{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T10:00:26Z","timestamp":1755597626387,"version":"3.37.3"},"reference-count":59,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","clinicalnutritionespen.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Nutrition ESPEN"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.clnesp.2024.09.018","type":"journal-article","created":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T06:36:34Z","timestamp":1727418994000},"page":"100-106","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["The causal relationship between hydatidiform mole and nutrients: A two-sample Mendelian randomization study"],"prefix":"10.1016","volume":"64","author":[{"given":"Guohua","family":"Zhu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tingting","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruhe","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5413-7836","authenticated-orcid":false,"given":"Yan","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.clnesp.2024.09.018_bib1","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1097\/IGC.0000000000000754","article-title":"A\u00a0reappraisal of the incidence of placental hydatidiform mole using selective molecular genotyping","volume":"26","author":"Colgan","year":"2016","journal-title":"Int J Gynecol Cancer"},{"key":"10.1016\/j.clnesp.2024.09.018_bib2","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.ygyno.2015.11.014","article-title":"Trends in incidence for gestational trophoblastic disease over the last 20 years in a population-based study","volume":"140","author":"Eysbouts","year":"2016","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.clnesp.2024.09.018_bib3","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1080\/0284186X.2018.1438653","article-title":"Temporal trends in incidence and outcome of hydatidiform mole: a retrospective cohort study","volume":"57","author":"Joneborg","year":"2018","journal-title":"Acta Oncol"},{"key":"10.1016\/j.clnesp.2024.09.018_bib4","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1146\/annurev-pathol-052016-100237","article-title":"Hydatidiform moles: genetic basis and precision diagnosis","volume":"12","author":"Hui","year":"2017","journal-title":"Annu Rev Pathol"},{"issue":"Suppl 1","key":"10.1016\/j.clnesp.2024.09.018_bib5","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1002\/ijgo.13877","article-title":"Diagnosis and management of gestational trophoblastic disease: 2021 update","volume":"155","author":"Ngan","year":"2021","journal-title":"Int J Gynaecol Obstet"},{"key":"10.1016\/j.clnesp.2024.09.018_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.eujim.2022.102179","article-title":"Effect of a diet based on Iranian traditional medicine on inflammatory markers and clinical outcomes in COVID-19 patients: a double-blind, randomized, controlled trial","volume":"55","author":"Hajibeygi","year":"2022","journal-title":"Eur J Integr Med"},{"key":"10.1016\/j.clnesp.2024.09.018_bib7","doi-asserted-by":"crossref","first-page":"3556","DOI":"10.1080\/01635581.2022.2079688","article-title":"Dietary factors and incidence of hydatidiform mole: an ecological study","volume":"74","author":"Wang","year":"2022","journal-title":"Nutr Cancer"},{"key":"10.1016\/j.clnesp.2024.09.018_bib8","doi-asserted-by":"crossref","first-page":"55","DOI":"10.34172\/ddj.2023.428","article-title":"The role of vitamins deficiency in the development of hydatidiform moles: mechanism and function","volume":"12","author":"Banaei","year":"2022","journal-title":"Dis Diagn"},{"key":"10.1016\/j.clnesp.2024.09.018_bib9","article-title":"Relationship between vitamin levels and history of hydatiform mole in women: a systematic review study","volume":"23","author":"Banaei","year":"2020","journal-title":"IJOGI"},{"key":"10.1016\/j.clnesp.2024.09.018_bib10","doi-asserted-by":"crossref","DOI":"10.6061\/clinics\/2020\/e1724","article-title":"Association between antioxidant vitamins and oxidative stress among patients with a complete hydatidiform mole","volume":"75","author":"Ferraz","year":"2020","journal-title":"Clinics"},{"key":"10.1016\/j.clnesp.2024.09.018_bib11","first-page":"4991","article-title":"The relationship between complete hydatidiform mole and serum Vitamin D level: a prospective case-control study","volume":"26","author":"G\u00fcnd\u00fcz","year":"2022","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"10.1016\/j.clnesp.2024.09.018_bib12","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1093\/humupd\/dmi021","article-title":"Hyperemesis gravidarum, a literature review","volume":"11","author":"Verberg","year":"2005","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.clnesp.2024.09.018_bib13","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.34408","article-title":"The MR-Base platform supports systematic causal inference across the human phenome","volume":"7","author":"Hemani","year":"2018","journal-title":"Elife"},{"key":"10.1016\/j.clnesp.2024.09.018_bib14","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1001\/jama.2021.18236","article-title":"Strengthening the reporting of observational studies in epidemiology using mendelian randomization: the STROBE-MR statement","volume":"326","author":"Skrivankova","year":"2021","journal-title":"JAMA"},{"key":"10.1016\/j.clnesp.2024.09.018_bib15","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2023.31558","article-title":"Genetic variants, serum 25-hydroxyvitamin D levels, and sarcopenia: a mendelian randomization analysis","volume":"6","author":"Sha","year":"2023","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.clnesp.2024.09.018_bib16","doi-asserted-by":"crossref","DOI":"10.1093\/pcmedi\/pbad023","article-title":"Investigating the gut microbiota's influence on psoriasis and psoriatic arthritis risk: a Mendelian randomization analysis","volume":"6","author":"Yu","year":"2023","journal-title":"Precis Clin Med"},{"key":"10.1016\/j.clnesp.2024.09.018_bib17","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.746998","article-title":"Causal relationship between gut microbiota and autoimmune diseases: a two-sample mendelian randomization study","volume":"12","author":"Xu","year":"2022","journal-title":"Front Immunol"},{"author":"Elsworth","key":"10.1016\/j.clnesp.2024.09.018_bib18"},{"key":"10.1016\/j.clnesp.2024.09.018_bib19","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1111\/add.16019","article-title":"Education plays a crucial role in the pathway from poverty to smoking: a Mendelian randomization study","volume":"118","author":"Shi","year":"2023","journal-title":"Addiction"},{"key":"10.1016\/j.clnesp.2024.09.018_bib20","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1093\/ije\/dyv080","article-title":"Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression","volume":"44","author":"Bowden","year":"2015","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.clnesp.2024.09.018_bib21","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1002\/gepi.21758","article-title":"Mendelian randomization analysis with multiple genetic variants using summarized data","volume":"37","author":"Burgess","year":"2013","journal-title":"Genet Epidemiol"},{"key":"10.1016\/j.clnesp.2024.09.018_bib22","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/s41588-018-0099-7","article-title":"Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases","volume":"50","author":"Verbanck","year":"2018","journal-title":"Nat Genet"},{"key":"10.1016\/j.clnesp.2024.09.018_bib23","doi-asserted-by":"crossref","first-page":"129","DOI":"10.17532\/jhsci.2013.77","article-title":"Epidemiological factors and pathomorphologic characteristics of hydatidiform mole","volume":"3","author":"Muminhod\u017ei\u0107","year":"2013","journal-title":"JHSCI"},{"key":"10.1016\/j.clnesp.2024.09.018_bib24","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1097\/AOG.0000000000004240","article-title":"Gestational trophoblastic disease: current evaluation and management","volume":"137","author":"Soper","year":"2021","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.clnesp.2024.09.018_bib25","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1002\/humu.24439","article-title":"Biallelic NLRP7 variants in patients with recurrent hydatidiform mole: a review and expert consensus","volume":"43","author":"Slim","year":"2022","journal-title":"Hum Mutat"},{"key":"10.1016\/j.clnesp.2024.09.018_bib26","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/s13073-019-0694-y","article-title":"A\u00a0KHDC3L mutation resulting in recurrent hydatidiform mole causes genome-wide DNA methylation loss in oocytes and persistent imprinting defects post-fertilisation","volume":"11","author":"Demond","year":"2019","journal-title":"Genome Med"},{"key":"10.1016\/j.clnesp.2024.09.018_bib27","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s00428-020-02802-y","article-title":"Germline NLRP7 mutations: genomic imprinting and hydatidiform mole","volume":"477","author":"Hui","year":"2020","journal-title":"Virchows Arch"},{"key":"10.1016\/j.clnesp.2024.09.018_bib28","doi-asserted-by":"crossref","DOI":"10.1210\/endocr\/bqaa023","article-title":"Roles of vitamin D in reproductive systems and assisted reproductive technology","volume":"161","author":"Chen","year":"2020","journal-title":"Endocrinology"},{"key":"10.1016\/j.clnesp.2024.09.018_bib29","doi-asserted-by":"crossref","first-page":"678","DOI":"10.3390\/nu16050678","article-title":"Epigenetic genome modifications during pregnancy: the impact of essential nutritional supplements on DNA methylation","volume":"16","author":"Socha","year":"2024","journal-title":"Nutrients"},{"key":"10.1016\/j.clnesp.2024.09.018_bib30","first-page":"314","article-title":"Folate deficiency and pregnancy outcome","volume":"49","year":"1991","journal-title":"Nutr Rev"},{"key":"10.1016\/j.clnesp.2024.09.018_bib31","first-page":"1","article-title":"Maternal usage of varying levels of dietary folate affects the postnatal development of cerebellar folia and cortical layer volumes","author":"Mwachaka","year":"2024","journal-title":"Nutr Neurosci"},{"key":"10.1016\/j.clnesp.2024.09.018_bib32","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1055\/s-0034-1383058","article-title":"Folate metabolism and human reproduction","volume":"74","author":"Thaler","year":"2014","journal-title":"Geburtshilfe Frauenheilkd"},{"key":"10.1016\/j.clnesp.2024.09.018_bib33","first-page":"1336","article-title":"Methylenetetrahydrofolate reductase polymorphism affects the change in homocysteine and folate concentrations resulting from low dose folic acid supplementation in women with unexplained recurrent miscarriages","volume":"128","author":"Nelen","year":"1998","journal-title":"J\u00a0Nutr"},{"key":"10.1016\/j.clnesp.2024.09.018_bib34","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1056\/NEJM199911113412001","article-title":"Prevention of neural-tube defects with folic acid in China","volume":"341","author":"Berry","year":"1999","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.clnesp.2024.09.018_bib35","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1093\/ajcn\/nqaa259","article-title":"Knowledge gaps in understanding the metabolic and clinical effects of excess folates\/folic acid: a summary, and perspectives, from an NIH workshop","volume":"112","author":"Maruvada","year":"2020","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.clnesp.2024.09.018_bib36","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/nyas.13499","article-title":"Safety of folic acid","volume":"1414","author":"Field","year":"2018","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.clnesp.2024.09.018_bib37","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.biochi.2016.04.010","article-title":"Excessive folic acid intake and relation to adverse health outcome","volume":"126","author":"Selhub","year":"2016","journal-title":"Biochimie"},{"key":"10.1016\/j.clnesp.2024.09.018_bib38","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1038\/s41379-020-00668-8","article-title":"Methylation profiles of imprinted genes are distinct between mature ovarian teratoma, complete hydatidiform mole, and extragonadal mature teratoma","volume":"34","author":"Kato","year":"2021","journal-title":"Mod Pathol"},{"key":"10.1016\/j.clnesp.2024.09.018_bib39","doi-asserted-by":"crossref","first-page":"4999","DOI":"10.3390\/ijms20204999","article-title":"Dysregulation of placental functions and immune pathways in complete hydatidiform moles","volume":"20","author":"King","year":"2019","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.clnesp.2024.09.018_bib40","doi-asserted-by":"crossref","DOI":"10.1093\/eep\/dvaa018","article-title":"Impact of mothers' early life exposure to low or high folate on progeny outcome and DNA methylation patterns","volume":"6","author":"Ly","year":"2020","journal-title":"Environmental Epigenetics"},{"year":"2016","series-title":"Crosstalk between vitamin B and immunity","author":"Conti","key":"10.1016\/j.clnesp.2024.09.018_bib41"},{"key":"10.1016\/j.clnesp.2024.09.018_bib42","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1046\/j.1523-5408.2001.00142.x","article-title":"The effects of vitamin E, vitamin B 6 , and vitamin B 12 on immune function","volume":"4","author":"Gay","year":"2001","journal-title":"Nutr Clin Care"},{"key":"10.1016\/j.clnesp.2024.09.018_bib43","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1186\/1471-2105-10-273","article-title":"The B6 database: a tool for the description and classification of vitamin B6-dependent enzymatic activities and of the corresponding protein families","volume":"10","author":"Percudani","year":"2009","journal-title":"BMC Bioinf"},{"key":"10.1016\/j.clnesp.2024.09.018_bib44","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.nut.2007.12.003","article-title":"Plasma pyridoxal 5\u2032-phosphate and high-sensitivity C-reactive protein are independently associated with an increased risk of coronary artery disease","volume":"24","author":"Cheng","year":"2008","journal-title":"Nutrition"},{"key":"10.1016\/j.clnesp.2024.09.018_bib45","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1161\/01.STR.0000106481.59944.2F","article-title":"Inflammation, homocysteine, and vitamin B6 status after ischemic stroke","volume":"35","author":"Kelly","year":"2004","journal-title":"Stroke"},{"key":"10.1016\/j.clnesp.2024.09.018_bib46","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.3324\/haematol.11318","article-title":"Low vitamin B6 levels and the risk of recurrent venous thromboembolism","volume":"92","author":"Hron","year":"2007","journal-title":"Haematologica"},{"key":"10.1016\/j.clnesp.2024.09.018_bib47","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1111\/j.1749-6632.1990.tb28073.x","article-title":"Regulation of immune responses by vitamin B6","volume":"585","author":"Chandra","year":"1990","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.clnesp.2024.09.018_bib48","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1111\/j.1753-4887.1993.tb03109.x","article-title":"Vitamin B6 and immune competence","volume":"51","author":"Rall","year":"1993","journal-title":"Nutr Rev"},{"key":"10.1016\/j.clnesp.2024.09.018_bib49","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1271\/bbb.62.1008","article-title":"Effects of vitamin B6 deficiency on cytokine levels and lymphocytes in mice","volume":"62","author":"Doke","year":"1998","journal-title":"Biosci, Biotechnol, Biochem"},{"key":"10.1016\/j.clnesp.2024.09.018_bib50","doi-asserted-by":"crossref","first-page":"8199","DOI":"10.3390\/nu7095388","article-title":"Magnesium in prevention and therapy","volume":"7","author":"Gr\u00f6ber","year":"2015","journal-title":"Nutrients"},{"key":"10.1016\/j.clnesp.2024.09.018_bib51","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1007\/s001080050249","article-title":"St\u00f6rungen des Magnesiumhaushalts","volume":"39","author":"Kisters","year":"1998","journal-title":"Internist"},{"key":"10.1016\/j.clnesp.2024.09.018_bib52","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1056\/NEJMra1503102","article-title":"Electrolyte and acid-base disturbances in patients with diabetes mellitus","volume":"373","author":"Palmer","year":"2015","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.clnesp.2024.09.018_bib53","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1016\/j.amjhyper.2005.02.007","article-title":"Pulse pressure, plasma magnesium status, and antihypertensive therapy","volume":"18","author":"Kisters","year":"2005","journal-title":"Am J Hypertens"},{"key":"10.1016\/j.clnesp.2024.09.018_bib54","first-page":"493","article-title":"Trace elements in the serum and cancerous tissue in patients with trophoblastic carcinoma","volume":"69","author":"Fu","year":"1989","journal-title":"Zhonghua Yixue Zazhi"},{"key":"10.1016\/j.clnesp.2024.09.018_bib55","article-title":"A\u00a0Case-control study of vitamin A level in hydatidiform mole","volume":"153","author":"Andrijono","year":"1997","journal-title":"Med J Indones"},{"key":"10.1016\/j.clnesp.2024.09.018_bib56","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0002-9378(88)90785-5","article-title":"Dietary factors and risk of trophoblastic disease","volume":"158","author":"Parazzini","year":"1988","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.clnesp.2024.09.018_bib57","first-page":"285","article-title":"Serum levels of folate, vitamin B12 and homocysteine in complete hydatidiform mole","volume":"49","author":"Harma","year":"2004","journal-title":"J\u00a0Reprod Med"},{"key":"10.1016\/j.clnesp.2024.09.018_bib58","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1007\/s00404-008-0637-0","article-title":"Plasma homocysteine, vitamin B12 and folate levels in hydatidiform moles and histopathological subtypes","volume":"278","author":"Kokanal\u0131","year":"2008","journal-title":"Arch Gynecol Obstet"},{"key":"10.1016\/j.clnesp.2024.09.018_bib59","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.nutos.2022.06.006","article-title":"The effect of Vitamin C and Zn supplementation on the immune system and clinical outcomes in COVID-19 patients","volume":"44","author":"Firouzi","year":"2022","journal-title":"Clin Nutr Open Sci"}],"container-title":["Clinical Nutrition ESPEN"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405457724013226?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405457724013226?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,2]],"date-time":"2024-12-02T12:44:02Z","timestamp":1733143442000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405457724013226"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":59,"alternative-id":["S2405457724013226"],"URL":"https:\/\/doi.org\/10.1016\/j.clnesp.2024.09.018","relation":{},"ISSN":["2405-4577"],"issn-type":[{"type":"print","value":"2405-4577"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The causal relationship between hydatidiform mole and nutrients: A two-sample Mendelian randomization study","name":"articletitle","label":"Article Title"},{"value":"Clinical Nutrition ESPEN","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clnesp.2024.09.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}