{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T02:23:42Z","timestamp":1774059822495,"version":"3.50.1"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2703100"],"award-info":[{"award-number":["2022YFC2703100"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011176","name":"Peking Union Medical College","doi-asserted-by":"publisher","award":["3332025097"],"award-info":[{"award-number":["3332025097"]}],"id":[{"id":"10.13039\/501100011176","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","clinicalnutritionespen.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Nutrition ESPEN"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.clnesp.2026.102953","type":"journal-article","created":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T16:31:28Z","timestamp":1769790688000},"page":"102953","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Prognostic value of abdominal obesity indicators for all-cause mortality in familial hypercholesterolemia"],"prefix":"10.1016","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2002-5833","authenticated-orcid":false,"given":"Weida","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Runzhen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingxuan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ye","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kun","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuyang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.clnesp.2026.102953_bib1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19113426","article-title":"Familial hypercholesterolemia: the Most frequent cholesterol metabolism disorder caused disease","volume":"19","author":"Benito-Vicente","year":"2018","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.clnesp.2026.102953_bib2","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.114.001236","article-title":"Mortality among patients with familial hypercholesterolemia: a registry-based study in Norway, 1992-2010","volume":"3","author":"Mundal","year":"2014","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.clnesp.2026.102953_bib3","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.atherosclerosis.2020.12.019","article-title":"2.5-fold increased risk of recurrent acute myocardial infarction with familial hypercholesterolemia","volume":"319","author":"Svendsen","year":"2021","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.clnesp.2026.102953_bib4","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1161\/CIRCULATIONAHA.119.044795","article-title":"Prevalence of familial hypercholesterolemia among the general population and patients with atherosclerotic cardiovascular disease: a systematic review and meta-analysis","volume":"141","author":"Hu","year":"2020","journal-title":"Circulation"},{"key":"10.1016\/j.clnesp.2026.102953_bib5","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s11886-021-01565-5","article-title":"Familial hypercholesterolemia: global burden and approaches","volume":"23","author":"Tokgozoglu","year":"2021","journal-title":"Curr Cardiol Rep"},{"key":"10.1016\/j.clnesp.2026.102953_bib6","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.pcad.2019.10.003","article-title":"Reducing cardiovascular risk in patients with familial hypercholesterolemia: risk prediction and lipid management","volume":"62","author":"Miname","year":"2019","journal-title":"Prog Cardiovasc Dis"},{"key":"10.1016\/j.clnesp.2026.102953_bib7","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2022.1026243","article-title":"Correlation of cardiovascular risk predictors with overweight and obesity in patients with familial hypercholesterolemia","volume":"9","author":"Wang","year":"2022","journal-title":"Front Cardiovas Med"},{"key":"10.1016\/j.clnesp.2026.102953_bib8","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.atherosclerosis.2016.09.010","article-title":"Epicardial fat is associated with severity of subclinical coronary atherosclerosis in familial hypercholesterolemia","volume":"254","author":"Mangili","year":"2016","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.clnesp.2026.102953_bib9","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jacl.2018.10.012","article-title":"Risk factors for cardiovascular disease in heterozygous familial hypercholesterolemia: a systematic review and meta-analysis","volume":"13","author":"Akioyamen","year":"2019","journal-title":"J Clin Lipidol"},{"key":"10.1016\/j.clnesp.2026.102953_bib10","article-title":"Body mass index and mortality in patients with and without diabetes mellitus","volume":"34","author":"Akirov","year":"2018","journal-title":"Diab\/Metabol Res Rev"},{"key":"10.1016\/j.clnesp.2026.102953_bib11","doi-asserted-by":"crossref","DOI":"10.1111\/obr.13107","article-title":"Body mass index and all-cause mortality in patients with percutaneous coronary intervention: a dose-response meta-analysis of obesity paradox","volume":"22","author":"Mei","year":"2021","journal-title":"Obes Rev : Off J Int Ass Study Obes"},{"key":"10.1016\/j.clnesp.2026.102953_bib12","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/S0140-6736(16)30175-1","article-title":"Body-mass index and all-cause mortality: individual-participant-data meta-analysis of 239 prospective studies in four continents","volume":"388","author":"Global","year":"2016","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.clnesp.2026.102953_bib13","doi-asserted-by":"crossref","DOI":"10.1111\/obr.13088","article-title":"Visceral obesity and incident cancer and cardiovascular disease: an integrative review of the epidemiological evidence","volume":"22","author":"Silveira","year":"2021","journal-title":"Obes Rev : Off J Int Ass Study Obes"},{"key":"10.1016\/j.clnesp.2026.102953_bib14","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1093\/eurheartj\/ehad083","article-title":"Anthropometric measures and adverse outcomes in heart failure with reduced ejection fraction: revisiting the obesity paradox","volume":"44","author":"Butt","year":"2023","journal-title":"Eur Heart J"},{"key":"10.1016\/j.clnesp.2026.102953_bib15","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.mayocp.2013.11.011","article-title":"A pooled analysis of waist circumference and mortality in 650,000 adults","volume":"89","author":"Cerhan","year":"2014","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.clnesp.2026.102953_bib16","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1111\/obr.12666","article-title":"Effectiveness of A Body Shape Index (ABSI) in predicting chronic diseases and mortality: a systematic review and meta-analysis","volume":"19","author":"Ji","year":"2018","journal-title":"Obes Rev : Off J Int Ass Study Obes"},{"key":"10.1016\/j.clnesp.2026.102953_bib17","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1093\/ajcn\/nqab412","article-title":"Associations of longitudinal trajectories in body roundness index with mortality and cardiovascular outcomes: a cohort study","volume":"115","author":"Wu","year":"2022","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.clnesp.2026.102953_bib18","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1108\/IJOPH-07-2024-0037","article-title":"Health behind bars: obesity and cardiometabolic risk according to different indicators in incarcerated men","volume":"21","author":"Atan","year":"2025","journal-title":"Int J Pris Health"},{"key":"10.1016\/j.clnesp.2026.102953_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.diabres.2025.112243","article-title":"The relationship between anthropometric indices and cardiovascular risk in patients with type 2 diabetes mellitus","volume":"224","author":"Arslan","year":"2025","journal-title":"Diabetes Res Clin Pract"},{"key":"10.1016\/j.clnesp.2026.102953_bib20","article-title":"Trends in obesity and adiposity measures by race or ethnicity among adults in the United States 2011-18: population based study","volume":"372","author":"Liu","year":"2021","journal-title":"BMJ (Clinical research ed)"},{"key":"10.1016\/j.clnesp.2026.102953_bib21","article-title":"Trends in the prevalence of metabolically healthy obesity among US adults, 1999-2018","volume":"6","author":"Wang","year":"2023","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.clnesp.2026.102953_bib22","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1186\/s12944-023-01908-x","article-title":"A cross-sectional study exploring the relationship between the dietary inflammatory index and hyperlipidemia based on the National Health and Nutrition Examination Survey (2005-2018)","volume":"22","author":"Han","year":"2023","journal-title":"Lipids Health Dis"},{"key":"10.1016\/j.clnesp.2026.102953_bib23","article-title":"Association of phthalate exposure with all-cause mortality across renal function status: the U.S. National Health and Nutrition Examination Survey, 2005-2018","volume":"270","author":"Tao","year":"2023","journal-title":"Ecotoxicol Environ Saf"},{"key":"10.1016\/j.clnesp.2026.102953_bib24","doi-asserted-by":"crossref","first-page":"e422","DOI":"10.1016\/S2468-2667(23)00081-6","article-title":"Social determinants of health and premature death among adults in the USA from 1999 to 2018: a national cohort study","volume":"8","author":"Bundy","year":"2023","journal-title":"Lancet Public Health"},{"key":"10.1016\/j.clnesp.2026.102953_bib25","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s13098-023-01009-w","article-title":"Association of triglyceride-glucose index with atherosclerotic cardiovascular disease and mortality among familial hypercholesterolemia patients","volume":"15","author":"Wen","year":"2023","journal-title":"Diabetol Metab Syndr"},{"key":"10.1016\/j.clnesp.2026.102953_bib26","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s12944-020-01428-y","article-title":"Evaluation of cardiovascular risk factors in patients with familial hypercholesterolemia from the North-Eastern area of Romania","volume":"20","author":"Vlad","year":"2021","journal-title":"Lipids Health Dis"},{"key":"10.1016\/j.clnesp.2026.102953_bib27","series-title":"2019 public-use linked mortality files","year":"2022"},{"key":"10.1016\/j.clnesp.2026.102953_bib28","doi-asserted-by":"crossref","first-page":"837","DOI":"10.2307\/2531595","article-title":"Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach","volume":"44","author":"DeLong","year":"1988","journal-title":"Biometrics"},{"key":"10.1016\/j.clnesp.2026.102953_bib29","doi-asserted-by":"crossref","first-page":"851","DOI":"10.5114\/aoms.2016.58928","article-title":"Obesity and inflammation: the linking mechanism and the complications","volume":"13","author":"Ellulu","year":"2017","journal-title":"Arch Med Sci : AMS"},{"key":"10.1016\/j.clnesp.2026.102953_bib30","doi-asserted-by":"crossref","first-page":"587","DOI":"10.2147\/DMSO.S67400","article-title":"Mechanism linking diabetes mellitus and obesity","volume":"7","author":"Al-Goblan","year":"2014","journal-title":"Diabetes, Metab Syndrome Obes Targets Ther"},{"key":"10.1016\/j.clnesp.2026.102953_bib31","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1161\/CIRCULATIONAHA.106.666941","article-title":"Adiponectin cardioprotection after myocardial ischemia\/reperfusion involves the reduction of oxidative\/nitrative stress","volume":"115","author":"Tao","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.clnesp.2026.102953_bib32","doi-asserted-by":"crossref","first-page":"2440","DOI":"10.1056\/NEJMsa1909301","article-title":"Projected U.S. state-level prevalence of adult obesity and severe obesity","volume":"381","author":"Ward","year":"2019","journal-title":"N Engl J Med"},{"key":"10.1016\/j.clnesp.2026.102953_bib33","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1038\/ijo.2011.100","article-title":"Body mass index classification misses subjects with increased cardiometabolic risk factors related to elevated adiposity","volume":"36","author":"G\u00f3mez-Ambrosi","year":"2012","journal-title":"Int J Obes"},{"key":"10.1016\/j.clnesp.2026.102953_bib34","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.jshs.2020.10.005","article-title":"The association of grip strength with cardiovascular diseases and all-cause mortality in people with hypertension: findings from the Prospective Urban Rural Epidemiology China Study","volume":"10","author":"Liu","year":"2021","journal-title":"J Sport Heal Sci"},{"key":"10.1016\/j.clnesp.2026.102953_bib35","doi-asserted-by":"crossref","DOI":"10.1186\/s42269-025-01374-8","article-title":"The weight-loss paradox in older adults: balancing fat loss with muscle preservation","volume":"49","author":"Arslan","year":"2025","journal-title":"Bull Natl Res Cent"},{"key":"10.1016\/j.clnesp.2026.102953_bib36","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1016\/j.jacl.2016.08.010","article-title":"Identification and characterization of severe familial hypercholesterolemia in patients presenting for cardiac catheterization","volume":"10","author":"Zafrir","year":"2016","journal-title":"J Clin Lipidol"},{"key":"10.1016\/j.clnesp.2026.102953_bib37","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1186\/s12889-019-7212-4","article-title":"The prevalence and related factors of familial hypercholesterolemia in rural population of China using Chinese modified Dutch Lipid Clinic Network definition","volume":"19","author":"Wang","year":"2019","journal-title":"BMC Public Health"},{"key":"10.1016\/j.clnesp.2026.102953_bib38","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1186\/s12933-023-02072-3","article-title":"Obesity indices and the risk of total and cardiovascular mortality among people with diabetes: a long-term follow-up study in Taiwan","volume":"22","author":"Lu","year":"2023","journal-title":"Cardiovasc Diabetol"},{"key":"10.1016\/j.clnesp.2026.102953_bib39","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1007\/s11886-013-0446-3","article-title":"The obesity paradox in diabetes","volume":"16","author":"Carnethon","year":"2014","journal-title":"Curr Cardiol Rep"},{"key":"10.1016\/j.clnesp.2026.102953_bib40","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0039504","article-title":"A new body shape index predicts mortality hazard independently of body mass index","volume":"7","author":"Krakauer","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.clnesp.2026.102953_bib41","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s13098-018-0323-8","article-title":"Relationship between \"a body shape index (ABSI)\" and body composition in obese patients with type 2 diabetes","volume":"10","author":"Gomez-Peralta","year":"2018","journal-title":"Diabetol Metab Syndr"},{"key":"10.1016\/j.clnesp.2026.102953_bib42","doi-asserted-by":"crossref","DOI":"10.1136\/bmjdrc-2015-000188","article-title":"Indirect measure of visceral adiposity 'A Body Shape Index' (ABSI) is associated with arterial stiffness in patients with type 2 diabetes","volume":"4","author":"Bouchi","year":"2016","journal-title":"BMJ Open Diab Res Care"},{"key":"10.1016\/j.clnesp.2026.102953_bib43","doi-asserted-by":"crossref","DOI":"10.1136\/bmjdrc-2023-003474","article-title":"Association of body indices and risk of mortality in patients with type 2 diabetes","volume":"11","author":"Li","year":"2023","journal-title":"BMJ Open Diab Res Care"}],"container-title":["Clinical Nutrition ESPEN"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405457726000483?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405457726000483?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T01:54:39Z","timestamp":1774058079000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405457726000483"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":43,"alternative-id":["S2405457726000483"],"URL":"https:\/\/doi.org\/10.1016\/j.clnesp.2026.102953","relation":{},"ISSN":["2405-4577"],"issn-type":[{"value":"2405-4577","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prognostic value of abdominal obesity indicators for all-cause mortality in familial hypercholesterolemia","name":"articletitle","label":"Article Title"},{"value":"Clinical Nutrition ESPEN","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clnesp.2026.102953","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"102953"}}