{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:11:22Z","timestamp":1779235882026,"version":"3.51.4"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","clinicalnutritionespen.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Nutrition ESPEN"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.clnesp.2025.06.045","type":"journal-article","created":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T13:37:48Z","timestamp":1751377068000},"page":"31-36","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Safety and clinical efficacy of early enteral nutrition in children with extracorporeal membrane oxygenation: A retrospective cohort study"],"prefix":"10.1016","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-0595-0518","authenticated-orcid":false,"given":"Jinjiu","family":"Hu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiaoying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Wan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiufan","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YangFan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiao","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ye","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yonglin","family":"Weng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuqian","family":"Meng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2224-4922","authenticated-orcid":false,"given":"Xianlan","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.clnesp.2025.06.045_bib1","doi-asserted-by":"crossref","first-page":"2204","DOI":"10.1097\/CCM.0b013e31824e18a8","article-title":"Nutritional practices and their relationship to clinical outcomes in critically ill children--an international multicenter cohort study","volume":"40","author":"Mehta","year":"2012","journal-title":"Crit Care Med"},{"key":"10.1016\/j.clnesp.2025.06.045_bib2","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1097\/MAT.0000000000001767","article-title":"Extracorporeal life support organization guidelines for the provision and assessment of nutritional support in the neonatal and pediatric ECMO patient","volume":"68","author":"Lee","year":"2022","journal-title":"ASAIO J"},{"key":"10.1016\/j.clnesp.2025.06.045_bib3","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s13019-015-0211-3","article-title":"The influence of extracorporeal membrane oxygenation therapy on intestinal mucosal barrier in a porcine model for post-traumatic acute respiratory distress syndrome","volume":"10","author":"Ni","year":"2015","journal-title":"J Cardiothorac Surg"},{"key":"10.1016\/j.clnesp.2025.06.045_bib4","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1203\/PDR.0b013e3181e4c9f8","article-title":"Extracorporeal membrane oxygenation causes loss of intestinal epithelial barrier in the newborn piglet","volume":"68","author":"Kurundkar","year":"2010","journal-title":"Pediatr Res"},{"key":"10.1016\/j.clnesp.2025.06.045_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.nut.2021.111222","article-title":"Early enteral nutrition and factors related to in-hospital mortality in people on extracorporeal membrane oxygenation","volume":"89","author":"Kim","year":"2021","journal-title":"Nutrition"},{"key":"10.1016\/j.clnesp.2025.06.045_bib6","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1016\/j.clnu.2023.07.021","article-title":"Safety and outcome of early enteral nutrition in patients receiving extracorporeal membrane oxygenation","volume":"42","author":"Lu","year":"2023","journal-title":"Clin Nutr"},{"key":"10.1016\/j.clnesp.2025.06.045_bib7","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1002\/jpen.2467","article-title":"Medical nutrition therapy in patients receiving ECMO: evidence-Based guidance for clinical practice","volume":"47","author":"Dresen","year":"2023","journal-title":"JPEN - J Parenter Enter Nutr"},{"key":"10.1016\/j.clnesp.2025.06.045_bib8","doi-asserted-by":"crossref","first-page":"2778","DOI":"10.21037\/tp-20-349","article-title":"Enteral feeding and the microbiome in critically ill children: a narrative review","volume":"10","author":"Fan","year":"2021","journal-title":"Transl Pediatr"},{"key":"10.1016\/j.clnesp.2025.06.045_bib9","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/s00134-019-05922-5","article-title":"Nutritional support for children during critical illness: European society of pediatric and neonatal intensive care (ESPNIC) metabolism, endocrine and nutrition section position statement and clinical recommendations","volume":"46","author":"Tume","year":"2020","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.clnesp.2025.06.045_bib10","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1177\/0148607117711387","article-title":"Guidelines for the provision and assessment of nutrition support therapy in the pediatric critically ill patient: society of critical care medicine and American society for parenteral and enteral nutrition","volume":"41","author":"Mehta","year":"2017","journal-title":"J Parenter Enteral Nutr"},{"key":"10.1016\/j.clnesp.2025.06.045_bib11","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1097\/MPG.0000000000003317","article-title":"Early enteral nutrition and gastrointestinal complications in pediatric patients on extracorporeal membrane oxygenation","volume":"74","author":"Perez","year":"2022","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.clnesp.2025.06.045_bib12","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1097\/MPG.0000000000003496","article-title":"Vasopressors and enteral nutrition in the survival rate of children during extracorporeal membrane oxygenation","volume":"75","author":"Alexander","year":"2022","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.clnesp.2025.06.045_bib13","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1177\/0148607114546533","article-title":"Safety of enteral feedings in critically ill children receiving vasoactive agents","volume":"40","author":"Panchal","year":"2016","journal-title":"J Parenter Enteral Nutr"},{"key":"10.1016\/j.clnesp.2025.06.045_bib14","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.clnesp.2018.05.005","article-title":"Nutritional practices and adequacy in children supported on extracorporeal membrane oxygenation","volume":"26","author":"Ong","year":"2018","journal-title":"Clinical Nutrition ESPEN"},{"key":"10.1016\/j.clnesp.2025.06.045_bib15","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1002\/ncp.10922","article-title":"Early vs late enteral nutrition in pediatric intensive care unit: barriers, benefits, and complications","volume":"38","author":"Jose Solana","year":"2023","journal-title":"Nutr Clin Pract"},{"key":"10.1016\/j.clnesp.2025.06.045_bib16","article-title":"Research progress on nutritional support in the neonatal and pediatric populations receiving extracorporeal membrane oxygenation","volume":"11","author":"Zhang","year":"2024","journal-title":"Front Nutr"},{"key":"10.1016\/j.clnesp.2025.06.045_bib17","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1002\/jpen.2626","article-title":"Enteral nutrition in children and adolescents who receive extracorporeal membrane oxygenation and its impact on complications and mortality: a systematic review and meta-analysis","volume":"48","author":"Li","year":"2024","journal-title":"J Parenter Enteral Nutr"},{"key":"10.1016\/j.clnesp.2025.06.045_bib18","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1002\/jpen.1032","article-title":"Impact of early initiation of enteral nutrition on survival during pediatric extracorporeal membrane oxygenation","volume":"42","author":"Greathouse","year":"2018","journal-title":"J Parenter Enteral Nutr"},{"key":"10.1016\/j.clnesp.2025.06.045_bib19","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.clnu.2019.03.026","article-title":"Definitions, predictors and outcomes of feeding intolerance in critically ill children: a systematic review","volume":"39","author":"Eveleens","year":"2020","journal-title":"Clin Nutr"},{"key":"10.1016\/j.clnesp.2025.06.045_bib20","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1111\/aor.14246","article-title":"Risk factors of pediatric venoarterial extracorporeal membrane oxygenation-related gastrointestinal bleeding after open-heart surgeries","volume":"46","author":"Yang","year":"2022","journal-title":"Artif Organs"},{"key":"10.1016\/j.clnesp.2025.06.045_bib21","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1097\/PCC.0000000000000474","article-title":"Neuroimaging, pain sensitivity, and neuropsychological functioning in school-age neonatal extracorporeal membrane oxygenation survivors exposed to opioids and sedatives","volume":"16","author":"van den Bosch","year":"2015","journal-title":"Pediatr Crit Care Med"},{"key":"10.1016\/j.clnesp.2025.06.045_bib22","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S2468-1253(18)30008-6","article-title":"Pathophysiology, diagnosis, and management of opioid-induced constipation","volume":"3","author":"Farmer","year":"2018","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"10.1016\/j.clnesp.2025.06.045_bib23","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1177\/0148607116673185","article-title":"Underweight status is an independent predictor of In-Hospital mortality in pediatric patients on extracorporeal membrane oxygenation","volume":"42","author":"Anton-Martin","year":"2018","journal-title":"J Parenter Enteral Nutr"},{"key":"10.1016\/j.clnesp.2025.06.045_bib24","doi-asserted-by":"crossref","first-page":"692","DOI":"10.37290\/ctnr2641-452X.22:692-696","article-title":"Parenteral versus enteral nutrition on perioperative cognitive function in anesthesia patients","volume":"22","author":"Gao","year":"2024","journal-title":"Curr Top Nutraceutical Res"},{"key":"10.1016\/j.clnesp.2025.06.045_bib25","article-title":"Changes of gut microbiota under different nutritional methods in elderly patients with severe COVID-19 and their relationship with prognosis","volume":"14","author":"Zhang","year":"2023","journal-title":"Front Immunol"}],"container-title":["Clinical Nutrition ESPEN"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405457725003924?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405457725003924?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T23:53:18Z","timestamp":1779234798000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405457725003924"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":25,"alternative-id":["S2405457725003924"],"URL":"https:\/\/doi.org\/10.1016\/j.clnesp.2025.06.045","relation":{},"ISSN":["2405-4577"],"issn-type":[{"value":"2405-4577","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Safety and clinical efficacy of early enteral nutrition in children with extracorporeal membrane oxygenation: A retrospective cohort study","name":"articletitle","label":"Article Title"},{"value":"Clinical Nutrition ESPEN","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clnesp.2025.06.045","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}