{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T21:50:03Z","timestamp":1791669003778,"version":"4.3.4"},"reference-count":100,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","clinicalnutritionespen.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Nutrition ESPEN"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.clnesp.2026.105166","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T20:50:29Z","timestamp":1791319829000},"page":"105166","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Insights into natural dietary components as indirect modulators of glucagon-like Peptide-1 receptor signaling in weight management"],"prefix":"10.1016","volume":"76","author":[{"given":"Chapa","family":"Ramasinghe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0739-3735","authenticated-orcid":false,"given":"Baojun","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clnesp.2026.105166_bib1","article-title":"The global burden of disease attributable to high body mass index in 195 countries and territories","volume":"vols. 1\u201319","author":"Id","year":"2020"},{"issue":"February","key":"10.1016\/j.clnesp.2026.105166_bib2","article-title":"Articles trends and predictions of malnutrition and obesity in 204 countries and territories: an analysis of the global burden of disease study 2019","volume":"57","author":"Chong","year":"2023","journal-title":"EClinicalMedicine"},{"key":"10.1016\/j.clnesp.2026.105166_bib3","series-title":"The epidemiological burden of obesity in childhood: a worldwide epidemic requiring urgent action","first-page":"1","author":"Cesare","year":"2025"},{"issue":"3","key":"10.1016\/j.clnesp.2026.105166_bib4","doi-asserted-by":"crossref","first-page":"205","DOI":"10.7861\/clinmedicine.19-3-205","article-title":"Current treatments for obesity","volume":"19","author":"Ruban","year":"2019","journal-title":"Clin Med"},{"issue":"4","key":"10.1016\/j.clnesp.2026.105166_bib5","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.cmet.2024.03.007","article-title":"Review our extended microbiome: the human-relevant metabolites and biology of fermented foods","volume":"36","author":"Caffrey","year":"2024","journal-title":"Cell Metab"},{"issue":"123456789","key":"10.1016\/j.clnesp.2026.105166_bib6","first-page":"1","article-title":"The relationship between dietary intake of live microbes and insulin resistance among healthy adults in the US: a cross - sectional study from NHANES 2003 \u2013 2020","author":"Gu","year":"2024","journal-title":"Sci Rep"},{"key":"10.1016\/j.clnesp.2026.105166_bib7","article-title":"Effect of diabetes-speci fi c nutrition formulas on satiety and hunger hormones in patients with type 2 diabetes","volume":"4\u20139","author":"Mottalib","year":"2019","journal-title":"Nutr Diabetes"},{"key":"10.1016\/j.clnesp.2026.105166_bib8","series-title":"An insight into the treatment strategies of obesity using semaglutide and its competitive analogues: a review article","author":"Rao","year":"2022"},{"issue":"6","key":"10.1016\/j.clnesp.2026.105166_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.lanhl.2025.100709","article-title":"Influence of age on the association of vascular risk factors with acute stroke (INTERSTROKE): a case\u2013control study","volume":"6","author":"Reddin","year":"2025","journal-title":"Lancet Healthy Longev"},{"key":"10.1016\/j.clnesp.2026.105166_bib10","series-title":"Biology of incretins: GLP-1 and GIP","author":"Baggio","year":"2007"},{"key":"10.1016\/j.clnesp.2026.105166_bib11","series-title":"Glucagon-like peptide 1 (GLP-1) in biology and pathology","author":"Meier","year":"2005"},{"key":"10.1016\/j.clnesp.2026.105166_bib12","volume":"vols. 1\u201313","author":"Jensterle","year":"2021"},{"key":"10.1016\/j.clnesp.2026.105166_bib13","first-page":"1","volume":"vol. 1","author":"Lymperopoulos","year":"2025"},{"key":"10.1016\/j.clnesp.2026.105166_bib14","series-title":"Comparative effectiveness of GLP-1 receptor agonists on glycaemic control, body weight, and lipid profile for type 2 diabetes: systematic review and network meta-analysis","author":"Yao","year":"2024"},{"issue":"5","key":"10.1016\/j.clnesp.2026.105166_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s44446-025-00038-y","article-title":"GLP - 1 receptor agonism: a transformative approach for managing type - 2 diabetes and obesity","volume":"33","author":"Alharbi","year":"2025","journal-title":"Saudi Pharm J"},{"key":"10.1016\/j.clnesp.2026.105166_bib16","series-title":"GLP-1 receptor agonists: exploration of transformation from metabolic regulation to multi-organ therapy","first-page":"1","author":"Gong","year":"2025"},{"key":"10.1016\/j.clnesp.2026.105166_bib17","series-title":"Liraglutide, a glucagon-like peptide-1 receptor agonist, inhibits bone loss in an animal model of osteoporosis with or without diabetes","author":"Patti","year":"2024"},{"issue":"9","key":"10.1016\/j.clnesp.2026.105166_bib18","doi-asserted-by":"crossref","first-page":"6421","DOI":"10.1074\/jbc.M111.310342","article-title":"Regulation of adipocyte formation by GLP-1\/GLP-1R","volume":"287","author":"Challa","year":"2012","journal-title":"J Biol Chem"},{"issue":"10","key":"10.1016\/j.clnesp.2026.105166_bib19","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1016\/j.metabol.2012.03.002","article-title":"GLP-1 analog liraglutide protects against oxidative stress and albuminuria in streptozotocin-induced diabetic rats via protein kinase A-mediated inhibition of renal NAD(P)H oxidases","volume":"61","author":"Hendarto","year":"2012","journal-title":"Metabolism"},{"issue":"3","key":"10.1016\/j.clnesp.2026.105166_bib20","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1016\/j.bbrc.2009.12.075","article-title":"Biochemical and biophysical research communications Glucagon-like peptide-1 (GLP-1) inhibits advanced glycation end product (AGE) -induced up-regulation of VCAM-1 mRNA levels in endothelial cells by suppressing AGE receptor (RAGE) expression","volume":"391","author":"Ishibashi","year":"2010","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.clnesp.2026.105166_bib58","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1152\/ajpendo.00471.2012","article-title":"Gustducin couples fatty acid receptors to GLP-1 release in Colon","volume":"67","author":"Li","year":"2013","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"11","key":"10.1016\/j.clnesp.2026.105166_bib91","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.2337\/dci24-0003","article-title":"Efficacy and safety of GLP-1 medicines for type 2 diabetes and obesity","volume":"47","author":"Drucker","year":"2024","journal-title":"Diabetes Care"},{"issue":"4","key":"10.1016\/j.clnesp.2026.105166_bib64","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.dld.2013.10.021","article-title":"The bile acid TGR5 membrane receptor: from basic research to clinical application","volume":"46","author":"Duboc","year":"2014","journal-title":"Dig Liver Dis"},{"issue":"2","key":"10.1016\/j.clnesp.2026.105166_bib92","doi-asserted-by":"crossref","first-page":"364","DOI":"10.2337\/db11-1019","article-title":"Short-chain fatty acids stimulate glucagon-like peptide-1 secretion via the G-protein-coupled receptor FFAR2","volume":"61","author":"Tolhurst","year":"2012","journal-title":"Diabetes"},{"key":"10.1016\/j.clnesp.2026.105166_bib59","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.ejpb.2019.09.009","article-title":"Inorganic mesoporous particles for controlled \u03b1-linolenic acid delivery to stimulate GLP-1 secretion in vitro","volume":"144","author":"Kamakura","year":"2019","journal-title":"Eur J Pharm Biopharm"},{"issue":"6","key":"10.1016\/j.clnesp.2026.105166_bib80","article-title":"Potential role of phytochemicals as glucagon-like peptide 1 receptor (GLP-1R) agonists in the treatment of diabetes mellitus In pharmaceuticals","volume":"17","author":"Abiola","year":"2024","journal-title":"Multidisciplinary Digital Publishing Institute"},{"issue":"8","key":"10.1016\/j.clnesp.2026.105166_bib87","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1038\/s41573-025-01183-8","article-title":"GLP-1-based therapies for diabetes, obesity and beyond","volume":"24","author":"Drucker","year":"2025","journal-title":"Nat Rev Drug Discov"},{"issue":"6","key":"10.1016\/j.clnesp.2026.105166_bib41","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.nut.2012.11.015","article-title":"Nutrients related to GLP1 secretory responses","volume":"29","author":"Mansour","year":"2013","journal-title":"Nutrition"},{"issue":"3 56\u20133","key":"10.1016\/j.clnesp.2026.105166_bib61","article-title":"Effects of intraduodenal fatty acids on appetite, antropyloroduodenal motility, and plasma CCK and GLP-1 in humans vary with their chain length","volume":"287","author":"Feltrin","year":"2004","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"14","key":"10.1016\/j.clnesp.2026.105166_bib93","first-page":"6553","article-title":"Recent progress on bile acid receptor modulators for treatment of metabolic diseases. In journal of medicinal chemistry","volume":"59","author":"Xu","year":"2016","journal-title":"Am Chem Soc"},{"key":"10.1016\/j.clnesp.2026.105166_bib84","series-title":"Optimizing endogenous GLP-1 holistically","author":"Carscadden","year":"2025"},{"issue":"Number 8","key":"10.1016\/j.clnesp.2026.105166_bib88","article-title":"Emerging frontiers in GLP-1 therapeutics: a comprehensive evidence base (2025). In pharmaceutics","volume":"17","author":"Patel","year":"2025","journal-title":"Multidisciplinary Digital Publishing Institute (MDPI)"},{"issue":"1","key":"10.1016\/j.clnesp.2026.105166_bib65","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.livres.2017.04.001","article-title":"Bile acid receptors link nutrient sensing to metabolic regulation","volume":"1","author":"Li","year":"2017","journal-title":"In Liver Research"},{"issue":"13","key":"10.1016\/j.clnesp.2026.105166_bib66","doi-asserted-by":"crossref","first-page":"260","DOI":"10.4239\/wjd.v7.i13.260","article-title":"Role of bile acids in the regulation of the metabolic pathways","volume":"7","author":"Taoka","year":"2016","journal-title":"World J Diabetes"},{"key":"10.1016\/j.clnesp.2026.105166_bib94","doi-asserted-by":"crossref","first-page":"4221","DOI":"10.2147\/DMSO.S216054","article-title":"Long-acting injectable glp-1 receptor agonists for the treatment of adults with type 2 diabetes: perspectives from clinical practice","volume":"13","author":"Morieri","year":"2020","journal-title":"Diabetes Metab Syndr Obes"},{"key":"10.1016\/j.clnesp.2026.105166_bib86","doi-asserted-by":"crossref","DOI":"10.3390\/diabetology6060052","article-title":"Addressing the shortage of GLP-1 RA and dual GIP\/GLP-1 RA-Based therapies\u2014A systematic review","volume":"6","author":"Altabas","year":"2025","journal-title":"In Diabetology"},{"issue":"3","key":"10.1016\/j.clnesp.2026.105166_bib82","article-title":"The commercial availability of plant-based phytochemical components used in GLP-1 inhibition for the treatment of type-2 diabetes. In phytomedicine plus","volume":"5","author":"Kour","year":"2025","journal-title":"Elsevier B V"},{"issue":"9","key":"10.1016\/j.clnesp.2026.105166_bib90","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1007\/s00592-025-02534-y","article-title":"Beyond GLP-1: efficacy and safety of dual and triple incretin agonists in personalized type 2 diabetes Care\u2014A systematic review and network meta-analysis","volume":"62","author":"Yan","year":"2025","journal-title":"Acta Diabetol"},{"key":"10.1016\/j.clnesp.2026.105166_bib85","doi-asserted-by":"crossref","DOI":"10.1016\/j.csbr.2025.100069","article-title":"In silico exploration of phytochemicals for GLP-1 receptor agonists for the treatment of type 2 diabetes","volume":"2","author":"Kour","year":"2025","journal-title":"Computational and Structural Biotechnology Reports"},{"issue":"37","key":"10.1016\/j.clnesp.2026.105166_bib81","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5530\/phrev.20252106","article-title":"Natural bioactives targeting the GLP-1 pathway: a promising approach for diabetes management","volume":"19","author":"Kolhe","year":"2025","journal-title":"Pharmacogn Rev"},{"key":"10.1016\/j.clnesp.2026.105166_bib95","doi-asserted-by":"crossref","DOI":"10.1093\/ajcn\/80.5.1246","article-title":"Glycemia and insulinemia in healthy subjects after lactose-equivalent meals of milk and other food proteins: the role of plasma amino acids and incretins 1-3","volume":"80","author":"Nilsson","year":"2004","journal-title":"Am J Clin Nutr"},{"issue":"10","key":"10.1016\/j.clnesp.2026.105166_bib96","doi-asserted-by":"crossref","DOI":"10.3390\/nano14100840","article-title":"Encapsulation of Tenebrio molitor hydrolysate with DPP-IV inhibitory activity by electrospraying and spray-drying","volume":"14","author":"Berraquero-Garc\u00eda","year":"2024","journal-title":"Nanomaterials"},{"issue":"1","key":"10.1016\/j.clnesp.2026.105166_bib63","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.bbrc.2005.01.139","article-title":"Bile acids promote glucagon-like peptide-1 secretion through TGR5 in a murine enteroendocrine cell line STC-1","volume":"329","author":"Katsuma","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"issue":"5","key":"10.1016\/j.clnesp.2026.105166_bib39","doi-asserted-by":"crossref","DOI":"10.1152\/ajpendo.90637.2008","article-title":"Dietary resistant starch upregulates total GLP-1 and PYY in a sustained day-long manner through fermentation in rodents","volume":"295","author":"Zhou","year":"2008","journal-title":"American Journal of Physiology - Endocrinology and Metabolism"},{"issue":"2","key":"10.1016\/j.clnesp.2026.105166_bib97","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/nu13020527","article-title":"High \u03b2-glucan barley supplementation improves glucose tolerance by increasing GLP-1 secretion in diet-induced obesity mice","volume":"13","author":"Suzuki","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.clnesp.2026.105166_bib21","first-page":"259","volume":"vol. 4","author":"Migu\u00e9ns-g\u00f3mez","year":"2021"},{"issue":"9","key":"10.1016\/j.clnesp.2026.105166_bib22","doi-asserted-by":"crossref","first-page":"4702","DOI":"10.1039\/C8FO01059E","article-title":"Stimulation of CCK and GLP-1 secretion and expression in STC-1 cells by human jejunal contents and in vitro gastrointestinal digests from casein and whey proteins","volume":"9","author":"Santos-Hern\u00e1ndez","year":"2018","journal-title":"Food & function"},{"key":"10.1016\/j.clnesp.2026.105166_bib23","volume":"8","author":"Cudennec","year":"2017","journal-title":"Protein Digestion-Derived Peptides and the Peripheral Regulation of Food Intake"},{"issue":"3","key":"10.1016\/j.clnesp.2026.105166_bib24","doi-asserted-by":"crossref","DOI":"10.3390\/nu12030775","article-title":"The appetite \u2212 suppressant and GLP-1-Stimulating effects of whey proteins in Obese subjects are associated with increased circulating levels of specific amino acids","volume":"12","author":"Rigamonti","year":"2020","journal-title":"Nutrients"},{"issue":"4","key":"10.1016\/j.clnesp.2026.105166_bib25","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1093\/ajcn\/nqy019","article-title":"A small dose of whey protein co-ingested with mixed-macronutrient breakfast and lunch meals improves postprandial glycemia and suppresses appetite in men with type 2 diabetes: a randomized controlled trial","volume":"107","author":"King","year":"2018","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.clnesp.2026.105166_bib26","doi-asserted-by":"crossref","DOI":"10.1017\/jns.2021.41","article-title":"Postprandial effects of a whey protein-based multi-ingredient nutritional drink compared with a normal breakfast on glucose, insulin, and active GLP-1 response among type 2 diabetic subjects: a crossover randomized controlled trial","volume":"10","author":"Sridonpai","year":"2021","journal-title":"J Nutr Sci"},{"key":"10.1016\/j.clnesp.2026.105166_bib27","series-title":"Evaluation of casein & whey protein hydrolysates as well as milk fermentates from Lactobacillus helveticus for expression of gut hormones","first-page":"409","author":"Chaudhari","year":"2017"},{"key":"10.1016\/j.clnesp.2026.105166_bib28","series-title":"Appetite control and gastrointestinal hormonal behavior (CCK , GLP-1 , PYY 1 \u2013 36) following low doses of a whey protein-rich nutraceutic","author":"Giuseppe","year":"2013"},{"issue":"December 2017","key":"10.1016\/j.clnesp.2026.105166_bib29","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.foodchem.2018.01.107","article-title":"A casein hydrolysate increases GLP-1 secretion and reduces food intake","volume":"252","author":"Halloran","year":"2018","journal-title":"Food Chem"},{"key":"10.1016\/j.clnesp.2026.105166_bib30","series-title":"Blue whiting (Micromesistius poutassou) protein hydrolysates Co-Culture integrity","author":"Heffernan","year":"2022"},{"issue":"1","key":"10.1016\/j.clnesp.2026.105166_bib31","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1017\/S0029665113003601","article-title":"Food protein hydrolysates as a source of dipeptidyl peptidase IV inhibitory peptides for the management of type 2 diabetes","volume":"73","author":"Power","year":"2014","journal-title":"Proceedings of the Nutrition Society"},{"issue":"3","key":"10.1016\/j.clnesp.2026.105166_bib99","first-page":"217","volume":"33","author":"Lafarga","year":"2016","journal-title":"Bioactive protein hydrolysates in the functional food ingredient industry: Overcoming current challenges Food Reviews International"},{"key":"10.1016\/j.clnesp.2026.105166_bib32","series-title":"Secretion. 6628","author":"Nobile","year":"2016"},{"issue":"July","key":"10.1016\/j.clnesp.2026.105166_bib33","article-title":"Assessment of the effects of soy varieties and processing on protein quality, digestibility and intestinal bioactivity (DPP-IV inhibition and total GLP-1 release)","volume":"23","author":"Accardo","year":"2025"},{"issue":"0","key":"10.1016\/j.clnesp.2026.105166_bib34","first-page":"1","article-title":"Proteins and peptides from vegetable food sources as therapeutic adjuvants for the type 2 diabetes mellitus","volume":"0","author":"Chan-zapata","year":"2020","journal-title":"Crit Rev Food Sci Nutr"},{"issue":"8","key":"10.1016\/j.clnesp.2026.105166_bib98","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.1039\/C4FO01054J","article-title":"Rice protein hydrolysates stimulate GLP-1 secretion, reduce GLP-1 degradation, and lower the glycemic response in rats","volume":"6","author":"Ishikawa","year":"2015","journal-title":"Food & Function"},{"key":"10.1016\/j.clnesp.2026.105166_bib35","series-title":"Slow digestion-oriented dietary strategy to sustain the secretion of GLP-1 for improved glucose homeostasis","first-page":"1","author":"Qin","year":"2021"},{"issue":"3","key":"10.1016\/j.clnesp.2026.105166_bib36","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.nut.2008.08.012","article-title":"Dairy protein and leucine alter GLP-1 release and mRNA of genes involved in intestinal lipid metabolism in vitro","volume":"25","author":"Chen","year":"2009","journal-title":"NUT"},{"issue":"9","key":"10.1016\/j.clnesp.2026.105166_bib37","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.molmet.2016.05.012","article-title":"Microbial regulation of GLP-1 and L-cell biology","volume":"5","author":"Greiner","year":"2016","journal-title":"Mol Metabol"},{"issue":"10","key":"10.1016\/j.clnesp.2026.105166_bib38","doi-asserted-by":"crossref","first-page":"3139","DOI":"10.1080\/10408398.2022.2130160","article-title":"The role of dietary fibers in regulating appetite, an overview of mechanisms and weight consequences","volume":"64","author":"Akhlaghi","year":"2024","journal-title":"Crit Rev Food Sci Nutr"},{"issue":"5","key":"10.1016\/j.clnesp.2026.105166_bib40","doi-asserted-by":"crossref","DOI":"10.3390\/metabo12050420","article-title":"The sensory mechanisms of nutrient-induced GLP-1 secretion. In metabolites","volume":"12","author":"Hj\u00f8rne","year":"2022","journal-title":"Metabolites"},{"issue":"3","key":"10.1016\/j.clnesp.2026.105166_bib42","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1038\/s42255-024-00988-y","article-title":"Resistant starch intake facilitates weight loss in humans by reshaping the gut microbiota","volume":"6","author":"Li","year":"2024","journal-title":"Nat Metab"},{"issue":"7","key":"10.1016\/j.clnesp.2026.105166_bib43","doi-asserted-by":"crossref","first-page":"5749","DOI":"10.1039\/D0FO00855A","article-title":"Health beneficial effects of resistant starch on diabetes and obesity: via regulation of gut microbiota","volume":"11","author":"Liu","year":"2020","journal-title":"A review In Food and Function"},{"key":"10.1016\/j.clnesp.2026.105166_bib44","article-title":"Arabinoxylan as well as \u03b2-glucan in barley promotes GLP-1 secretion by increasing short-chain fatty acids production","volume":"32","author":"Mio","year":"2022","journal-title":"Biochem Biophys Rep"},{"key":"10.1016\/j.clnesp.2026.105166_bib45","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.640602","article-title":"Dietary fiber is essential to maintain intestinal size, L-Cell secretion, and intestinal integrity in mice","volume":"12","author":"Hunt","year":"2021","journal-title":"Front Endocrinol"},{"issue":"23","key":"10.1016\/j.clnesp.2026.105166_bib46","doi-asserted-by":"crossref","DOI":"10.3390\/foods11233934","article-title":"The effects of soluble dietary fibers on glycemic response: an overview and futures perspectives","volume":"11","author":"Giuntini","year":"2022","journal-title":"Foods"},{"issue":"6","key":"10.1016\/j.clnesp.2026.105166_bib47","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.3390\/nu5062093","article-title":"The role of viscosity and fermentability of dietary fibers on satiety- and adiposity-related hormones in rats","volume":"5","author":"Schroeder","year":"2013","journal-title":"Nutrients"},{"issue":"2","key":"10.1016\/j.clnesp.2026.105166_bib48","doi-asserted-by":"crossref","first-page":"222","DOI":"10.3346\/jkms.2016.31.2.222","article-title":"Improving effect of the acute administration of dietary fiber-enriched cereals on blood glucose levels and gut hormone secretion","volume":"31","author":"Kim","year":"2016","journal-title":"J Kor Med Sci"},{"issue":"2","key":"10.1016\/j.clnesp.2026.105166_bib49","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1530\/EC-14-0036","article-title":"Efficacy of increased resistant starch consumption in human type 2 diabetes","volume":"3","author":"Bodinham","year":"2014","journal-title":"Endocrine Connections"},{"issue":"Number 20","key":"10.1016\/j.clnesp.2026.105166_bib50","doi-asserted-by":"crossref","DOI":"10.3390\/molecules27207111","article-title":"Research progress on hypoglycemic mechanisms of resistant starch: a review","volume":"27","author":"Liu","year":"2022","journal-title":"Molecules"},{"issue":"48","key":"10.1016\/j.clnesp.2026.105166_bib51","doi-asserted-by":"crossref","first-page":"11928","DOI":"10.1021\/jf303083r","article-title":"Resistant starch and pullulan reduce postprandial glucose, insulin, and GLP-1, but have no effect on satiety in healthy humans","volume":"60","author":"Klosterbuer","year":"2012","journal-title":"J Agric Food Chem"},{"issue":"7","key":"10.1016\/j.clnesp.2026.105166_bib52","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1007\/s13300-022-01283-3","article-title":"A pilot study to assess glucose, insulin, and incretin responses following novel high resistant starch rice ingestion in healthy men","volume":"13","author":"Takahashi","year":"2022","journal-title":"Diabetes Therapy"},{"issue":"1","key":"10.1016\/j.clnesp.2026.105166_bib53","doi-asserted-by":"crossref","DOI":"10.1186\/s40168-017-0230-5","article-title":"Resistant starch can improve insulin sensitivity independently of the gut microbiota","volume":"5","author":"Bindels","year":"2017","journal-title":"Microbiome"},{"issue":"12","key":"10.1016\/j.clnesp.2026.105166_bib54","doi-asserted-by":"crossref","first-page":"2688","DOI":"10.1007\/s00125-015-3754-x","article-title":"Endogenous GLP-1 mediates postprandial reductions in activation in central reward and satiety areas in patients with type 2 diabetes","volume":"58","author":"ten Kulve","year":"2015","journal-title":"Diabetologia"},{"key":"10.1016\/j.clnesp.2026.105166_bib55","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.physbeh.2014.06.015","article-title":"Ability of GLP-1 to decrease food intake is dependent on nutritional status","volume":"135","author":"Ronveaux","year":"2014","journal-title":"Physiol Behav"},{"issue":"13","key":"10.1016\/j.clnesp.2026.105166_bib56","doi-asserted-by":"crossref","first-page":"4331","DOI":"10.1080\/10408398.2022.2141190","article-title":"The role of cereal soluble fiber in the beneficial modulation of glycometabolic gastrointestinal hormones","volume":"64","author":"Kabisch","year":"2024","journal-title":"Crit Rev Food Sci Nutr"},{"issue":"4","key":"10.1016\/j.clnesp.2026.105166_bib57","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1111\/jdi.14139","article-title":"Resistant starch and type 2 diabetes mellitus: clinical perspective","volume":"15","author":"Kim","year":"2024","journal-title":"J Diabetes Investig"},{"issue":"11","key":"10.1016\/j.clnesp.2026.105166_bib60","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1007\/s00125-002-0964-9","article-title":"Interaction between specific fatty acids, GLP-1 and insulin secretion in humans","volume":"45","author":"Beysen","year":"2002","journal-title":"Diabetologia"},{"issue":"5","key":"10.1016\/j.clnesp.2026.105166_bib62","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0177605","article-title":"Long chain saturated and unsaturated fatty acids exert opposing effects on viability and function of GLP-1-producing cells: mechanisms of lipotoxicity","volume":"12","author":"Thombare","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.clnesp.2026.105166_bib67","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.coph.2017.09.008","article-title":"Modulating bile acid pathways and TGR5 receptors for treating liver and GI diseases","volume":"37","author":"Malhi","year":"2017","journal-title":"Curr Opin Pharmacol"},{"issue":"12","key":"10.1016\/j.clnesp.2026.105166_bib68","article-title":"Original article mechanism of bile acid-regulated glucose and lipid metabolism in duodenal-jejunal bypass","volume":"8","author":"Chai","year":"2015","journal-title":"Int J Clin Exp Pathol"},{"issue":"3","key":"10.1016\/j.clnesp.2026.105166_bib69","doi-asserted-by":"crossref","DOI":"10.1016\/j.phyplu.2025.100825","article-title":"Phytomedicine plus the commercial availability of plant-based phytochemical components used in GLP-1 inhibition for the treatment of type-2 diabetes","volume":"5","author":"Kour","year":"2025","journal-title":"Phytomed Plus"},{"key":"10.1016\/j.clnesp.2026.105166_bib70","article-title":"A comprehensive review on natural remedies for diabetes","volume":"1\u201316","author":"Saxena","year":"2025","journal-title":"A Metabolic Disorder"},{"issue":"2","key":"10.1016\/j.clnesp.2026.105166_bib71","doi-asserted-by":"crossref","first-page":"9","DOI":"10.53388\/FH2024009","article-title":"Dietary modulation of Glucagon-like peptide 1 secretion: insights and innovations","volume":"6","author":"Wang","year":"2024","journal-title":"Food and Health"},{"issue":"0","key":"10.1016\/j.clnesp.2026.105166_bib72","first-page":"1","article-title":"Hypoglycemic bioactivity of anthocyanins: a review on proposed targets and potential signaling pathways","volume":"0","author":"Li","year":"2022","journal-title":"Crit Rev Food Sci Nutr"},{"key":"10.1016\/j.clnesp.2026.105166_bib73","series-title":"PT","author":"Saulite","year":"2018"},{"issue":"5","key":"10.1016\/j.clnesp.2026.105166_bib103","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1089\/jmf.2024.k.0251","article-title":"Hypoglycemic effect of black tea and its mechanism: regulation of glycometabolism and intestinal flora","volume":"28","author":"Li","year":"2025","journal-title":"Journal of Medicinal Food"},{"issue":"Number 3","key":"10.1016\/j.clnesp.2026.105166_bib74","article-title":"The emerging role of polyphenols in the management of type 2 diabetes. In molecules","volume":"26","author":"Wang","year":"2021","journal-title":"MDPI AG"},{"key":"10.1016\/j.clnesp.2026.105166_bib75","series-title":"Oxidative stress in type 2 diabetes: pathogenetic mechanisms and therapeutic strategies","first-page":"968","author":"Sottero","year":"2015"},{"issue":"Number 1","key":"10.1016\/j.clnesp.2026.105166_bib76","article-title":"The potential of the flavonoid content of Ipomoea batatas L. as an alternative analog GLP-1 for diabetes type 2 treatment\u2014systematic review. In metabolites","volume":"14","author":"Dewi","year":"2024","journal-title":"Multidisciplinary Digital Publishing Institute"},{"key":"10.1016\/j.clnesp.2026.105166_bib77","volume":"2019","author":"Kartinah","year":"2019"},{"issue":"Number 16","key":"10.1016\/j.clnesp.2026.105166_bib78","article-title":"Beyond GLP-1 agonists: an adaptive ketogenic\u2013mediterranean protocol to counter metabolic adaptation in obesity management. In nutrients","volume":"17","author":"Garc\u00eda-Gorrita","year":"2025","journal-title":"Multidisciplinary Digital Publishing Institute"},{"key":"10.1016\/j.clnesp.2026.105166_bib79","series-title":"Novel nutrient based approaches for appetite regulation and obesity","author":"Lorinczova","year":"2025"},{"key":"10.1016\/j.clnesp.2026.105166_bib83","article-title":"Exploring the underlying mechanisms of obesity and diabetes and the potential of traditional Chinese medicine: an overview of the literature","volume":"14","author":"Chen","year":"2023","journal-title":"Front Endocrinol"},{"issue":"10","key":"10.1016\/j.clnesp.2026.105166_bib89","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1007\/s00125-017-4354-8","article-title":"GLP-1\/glucagon receptor co-agonism for treatment of obesity","volume":"60","author":"S\u00e1nchez-Garrido","year":"2017","journal-title":"Diabetologia"}],"container-title":["Clinical Nutrition ESPEN"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405457726022631?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405457726022631?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T21:26:24Z","timestamp":1791667584000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405457726022631"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":100,"alternative-id":["S2405457726022631"],"URL":"https:\/\/doi.org\/10.1016\/j.clnesp.2026.105166","relation":{},"ISSN":["2405-4577"],"issn-type":[{"value":"2405-4577","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Insights into natural dietary components as indirect modulators of glucagon-like Peptide-1 receptor signaling in weight management","name":"articletitle","label":"Article Title"},{"value":"Clinical Nutrition ESPEN","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clnesp.2026.105166","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"105166"}}