{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T20:16:07Z","timestamp":1788552967795,"version":"build-2803163510"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100017804","name":"City of Hope","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017804","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","clinical-lymphoma-myeloma-leukemia.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Lymphoma Myeloma and Leukemia"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.clml.2026.08.004","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T15:12:54Z","timestamp":1786374774000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Gut Microbiome Composition Is Associated With Response to CD38 Antibody (Daratumumab) Treatment Among Relapsed Multiple Myeloma Patients"],"prefix":"10.1016","author":[{"given":"Myo","family":"Htut","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1751-3043","authenticated-orcid":false,"given":"Keehoon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nitya","family":"Nathwani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5158-5131","authenticated-orcid":false,"given":"Michael","family":"Rosenzweig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murali","family":"Janakiram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Goldsmith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2254-6894","authenticated-orcid":false,"given":"James F.","family":"Sanchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha","family":"Scott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Keats","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amrita","family":"Krishnan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven T.","family":"Rosen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2597-9393","authenticated-orcid":false,"given":"Sophia S.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clml.2026.08.004_bib0001","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1021\/acs.chemrev.2c00431","article-title":"Microbiome and Human Health: Current Understanding, Engineering, and Enabling Technologies","volume":"123","author":"Aggarwal","year":"2023","journal-title":"Chemical reviews"},{"key":"10.1016\/j.clml.2026.08.004_bib0002","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.ccell.2018.03.015","article-title":"The Influence of the Gut Microbiome on Cancer, Immunity, and Cancer Immunotherapy","volume":"33","author":"Gopalakrishnan","year":"2018","journal-title":"Cancer cell"},{"key":"10.1016\/j.clml.2026.08.004_bib0003","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1038\/s41396-023-01483-0","article-title":"Potential effects of gut microbiota on host cancers: focus on immunity, DNA damage, cellular pathways, and anticancer therapy","volume":"17","author":"Sun","year":"2023","journal-title":"The ISME journal"},{"key":"10.1016\/j.clml.2026.08.004_bib0004","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2024.107321","article-title":"Host-Gut Microbiota Metabolic Interactions and Their Role in Precision Diagnosis and Treatment of Gastrointestinal Cancers","volume":"207","author":"Cao","year":"2024","journal-title":"Pharmacological research"},{"key":"10.1016\/j.clml.2026.08.004_bib0005","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/s41698-025-01034-0","article-title":"The role of the gut microbiota in chemotherapy response, efficacy and toxicity: a systematic review","volume":"9","author":"Bohm","year":"2025","journal-title":"NPJ precision oncology"},{"key":"10.1016\/j.clml.2026.08.004_bib0006","doi-asserted-by":"crossref","first-page":"e82","DOI":"10.1016\/j.clml.2024.08.008","article-title":"Impact of Gut Microbiota on Lymphoma: New Frontiers in Cancer Research","volume":"25","author":"Sanabani","year":"2025","journal-title":"Clinical lymphoma, myeloma & leukemia"},{"key":"10.1016\/j.clml.2026.08.004_bib0007","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1182\/bloodadvances.2019032276","article-title":"Minimal residual disease negativity in multiple myeloma is associated with intestinal microbiota composition","volume":"3","author":"Pianko","year":"2019","journal-title":"Blood advances"},{"key":"10.1016\/j.clml.2026.08.004_bib0008","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1016\/j.bbmt.2019.04.007","article-title":"Gastrointestinal Microbiome and Mycobiome Changes during Autologous Transplantation for Multiple Myeloma: Results of a Prospective Pilot Study","volume":"25","author":"El Jurdi","year":"2019","journal-title":"Biology of blood and marrow transplantation: journal of the American Society for Blood and Marrow Transplantation"},{"key":"10.1016\/j.clml.2026.08.004_bib0009","doi-asserted-by":"crossref","first-page":"8269","DOI":"10.12659\/MSM.919988","article-title":"Fecal Microbiota Taxonomic Shifts in Chinese Multiple Myeloma Patients Analyzed by Quantitative Polimerase Chain Reaction (QPCR) and 16S rRNA High-Throughput Sequencing","volume":"25","author":"Zhang","year":"2019","journal-title":"Medical science monitor: international medical journal of experimental and clinical research"},{"key":"10.1016\/j.clml.2026.08.004_bib0010","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-025-65312-y","article-title":"Microbiome modulation uncouples efficacy and toxicity induced by immune checkpoint blockade in mouse multiple myeloma","volume":"16","author":"Cogrossi","year":"2025","journal-title":"Nat Commun"},{"key":"10.1016\/j.clml.2026.08.004_bib0011","doi-asserted-by":"crossref","first-page":"4832","DOI":"10.1038\/s41467-018-07305-8","article-title":"Microbiota-driven interleukin-17-producing cells and eosinophils synergize to accelerate multiple myeloma progression","volume":"9","author":"Calcinotto","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.clml.2026.08.004_bib0012","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1080\/10428194.2022.2131410","article-title":"Perturbation of the gut microbiome and association with outcomes following autologous stem cell transplantation in patients with multiple myeloma","volume":"64","author":"D'Angelo","year":"2023","journal-title":"Leukemia & lymphoma"},{"key":"10.1016\/j.clml.2026.08.004_bib0013","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms13102302","article-title":"Associations Between the Gut Microbiome and Outcomes in Autologous Stem Cell Transplantation: A Systematic Review","volume":"13","author":"Pitts","year":"2025","journal-title":"Microorganisms"},{"key":"10.1016\/j.clml.2026.08.004_bib0014","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/1471-2180-12-56","article-title":"BactQuant: an enhanced broad-coverage bacterial quantitative real-time PCR assay","volume":"12","author":"Liu","year":"2012","journal-title":"BMC microbiology"},{"key":"10.1016\/j.clml.2026.08.004_bib0015","doi-asserted-by":"crossref","first-page":"e328","DOI":"10.1016\/S1470-2045(16)30206-6","article-title":"International Myeloma Working Group consensus criteria for response and minimal residual disease assessment in multiple myeloma","volume":"17","author":"Kumar","year":"2016","journal-title":"The Lancet. Oncology"},{"key":"10.1016\/j.clml.2026.08.004_bib0016","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1038\/s41587-019-0209-9","article-title":"Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2","volume":"37","author":"Bolyen","year":"2019","journal-title":"Nature Biotechnology"},{"key":"10.1016\/j.clml.2026.08.004_bib0017","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1186\/s12859-023-05219-x","article-title":"Bayesian compositional regression with microbiome features via variational inference","volume":"24","author":"Scott","year":"2023","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.clml.2026.08.004_bib0018","series-title":"Microbiome Analysis: Methods and Protocols","first-page":"113","author":"Hall","year":"2018"},{"key":"10.1016\/j.clml.2026.08.004_bib0019","doi-asserted-by":"crossref","first-page":"3514","DOI":"10.1038\/s41467-020-17041-7","article-title":"Analysis of compositions of microbiomes with bias correction","volume":"11","author":"Lin","year":"2020","journal-title":"Nature Communications"},{"key":"10.1016\/j.clml.2026.08.004_bib0020","doi-asserted-by":"crossref","first-page":"906","DOI":"10.3389\/fimmu.2020.00906","article-title":"The Genus Alistipes: Gut Bacteria With Emerging Implications to Inflammation, Cancer, and Mental Health","volume":"11","author":"Parker","year":"2020","journal-title":"Frontiers in immunology"},{"key":"10.1016\/j.clml.2026.08.004_bib0021","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2019.108324","article-title":"Green tea polyphenols decrease weight gain, ameliorate alteration of gut microbiota, and mitigate intestinal inflammation in canines with high-fat-diet-induced obesity","volume":"78","author":"Li","year":"2020","journal-title":"The Journal of nutritional biochemistry"},{"key":"10.1016\/j.clml.2026.08.004_bib0022","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1556\/030.2021.01366","article-title":"Interactions between immune system and the microbiome of skin, blood and gut in pathogenesis of rosacea","volume":"68","author":"Joura","year":"2021","journal-title":"Acta microbiologica et immunologica Hungarica"},{"key":"10.1016\/j.clml.2026.08.004_bib0023","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s00203-024-03834-7","article-title":"Butyrate's (a short-chain fatty acid) microbial synthesis, absorption, and preventive roles against colorectal and lung cancer","volume":"206","author":"Karim","year":"2024","journal-title":"Archives of microbiology"},{"key":"10.1016\/j.clml.2026.08.004_bib0024","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2025.10.003","article-title":"Faecalibacterium prausnitzii Induces an Anti-inflammatory Response and a Metabolic Reprogramming in Human Monocytes","author":"Danne","year":"2026","journal-title":"Gastroenterology"},{"key":"10.1016\/j.clml.2026.08.004_bib0025","doi-asserted-by":"crossref","DOI":"10.1093\/nutrit\/nuaf200","article-title":"The Role of Gut Microbiota in Chronic Noncommunicable Diseases: An Overview of the Last Decade","author":"Minari","year":"2025","journal-title":"Nutrition reviews"},{"key":"10.1016\/j.clml.2026.08.004_bib0026","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.1007\/s00394-024-03470-3","article-title":"What is the link between the dietary inflammatory index and the gut microbiome? A systematic review","volume":"63","author":"Mirhosseini","year":"2024","journal-title":"European journal of nutrition"},{"key":"10.1016\/j.clml.2026.08.004_bib0027","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1186\/s12967-020-02539-x","article-title":"Gut microbiota from coronary artery disease patients contributes to vascular dysfunction in mice by regulating bile acid metabolism and immune activation","volume":"18","author":"Liu","year":"2020","journal-title":"Journal of translational medicine"},{"key":"10.1016\/j.clml.2026.08.004_bib0028","article-title":"Susceptibility to febrile malaria is associated with an inflammatory gut microbiome","author":"Schmidt","year":"2024","journal-title":"Research square"},{"key":"10.1016\/j.clml.2026.08.004_bib0029","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1186\/s12967-025-07192-w","article-title":"Ruminococcus torques ameliorates the inflammation bowel disease and gut barrier dysfunction by modulating gut microbiota and bile acid metabolism","volume":"23","author":"Lou","year":"2025","journal-title":"Journal of translational medicine"},{"key":"10.1016\/j.clml.2026.08.004_bib0030","doi-asserted-by":"crossref","DOI":"10.3390\/ijms26083630","article-title":"Segatella copri Outer-Membrane Vesicles Are Internalized by Human Macrophages and Promote a Pro-Inflammatory Profile","volume":"26","author":"Sepulveda-Pontigo","year":"2025","journal-title":"International journal of molecular sciences"},{"key":"10.1016\/j.clml.2026.08.004_bib0031","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2025.116755","article-title":"Mucosal innate immune activation as the trigger to Prevotella species-induced arthritis in genetically resistant mice","volume":"45","author":"Maeda","year":"2026","journal-title":"Cell reports"},{"key":"10.1016\/j.clml.2026.08.004_bib0032","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.clml.2021.01.018","article-title":"Real-World Treatment of Patients With Relapsed\/Refractory Myeloma","volume":"21","author":"Ntanasis-Stathopoulos","year":"2021","journal-title":"Clinical lymphoma, myeloma & leukemia"}],"container-title":["Clinical Lymphoma Myeloma and Leukemia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2152265026002545?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2152265026002545?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T19:54:10Z","timestamp":1788551650000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2152265026002545"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":32,"alternative-id":["S2152265026002545"],"URL":"https:\/\/doi.org\/10.1016\/j.clml.2026.08.004","relation":{},"ISSN":["2152-2650"],"issn-type":[{"value":"2152-2650","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gut Microbiome Composition Is Associated With Response to CD38 Antibody (Daratumumab) Treatment Among Relapsed Multiple Myeloma Patients","name":"articletitle","label":"Article Title"},{"value":"Clinical Lymphoma Myeloma and Leukemia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clml.2026.08.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}