{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:12:03Z","timestamp":1779235923840,"version":"3.51.4"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","clinicalnutritionespen.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Nutrition ESPEN"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.clnesp.2025.07.1132","type":"journal-article","created":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T23:01:41Z","timestamp":1754434901000},"page":"477-481","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Relationship between body mass index and nutritional status across genetic subtypes of Prader-Willi syndrome"],"prefix":"10.1016","volume":"69","author":[{"given":"Romina","family":"Ceccomancini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Delfina","family":"Mendiola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Let\u00edcia","family":"Nunes-Campos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorgelina","family":"Stegmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.clnesp.2025.07.1132_bib1","doi-asserted-by":"crossref","first-page":"579","DOI":"10.2147\/DMSO.S141352","article-title":"Obesity management in Prader-Willi syndrome: current perspectives","volume":"11","author":"Crin\u00f2","year":"2018","journal-title":"Diabetes Metab Syndr Obes"},{"issue":"1","key":"10.1016\/j.clnesp.2025.07.1132_bib2","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1038\/gim.0b013e31822bead0","article-title":"Prader-Willi syndrome","volume":"14","author":"Cassidy","year":"2012","journal-title":"Genet Med"},{"key":"10.1016\/j.clnesp.2025.07.1132_bib3","doi-asserted-by":"crossref","first-page":"864","DOI":"10.3389\/fendo.2019.00864","article-title":"Genotype-phenotype relationships and endocrine findings in Prader-Willi syndrome","volume":"10","author":"Costa","year":"2019","journal-title":"Front Endocrinol"},{"key":"10.1016\/j.clnesp.2025.07.1132_bib4","first-page":"113","article-title":"Dietary management for adolescents with Prader-Willi syndrome","volume":"11","author":"Miller","year":"2020","journal-title":"Adolesc Health Med Ther"},{"issue":"6","key":"10.1016\/j.clnesp.2025.07.1132_bib5","doi-asserted-by":"crossref","first-page":"288","DOI":"10.3390\/genes9060288","article-title":"Hyperphagia and obesity in prader\u2212Willi syndrome: PCSK1 deficiency and beyond?","volume":"9","author":"Ramos-Molina","year":"2018","journal-title":"Genes (Basel)"},{"issue":"14","key":"10.1016\/j.clnesp.2025.07.1132_bib6","doi-asserted-by":"crossref","first-page":"4033","DOI":"10.3390\/jcm11144033","article-title":"Health problems in adults with Prader-Willi syndrome of different genetic subtypes: cohort study, meta-analysis and review of the literature","volume":"11","author":"Rosenberg","year":"2022","journal-title":"J Clin Med"},{"issue":"17","key":"10.1016\/j.clnesp.2025.07.1132_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.medcli.2009.06.014","article-title":"Diagn\u00f3stico del s\u00edndrome de Prader-Willi","volume":"133","author":"Garnacho","year":"2009","journal-title":"Med Clin (Barc)"},{"issue":"8","key":"10.1016\/j.clnesp.2025.07.1132_bib8","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1515\/jpem-2001-0805","article-title":"Sustained benefits of growth hormone on body composition, fat utilization, physical strength and agility, and growth in Prader-Willi syndrome are dose-dependent","volume":"14","author":"Carrel","year":"2001","journal-title":"J Pediatr Endocrinol Metab"},{"issue":"1","key":"10.1016\/j.clnesp.2025.07.1132_bib9","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1186\/s13023-020-01527-0","article-title":"Early start of growth hormone is associated with positive effects on auxology and metabolism in Prader-Willi-syndrome","volume":"15","author":"Magill","year":"2020","journal-title":"Orphanet J Rare Dis"},{"issue":"3\u20134","key":"10.1016\/j.clnesp.2025.07.1132_bib10","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1007\/s10354-007-0382-1","article-title":"Ver\u00e4nderung des Kohlenhydratstoffwechsels und der Insulinresistenz bei Patienten mit Prader-Willi-Syndrom unter einer Wachstumshormontherapie","volume":"157","author":"L\u00e4mmer","year":"2007","journal-title":"Wien Med Wochenschr"},{"issue":"8","key":"10.1016\/j.clnesp.2025.07.1132_bib11","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1249\/00005768-199208000-00020","article-title":"Anthropometric standardization reference manual","volume":"24","author":"Lohman","year":"1992","journal-title":"Med Sci Sports Exerc"},{"key":"10.1016\/j.clnesp.2025.07.1132_bib12","first-page":"76","article-title":"WHO child growth standards based on length\/height, weight and age","volume":"450","year":"2006","journal-title":"Acta Paediatr Suppl"},{"issue":"1","key":"10.1016\/j.clnesp.2025.07.1132_bib13","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/ijpo.12177","article-title":"Mechanisms of obesity in Prader-Willi syndrome","volume":"13","author":"Khan","year":"2018","journal-title":"Pediatr Obes"},{"issue":"10","key":"10.1016\/j.clnesp.2025.07.1132_bib14","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1007\/s40618-021-01574-9","article-title":"Obesity in Prader-Willi syndrome: physiopathological mechanisms, nutritional and pharmacological approaches","volume":"44","author":"Muscogiuri","year":"2021","journal-title":"J Endocrinol Investig"},{"key":"10.1016\/j.clnesp.2025.07.1132_bib15","series-title":"GeneReviews(\u00ae) [Internet]","article-title":"Prader-Willi syndrome","author":"Driscoll","year":"1993"},{"issue":"2","key":"10.1016\/j.clnesp.2025.07.1132_bib16","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1038\/sj.ijo.0803115","article-title":"Circulating adiponectin levels, body composition and obesity-related variables in Prader-Willi syndrome: comparison with obese subjects","volume":"30","author":"Kennedy","year":"2006","journal-title":"Int J Obes (Lond)"},{"issue":"10","key":"10.1016\/j.clnesp.2025.07.1132_bib17","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1038\/oby.2006.193","article-title":"Body composition and fatness patterns in Prader-Willi syndrome: comparison with simple obesity","volume":"14","author":"Theodoro","year":"2006","journal-title":"Obesity (Silver Spring)"},{"issue":"1","key":"10.1016\/j.clnesp.2025.07.1132_bib18","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/j.1399-0004.2005.00377.x","article-title":"Impact of molecular mechanisms, including deletion size, on Prader-Willi syndrome phenotype: study of 75 patients: phenotypic variability in PWS","volume":"67","author":"Varela","year":"2005","journal-title":"Clin Genet"},{"issue":"4","key":"10.1016\/j.clnesp.2025.07.1132_bib19","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1111\/cge.14477","article-title":"Genotype-phenotype correlation in Prader-Willi syndrome: a large-sample analysis in China","volume":"105","author":"Mao","year":"2024","journal-title":"Clin Genet"},{"issue":"7","key":"10.1016\/j.clnesp.2025.07.1132_bib20","doi-asserted-by":"crossref","first-page":"736","DOI":"10.3390\/genes11070736","article-title":"Growth trajectories in genetic subtypes of Prader-Willi syndrome","volume":"11","author":"Shepherd","year":"2020","journal-title":"Genes (Basel)"},{"issue":"1","key":"10.1016\/j.clnesp.2025.07.1132_bib21","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1002\/ajmg.a.61408","article-title":"Molecular subtype and growth hormone effects on dysmorphology in Prader-Willi syndrome","volume":"182","author":"Oldzej","year":"2020","journal-title":"Am J Med Genet A"},{"issue":"103952","key":"10.1016\/j.clnesp.2025.07.1132_bib22","article-title":"The paradox of Prader-Willi syndrome revisited: making sense of the phenotype","volume":"78","author":"Holland","year":"2022","journal-title":"EBioMedicine"},{"issue":"3","key":"10.1016\/j.clnesp.2025.07.1132_bib23","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1172\/JCI99725","article-title":"Hypothalamic loss of Snord116 and Prader-Willi syndrome hyperphagia: the buck stops here?","volume":"128","author":"Rodriguez","year":"2018","journal-title":"J Clin Investig"},{"issue":"8","key":"10.1016\/j.clnesp.2025.07.1132_bib24","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.185159","article-title":"Investigation of a mouse model of Prader-Willi syndrome with combined disruption of necdin and Magel2","volume":"10","author":"Barelle","year":"2025","journal-title":"JCI Insight"},{"issue":"1","key":"10.1016\/j.clnesp.2025.07.1132_bib25","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1186\/s13023-024-03157-2","article-title":"Investigating the correlation between genotype and phenotype in Prader-Willi syndrome: a study of 45 cases from Brazil","volume":"19","author":"Cintra","year":"2024","journal-title":"Orphanet J Rare Dis"},{"key":"10.1016\/j.clnesp.2025.07.1132_bib26","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2022.1041943","article-title":"Do the diverse phenotypes of Prader-Willi syndrome reflect extremes of covariation in typical populations?","volume":"13","author":"Salminen","year":"2022","journal-title":"Front Genet"},{"issue":"6","key":"10.1016\/j.clnesp.2025.07.1132_bib27","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0036889","article-title":"Changes in body weight and psychotropic drugs: a systematic synthesis of the literature","volume":"7","author":"Dent","year":"2012","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.clnesp.2025.07.1132_bib28","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1055\/a-2405-5087","article-title":"Metabolische unerw\u00fcnschte Arzneimittelwirkungen von Psychopharmaka","volume":"93","author":"Gahr","year":"2025","journal-title":"Fortschr Neurol Psychiatr"},{"issue":"Supplement 1","key":"10.1016\/j.clnesp.2025.07.1132_bib29","doi-asserted-by":"crossref","DOI":"10.2165\/00023210-200519001-00001","article-title":"Second-generation (atypical) antipsychotics and metabolic effects: a comprehensive literature review","volume":"19","author":"Newcomer","year":"2005","journal-title":"CNS Drugs"},{"issue":"4","key":"10.1016\/j.clnesp.2025.07.1132_bib30","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1093\/schbul\/sbaa191","article-title":"Does switching antipsychotics ameliorate weight gain in patients with severe mental illness? A systematic review and meta-analysis","volume":"47","author":"Siskind","year":"2021","journal-title":"Schizophr Bull"},{"issue":"8","key":"10.1016\/j.clnesp.2025.07.1132_bib31","first-page":"1505","article-title":"Metabolic adverse effects of psychotropic drug therapy: a systematic review","volume":"13","author":"Sep\u00falveda-Lizcano","year":"2023","journal-title":"Eur J Investig Health Psychol Educ"},{"issue":"5","key":"10.1016\/j.clnesp.2025.07.1132_bib32","doi-asserted-by":"crossref","first-page":"e32","DOI":"10.1111\/j.1467-789X.2010.00800.x","article-title":"Weight gain following treatment with valproic acid: pathogenetic mechanisms and clinical implications: valproic acid and weight gain","volume":"12","author":"Verrotti","year":"2011","journal-title":"Obes Rev"},{"issue":"4","key":"10.1016\/j.clnesp.2025.07.1132_bib33","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1089\/cap.2016.0133","article-title":"Effect of psychopharmacotherapy on body mass index among children and adolescents with bipolar disorders","volume":"27","author":"Patel","year":"2017","journal-title":"J Child Adolesc Psychopharmacol"},{"issue":"5","key":"10.1016\/j.clnesp.2025.07.1132_bib34","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1002\/ajmg.a.33951","article-title":"Nutritional phases in Prader-Willi syndrome","volume":"155A","author":"Miller","year":"2011","journal-title":"Am J Med Genet A"},{"issue":"9","key":"10.1016\/j.clnesp.2025.07.1132_bib35","doi-asserted-by":"crossref","first-page":"1950","DOI":"10.3390\/nu14091950","article-title":"Prader-Willi syndrome: possibilities of weight gain prevention and treatment","volume":"14","author":"Erhardt","year":"2022","journal-title":"Nutrients"},{"issue":"7","key":"10.1016\/j.clnesp.2025.07.1132_bib36","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1515\/JPEM.2008.21.7.651","article-title":"Successful early dietary intervention avoids obesity in patients with Prader-Willi syndrome: a ten-year follow-up","volume":"21","author":"Schmidt","year":"2008","journal-title":"J Pediatr Endocrinol Metab"}],"container-title":["Clinical Nutrition ESPEN"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405457725028839?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405457725028839?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T23:53:52Z","timestamp":1779234832000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405457725028839"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":36,"alternative-id":["S2405457725028839"],"URL":"https:\/\/doi.org\/10.1016\/j.clnesp.2025.07.1132","relation":{},"ISSN":["2405-4577"],"issn-type":[{"value":"2405-4577","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Relationship between body mass index and nutritional status across genetic subtypes of Prader-Willi syndrome","name":"articletitle","label":"Article Title"},{"value":"Clinical Nutrition ESPEN","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clnesp.2025.07.1132","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}