{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T23:18:23Z","timestamp":1785367103673,"version":"3.55.0"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","clinicalnutritionespen.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Nutrition ESPEN"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.clnesp.2025.11.157","type":"journal-article","created":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T17:28:44Z","timestamp":1764869324000},"page":"102837","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Application of machine learning to create a prediction model for the need of aggressive nutritional intervention during head &amp; neck cancer radiotherapy"],"prefix":"10.1016","volume":"71","author":[{"given":"Animesh","family":"Saha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shreya","family":"Manna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biplab","family":"Sarkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subhrasnigdha","family":"Biswal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirubha","family":"George","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandipan","family":"Roy Chowdhury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swati","family":"Modak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clnesp.2025.11.157_bib1","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.radonc.2022.04.016","article-title":"Use of deep learning to predict the need for aggressive nutritional supplementation during head and neck radiotherapy","volume":"171","author":"Dohopolski","year":"2022","journal-title":"Radiother Oncol J Eur Soc Therapeut Radiol Oncol"},{"issue":"6","key":"10.1016\/j.clnesp.2025.11.157_bib2","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1007\/s00066-003-1077-1","article-title":"Early morbidity after radiotherapy with or without chemotherapy in advanced head and neck cancer. Experience from four nonrandomized studies","volume":"179","author":"Bieri","year":"2003","journal-title":"Strahlenther Onkol"},{"issue":"3","key":"10.1016\/j.clnesp.2025.11.157_bib3","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.ijrobp.2009.12.032","article-title":"Enteral feeding during chemoradiotherapy for advanced head-and-neck cancer: a single-institution experience using a reactive approach","volume":"79","author":"Clavel","year":"2011","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"6","key":"10.1016\/j.clnesp.2025.11.157_bib4","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1067\/mhn.2001.120428","article-title":"Predictors of weight loss during radiation therapy","volume":"125","author":"Beaver","year":"2001","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"6","key":"10.1016\/j.clnesp.2025.11.157_bib5","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1188\/07.CJON.875-880","article-title":"Nutritional support during radiotherapy for head and neck cancer: the role of prophylactic feeding tube placement","volume":"11","author":"Cady","year":"2007","journal-title":"Clin J Oncol Nurs"},{"issue":"9","key":"10.1016\/j.clnesp.2025.11.157_bib6","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.clon.2013.04.003","article-title":"Predictors of weight loss during conformal radiotherapy for head and neck cancers - how important are planning target volumes?","volume":"25","author":"Mallick","year":"2013","journal-title":"Clin Oncol"},{"issue":"10","key":"10.1016\/j.clnesp.2025.11.157_bib7","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1002\/hed.21624","article-title":"Impact of early percutaneous endoscopic gastrostomy tube placement on nutritional status and hospitalization in patients with head and neck cancer receiving definitive chemoradiation therapy","volume":"33","author":"Rutter","year":"2011","journal-title":"Head Neck"},{"issue":"2","key":"10.1016\/j.clnesp.2025.11.157_bib8","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1111\/j.1749-4486.2009.01889.x","article-title":"Complications following gastrostomy tube insertion in patients with head and neck cancer: a prospective multi-institution study, systematic review and meta-analysis","volume":"34","author":"Grant","year":"2009","journal-title":"Clin Otolaryngol"},{"issue":"2","key":"10.1016\/j.clnesp.2025.11.157_bib9","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s00455-011-9360-2","article-title":"Does PEG use cause dysphagia in head and neck cancer patients?","volume":"27","author":"Langmore","year":"2012","journal-title":"Dysphagia"},{"issue":"8","key":"10.1016\/j.clnesp.2025.11.157_bib10","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.3748\/wjg.v17.i8.1004","article-title":"Prophylactic PEG placement in head and neck cancer: how many feeding tubes are unused (and unnecessary)?","volume":"17","author":"Madhoun","year":"2011","journal-title":"World J Gastroenterol"},{"issue":"2","key":"10.1016\/j.clnesp.2025.11.157_bib11","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.radonc.2016.01.019","article-title":"Beyond mean pharyngeal constrictor dose for beam path toxicity in non-target swallowing muscles: dose-volume correlates of chronic radiation-associated dysphagia (RAD) after oropharyngeal intensity modulated radiotherapy","volume":"118","year":"2016","journal-title":"Radiother Oncol"},{"issue":"1","key":"10.1016\/j.clnesp.2025.11.157_bib12","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.radonc.2010.08.013","article-title":"Characteristics of response of oral and pharyngeal mucosa in patients receiving chemo-IMRT for head and neck cancer using hypofractionated accelerated radiotherapy","volume":"97","author":"Bhide","year":"2010","journal-title":"Radiother Oncol"},{"issue":"5","key":"10.1016\/j.clnesp.2025.11.157_bib13","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1016\/j.ijrobp.2009.10.002","article-title":"Candidate dosimetric predictors of long-term swallowing dysfunction after oropharyngeal intensity-modulated radiotherapy","volume":"78","author":"Schwartz","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"3","key":"10.1016\/j.clnesp.2025.11.157_bib14","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.radonc.2011.05.015","article-title":"Delineation of organs at risk involved in swallowing for radiotherapy treatment planning","volume":"101","author":"Christianen","year":"2011","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.clnesp.2025.11.157_bib15","first-page":"27","article-title":"Incorporating spatial dose metrics in machine learning-based normal tissue complication probability (NTCP) models of severe acute dysphagia resulting from head and neck radiotherapy","volume":"8","author":"Dean","year":"2018","journal-title":"Clin Transl Radiat Oncol"},{"issue":"1","key":"10.1016\/j.clnesp.2025.11.157_bib16","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1186\/s12885-016-2813-0","article-title":"DARS: a phase III randomised multicentre study of dysphagia- optimised intensity- modulated radiotherapy (Do-IMRT) versus standard intensity- modulated radiotherapy (S-IMRT) in head and neck cancer","volume":"16","author":"Petkar","year":"2016","journal-title":"BMC Cancer"},{"key":"10.1016\/j.clnesp.2025.11.157_bib17","series-title":"Common terminology criteria for adverse events (CTCAE) version 5.0","year":"2017"},{"issue":"3","key":"10.1016\/j.clnesp.2025.11.157_bib18","doi-asserted-by":"crossref","first-page":"e93","DOI":"10.1016\/j.ijrobp.2010.12.067","article-title":"Chemo-IMRT of oropharyngeal cancer aiming to reduce dysphagia: swallowing organs late complication probabilities and dosimetric correlates","volume":"81","author":"Eisbruch","year":"2011","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"3","key":"10.1016\/j.clnesp.2025.11.157_bib19","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.radonc.2009.05.013","article-title":"Anatomical changes in the pharyngeal constrictors after chemo-irradiation of head and neck cancer and their dose-effect relationships: MRI-based study","volume":"93","author":"Popovtzer","year":"2009","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.clnesp.2025.11.157_bib20","doi-asserted-by":"crossref","first-page":"S74","DOI":"10.1016\/j.ijrobp.2005.07.128","article-title":"Dosimetric correlation of oral cavity dose with acute Mucositis in patients treated with intensity modulated radiation therapy (IMRT) and chemotherapy","volume":"63","author":"Shogan","year":"2005","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"1","key":"10.1016\/j.clnesp.2025.11.157_bib21","doi-asserted-by":"crossref","first-page":"S566","DOI":"10.1016\/j.ijrobp.2014.05.1711","article-title":"Gross tumor volume size and oral cavity dose drive dysphagia in definitive (Chemo) IMRT for head and neck cancer","volume":"90","author":"Anderson","year":"2014","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"3","key":"10.1016\/j.clnesp.2025.11.157_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijrobp.2008.01.060","article-title":"Prospective evaluation to establish a dose response for clinical oral mucositis in patients undergoing head-and-neck conformal radiotherapy","volume":"72","author":"Narayan","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"7","key":"10.1016\/j.clnesp.2025.11.157_bib23","first-page":"837","article-title":"Early nutritional intervention improves treatment tolerance and outcomes in head and neck cancer patients undergoing concurrent chemoradiotherapy","volume":"18","author":"Paccagnella","year":"2010","journal-title":"Supp Care Cancer Off J Multinat Assoc Support Care Cancer"},{"issue":"3","key":"10.1016\/j.clnesp.2025.11.157_bib24","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.adro.2017.11.006","article-title":"Evaluation of classification and regression tree (CART) model in weight loss prediction following head and neck cancer radiation therapy","volume":"3","author":"Cheng","year":"2018","journal-title":"Adv Radiat Oncol"},{"issue":"1","key":"10.1016\/j.clnesp.2025.11.157_bib25","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.radonc.2016.05.015","article-title":"Normal tissue complication probability (NTCP) modelling using spatial dose metrics and machine learning methods for severe acute oral mucositis resulting from head and neck radiotherapy","volume":"120","author":"Dean","year":"2016","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.clnesp.2025.11.157_bib27","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2024.1346797","article-title":"Impact of radiation dose distribution on nutritional supplementation needs in head and neck cancer radiotherapy: a voxel-based machine learning approach","volume":"14","author":"Madhavan","year":"2024","journal-title":"Front Oncol"}],"container-title":["Clinical Nutrition ESPEN"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405457725031511?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405457725031511?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T21:33:21Z","timestamp":1768944801000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405457725031511"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":26,"alternative-id":["S2405457725031511"],"URL":"https:\/\/doi.org\/10.1016\/j.clnesp.2025.11.157","relation":{},"ISSN":["2405-4577"],"issn-type":[{"value":"2405-4577","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Application of machine learning to create a prediction model for the need of aggressive nutritional intervention during head & neck cancer radiotherapy","name":"articletitle","label":"Article Title"},{"value":"Clinical Nutrition ESPEN","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clnesp.2025.11.157","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"102837"}}