":"Spectrum of mutations in the gene for autosomal recessive polycystic kidney disease (ARPKD\/PKHD1)","volume":"14","author":"Bergmann","year":"2003","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.clml.2023.01.003_bib0039","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.7314\/APJCP.2014.15.3.1441","article-title":"EphB1 and Ephrin-B, new potential biomarkers for squamous cell\/adenosquamous carcinomas and adenocarcinomas of the gallbladder","volume":"15","author":"Yuan","year":"2014","journal-title":"Asian Pac J Cancer Prev"},{"key":"10.1016\/j.clml.2023.01.003_bib0040","first-page":"10092","article-title":"Prognostic values of EphB1\/B2 and p-EphB1\/B2 expression in non-small cell lung cancer","volume":"10","author":"Li","year":"2017","journal-title":"Int J Clin Exp Pathol"},{"key":"10.1016\/j.clml.2023.01.003_bib0041","doi-asserted-by":"crossref","first-page":"8929","DOI":"10.18632\/oncotarget.3369","article-title":"Knockdown of EphB1 receptor decreases medulloblastoma cell growth and migration and increases cellular radiosensitization","volume":"6","author":"Bhatia","year":"2015","journal-title":"Oncotarget"}],"container-title":["Clinical Lymphoma Myeloma and Leukemia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2152265023000150?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2152265023000150?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T00:40:50Z","timestamp":1761871250000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2152265023000150"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4]]},"references-count":41,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["S2152265023000150"],"URL":"https:\/\/doi.org\/10.1016\/j.clml.2023.01.003","relation":{},"ISSN":["2152-2650"],"issn-type":[{"value":"2152-2650","type":"print"}],"subject":[],"published":{"date-parts":[[2023,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Whole-Exome Sequencing Revealed the Mutational Profiles of Primary Central Nervous System Lymphoma","name":"articletitle","label":"Article Title"},{"value":"Clinical Lymphoma Myeloma and Leukemia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clml.2023.01.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}