{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T11:07:33Z","timestamp":1770980853796,"version":"3.50.1"},"reference-count":31,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2005,6,1]],"date-time":"2005-06-01T00:00:00Z","timestamp":1117584000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Nutrition"],"published-print":{"date-parts":[[2005,6]]},"DOI":"10.1016\/j.clnu.2004.11.013","type":"journal-article","created":{"date-parts":[[2005,5,15]],"date-time":"2005-05-15T11:13:40Z","timestamp":1116155620000},"page":"360-366","source":"Crossref","is-referenced-by-count":61,"title":["Cardioprotective effects of Ilex paraguariensis extract: evidence for a nitric oxide-dependent mechanism"],"prefix":"10.1016","volume":"24","author":[{"given":"Guillermo","family":"Schinella","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliana C.","family":"Fantinelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susana M.","family":"Mosca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2\u20133","key":"10.1016\/j.clnu.2004.11.013_bib1","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0378-8741(01)00179-9","article-title":"Choleretic effect and intestinal propulsion of \u201cmate\u201d (Ilex paraguariensis) and its substitutes or adulterants","volume":"75","author":"Gorzalczany","year":"2001","journal-title":"J Ethnopharmacol"},{"issue":"3","key":"10.1016\/j.clnu.2004.11.013_bib2","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0024-3205(02)02242-7","article-title":"The botanical extracts of Achyroclide satureoides and Ilex paraguariensis prevent methylglyoxal-induced inhibition of plasminogen and antithrombin III","volume":"72","author":"Gugliucci","year":"2002","journal-title":"Life Sci"},{"key":"10.1016\/j.clnu.2004.11.013_bib3","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0378-8741(97)00140-2","article-title":"Endothelium-dependent vasorelaxing activity of aqueous extracts of Ilex paraguariensis on mesenteric arterial bed of rats","volume":"60","author":"Muccilo Baisch","year":"1998","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.clnu.2004.11.013_bib4","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1006\/bbrc.2000.2293","article-title":"Antioxidant effects of an aqueous extract of Ilex paraguariensis","volume":"269","author":"Schinella","year":"2000","journal-title":"Biochem Biophy Res Commun"},{"issue":"10","key":"10.1016\/j.clnu.2004.11.013_bib5","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1016\/S0271-5317(00)80024-X","article-title":"Antioxidant activity of Ilex paraguariensis and related species","volume":"20","author":"Filip","year":"2000","journal-title":"Nutr Res"},{"key":"10.1016\/j.clnu.2004.11.013_bib6","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1006\/bbrc.1996.1030","article-title":"Antioxidant effects of Ilex paraguariensis","volume":"224","author":"Gugliucci","year":"1996","journal-title":"Biochem Biophy Res Commun"},{"issue":"3","key":"10.1016\/j.clnu.2004.11.013_bib7","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1089\/107555303765551606","article-title":"Antioxidant activity of a botanical extract preparation of Ilex paraguariensis","volume":"9","author":"Bracesco","year":"2003","journal-title":"J Altern Complem Med"},{"key":"10.1016\/j.clnu.2004.11.013_bib8","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/S0367-326X(01)00331-8","article-title":"Phenolic compounds in seven South American Ilex species","volume":"72","author":"Filip","year":"2001","journal-title":"Fitoterapia"},{"key":"10.1016\/j.clnu.2004.11.013_bib9","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1152\/physrev.1999.79.2.609","article-title":"Molecular and cellular mechanisms of myocardial stunning","volume":"79","author":"Bolli","year":"1999","journal-title":"Physiol Rev"},{"key":"10.1016\/j.clnu.2004.11.013_bib10","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1161\/01.CIR.83.3.1006","article-title":"Treatment with deferoxamine during ischemia improves functional and metabolic recovery and reduces reperfusion-induced oxygen radical generation in rabbit hearts","volume":"83","author":"Williams","year":"1991","journal-title":"Circulation"},{"key":"10.1016\/j.clnu.2004.11.013_bib11","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1097\/00005344-199308000-00025","article-title":"Comparison of N-methyl hexanoylhydroxamic acid, a novel antioxidant, with desferrioxamine and N-acetyl cysteine against reperfusion-induced dysfunctions in isolated rat heart","volume":"22","author":"Collis","year":"1993","journal-title":"J Cardiovasc Pharmacol"},{"issue":"1\u20132","key":"10.1016\/j.clnu.2004.11.013_bib12","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1023\/A:1019992124986","article-title":"Protective effects of antioxidative serotonin derivatives isolated from safflower against postischemic myocardial dysfunction","volume":"238","author":"Hotta","year":"2002","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.clnu.2004.11.013_bib13","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/S0008-6363(00)00078-X","article-title":"Status of myocardial antioxidants in ischemia-reperfusion injury","volume":"18","author":"Dhalla","year":"2000","journal-title":"Cardiovasc Res"},{"issue":"3","key":"10.1016\/j.clnu.2004.11.013_bib14","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.cardiores.2003.09.019","article-title":"Nitric oxide in myocardial ischemia\/reperfusion injury","volume":"61","author":"Schulz","year":"2004","journal-title":"Cardiovasc Res"},{"issue":"8","key":"10.1016\/j.clnu.2004.11.013_bib15","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1016\/S0735-1097(02)02268-4","article-title":"Infarct size limitation by nicorandil","volume":"40","author":"Tsuchida","year":"2002","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.clnu.2004.11.013_bib16","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0008-6363(98)00142-4","article-title":"Role of protein kinase C as a cellular mediator of ischemic preconditioning","volume":"40","author":"Simkhovich","year":"1998","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.clnu.2004.11.013_bib17","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/S0076-6879(78)52032-6","article-title":"Microsomal lipid peroxidation","volume":"52","author":"Buege","year":"1978","journal-title":"Methods Enzymol"},{"issue":"12","key":"10.1016\/j.clnu.2004.11.013_bib18","doi-asserted-by":"crossref","first-page":"4695","DOI":"10.1073\/pnas.86.12.4695","article-title":"Direct evidence that oxygen-derived free radicals contribute to postischemic myocardial dysfunction in the intact dog","volume":"86","author":"Bolli","year":"1986","journal-title":"Proc Natl Acad Sci USA"},{"issue":"3","key":"10.1016\/j.clnu.2004.11.013_bib19","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.cardiores.2003.10.025","article-title":"New concepts in reactive oxygen species and cardiovascular reperfusion physiology","volume":"61","author":"Becker","year":"2004","journal-title":"Cardiovasc Res"},{"issue":"2","key":"10.1016\/j.clnu.2004.11.013_bib20","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/S0891-5849(97)00229-3","article-title":"A short burst of oxygen radicals at reflow induces sustained release of oxidized glutathione from postischemic hearts","volume":"24","author":"Tritto","year":"1998","journal-title":"Free Radical Biol Med"},{"key":"10.1016\/j.clnu.2004.11.013_bib21","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/0891-5849(92)90092-U","article-title":"Reduction of infarct size by cell-permeable oxygen metabolite scavengers","volume":"12","author":"Lesnefsky","year":"1992","journal-title":"Free Radical Biol Med"},{"key":"10.1016\/j.clnu.2004.11.013_bib22","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1016\/S0891-5849(98)00014-8","article-title":"Effects of a novel, low-molecular weight inhibitor of lipid peroxidation on ischemia-reperfusion injury in isolated rat hearts and in cultured cardiomyocytes","volume":"24","author":"Nagy","year":"1998","journal-title":"Free Radical Biol Med"},{"issue":"4","key":"10.1016\/j.clnu.2004.11.013_bib23","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1016\/S0002-9440(10)63514-6","article-title":"Antiapoptotic effect and inhibition of ischemia\/reperfusion-induced myocardial injury in metallothionein-overexpressing transgenic mice","volume":"163","author":"Kang","year":"2003","journal-title":"Am J Pathol"},{"key":"10.1016\/j.clnu.2004.11.013_bib24","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1006\/jmcc.2001.1462","article-title":"Cardioprotective function of inducible nitric oxide synthase and role of nitric oxide in myocardial ischemia and preconditioning","volume":"33","author":"Bolli","year":"2001","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.clnu.2004.11.013_bib25","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/S0008-6363(99)00169-8","article-title":"Interactions between NO and reactive oxygen species","volume":"43","author":"Kodja","year":"1999","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.clnu.2004.11.013_bib26","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1161\/01.RES.87.10.840","article-title":"Endothelial dysfunction in cardiovascular diseases","volume":"87","author":"Cai","year":"2000","journal-title":"Circ Res"},{"issue":"6","key":"10.1016\/j.clnu.2004.11.013_bib27","doi-asserted-by":"crossref","first-page":"H2752","DOI":"10.1152\/ajpheart.2000.279.6.H2752","article-title":"Nitric oxide","volume":"279","author":"Lochner","year":"2000","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.clnu.2004.11.013_bib28","doi-asserted-by":"crossref","first-page":"2617","DOI":"10.1161\/01.CIR.103.21.2617","article-title":"Mitochondria as targets for nitric oxide-induced protection during simulated ischemia and reoxygenation in isolated neonatal cardiomyocytes","volume":"103","author":"Rakhit","year":"2001","journal-title":"Circulation"},{"issue":"11","key":"10.1016\/j.clnu.2004.11.013_bib29","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1006\/jmcc.2001.1468","article-title":"Mitochondrial K(ATP) channel as an end effector of cardioprotection during late preconditioning","volume":"33","author":"Wang","year":"2001","journal-title":"J Mol Cell Cardiol"},{"issue":"6","key":"10.1016\/j.clnu.2004.11.013_bib30","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1097\/00005344-200306000-00017","article-title":"Quinaprilat reduces myocardial infarct size involving nitric oxide production and mitochondrial KATP channel in rabbits","volume":"41","author":"Chen","year":"2003","journal-title":"J Cardiovasc Pharmacol"},{"issue":"1","key":"10.1016\/j.clnu.2004.11.013_bib31","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s002100000255","article-title":"Comparison of the protective effects of ischemic preconditioning and the Na+\/H+ exchanger blockade","volume":"362","author":"Mosca","year":"2000","journal-title":"Naunyn\u2013Schmiedeberg's Arch Pharmacol"}],"container-title":["Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0261561404002092?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0261561404002092?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,2,20]],"date-time":"2019-02-20T17:00:24Z","timestamp":1550682024000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0261561404002092"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,6]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2005,6]]}},"alternative-id":["S0261561404002092"],"URL":"https:\/\/doi.org\/10.1016\/j.clnu.2004.11.013","relation":{},"ISSN":["0261-5614"],"issn-type":[{"value":"0261-5614","type":"print"}],"subject":[],"published":{"date-parts":[[2005,6]]}}}