{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T12:49:15Z","timestamp":1768826955319,"version":"3.49.0"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,7,20]],"date-time":"2022-07-20T00:00:00Z","timestamp":1658275200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001720","name":"Nutricia Research Foundation","doi-asserted-by":"publisher","award":["2016-33"],"award-info":[{"award-number":["2016-33"]}],"id":[{"id":"10.13039\/501100001720","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002996","name":"Hartstichting","doi-asserted-by":"publisher","award":["2015T042"],"award-info":[{"award-number":["2015T042"]}],"id":[{"id":"10.13039\/501100002996","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","clinicalnutritionespen.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Nutrition ESPEN"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1016\/j.clnesp.2022.07.009","type":"journal-article","created":{"date-parts":[[2022,7,30]],"date-time":"2022-07-30T21:19:30Z","timestamp":1659215970000},"page":"97-103","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Effects of fructose restriction on blood pressure: Secondary analysis of a double-blind randomized controlled trial"],"prefix":"10.1016","volume":"51","author":[{"given":"Lise E.F.","family":"Janssen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nynke","family":"Simons","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pomme I.H.G.","family":"Simons","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2128-8029","authenticated-orcid":false,"given":"Nicolaas C.","family":"Schaper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5819-2488","authenticated-orcid":false,"given":"Edith J.M.","family":"Feskens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5934-2983","authenticated-orcid":false,"given":"Liesbeth M.C.","family":"van der Ploeg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1985-4877","authenticated-orcid":false,"given":"Mathias D.G.","family":"Van den Eynde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Casper G.","family":"Schalkwijk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1747-8452","authenticated-orcid":false,"given":"Alfons J.H.M.","family":"Houben","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Coen D.A.","family":"Stehouwer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martijn C.G.J.","family":"Brouwers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.clnesp.2022.07.009_bib1","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1093\/ajcn\/79.4.537","article-title":"Consumption of high-fructose corn syrup in beverages may play a role in the epidemic of obesity","volume":"79","author":"Bray","year":"2004","journal-title":"Am J Clin Nutr"},{"issue":"8","key":"10.1016\/j.clnesp.2022.07.009_bib2","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1001\/jama.292.8.927","article-title":"Sugar-sweetened beverages, weight gain, and incidence of type 2 diabetes in young and middle-aged women","volume":"292","author":"Schulze","year":"2004","journal-title":"JAMA"},{"issue":"4","key":"10.1016\/j.clnesp.2022.07.009_bib3","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1093\/ajcn\/86.4.899","article-title":"Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease","volume":"86","author":"Johnson","year":"2007","journal-title":"Am J Clin Nutr"},{"issue":"20","key":"10.1016\/j.clnesp.2022.07.009_bib4","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1001\/jama.2010.650","article-title":"US trends in prevalence, awareness, treatment, and control of hypertension, 1988-2008","volume":"303","author":"Egan","year":"2010","journal-title":"JAMA"},{"issue":"1","key":"10.1016\/j.clnesp.2022.07.009_bib5","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1097\/MOL.0000000000000042","article-title":"Fructose vs. glucose and metabolism: do the metabolic differences matter?","volume":"25","author":"Sievenpiper","year":"2014","journal-title":"Curr Opin Lipidol"},{"issue":"5","key":"10.1016\/j.clnesp.2022.07.009_bib6","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1161\/01.HYP.10.5.512","article-title":"Fructose-induced insulin resistance and hypertension in rats","volume":"10","author":"Hwang","year":"1987","journal-title":"Hypertension"},{"issue":"5","key":"10.1016\/j.clnesp.2022.07.009_bib7","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1097\/HJH.0000000000000551","article-title":"The mechanisms underlying fructose-induced hypertension: a review","volume":"33","author":"Klein","year":"2015","journal-title":"J\u00a0Hypertens"},{"issue":"4","key":"10.1016\/j.clnesp.2022.07.009_bib8","first-page":"289","article-title":"Endogenous fructose production: what do we know and how relevant is it?","volume":"22","author":"Andres-Hernando","year":"2019","journal-title":"Curr Opin Clin Nutr Metab Care"},{"issue":"3","key":"10.1016\/j.clnesp.2022.07.009_bib9","doi-asserted-by":"crossref","first-page":"R730","DOI":"10.1152\/ajpregu.00680.2007","article-title":"Fructose ingestion acutely elevates blood pressure in healthy young humans","volume":"294","author":"Brown","year":"2008","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"4","key":"10.1016\/j.clnesp.2022.07.009_bib10","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1161\/HYPERTENSIONAHA.111.182311","article-title":"Effect of fructose on blood pressure: a systematic review and meta-analysis of controlled feeding trials","volume":"59","author":"Ha","year":"2012","journal-title":"Hypertension"},{"issue":"4","key":"10.1016\/j.clnesp.2022.07.009_bib11","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1080\/07315724.2014.916237","article-title":"Total fructose intake and risk of hypertension: a systematic review and meta-analysis of prospective cohorts","volume":"33","author":"Jayalath","year":"2014","journal-title":"J\u00a0Am Coll Nutr"},{"issue":"3","key":"10.1016\/j.clnesp.2022.07.009_bib12","doi-asserted-by":"crossref","first-page":"F625","DOI":"10.1152\/ajprenal.00140.2005","article-title":"A\u00a0causal role for uric acid in fructose-induced metabolic syndrome","volume":"290","author":"Nakagawa","year":"2006","journal-title":"Am J Physiol Ren Physiol"},{"issue":"4","key":"10.1016\/j.clnesp.2022.07.009_bib13","doi-asserted-by":"crossref","first-page":"F710","DOI":"10.1152\/ajprenal.00454.2007","article-title":"Effects of febuxostat on metabolic and renal alterations in rats with fructose-induced metabolic syndrome","volume":"294","author":"S\u00e1nchez-Lozada","year":"2008","journal-title":"Am J Physiol Ren Physiol"},{"issue":"7","key":"10.1016\/j.clnesp.2022.07.009_bib14","article-title":"Moderate (20%) fructose-enriched diet stimulates salt-sensitive hypertension with increased salt retention and decreased renal nitric oxide","volume":"5","author":"Gordish","year":"2017","journal-title":"Phys Rep"},{"issue":"2","key":"10.1016\/j.clnesp.2022.07.009_bib15","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1161\/HYPERTENSIONAHA.118.12150","article-title":"Multilayered interplay between fructose and salt in development of hypertension","volume":"73","author":"Eren","year":"2019","journal-title":"Hypertension"},{"issue":"2","key":"10.1016\/j.clnesp.2022.07.009_bib16","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1093\/ajcn\/nqaa332","article-title":"Effects of fructose restriction on liver steatosis (FRUITLESS); a double-blind randomized controlled trial","volume":"113","author":"Simons","year":"2021","journal-title":"Am J Clin Nutr"},{"issue":"4","key":"10.1016\/j.clnesp.2022.07.009_bib17","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1038\/ejcn.2014.267","article-title":"Fructose consumption in The Netherlands: the Dutch National food consumption survey 2007-2010","volume":"69","author":"Sluik","year":"2015","journal-title":"Eur J Clin Nutr"},{"issue":"20","key":"10.1016\/j.clnesp.2022.07.009_bib18","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1001\/jama.2013.281053","article-title":"World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects","volume":"310","year":"2013","journal-title":"JAMA"},{"key":"10.1016\/j.clnesp.2022.07.009_bib19","article-title":"Kidney and vascular function in adult patients with hereditary fructose intolerance","volume":"23","author":"Simons","year":"2020","journal-title":"Mol Genet Metab Rep"},{"key":"10.1016\/j.clnesp.2022.07.009_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.niox.2014.07.003","article-title":"Evaluation of endothelial function by peripheral arterial tonometry and relation with the nitric oxide pathway","volume":"42","author":"Hedetoft","year":"2014","journal-title":"Nitric Oxide"},{"issue":"3","key":"10.1016\/j.clnesp.2022.07.009_bib21","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1152\/japplphysiol.01397.2013","article-title":"New approach to measure cutaneous microvascular function: an improved test of NO-mediated vasodilation by thermal hyperemia","volume":"117","author":"Choi","year":"2014","journal-title":"J\u00a0Appl Physiol (1985)"},{"issue":"18","key":"10.1016\/j.clnesp.2022.07.009_bib22","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1161\/CIRCULATIONAHA.116.023446","article-title":"Prediabetes and type 2 diabetes are associated with generalized microvascular dysfunction: the Maastricht study","volume":"134","author":"Sorensen","year":"2016","journal-title":"Circulation"},{"issue":"12","key":"10.1016\/j.clnesp.2022.07.009_bib23","doi-asserted-by":"crossref","first-page":"2439","DOI":"10.1097\/HJH.0000000000000348","article-title":"Age, waist circumference, and blood pressure are associated with skin microvascular flow motion: the Maastricht Study","volume":"32","author":"Muris","year":"2014","journal-title":"J\u00a0Hypertens"},{"key":"10.1016\/j.clnesp.2022.07.009_bib24","article-title":"Development and validation of a UPLC-MS\/MS method to quantify fructose in serum and urine","volume":"1155","author":"Buziau","year":"2020","journal-title":"J\u00a0Chromatogr B Anal Technol Biomed Life Sci"},{"issue":"7","key":"10.1016\/j.clnesp.2022.07.009_bib25","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1017\/S0033291713002043","article-title":"Endothelial dysfunction is associated with a greater depressive symptom score in a general elderly population: the Hoorn Study","volume":"44","author":"van Sloten","year":"2014","journal-title":"Psychol Med"},{"key":"10.1016\/j.clnesp.2022.07.009_bib26","doi-asserted-by":"crossref","DOI":"10.4061\/2011\/392708","article-title":"The role of salt in the pathogenesis of fructose-induced hypertension","volume":"2011","author":"Soleimani","year":"2011","journal-title":"Int J Nephrol"},{"issue":"11","key":"10.1016\/j.clnesp.2022.07.009_bib27","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2015-010874","article-title":"Cross-sectional survey of the amount of free sugars and calories in carbonated sugar-sweetened beverages on sale in the UK","volume":"6","author":"Hashem","year":"2016","journal-title":"BMJ Open"},{"issue":"1","key":"10.1016\/j.clnesp.2022.07.009_bib28","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1186\/s12889-017-4497-z","article-title":"Policy lessons from health taxes: a systematic review of empirical studies","volume":"17","author":"Wright","year":"2017","journal-title":"BMC Public Health"},{"issue":"10","key":"10.1016\/j.clnesp.2022.07.009_bib29","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.2105\/AJPH.2016.303362","article-title":"Impact of the Berkeley excise tax on sugar-sweetened beverage consumption","volume":"106","author":"Falbe","year":"2016","journal-title":"Am J Public Health"},{"issue":"1","key":"10.1016\/j.clnesp.2022.07.009_bib30","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1017\/S1368980017001392","article-title":"Ultra-processed foods and the limits of product reformulation","volume":"21","author":"Scrinis","year":"2018","journal-title":"Public Health Nutr"},{"issue":"6","key":"10.1016\/j.clnesp.2022.07.009_bib31","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1161\/CIRCULATIONAHA.112.093245","article-title":"The assessment of endothelial function: from research into clinical practice","volume":"126","author":"Flammer","year":"2012","journal-title":"Circulation"},{"issue":"7","key":"10.1016\/j.clnesp.2022.07.009_bib32","doi-asserted-by":"crossref","DOI":"10.3390\/nu9070791","article-title":"Salt reductions in some foods in The Netherlands: monitoring of food composition and salt intake","volume":"9","author":"Temme","year":"2017","journal-title":"Nutrients"},{"issue":"1\u20132","key":"10.1016\/j.clnesp.2022.07.009_bib33","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1023\/A:1020835229591","article-title":"Dietary vitamin E and C supplementation prevents fructose induced hypertension in rats","volume":"241","author":"Vasdev","year":"2002","journal-title":"Mol Cell Biochem"},{"issue":"1","key":"10.1016\/j.clnesp.2022.07.009_bib34","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S1734-1140(09)70008-8","article-title":"Antihypertensive effects of the flavonoid quercetin","volume":"61","author":"Perez-Vizcaino","year":"2009","journal-title":"Pharmacol Rep"}],"container-title":["Clinical Nutrition ESPEN"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405457722004193?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405457722004193?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T07:04:59Z","timestamp":1762499099000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405457722004193"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":34,"alternative-id":["S2405457722004193"],"URL":"https:\/\/doi.org\/10.1016\/j.clnesp.2022.07.009","relation":{},"ISSN":["2405-4577"],"issn-type":[{"value":"2405-4577","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of fructose restriction on blood pressure: Secondary analysis of a double-blind randomized controlled trial","name":"articletitle","label":"Article Title"},{"value":"Clinical Nutrition ESPEN","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clnesp.2022.07.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s). Published by Elsevier Ltd on behalf of European Society for Clinical Nutrition and Metabolism.","name":"copyright","label":"Copyright"}]}}