{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T14:10:28Z","timestamp":1777039828295,"version":"3.51.4"},"reference-count":15,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100009053","name":"DBT\/Wellcome Trust India Alliance","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","clinicalnutritionespen.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Nutrition ESPEN"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.clnesp.2024.04.024","type":"journal-article","created":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T06:04:19Z","timestamp":1715580259000},"page":"76-80","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Effect of calcium supplementation on reversing metformin-based inhibition of vitamin B12 bioavailability in healthy adults using a [13C] cyanocobalamin tracer \u2013 A pilot study"],"prefix":"10.1016","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1437-7717","authenticated-orcid":false,"given":"Jananee","family":"Muralidharan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gunjit Glen","family":"Romould","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0986-0165","authenticated-orcid":false,"given":"Sindhu","family":"Kashyap","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roshni","family":"Pasanna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ambily","family":"Sivadas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4956-9391","authenticated-orcid":false,"given":"Harshpal S.","family":"Sachdev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anura V.","family":"Kurpad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarita","family":"Devi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.clnesp.2024.04.024_bib1","doi-asserted-by":"crossref","first-page":"107","DOI":"10.2991\/jegh.k.191028.001","article-title":"Epidemiology of type 2 diabetes - global burden of disease and forecasted trends","volume":"10","author":"Khan","year":"2020","journal-title":"J\u00a0Epidemiol Glob Health"},{"issue":"11","key":"10.1016\/j.clnesp.2024.04.024_bib2","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1016\/S2213-8587(15)00291-0","article-title":"Long-term effects of lifestyle intervention or metformin on diabetes development and microvascular complications over 15-year follow-up: the Diabetes Prevention Program Outcomes Study","volume":"3","year":"2015","journal-title":"Lancet Diabetes Endocrinol"},{"key":"10.1016\/j.clnesp.2024.04.024_bib3","series-title":"StatPearls [internet]","article-title":"Metformin","author":"Corcoran","year":"2023"},{"issue":"1","key":"10.1016\/j.clnesp.2024.04.024_bib4","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2015-010210","article-title":"Trends in incidence, prevalence and prescribing in type 2 diabetes mellitus between 2000 and 2013 in primary care: a retrospective cohort study","volume":"6","author":"Sharma","year":"2016","journal-title":"BMJ Open"},{"key":"10.1016\/j.clnesp.2024.04.024_bib5","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.diabet.2016.03.008","article-title":"Association between metformin and vitamin B12 deficiency in patients with type 2 diabetes: a systematic review and meta-analysis","volume":"42","author":"Chapman","year":"2016","journal-title":"Diabetes Metabol"},{"issue":"46","key":"10.1016\/j.clnesp.2024.04.024_bib6","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000017918","article-title":"Association between metformin dose and vitamin B12 deficiency in patients with type 2 diabetes","volume":"98","author":"Kim","year":"2019","journal-title":"Medicine (Baltim)"},{"issue":"5","key":"10.1016\/j.clnesp.2024.04.024_bib7","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1046\/j.1365-2796.2003.01213.x","article-title":"Effects of short-term treatment with metformin on serum concentrations of homocysteine, folate and vitamin B12 in type 2 diabetes mellitus: a randomized, placebo-controlled trial","volume":"254","author":"Wulffel\u00e9","year":"2003","journal-title":"J\u00a0Intern Med"},{"issue":"Suppl 1","key":"10.1016\/j.clnesp.2024.04.024_bib8","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.2337\/dc23-Srev","article-title":"Summary of revisions: Standards of care in diabetes-2023","volume":"46","author":"ElSayed","year":"2023","journal-title":"Diabetes Care"},{"issue":"9","key":"10.1016\/j.clnesp.2024.04.024_bib9","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.2337\/diacare.23.9.1227","article-title":"Increased intake of calcium reverses vitamin B12 malabsorption induced by metformin","volume":"23","author":"Bauman","year":"2000","journal-title":"Diabetes Care"},{"issue":"7287","key":"10.1016\/j.clnesp.2024.04.024_bib10","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/nature08874","article-title":"Structural basis for receptor recognition of vitamin-B 12\u2013intrinsic factor complexes","volume":"464","author":"Andersen","year":"2010","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.clnesp.2024.04.024_bib11","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1093\/ajcn\/nqaa221","article-title":"Measuring vitamin B-12 bioavailability with [13C]-cyanocobalamin in humans","volume":"112","author":"Devi","year":"2020","journal-title":"Am J Clin Nutr"},{"issue":"5","key":"10.1016\/j.clnesp.2024.04.024_bib12","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1007\/s12603-015-0605-x","article-title":"Vitamin B12 deficiency induced by the use of gastric acid inhibitors: calcium supplements as a potential effect modifier","volume":"20","author":"Presse","year":"2016","journal-title":"J\u00a0Nutr Health Aging"},{"issue":"4","key":"10.1016\/j.clnesp.2024.04.024_bib13","doi-asserted-by":"crossref","first-page":"448","DOI":"10.3109\/00365515809051257","article-title":"Inhibition of radiovitamin B12 absorption by ethylenediaminetetraacetate (EDTA) and its reversal by calcium ions","volume":"10","author":"Grasbeck","year":"1958","journal-title":"Scand J Clin Lab Invest"},{"key":"10.1016\/j.clnesp.2024.04.024_bib14","first-page":"58","article-title":"The effects of metformin and metformin plus calcium treatments on serum vitamin B12 levels","volume":"9","author":"Kocaciftci","year":"2013","journal-title":"Nobel Medicus"},{"key":"10.1016\/j.clnesp.2024.04.024_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/S2213-8587(23)00119-5","article-title":"Metabolic non-communicable disease health report of India: the ICMR-INDIAB national cross-sectional study (ICMR-INDIAB-17)","author":"Anjana","year":"2023","journal-title":"Lancet Diabetes Endocrinol"}],"container-title":["Clinical Nutrition ESPEN"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405457724001189?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405457724001189?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T20:22:09Z","timestamp":1718742129000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405457724001189"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":15,"alternative-id":["S2405457724001189"],"URL":"https:\/\/doi.org\/10.1016\/j.clnesp.2024.04.024","relation":{},"ISSN":["2405-4577"],"issn-type":[{"value":"2405-4577","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of calcium supplementation on reversing metformin-based inhibition of vitamin B12 bioavailability in healthy adults using a [13C] cyanocobalamin tracer \u2013 A pilot study","name":"articletitle","label":"Article Title"},{"value":"Clinical Nutrition ESPEN","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clnesp.2024.04.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}