{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:35:59Z","timestamp":1787099759311,"version":"build-2736575974"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","clinicalnutritionespen.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Nutrition ESPEN"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.clnesp.2024.03.018","type":"journal-article","created":{"date-parts":[[2024,3,22]],"date-time":"2024-03-22T00:09:23Z","timestamp":1711066163000},"page":"151-157","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["The effect of eight weeks combined training with omega-3 supplementation on the levels of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 in older women"],"prefix":"10.1016","volume":"61","author":[{"given":"Ehsan","family":"Arabzadeh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Negin","family":"Karimi Nazar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mandana","family":"Gholami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4781-8486","authenticated-orcid":false,"given":"Mohammad Sadra","family":"Roshani Koosha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6500-4895","authenticated-orcid":false,"given":"Mehdi","family":"Zargani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clnesp.2024.03.018_bib1","first-page":"65","article-title":"Addressing obesity in aging patients","volume":"102","author":"Batsis","year":"2018","journal-title":"Medical Clinics"},{"key":"10.1016\/j.clnesp.2024.03.018_bib2","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.rec.2011.05.003","article-title":"Cardiovascular disease in the elderly","volume":"64","author":"Jackson","year":"2011","journal-title":"Revista Espa\u00f1ola de Cardiolog\u00eda (English Edition)"},{"key":"10.1016\/j.clnesp.2024.03.018_bib3","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1001\/jama.2009.2008","article-title":"Association of marine omega-3 fatty acid levels with telomeric aging in patients with coronary heart disease","volume":"303","author":"Farzaneh-Far","year":"2010","journal-title":"JAMA"},{"key":"10.1016\/j.clnesp.2024.03.018_bib4","first-page":"2018","article-title":"Automated diagnosis of coronary artery disease: a review and workflow","author":"Wah","year":"2018","journal-title":"Cardiol Res Pract"},{"key":"10.1016\/j.clnesp.2024.03.018_bib5","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1160\/TH14-12-1014","article-title":"The impact of selectins on mortality in stable carotid atherosclerosis","volume":"114","author":"Hoke","year":"2015","journal-title":"Thromb Haemostasis"},{"key":"10.1016\/j.clnesp.2024.03.018_bib6","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.atherosclerosis.2015.07.035","article-title":"Biologic plausibility, cellular effects, and molecular mechanisms of eicosapentaenoic acid (EPA) in atherosclerosis","volume":"242","author":"Borow","year":"2015","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.clnesp.2024.03.018_bib7","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.ijcard.2005.05.008","article-title":"Increased plasma soluble adhesion molecules; ICAM-1, VCAM-1, and E-selectin levels in patients with slow coronary flow","volume":"108","author":"Turhan","year":"2006","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.clnesp.2024.03.018_bib8","doi-asserted-by":"crossref","first-page":"297","DOI":"10.2147\/JIR.S170262","article-title":"Cell adhesion molecules and exercise","author":"Koh","year":"2018","journal-title":"J\u00a0Inflamm Res"},{"key":"10.1016\/j.clnesp.2024.03.018_bib9","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/S1734-1140(09)70004-0","article-title":"ICAM-1 signaling in endothelial cells","volume":"61","author":"Lawson","year":"2009","journal-title":"Pharmacol Rep"},{"key":"10.1016\/j.clnesp.2024.03.018_bib10","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1160\/TH14-02-0151","article-title":"Coronary artery endothelial cells and microparticles increase expression of VCAM-1 in myocardial infarction","volume":"113","author":"Radecke","year":"2015","journal-title":"Thromb Haemostasis"},{"key":"10.1016\/j.clnesp.2024.03.018_bib11","doi-asserted-by":"crossref","first-page":"2292","DOI":"10.1161\/ATVBAHA.107.149179","article-title":"Vascular adhesion molecules in atherosclerosis","volume":"27","author":"Galkina","year":"2007","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.clnesp.2024.03.018_bib12","doi-asserted-by":"crossref","DOI":"10.6061\/clinics\/2018\/e203","article-title":"Relationship between circulating VCAM-1, ICAM-1, E-selectin and MMP9 and the extent of coronary lesions","volume":"73","author":"Santos","year":"2018","journal-title":"Clinics"},{"key":"10.1016\/j.clnesp.2024.03.018_bib13","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1161\/01.CIR.102.13.1549","article-title":"Value of serum-soluble intercellular adhesion molecule-1 for the noninvasive risk assessment of transplant coronary artery disease, posttransplant ischemic events, and cardiac graft failure","volume":"102","author":"Labarrere","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.clnesp.2024.03.018_bib14","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.cyto.2005.04.007","article-title":"Soluble ICAM-1: a marker of vascular and lifestyle","volume":"31","author":"Witkowska","year":"2005","journal-title":"Cytokine"},{"key":"10.1016\/j.clnesp.2024.03.018_bib15","first-page":"193","article-title":"The effect of eight week interval training on the serum VCAM-1 and PAI-1 in obesity women","volume":"10","author":"Mosaffa","year":"2018","journal-title":"Journal of Sport Biosciences"},{"key":"10.1016\/j.clnesp.2024.03.018_bib16","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.freeradbiomed.2018.10.444","article-title":"Exercise effects on physiological function during aging","volume":"132","author":"Radak","year":"2019","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.clnesp.2024.03.018_bib17","first-page":"137","article-title":"Effect of a karate competition on indicators of inflammation and muscletissue injury in soldier's karate-ka","volume":"17","author":"Shirvani","year":"2015","journal-title":"Journal of Military Medicine"},{"key":"10.1016\/j.clnesp.2024.03.018_bib18","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1136\/bmj.38755.366331.2F","article-title":"Risks and benefits of omega 3 fats for mortality, cardiovascular disease, and cancer: systematic review","volume":"332","author":"Hooper","year":"2006","journal-title":"Bmj"},{"key":"10.1016\/j.clnesp.2024.03.018_bib19","doi-asserted-by":"crossref","first-page":"355","DOI":"10.3390\/nu2030355","article-title":"Omega-3 fatty acids and inflammatory processes","volume":"2","author":"Calder","year":"2010","journal-title":"Nutrients"},{"key":"10.1016\/j.clnesp.2024.03.018_bib20","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1161\/ATVBAHA.108.171736","article-title":"In\u00a0vivo and in\u00a0vitro inhibition of monocyte adhesion to endothelial cells and endothelial adhesion molecules by eicosapentaenoic acid","volume":"28","author":"Yamada","year":"2008","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.clnesp.2024.03.018_bib21","first-page":"35","article-title":"Effects of regular aerobic training accompanied by omega-3 supplementation on soluble intercellular adhesion molecule-1 and lipid profiles of obese elderly women","volume":"8","author":"Tofighi","year":"2013","journal-title":"Iranian Journal of Nutrition Sciences & Food Technology"},{"key":"10.1016\/j.clnesp.2024.03.018_bib22","first-page":"125","article-title":"The effects of aerobic training and omega-3 fatty acid supplement on sICAM-1 in old males","volume":"1","author":"Mogharnasi","year":"2013","journal-title":"Journal of Sport Biosciences"},{"key":"10.1016\/j.clnesp.2024.03.018_bib23","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/BF00280883","article-title":"Homeostasis model assessment: insulin resistance and \u03b2-cell function from fasting plasma glucose and insulin concentrations in man","volume":"28","author":"Matthews","year":"1985","journal-title":"Diabetologia"},{"key":"10.1016\/j.clnesp.2024.03.018_bib24","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.2337\/dc06-1760","article-title":"Beneficial effects of a 4-week exercise program on plasma concentrations of adhesion molecules","volume":"30","author":"Tonjes","year":"2007","journal-title":"Diabetes Care"},{"key":"10.1016\/j.clnesp.2024.03.018_bib25","doi-asserted-by":"crossref","first-page":"44","DOI":"10.2298\/VSP0901044R","article-title":"Effects of physical exercise on inflammatory parameters and risk for repeated acute coronary syndrome in patients with ischemic heart disease","volume":"66","author":"Rankovi\u0107","year":"2009","journal-title":"Vojnosanit Pregl"},{"key":"10.1016\/j.clnesp.2024.03.018_bib26","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1111\/j.0300-9475.2004.01486.x","article-title":"Long-distance running modulates the expression of leucocyte and endothelial adhesion molecules","volume":"60","author":"Nielsen","year":"2004","journal-title":"Scand J Immunol"},{"key":"10.1016\/j.clnesp.2024.03.018_bib27","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.scispo.2016.12.004","article-title":"Effects of water-based endurance training, resistance training, and combined water and resistance training programs on visfatin and ICAM-1 levels in sedentary obese women","volume":"32","author":"Soori","year":"2017","journal-title":"Sci Sports"},{"key":"10.1016\/j.clnesp.2024.03.018_bib28","article-title":"Moderate-and high-intensity exercise improves lipoprotein profile and cholesterol efflux capacity in healthy young men","volume":"11","author":"Stanton","year":"2022","journal-title":"J\u00a0Am Heart Assoc"},{"key":"10.1016\/j.clnesp.2024.03.018_bib29","article-title":"Effects of different modes of exercise training on body composition and risk factors for cardiovascular disease in middle-aged men","volume":"9","author":"Mohammadi","year":"2018","journal-title":"Int J Prev Med"},{"key":"10.1016\/j.clnesp.2024.03.018_bib30","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/j.bbamcr.2008.01.004","article-title":"Visfatin enhances ICAM-1 and VCAM-1 expression through ROS-dependent NF-\u03baB activation in endothelial cells","volume":"1783","author":"Kim","year":"2008","journal-title":"Biochimica et Biophysica Acta (BBA)-Molecular Cell Research"},{"key":"10.1016\/j.clnesp.2024.03.018_bib31","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.3390\/antiox11061065","article-title":"The association of oxidative and antioxidant potential with cardiometabolic risk profile in the group of 60-to 65-year-old seniors from Central Poland","volume":"11","author":"So\u0142tysik","year":"2022","journal-title":"Antioxidants"},{"key":"10.1016\/j.clnesp.2024.03.018_bib32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11357-015-9799-4","article-title":"Effects of combined physical exercise training on DNA damage and repair capacity: role of oxidative stress changes","volume":"37","author":"Soares","year":"2015","journal-title":"Age"},{"key":"10.1016\/j.clnesp.2024.03.018_bib33","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1111\/jgs.12749","article-title":"Aerobic exercise and weight loss reduce vascular markers of inflammation and improve insulin sensitivity in obese women","volume":"62","author":"Ryan","year":"2014","journal-title":"J\u00a0Am Geriatr Soc"},{"issue":"6","key":"10.1016\/j.clnesp.2024.03.018_bib34","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.cjco.2023.02.009","article-title":"The impacts of exercise interventions on inflammatory markers and vascular adhesion molecules in patients with heart failure: a meta-analysis of RCTs","volume":"5","author":"Malandish","year":"2023","journal-title":"CJC Open"},{"key":"10.1016\/j.clnesp.2024.03.018_bib35","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1046\/j.1464-5491.2001.00410.x","article-title":"n-3 polyunsaturated fatty acid supplementation, monocyte adhesion molecule expression and pro-inflammatory mediators in Type 2 diabetes mellitus","volume":"18","author":"Sampson","year":"2001","journal-title":"Diabet Med"},{"key":"10.1016\/j.clnesp.2024.03.018_bib36","first-page":"253","article-title":"Short-term administration of omega-3 fatty acids in hemodialysis patients with balanced lipid metabolism","volume":"15","author":"Fiedler","year":"2005","journal-title":"J\u00a0Ren Nutr"},{"key":"10.1016\/j.clnesp.2024.03.018_bib37","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/j.jnutbio.2009.12.004","article-title":"Mechanisms underlying the cardioprotective effects of omega-3 polyunsaturated fatty acids","volume":"21","author":"Adkins","year":"2010","journal-title":"J\u00a0Nutr Biochem"},{"key":"10.1016\/j.clnesp.2024.03.018_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2023.106963","article-title":"Effects of marine-derived n\u20133 PUFA supplementation on soluble adhesion molecules: a systematic review and dose-response meta-analysis of randomized controlled trials","volume":"197","author":"Shirani","year":"2023","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.clnesp.2024.03.018_bib39","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1111\/pedi.12024","article-title":"Omega-3 polyunsaturated fatty acids reduce insulin resistance and triglycerides in obese children and adolescents","volume":"14","author":"Ju\u00e1rez-L\u00f3pez","year":"2013","journal-title":"Pediatr Diabetes"},{"key":"10.1016\/j.clnesp.2024.03.018_bib40","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.jnutbio.2018.10.012","article-title":"Effect of omega-3 fatty acids supplementation combined with lifestyle intervention on adipokines and biomarkers of endothelial dysfunction in obese adolescents with hypertriglyceridemia","volume":"64","author":"Huang","year":"2019","journal-title":"J\u00a0Nutr Biochem"},{"key":"10.1016\/j.clnesp.2024.03.018_bib41","article-title":"Eccentric resistance training and \u03b2-hydroxy-\u03b2-methylbutyrate free acid affects muscle PGC-1\u03b1 expression and serum irisin, nesfatin-1 and resistin in rats","volume":"222","author":"Shirvani","year":"2019","journal-title":"J\u00a0Exp Biol"},{"key":"10.1016\/j.clnesp.2024.03.018_bib42","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.arcmed.2011.06.010","article-title":"Supplementation of n3 long-chain polyunsaturated fatty acid synergistically decreases insulin resistance with weight loss of obese prepubertal and pubertal children","volume":"42","author":"L\u00f3pez-Alarc\u00f3n","year":"2011","journal-title":"Arch Med Res"},{"key":"10.1016\/j.clnesp.2024.03.018_bib43","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1038\/oby.2010.194","article-title":"Effects of eicosapentaenoic acid (EPA) treatment on insulin sensitivity in an animal model of diabetes: improvement of the inflammatory status","volume":"19","author":"Figueras","year":"2011","journal-title":"Obesity"},{"key":"10.1016\/j.clnesp.2024.03.018_bib44","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1194\/jlr.M200282-JLR200","article-title":"Omega-3 fatty acid supplementation accelerates chylomicron triglyceride clearance","volume":"44","author":"Park","year":"2003","journal-title":"J\u00a0Lipid Res"},{"issue":"1","key":"10.1016\/j.clnesp.2024.03.018_bib45","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1152\/japplphysiol.00123.2005","article-title":"Exercise-induced increase in muscle insulin sensitivity","volume":"99","author":"Holloszy","year":"2005","journal-title":"J\u00a0Appl Physiol"},{"key":"10.1016\/j.clnesp.2024.03.018_bib46","doi-asserted-by":"crossref","first-page":"3386","DOI":"10.2337\/db14-1771","article-title":"Increased skeletal muscle capillarization independently enhances insulin sensitivity in older adults after exercise training and detraining","volume":"64","author":"Prior","year":"2015","journal-title":"Diabetes"}],"container-title":["Clinical Nutrition ESPEN"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405457724000731?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405457724000731?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T06:23:58Z","timestamp":1721111038000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405457724000731"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":46,"alternative-id":["S2405457724000731"],"URL":"https:\/\/doi.org\/10.1016\/j.clnesp.2024.03.018","relation":{},"ISSN":["2405-4577"],"issn-type":[{"value":"2405-4577","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The effect of eight weeks combined training with omega-3 supplementation on the levels of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 in older women","name":"articletitle","label":"Article Title"},{"value":"Clinical Nutrition ESPEN","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clnesp.2024.03.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}