{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T20:08:57Z","timestamp":1790021337163,"version":"4.0.1"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T00:00:00Z","timestamp":1787184000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007680","name":"Universidad P\u00fablica de Navarra","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007680","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007329","name":"Universidad del Valle","doi-asserted-by":"publisher","award":["CTO 0776-2023-UNIVALLE- Conv-150"],"award-info":[{"award-number":["CTO 0776-2023-UNIVALLE- Conv-150"]}],"id":[{"id":"10.13039\/501100007329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007329","name":"Universidad del Valle","doi-asserted-by":"publisher","award":["151"],"award-info":[{"award-number":["151"]}],"id":[{"id":"10.13039\/501100007329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007329","name":"Universidad del Valle","doi-asserted-by":"publisher","award":["152"],"award-info":[{"award-number":["152"]}],"id":[{"id":"10.13039\/501100007329","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","clinicalnutritionespen.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Nutrition ESPEN"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.clnesp.2026.105056","type":"journal-article","created":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T15:26:15Z","timestamp":1787325975000},"page":"105056","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Postprandial metabolic flexibility during an oral glucose tolerance test in adults with excess body weight or excess adiposity: A sex-based comparison using indirect calorimetry"],"prefix":"10.1016","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6832-5379","authenticated-orcid":false,"given":"Miguel Alejandro","family":"Atencio-Osorio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0965-2182","authenticated-orcid":false,"given":"Hugo Alejandro","family":"Carrillo-Arango","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9773-5043","authenticated-orcid":false,"given":"Oxala","family":"G\u00f3mez-Hincapi\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isaac A.","family":"Chavez-Guevara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1506-4272","authenticated-orcid":false,"given":"Mikel","family":"Izquierdo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3075-6960","authenticated-orcid":false,"given":"Robinson","family":"Ram\u00edrez-V\u00e9lez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.clnesp.2026.105056_bib1","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/j.cmet.2017.04.015","article-title":"Metabolic flexibility in health and disease","volume":"25","author":"Goodpaster","year":"2017","journal-title":"Cell Metab"},{"issue":"2","key":"10.1016\/j.clnesp.2026.105056_bib2","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1079\/PNS2004349","article-title":"Metabolic flexibility","volume":"63","author":"Storlien","year":"2004","journal-title":"Proc Nutr Soc"},{"issue":"5","key":"10.1016\/j.clnesp.2026.105056_bib3","doi-asserted-by":"crossref","first-page":"E1009","DOI":"10.1152\/ajpendo.90558.2008","article-title":"Metabolic flexibility and insulin resistance","volume":"295","author":"Galgani","year":"2008","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"6","key":"10.1016\/j.clnesp.2026.105056_bib4","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1002\/oby.22783","article-title":"Direct relationship between metabolic flexibility measured during glucose clamp and prolonged fast in men","volume":"28","author":"Fern\u00e1ndez-Verdejo","year":"2020","journal-title":"Obesity"},{"issue":"1","key":"10.1016\/j.clnesp.2026.105056_bib5","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1038\/s41387-022-00184-5","article-title":"Absence of a sexual dimorphism in postprandial glucose metabolism after administration of a balanced mixed meal in healthy young volunteers","volume":"12","author":"Leone","year":"2022","journal-title":"Nutr Diabetes"},{"key":"10.1016\/j.clnesp.2026.105056_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.compbiomed.2024.109024","article-title":"Modeling sex-specific whole-body metabolic responses to feeding and fasting","volume":"181","author":"Abo","year":"2024","journal-title":"Comput Biol Med"},{"issue":"3","key":"10.1016\/j.clnesp.2026.105056_bib7","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/s00125-019-05040-3","article-title":"Sex differences in metabolic regulation and diabetes susceptibility","volume":"63","author":"Tramunt","year":"2020","journal-title":"Diabetologia"},{"issue":"1","key":"10.1016\/j.clnesp.2026.105056_bib8","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/s41574-020-00431-8","article-title":"Sexual dimorphism in cardiometabolic health: the role of adipose tissue, muscle and liver","volume":"17","author":"Goossens","year":"2021","journal-title":"Nat Rev Endocrinol"},{"issue":"5","key":"10.1016\/j.clnesp.2026.105056_bib9","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1017\/S0007114507853347","article-title":"Sex differences in fat storage, fat metabolism, and the health risks from obesity","volume":"99","author":"Power","year":"2008","journal-title":"Br J Nutr"},{"issue":"7","key":"10.1016\/j.clnesp.2026.105056_bib10","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1152\/japplphysiol.00121.2013","article-title":"Role of estrogen on skeletal muscle mitochondrial function in ovariectomized rats: a time course study in different fiber types","volume":"116","author":"Cavalcanti-de-Albuquerque","year":"2014","journal-title":"J Appl Physiol"},{"issue":"7","key":"10.1016\/j.clnesp.2026.105056_bib11","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1007\/s00394-011-0266-4","article-title":"Estrogen modulates abdominal adiposity and protects female mice from obesity and impaired glucose tolerance","volume":"51","author":"Stubbins","year":"2012","journal-title":"Eur J Nutr"},{"key":"10.1016\/j.clnesp.2026.105056_bib12","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2022.828522","article-title":"Sex and species differences in the development of diet-induced obesity and metabolic disturbances in rodents","volume":"9","author":"Maric","year":"2022","journal-title":"Front Nutr"},{"issue":"9","key":"10.1016\/j.clnesp.2026.105056_bib13","doi-asserted-by":"crossref","DOI":"10.1210\/jendso\/bvad099","article-title":"Sex differences in pancreatic \u03b2-cell physiology and glucose homeostasis in C57BL\/6J mice","volume":"7","author":"Jo","year":"2023","journal-title":"J Endocr Soc"},{"key":"10.1016\/j.clnesp.2026.105056_bib14","doi-asserted-by":"crossref","first-page":"61","DOI":"10.3389\/fendo.2015.00061","article-title":"Sexual dimorphism in glucose and lipid metabolism during fasting, hypoglycemia, and exercise","volume":"6","author":"Hedrington","year":"2015","journal-title":"Front Endocrinol"},{"issue":"1","key":"10.1016\/j.clnesp.2026.105056_bib15","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s40279-024-02154-6","article-title":"Circadian regulation of fatty acid metabolism in humans: is there evidence of an optimal time window for maximizing fat oxidation during exercise?","volume":"55","author":"Rubio-Valles","year":"2025","journal-title":"Sports Med"},{"issue":"5","key":"10.1016\/j.clnesp.2026.105056_bib16","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1038\/ijo.2010.5","article-title":"Diagnostic performance of body mass index to identify obesity as defined by body adiposity: a systematic review and meta-analysis","volume":"34","author":"Okorodudu","year":"2010","journal-title":"Int J Obes (Lond)"},{"issue":"3","key":"10.1016\/j.clnesp.2026.105056_bib17","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1093\/ajcn\/72.3.694","article-title":"Healthy percentage body fat ranges: an approach for developing guidelines based on body mass index","volume":"72","author":"Gallagher","year":"2000","journal-title":"Am J Clin Nutr"},{"issue":"2","key":"10.1016\/j.clnesp.2026.105056_bib18","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1590\/S0124-00642012000200004","article-title":"The Fantastic instrument\u2019s validity and reliability for measuring Colombian adults\u2019 life-style","volume":"14","author":"Ram\u00edrez-V\u00e9lez","year":"2012","journal-title":"Rev Salud Publica (Bogota)"},{"issue":"2","key":"10.1016\/j.clnesp.2026.105056_bib19","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1159\/000203363","article-title":"Waist-to-height ratio is a simple and effective obesity screening tool for cardiovascular risk factors","volume":"2","author":"Ashwell","year":"2009","journal-title":"Obes Facts"},{"issue":"7","key":"10.1016\/j.clnesp.2026.105056_bib22","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1373\/clinchem.2004.033175","article-title":"Atherogenic index of plasma [log(triglycerides\/HDL-cholesterol)]: theoretical and practical implications","volume":"50","author":"Dobi\u00e1sov\u00e1","year":"2004","journal-title":"Clin Chem"},{"key":"10.1016\/j.clnesp.2026.105056_bib23","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1089\/met.2008.0034","article-title":"The triglyceride and glucose index is a useful marker for identifying insulin resistance","volume":"6","author":"Simental-Mend\u00eda","year":"2008","journal-title":"Metab Syndr Relat Disord"},{"issue":"4","key":"10.1016\/j.clnesp.2026.105056_bib24","doi-asserted-by":"crossref","first-page":"763","DOI":"10.3945\/ajcn.112.035014","article-title":"Indirect calorimetry in humans: a postcalorimetric evaluation procedure for correction of metabolic monitor variability","volume":"97","author":"Schadewaldt","year":"2013","journal-title":"Am J Clin Nutr"},{"issue":"9","key":"10.1016\/j.clnesp.2026.105056_bib25","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1016\/j.jand.2015.04.003","article-title":"Evidence analysis library review of best practices for performing indirect calorimetry in healthy and non-critically ill individuals","volume":"115","author":"Fullmer","year":"2015","journal-title":"J Acad Nutr Diet"},{"issue":"4","key":"10.1016\/j.clnesp.2026.105056_bib26","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1113\/EP093162","article-title":"Acute systemic and energy metabolism responses to velocity-based resistance training following an oral glucose load in individuals with excess body weight","volume":"111","author":"Carrillo-Arango","year":"2026","journal-title":"Exp Physiol"},{"issue":"2","key":"10.1016\/j.clnesp.2026.105056_bib27","first-page":"628","article-title":"Calculation of substrate oxidation rates in vivo from gaseous exchange","volume":"55","author":"Frayn","year":"1983","journal-title":"J Appl Physiol Respir Environ Exerc Physiol"},{"key":"10.1016\/j.clnesp.2026.105056_bib28","series-title":"Statistical power analysis for the behavioral sciences","author":"Cohen","year":"1988"},{"issue":"1","key":"10.1016\/j.clnesp.2026.105056_bib29","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1093\/ajcn\/43.1.167","article-title":"The use of the glycemic index in predicting the blood glucose response to mixed meals","volume":"43","author":"Wolever","year":"1986","journal-title":"Am J Clin Nutr"},{"issue":"3","key":"10.1016\/j.clnesp.2026.105056_bib30","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/0026-0495(88)90110-2","article-title":"The theoretical bases of indirect calorimetry: a review","volume":"37","author":"Ferrannini","year":"1988","journal-title":"Metabolism"},{"issue":"7","key":"10.1016\/j.clnesp.2026.105056_bib31","doi-asserted-by":"crossref","first-page":"2764","DOI":"10.1172\/JCI67227","article-title":"AMPK, insulin resistance, and the metabolic syndrome","volume":"123","author":"Ruderman","year":"2013","journal-title":"J Clin Investig"},{"issue":"2","key":"10.1016\/j.clnesp.2026.105056_bib32","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.metabol.2009.06.029","article-title":"Contribution of skeletal muscle mass on sex differences in 2-hour plasma glucose levels after oral glucose load in Thai subjects with normal glucose tolerance","volume":"59","author":"Rattarasarn","year":"2010","journal-title":"Metabolism"},{"issue":"2","key":"10.1016\/j.clnesp.2026.105056_bib33","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1210\/jc.2010-1398","article-title":"Mechanism and effects of glucose absorption during an oral glucose tolerance test among females and males","volume":"96","author":"Anderwald","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"issue":"9","key":"10.1016\/j.clnesp.2026.105056_bib34","doi-asserted-by":"crossref","first-page":"2678","DOI":"10.1016\/j.numecd.2021.05.018","article-title":"Body surface area may explain sex differences in findings from the oral glucose tolerance test among subjects with normal glucose tolerance","volume":"31","author":"Palmu","year":"2021","journal-title":"Nutr Metabol Cardiovasc Dis"},{"key":"10.1016\/j.clnesp.2026.105056_bib35","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s13293-015-0033-y","article-title":"Sex differences in metabolic homeostasis, diabetes, and obesity","volume":"6","author":"Mauvais-Jarvis","year":"2015","journal-title":"Biol Sex Differ"},{"issue":"5","key":"10.1016\/j.clnesp.2026.105056_bib36","doi-asserted-by":"crossref","first-page":"677","DOI":"10.2337\/diabetes.49.5.677","article-title":"Fuel selection in human skeletal muscle in insulin resistance","volume":"49","author":"Kelley","year":"2000","journal-title":"Diabetes"},{"issue":"5708","key":"10.1016\/j.clnesp.2026.105056_bib37","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1126\/science.1104343","article-title":"Mitochondrial dysfunction and type 2 diabetes","volume":"307","author":"Lowell","year":"2005","journal-title":"Science"},{"issue":"7","key":"10.1016\/j.clnesp.2026.105056_bib38","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.2337\/diabetes.54.7.1926","article-title":"A high-fat diet coordinately downregulates genes required for mitochondrial oxidative phosphorylation in skeletal muscle","volume":"54","author":"Sparks","year":"2005","journal-title":"Diabetes"},{"key":"10.1016\/j.clnesp.2026.105056_bib39","doi-asserted-by":"crossref","first-page":"241","DOI":"10.3389\/fendo.2014.00241","article-title":"Sex-specific differences in lipid and glucose metabolism","volume":"5","author":"Varlamov","year":"2015","journal-title":"Front Endocrinol"},{"issue":"1","key":"10.1016\/j.clnesp.2026.105056_bib40","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s00421-021-04802-5","article-title":"Analysis of sex-based differences in energy substrate utilization during moderate-intensity aerobic exercise","volume":"122","author":"Cano","year":"2022","journal-title":"Eur J Appl Physiol"},{"issue":"8","key":"10.1016\/j.clnesp.2026.105056_bib41","doi-asserted-by":"crossref","first-page":"2252","DOI":"10.1210\/clinem\/dgab325","article-title":"Sex differences in the effect of testosterone on adipose tissue insulin resistance from overweight to obese adults","volume":"106","author":"Li","year":"2021","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"10.1016\/j.clnesp.2026.105056_bib42","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1210\/er.2015-1137","article-title":"Sex and gender differences in risk, pathophysiology and complications of type 2 diabetes mellitus","volume":"37","author":"Kautzky-Willer","year":"2016","journal-title":"Endocr Rev"},{"issue":"3","key":"10.1016\/j.clnesp.2026.105056_bib43","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/j.clnu.2022.01.031","article-title":"Validity of four commercially available metabolic carts for assessing resting metabolic rate and respiratory exchange ratio in non-ventilated humans","volume":"41","author":"Alcantara","year":"2022","journal-title":"Clin Nutr"}],"container-title":["Clinical Nutrition ESPEN"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405457726021534?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405457726021534?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T19:25:08Z","timestamp":1790018708000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405457726021534"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":41,"alternative-id":["S2405457726021534"],"URL":"https:\/\/doi.org\/10.1016\/j.clnesp.2026.105056","relation":{},"ISSN":["2405-4577"],"issn-type":[{"value":"2405-4577","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Postprandial metabolic flexibility during an oral glucose tolerance test in adults with excess body weight or excess adiposity: A sex-based comparison using indirect calorimetry","name":"articletitle","label":"Article Title"},{"value":"Clinical Nutrition ESPEN","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clnesp.2026.105056","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Ltd on behalf of European Society for Clinical Nutrition and Metabolism.","name":"copyright","label":"Copyright"}],"article-number":"105056"}}