{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T06:26:49Z","timestamp":1793946409290,"version":"4.8.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006416","name":"Universidade Estadual de Campinas","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006416","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"State of Sao Paulo Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","clinicalnutritionespen.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Nutrition ESPEN"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.clnesp.2026.105110","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T15:59:22Z","timestamp":1790265562000},"page":"105110","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["GLIM-defined malnutrition and cachexia are associated with overall survival in patients with hepatocellular carcinoma treated with sorafenib"],"prefix":"10.1016","volume":"76","author":[{"given":"Ananda Giovana Cabral","family":"Silva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yolanda Jos\u00e9 Ricardo Soares","family":"Manuel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fab\u00edola Furtuoso","family":"Zarpel\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata Erbert","family":"Contriciani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leo Victor","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra Regina","family":"Branbilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianni Shigeru Setoue","family":"Liveraro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00edgia de Moraes","family":"Antunes-Correa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Carolina Santos","family":"Mendes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0136-0943","authenticated-orcid":false,"given":"Jos\u00e9 Barreto Campello","family":"Carvalheira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clnesp.2026.105110_bib1","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.clnesp.2026.105110_bib2","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.jhep.2025.10.020","article-title":"BCLC strategy for prognosis prediction and treatment recommendations: the 2026 update","volume":"84","author":"Reig","year":"2026","journal-title":"J Hepatol"},{"key":"10.1016\/j.clnesp.2026.105110_bib3","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.annonc.2025.02.006","article-title":"Hepatocellular carcinoma: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up","volume":"36","author":"Vogel","year":"2025","journal-title":"Ann Oncol"},{"key":"10.1016\/j.clnesp.2026.105110_bib4","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1056\/NEJMoa1915745","article-title":"Atezolizumab plus bevacizumab in unresectable hepatocellular carcinoma","volume":"382","author":"Finn","year":"2020","journal-title":"N Engl J Med"},{"key":"10.1016\/j.clnesp.2026.105110_bib5","doi-asserted-by":"crossref","DOI":"10.1056\/EVIDoa2100070","article-title":"Tremelimumab plus durvalumab in unresectable hepatocellular carcinoma","volume":"1","author":"Abou-Alfa","year":"2022","journal-title":"NEJM Evid"},{"key":"10.1016\/j.clnesp.2026.105110_bib6","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1056\/NEJMoa0708857","article-title":"Sorafenib in advanced hepatocellular carcinoma","volume":"359","author":"Llovet","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1016\/j.clnesp.2026.105110_bib7","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2022.978110","article-title":"Association between sarcopenia and prognosis of hepatocellular carcinoma: a systematic review and meta-analysis","volume":"9","author":"Jiang","year":"2022","journal-title":"Front Nutr"},{"key":"10.1016\/j.clnesp.2026.105110_bib8","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.clnesp.2025.10.026","article-title":"Concurrent and predictive validity of the Global Leadership Initiative on Malnutrition (GLIM) criteria in patients with advanced hepatocellular carcinoma receiving systemic therapy","volume":"70","author":"Chen","year":"2025","journal-title":"Clin Nutr ESPEN"},{"key":"10.1016\/j.clnesp.2026.105110_bib9","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1111\/hepr.13959","article-title":"Significance of malnutrition defined with Global Leadership Initiative on Malnutrition criteria in patients with hepatocellular carcinoma after hepatic resection","volume":"53","author":"Harimoto","year":"2023","journal-title":"Hepatol Res"},{"key":"10.1016\/j.clnesp.2026.105110_bib10","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1186\/s12876-024-03438-x","article-title":"Reduced muscle mass is an important part of Global Leadership Initiative on Malnutrition criteria in nutritional diagnosis of hepatocellular carcinoma","volume":"24","author":"Li","year":"2024","journal-title":"BMC Gastroenterol"},{"key":"10.1016\/j.clnesp.2026.105110_bib11","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s00423-025-03703-x","article-title":"Achieving textbook outcome in liver resection for hepatocellular carcinoma: malnutrition's pivotal role","volume":"410","author":"Oji","year":"2025","journal-title":"Langenbecks Arch Surg"},{"key":"10.1016\/j.clnesp.2026.105110_bib12","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1016\/j.hpb.2023.08.012","article-title":"Impact of GLIM criteria-based malnutrition diagnosis on outcomes following liver resection for hepatocellular carcinoma","volume":"25","author":"Omiya","year":"2023","journal-title":"HPB (Oxford)"},{"key":"10.1016\/j.clnesp.2026.105110_bib13","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1080\/01635581.2024.2314317","article-title":"Prevalence of malnutrition in patients with hepatocellular carcinoma: a comparative study of GLIM criteria, NRS2002, and PG-SGA, and identification of independent risk factors","volume":"76","author":"Tan","year":"2024","journal-title":"Nutr Cancer"},{"key":"10.1016\/j.clnesp.2026.105110_bib14","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.jhep.2018.06.024","article-title":"EASL clinical practice guidelines on nutrition in chronic liver disease","volume":"70","year":"2019","journal-title":"J Hepatol"},{"key":"10.1016\/j.clnesp.2026.105110_bib15","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1038\/s41572-020-00240-3","article-title":"Hepatocellular carcinoma","volume":"7","author":"Llovet","year":"2021","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.clnesp.2026.105110_bib16","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1097\/SLA.0000000000002555","article-title":"Impact of sarcopenic obesity on outcomes in patients undergoing hepatectomy for hepatocellular carcinoma","volume":"269","author":"Kobayashi","year":"2019","journal-title":"Ann Surg"},{"key":"10.1016\/j.clnesp.2026.105110_bib17","doi-asserted-by":"crossref","first-page":"883","DOI":"10.4254\/wjh.v12.i11.883","article-title":"Malnutrition in cirrhosis: more food for thought","volume":"12","author":"Chapman","year":"2020","journal-title":"World J Hepatol"},{"key":"10.1016\/j.clnesp.2026.105110_bib18","doi-asserted-by":"crossref","DOI":"10.3390\/nu13020540","article-title":"Malnutrition in patients with liver cirrhosis","volume":"13","author":"Traub","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.clnesp.2026.105110_bib19","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1007\/s00262-020-02794-3","article-title":"Incorporating sarcopenia and inflammation with radiation therapy in patients with hepatocellular carcinoma treated with nivolumab","volume":"70","author":"Kim","year":"2021","journal-title":"Cancer Immunol Immunother"},{"key":"10.1016\/j.clnesp.2026.105110_bib20","doi-asserted-by":"crossref","first-page":"6967","DOI":"10.1002\/cam4.2593","article-title":"Myosteatosis in a systemic inflammation-dependent manner predicts favorable survival outcomes in locally advanced esophageal cancer","volume":"8","author":"Gabiatti","year":"2019","journal-title":"Cancer Med"},{"key":"10.1016\/j.clnesp.2026.105110_bib21","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1038\/s41430-022-01201-7","article-title":"Prognostic value of myosteatosis and systemic inflammation in patients with resectable gastric cancer: a retrospective study","volume":"77","author":"Lascala","year":"2023","journal-title":"Eur J Clin Nutr"},{"key":"10.1016\/j.clnesp.2026.105110_bib22","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.clnu.2025.03.018","article-title":"The GLIM consensus approach to diagnosis of malnutrition: a 5-year update","volume":"49","author":"Cederholm","year":"2025","journal-title":"Clin Nutr"},{"key":"10.1016\/j.clnesp.2026.105110_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbi.2019.103208","article-title":"The REDCap consortium: building an international community of software platform partners","volume":"95","author":"Harris","year":"2019","journal-title":"J Biomed Inf"},{"key":"10.1016\/j.clnesp.2026.105110_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.imu.2024.101608","article-title":"Improving resectable gastric cancer prognosis prediction: a machine learning analysis combining clinical features and body composition radiomics","volume":"52","author":"Liveraro","year":"2025","journal-title":"Inform Med Unlocked"},{"key":"10.1016\/j.clnesp.2026.105110_bib25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.clnu.2018.08.002","article-title":"GLIM criteria for the diagnosis of malnutrition - a consensus report from the global clinical nutrition community","volume":"38","author":"Cederholm","year":"2019","journal-title":"Clin Nutr"},{"key":"10.1016\/j.clnesp.2026.105110_bib27","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1200\/JCO.2012.45.2722","article-title":"Cancer cachexia in the age of obesity: skeletal muscle depletion is a powerful prognostic factor, independent of body mass index","volume":"31","author":"Martin","year":"2013","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.clnesp.2026.105110_bib26","first-page":"161","article-title":"Radiographic analysis of body composition by computerized axial tomography","volume":"17","author":"Heymsfield","year":"1981","journal-title":"Nutr Cancer"},{"key":"10.1016\/j.clnesp.2026.105110_bib28","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/nri3399","article-title":"Neutrophil recruitment and function in health and inflammation","volume":"13","author":"Kolaczkowska","year":"2013","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.clnesp.2026.105110_bib29","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.clnu.2015.03.001","article-title":"Diagnostic criteria for malnutrition - an ESPEN Consensus Statement","volume":"34","author":"Cederholm","year":"2015","journal-title":"Clin Nutr"},{"key":"10.1016\/j.clnesp.2026.105110_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.esmoop.2021.100092","article-title":"Cancer cachexia in adult patients: ESMO clinical practice guidelines(\u2606)","volume":"6","author":"Arends","year":"2021","journal-title":"ESMO Open"},{"key":"10.1016\/j.clnesp.2026.105110_bib31","doi-asserted-by":"crossref","first-page":"107","DOI":"10.5604\/16652681.1226821","article-title":"Sarcopenia predicts reduced survival in patients with hepatocellular carcinoma at first diagnosis","volume":"16","author":"Begini","year":"2017","journal-title":"Ann Hepatol"},{"key":"10.1016\/j.clnesp.2026.105110_bib32","doi-asserted-by":"crossref","first-page":"62","DOI":"10.15747\/ACNM.2021.13.2.62","article-title":"Clinical significance of sarcopenia in patients with advanced hepatocellular carcinoma undergoing sorafenib treatment","volume":"13","author":"Lee","year":"2021","journal-title":"Annals of Clinical Nutrition and Metabolism"},{"key":"10.1016\/j.clnesp.2026.105110_bib33","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.3892\/ol.2017.6287","article-title":"Prognostic significance of sarcopenia in patients with hepatocellular carcinoma undergoing sorafenib therapy","volume":"14","author":"Nishikawa","year":"2017","journal-title":"Oncol Lett"},{"key":"10.1016\/j.clnesp.2026.105110_bib34","doi-asserted-by":"crossref","DOI":"10.3390\/cancers16132315","article-title":"The negative impact of sarcopenia on hepatocellular carcinoma treatment outcomes","volume":"16","author":"Cespiati","year":"2024","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.clnesp.2026.105110_bib35","doi-asserted-by":"crossref","first-page":"3039","DOI":"10.1016\/j.asjsur.2024.02.004","article-title":"Predictive values of sarcopenia and systemic inflammation-based markers in advanced hepatocellular carcinoma after hepatectomy","volume":"47","author":"Utsumi","year":"2024","journal-title":"Asian J Surg"},{"key":"10.1016\/j.clnesp.2026.105110_bib36","doi-asserted-by":"crossref","first-page":"29","DOI":"10.3892\/mco.2023.2625","article-title":"Early variation of inflammatory indexes refines prognostic prediction in patients with hepatocellular carcinoma under systemic treatment","volume":"18","author":"Da Fonseca","year":"2023","journal-title":"Mol Clin Oncol"},{"issue":"5","key":"10.1016\/j.clnesp.2026.105110_bib37","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1016\/j.clnu.2022.03.024","article-title":"Comparison of the prevalence of 21 GLIM phenotypic and etiologic criteria combinations and association with 30-day outcomes in people with cancer: a retrospective observational study","volume":"41","author":"Kiss","year":"2022","journal-title":"Clin Nutr"},{"key":"10.1016\/j.clnesp.2026.105110_bib38","article-title":"Combined diagnostic efficacy of neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and Mean Platelet Volume (MPV) as biomarkers of systemic inflammation in the diagnosis of colorectal cancer","volume":"2019","author":"Stojkovic","year":"2019","journal-title":"Dis Markers"},{"key":"10.1016\/j.clnesp.2026.105110_bib39","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1007\/s12094-020-02509-1","article-title":"Prognostic value of neutrophil-to-lymphocyte ratio in advanced cancer patients receiving immunotherapy","volume":"23","author":"Vinal","year":"2021","journal-title":"Clin Transl Oncol"},{"key":"10.1016\/j.clnesp.2026.105110_bib40","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1111\/jhn.12759","article-title":"Comparison between criteria for diagnosing malnutrition in patients with advanced chronic liver disease: GLIM group proposal versus different nutritional screening tools","volume":"33","author":"Boulhosa","year":"2020","journal-title":"J Hum Nutr Diet"},{"key":"10.1016\/j.clnesp.2026.105110_bib41","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1002\/jpen.2452","article-title":"Comparison of the GLIM criteria with specific screening tool for diagnosing malnutrition in hospitalized patients with cirrhosis: a descriptive cross-sectional study","volume":"47","author":"Yang","year":"2023","journal-title":"JPEN - J Parenter Enter Nutr"},{"key":"10.1016\/j.clnesp.2026.105110_bib42","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2025.1610066","article-title":"Prognostic utility of the global leadership initiative on malnutrition criteria in predicting outcomes after hepatectomy for hepatocellular carcinoma: a multicenter, retrospective study","volume":"12","author":"Liang","year":"2025","journal-title":"Front Nutr"},{"key":"10.1016\/j.clnesp.2026.105110_bib43","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2021.774636","article-title":"Influence of malnutrition according to the GLIM criteria on the clinical outcomes of hospitalized patients with cancer","volume":"8","author":"Liu","year":"2021","journal-title":"Front Nutr"},{"key":"10.1016\/j.clnesp.2026.105110_bib44","first-page":"607","volume":"45","author":"Yin","year":"2021"},{"key":"10.1016\/j.clnesp.2026.105110_bib45","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/s00534-011-0461-y","article-title":"Negative impact of low body mass index on surgical outcomes after hepatectomy for hepatocellular carcinoma","volume":"19","author":"Okamura","year":"2012","journal-title":"J Hepatobiliary Pancreat Sci"},{"key":"10.1016\/j.clnesp.2026.105110_bib46","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.clnu.2021.11.008","article-title":"Different combinations of the GLIM criteria for patients awaiting a liver transplant: poor performance for malnutrition diagnosis but a potentially useful prognostic tool","volume":"41","author":"Santos","year":"2022","journal-title":"Clin Nutr"}],"container-title":["Clinical Nutrition ESPEN"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405457726022072?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405457726022072?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T05:39:47Z","timestamp":1793943587000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405457726022072"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":46,"alternative-id":["S2405457726022072"],"URL":"https:\/\/doi.org\/10.1016\/j.clnesp.2026.105110","relation":{},"ISSN":["2405-4577"],"issn-type":[{"value":"2405-4577","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"GLIM-defined malnutrition and cachexia are associated with overall survival in patients with hepatocellular carcinoma treated with sorafenib","name":"articletitle","label":"Article Title"},{"value":"Clinical Nutrition ESPEN","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clnesp.2026.105110","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Ltd on behalf of European Society for Clinical Nutrition and Metabolism.","name":"copyright","label":"Copyright"}],"article-number":"105110"}}