{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T02:32:15Z","timestamp":1784255535089,"version":"3.55.0"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100030953","name":"Tokyo Metropolitan Institute for Geriatrics and Gerontology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100030953","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","clinicalnutritionespen.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Nutrition ESPEN"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.clnesp.2025.07.006","type":"journal-article","created":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T11:20:13Z","timestamp":1751887213000},"page":"133-139","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Identification of metabolites associated with the development of sarcopenia in older women: A longitudinal nested case\u2013control study"],"prefix":"10.1016","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9788-2411","authenticated-orcid":false,"given":"Takashi","family":"Shida","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sho","family":"Hatanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narumi","family":"Kojima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahisa","family":"Ohta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazushi","family":"Maruo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosuke","family":"Osuka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Sasai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clnesp.2025.07.006_bib1","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.jamda.2019.12.012","article-title":"Asian working group for Sarcopenia: 2019 consensus update on Sarcopenia diagnosis and treatment","volume":"21","author":"Chen","year":"2020","journal-title":"J Am Med Dir Assoc"},{"key":"10.1016\/j.clnesp.2025.07.006_bib2","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1016\/j.jamda.2023.07.007","article-title":"Predictive capability of 5 sarcopenia diagnostic criteria for fall incidents in older Japanese women: the Otassha study","volume":"24","author":"Wakaba","year":"2023","journal-title":"J Am Med Dir Assoc"},{"key":"10.1016\/j.clnesp.2025.07.006_bib3","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1093\/ageing\/afq034","article-title":"Sarcopenia: european consensus on definition and diagnosis: report of the European working group on sarcopenia in older people","volume":"39","author":"Cruz-Jentoft","year":"2010","journal-title":"Age Ageing"},{"key":"10.1016\/j.clnesp.2025.07.006_bib4","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1007\/s12603-014-0465-9","article-title":"Sarcopenia according to the European working group on sarcopenia in older people (EWGSOP) versus dynapenia as a risk factor for disability in the elderly","volume":"18","author":"da Silva Alexandre","year":"2014","journal-title":"J Nutr Health Aging"},{"key":"10.1016\/j.clnesp.2025.07.006_bib5","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1093\/gerona\/glu034","article-title":"Association of sarcopenia with short- and long-term mortality in older adults admitted to acute care wards: results from the CRIME study","volume":"69","author":"Vetrano","year":"2014","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"10.1016\/j.clnesp.2025.07.006_bib6","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.jamda.2011.07.004","article-title":"Sarcopenia and mortality among older nursing home residents","volume":"13","author":"Landi","year":"2012","journal-title":"J Am Med Dir Assoc"},{"key":"10.1016\/j.clnesp.2025.07.006_bib7","doi-asserted-by":"crossref","first-page":"2636","DOI":"10.1016\/S0140-6736(19)31138-9","article-title":"Sarcopenia","volume":"393","author":"Cruz-Jentoft","year":"2019","journal-title":"Lancet"},{"key":"10.1016\/j.clnesp.2025.07.006_bib8","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.maturitas.2018.11.003","article-title":"The health economics burden of sarcopenia: a systematic review","volume":"119","author":"Bruy\u00e8re","year":"2019","journal-title":"Maturitas"},{"key":"10.1016\/j.clnesp.2025.07.006_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2021.101530","article-title":"Biomarkers shared by frailty and sarcopenia in older adults: a systematic review and meta-analysis","volume":"73","author":"Picca","year":"2022","journal-title":"Ageing Res Rev"},{"key":"10.1016\/j.clnesp.2025.07.006_bib10","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.3390\/cells11101698","article-title":"Redox control of signalling responses to contractile activity and ageing in skeletal muscle","volume":"11","author":"Jackson","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.clnesp.2025.07.006_bib11","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.18632\/aging.203926","article-title":"Pathway-based metabolomics study of sarcopenia-related traits in two US cohorts","volume":"14","author":"Zhao","year":"2022","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.clnesp.2025.07.006_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.exger.2022.111924","article-title":"Metabolomic profiles to explore biomarkers of severe sarcopenia in older men: a pilot study","volume":"167","author":"Shin","year":"2022","journal-title":"Exp Gerontol"},{"key":"10.1016\/j.clnesp.2025.07.006_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2022.101576","article-title":"Multi-omics research in sarcopenia: current progress and future prospects","volume":"76","author":"Liu","year":"2022","journal-title":"Ageing Res Rev"},{"key":"10.1016\/j.clnesp.2025.07.006_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2020.101164","article-title":"Promising biomarkers of human aging: in search of a multi-omics panel to understand the aging process from a multidimensional perspective","volume":"64","author":"Rivero-Segura","year":"2020","journal-title":"Ageing Res Rev"},{"key":"10.1016\/j.clnesp.2025.07.006_bib15","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1021\/ac403845u","article-title":"Development and quantitative evaluation of a high-resolution metabolomics technology","volume":"86","author":"Liu","year":"2014","journal-title":"Anal Chem"},{"key":"10.1016\/j.clnesp.2025.07.006_bib16","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1002\/jcsm.12895","article-title":"Identification of traumatic acid as a potential plasma biomarker for sarcopenia using a metabolomics-based approach","volume":"13","author":"Tsai","year":"2022","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"10.1016\/j.clnesp.2025.07.006_bib17","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.725518","article-title":"Signatures and clinical significance of amino acid flux in sarcopenia: a systematic review and meta-analysis","volume":"12","author":"Dai","year":"2021","journal-title":"Front Endocrinol"},{"key":"10.1016\/j.clnesp.2025.07.006_bib18","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s41999-023-00914-7","article-title":"Identification of a novel biomarker for sarcopenia diagnosis using serum metabolomic analysis: a pilot study","volume":"15","author":"Shida","year":"2024","journal-title":"Eur Geriatr Med"},{"key":"10.1016\/j.clnesp.2025.07.006_bib19","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1007\/s00774-023-01457-4","article-title":"Vitamin K insufficiency predicts incidence of frailty in community-dwelling older adults: the Otassha study","volume":"41","author":"Azuma","year":"2023","journal-title":"J Bone Miner Metabol"},{"key":"10.1016\/j.clnesp.2025.07.006_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v042.i08","article-title":"MatchIt: nonparametric preprocessing for parametric causal inference","volume":"42","author":"Ho","year":"2011","journal-title":"J Stat Software"},{"key":"10.1016\/j.clnesp.2025.07.006_bib21","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1186\/s40064-016-1809-1","article-title":"Simultaneous detection of lysine metabolites by a single LC-MS\/MS method: monitoring lysine degradation in mouse plasma","volume":"5","author":"Pena","year":"2016","journal-title":"SpringerPlus"},{"key":"10.1016\/j.clnesp.2025.07.006_bib22","doi-asserted-by":"crossref","first-page":"4309","DOI":"10.1172\/JCI64801","article-title":"2-Aminoadipic acid is a biomarker for diabetes risk","volume":"123","author":"Wang","year":"2013","journal-title":"J Clin Investig"},{"key":"10.1016\/j.clnesp.2025.07.006_bib23","article-title":"2-Aminoadipic acid (2-AAA) as a potential biomarker for insulin resistance in childhood obesity","volume":"9","author":"Lee","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/j.clnesp.2025.07.006_bib24","doi-asserted-by":"crossref","first-page":"2168","DOI":"10.1080\/09168451.2016.1210499","article-title":"Regulatory effects of the L-lysine metabolites, L-2-aminoadipic acid and L-pipecolic acid, on protein turnover in C2C12 myotubes","volume":"80","author":"Sato","year":"2016","journal-title":"Biosci Biotechnol Biochem"},{"key":"10.1016\/j.clnesp.2025.07.006_bib25","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s10522-016-9663-7","article-title":"L-Lysine suppresses myofibrillar protein degradation and autophagy in skeletal muscles of senescence-accelerated mouse prone 8","volume":"18","author":"Sato","year":"2017","journal-title":"Biogerontology"},{"key":"10.1016\/j.clnesp.2025.07.006_bib26","doi-asserted-by":"crossref","first-page":"330","DOI":"10.3390\/nu15020330","article-title":"Branched-chain amino acids and di-alanine supplementation in aged mice: a translational study on sarcopenia","volume":"15","author":"Mantuano","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.clnesp.2025.07.006_bib27","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s12970-018-0238-7","article-title":"\u03b2-Alanine supplementation increased physical performance and improved executive function following endurance exercise in middle-aged individuals","volume":"15","author":"Furst","year":"2018","journal-title":"J Int Soc Sports Nutr"},{"key":"10.1016\/j.clnesp.2025.07.006_bib28","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1096\/fj.04-2640fje","article-title":"Anabolic signaling deficits underlie amino acid resistance of wasting, aging muscle","volume":"19","author":"Cuthbertson","year":"2005","journal-title":"FASEB J"},{"issue":"1","key":"10.1016\/j.clnesp.2025.07.006_bib29","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1053\/j.jrn.2004.09.009","article-title":"Metabolic consequences of physical inactivity","volume":"15","author":"Biolo","year":"2005","journal-title":"J Ren Nutr"},{"key":"10.1016\/j.clnesp.2025.07.006_bib30","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1093\/ajcn\/nqy202","article-title":"Serum metabolites associated with dietary protein intake: results from the modification of diet in renal disease (MDRD) randomized clinical trial","volume":"109","author":"Rebholz","year":"2019","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.clnesp.2025.07.006_bib31","article-title":"Metabolite 2-aminoadipic acid: implications for metabolic disorders and therapeutic opportunities","volume":"16","author":"Shi","year":"2025","journal-title":"Front Pharmacol"}],"container-title":["Clinical Nutrition ESPEN"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405457725017565?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405457725017565?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T23:53:03Z","timestamp":1779234783000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405457725017565"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":31,"alternative-id":["S2405457725017565"],"URL":"https:\/\/doi.org\/10.1016\/j.clnesp.2025.07.006","relation":{},"ISSN":["2405-4577"],"issn-type":[{"value":"2405-4577","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification of metabolites associated with the development of sarcopenia in older women: A longitudinal nested case\u2013control study","name":"articletitle","label":"Article Title"},{"value":"Clinical Nutrition ESPEN","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clnesp.2025.07.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}