{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T14:03:05Z","timestamp":1793714585046,"version":"4.6.1"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["39087428"],"award-info":[{"award-number":["39087428"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["EXC 2155"],"award-info":[{"award-number":["EXC 2155"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","clinicalnutritionespen.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Nutrition ESPEN"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1016\/j.clnesp.2022.05.015","type":"journal-article","created":{"date-parts":[[2022,5,26]],"date-time":"2022-05-26T23:36:17Z","timestamp":1653608177000},"page":"212-217","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Selenium deficiency is associated with polyneuropathy in primary Sj\u00f6gren's syndrome"],"prefix":"10.1016","volume":"50","author":[{"given":"S.","family":"Hirsch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Skripuletz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Seeliger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Witte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Thiele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.clnesp.2022.05.015_bib1","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1136\/annrheumdis-2014-205375","article-title":"Epidemiology of primary Sj\u00f6gren\u2019s syndrome: a systematic review and meta-analysis","volume":"74","author":"Qin","year":"2015","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.clnesp.2022.05.015_bib2","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.3389\/fimmu.2019.01600","article-title":"Neuro-Sj\u00f6gren: peripheral neuropathy with limb weakness in Sj\u00f6gren\u2019s syndrome","volume":"10","author":"Seeliger","year":"2019","journal-title":"Front Immunol"},{"key":"10.1016\/j.clnesp.2022.05.015_bib3","first-page":"864","article-title":"Clinical subsets and presenting features in primary Sj\u00f6gren\u2019s syndrome: results from a Single Center Inception Cohort Study: abstract number: 627","volume":"67","author":"Baldini","year":"2015","journal-title":"Arthritis Rheumatol"},{"issue":"5","key":"10.1016\/j.clnesp.2022.05.015_bib4","doi-asserted-by":"crossref","DOI":"10.1097\/MED.0000000000000356","article-title":"Is selenium supplementation in autoimmune thyroid diseases justified?","volume":"24","author":"Winther","year":"2017","journal-title":"Curr Opin Endocrinol Diabetes Obes"},{"issue":"12","key":"10.1016\/j.clnesp.2022.05.015_bib5","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1089\/thy.2016.0256","article-title":"Selenium supplementation significantly reduces thyroid autoantibody levels in patients with chronic autoimmune thyroiditis: a systematic review and meta-analysis","volume":"26","author":"Wichman","year":"2016","journal-title":"Thyroid"},{"issue":"3","key":"10.1016\/j.clnesp.2022.05.015_bib6","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1038\/nrendo.2011.174","article-title":"Selenium, selenoproteins and the thyroid gland: interactions in health and disease","volume":"8","author":"Schomburg","year":"2012","journal-title":"Nat Rev Endocrinol"},{"issue":"5","key":"10.1016\/j.clnesp.2022.05.015_bib7","doi-asserted-by":"crossref","DOI":"10.1097\/MED.0000000000000190","article-title":"Selenium and the thyroid","volume":"22","author":"K\u00f6hrle","year":"2015","journal-title":"Curr Opin Endocrinol Diabetes Obes"},{"issue":"1","key":"10.1016\/j.clnesp.2022.05.015_bib8","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.beem.2009.08.013","article-title":"Iodine intake as a determinant of thyroid disorders in populations","volume":"24","author":"Laurberg","year":"2010","journal-title":"Best Pract Res Clin Endocrinol Metabol"},{"issue":"5","key":"10.1016\/j.clnesp.2022.05.015_bib9","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1089\/thy.2016.0635","article-title":"Multiple nutritional factors and the risk of Hashimoto's thyroiditis","volume":"27","author":"Hu","year":"2017","journal-title":"Thyroid"},{"issue":"1","key":"10.1016\/j.clnesp.2022.05.015_bib10","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1017\/S0029665118001192","article-title":"Multiple nutritional factors and thyroid disease, with particular reference to autoimmune thyroid disease","volume":"78","author":"Rayman","year":"2019","journal-title":"Proc Nutr Soc"},{"issue":"2","key":"10.1016\/j.clnesp.2022.05.015_bib11","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.clnu.2015.02.010","article-title":"The effect of the systemic inflammatory response on plasma zinc and selenium adjusted for albumin","volume":"35","author":"Ghashut","year":"2016","journal-title":"Clin Nutr"},{"issue":"1","key":"10.1016\/j.clnesp.2022.05.015_bib12","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/art.39859","article-title":"American College of Rheumatology\/European League Against Rheumatism classification criteria for primary Sj\u00f6gren\u2019s syndrome: a consensus and data-driven methodology involving three international patient cohorts","volume":"69","author":"Shiboski","year":"2016","journal-title":"Arthritis Rheumatol"},{"issue":"2","key":"10.1016\/j.clnesp.2022.05.015_bib13","first-page":"81","article-title":"Referenzwerte f\u00fcr die Spurenelemente Kupfer, Mangan, Selen und Zink im Serum von Kindern","volume":"21","author":"R\u00fckgauer","year":"1997","journal-title":"J\u00a0Lab Med."},{"key":"10.1016\/j.clnesp.2022.05.015_bib14","series-title":"Labor Und Diagnose. 8. Auflage","author":"Lothar","year":"2012"},{"issue":"2","key":"10.1016\/j.clnesp.2022.05.015_bib15","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.abb.2006.12.029","article-title":"Differential regulation of expression of cytosolic and mitochondrial thioredoxin reductase in rat liver and kidney","volume":"459","author":"Crosley","year":"2007","journal-title":"Arch Biochem Biophys"},{"issue":"5","key":"10.1016\/j.clnesp.2022.05.015_bib16","first-page":"1457S","article-title":"Selenium in the immune system","volume":"133","author":"Arthur","year":"2018","journal-title":"J\u00a0Nutr"},{"issue":"1","key":"10.1016\/j.clnesp.2022.05.015_bib17","doi-asserted-by":"crossref","first-page":"73","DOI":"10.3945\/an.114.007575","article-title":"Dietary selenium in adjuvant therapy of viral and bacterial infections","volume":"6","author":"Steinbrenner","year":"2015","journal-title":"Adv Nutr"},{"issue":"3","key":"10.1016\/j.clnesp.2022.05.015_bib18","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S0883-2927(99)00051-7","article-title":"Selenium distribution in the local environment of selected villages of the Keshan Disease belt, Zhangjiakou District, Hebei Province, People's Republic of China","volume":"15","author":"Johnson","year":"2000","journal-title":"Appl Geochem"},{"issue":"10","key":"10.1016\/j.clnesp.2022.05.015_bib19","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/S0891-5849(03)00101-1","article-title":"Coxsackievirus B3-resistant mice become susceptible in Se\/vitamin E deficiency","volume":"34","author":"Beck","year":"2003","journal-title":"Free Radic Biol Med"},{"issue":"2","key":"10.1016\/j.clnesp.2022.05.015_bib20","doi-asserted-by":"crossref","first-page":"259S","DOI":"10.1093\/ajcn\/57.2.259S","article-title":"The epidemiology of selenium deficiency in the etiological study of endemic diseases in China","volume":"57","author":"Ge","year":"1993","journal-title":"Am J Clin Nutr"},{"issue":"5","key":"10.1016\/j.clnesp.2022.05.015_bib21","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/nm0595-433","article-title":"Rapid genomic evolution of a non-virulent coxsackievirus B3 in selenium-deficient mice results in selection of identical virulent isolates","volume":"1","author":"Beck","year":"1995","journal-title":"Nat Med"},{"issue":"9","key":"10.1016\/j.clnesp.2022.05.015_bib22","doi-asserted-by":"crossref","first-page":"2897","DOI":"10.1002\/art.20463","article-title":"Evidence for coxsackievirus infection in primary Sj\u00f6gren's syndrome","volume":"50","author":"Triantafyllopoulou","year":"2004","journal-title":"Arthritis Rheum"},{"issue":"1","key":"10.1016\/j.clnesp.2022.05.015_bib23","first-page":"5","article-title":"Problematik, Klinik und Beispiele der Spurenelementvergiftung-Selen","volume":"79","author":"M\u00fcller","year":"2012","journal-title":"Toxichem Krimtech"},{"issue":"10","key":"10.1016\/j.clnesp.2022.05.015_bib24","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1001\/jamaneurol.2018.1669","article-title":"Selenium toxicity associated with reversible leukoencephalopathy and cortical blindness","volume":"75","author":"Rae","year":"2018","journal-title":"JAMA Neurol"}],"container-title":["Clinical Nutrition ESPEN"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405457722002807?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405457722002807?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T07:04:28Z","timestamp":1762499068000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405457722002807"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":24,"alternative-id":["S2405457722002807"],"URL":"https:\/\/doi.org\/10.1016\/j.clnesp.2022.05.015","relation":{},"ISSN":["2405-4577"],"issn-type":[{"value":"2405-4577","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Selenium deficiency is associated with polyneuropathy in primary Sj\u00f6gren's syndrome","name":"articletitle","label":"Article Title"},{"value":"Clinical Nutrition ESPEN","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clnesp.2022.05.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}