{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T20:14:26Z","timestamp":1760645666788},"reference-count":34,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2009,6,1]],"date-time":"2009-06-01T00:00:00Z","timestamp":1243814400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Nutrition"],"published-print":{"date-parts":[[2009,6]]},"DOI":"10.1016\/j.clnu.2009.01.011","type":"journal-article","created":{"date-parts":[[2009,2,24]],"date-time":"2009-02-24T16:23:48Z","timestamp":1235492628000},"page":"338-345","source":"Crossref","is-referenced-by-count":8,"title":["The protective effects of a fermented substance from Saccharomyces cerevisiae on carbon tetrachloride-induced liver damage in rats"],"prefix":"10.1016","volume":"28","author":[{"given":"Jinn-Tsyy","family":"Lai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Tsong","family":"Hsieh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsun-Lang","family":"Fang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Chuan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.clnu.2009.01.011_bib1","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1093\/jn\/134.3.489","article-title":"Glutathione metabolism and its implications for health","volume":"134","author":"Wu","year":"2004","journal-title":"J Nutr"},{"key":"10.1016\/j.clnu.2009.01.011_bib2","doi-asserted-by":"crossref","first-page":"237","DOI":"10.18388\/abp.2006_3384","article-title":"Glutathione and GSH-dependent enzymes in patients with liver cirrhosis and hepatocellular carcinoma","volume":"53","author":"Czeczot","year":"2006","journal-title":"Acta Biochim Pol"},{"key":"10.1016\/j.clnu.2009.01.011_bib3","first-page":"13","article-title":"Decrease of total, glutathione and cysteine SH in non-alcoholic cirrhosis","volume":"22","author":"Loguercio","year":"1990","journal-title":"Ital J Gastroenterol"},{"key":"10.1016\/j.clnu.2009.01.011_bib4","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/S0168-8278(04)00065-0","article-title":"Sulfur-containing amino acids attenuate the development of liver fibrosis in rats through down-regulation of stellate cell activation","volume":"40","author":"Matsui","year":"2004","journal-title":"J Hepatol"},{"key":"10.1016\/j.clnu.2009.01.011_bib5","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1111\/j.1600-0773.1997.tb02063.x","article-title":"Glutathione pretreatment lessens the acute liver injury induced by carbon tetrachloride","volume":"81","author":"Arosio","year":"1997","journal-title":"Pharmacol Toxicol"},{"key":"10.1016\/j.clnu.2009.01.011_bib6","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0378-4274(98)00030-7","article-title":"Preventive effect of \u03b3-glutamylcysteinylethyl ester on carbon tetrachloride-induced hepatic triglyceride accumulation in mice","volume":"95","author":"Nishida","year":"1998","journal-title":"Toxicol Lett"},{"key":"10.1016\/j.clnu.2009.01.011_bib7","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1055\/s-2002-26761","article-title":"Oxidative stress, plant-derived antioxidant and liver fibrosis","volume":"68","author":"Gebhardt","year":"2002","journal-title":"Planta Med"},{"key":"10.1016\/j.clnu.2009.01.011_bib8","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1385\/BTER:81:3:245","article-title":"Relationship of blood trace elements to liver damage, nutritional status, and oxidative stress in chronic nonalcoholic liver disease","volume":"81","author":"Loguercio","year":"2001","journal-title":"Biol Trace Elem Res"},{"key":"10.1016\/j.clnu.2009.01.011_bib9","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1023\/A:1006998028528","article-title":"Hepatic production of apolar aldehydes in rats with carbon tetrachloride-induced cirrhosis","volume":"198","author":"Ferre","year":"1999","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.clnu.2009.01.011_bib10","doi-asserted-by":"crossref","first-page":"703","DOI":"10.3748\/wjg.v10.i5.703","article-title":"Therapeutic effects and molecular mechanisms of anti-fibrosis herbs and selenium on rats with hepatic fibrosis","volume":"10","author":"He","year":"2004","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.clnu.2009.01.011_bib11","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s00253-004-1751-y","article-title":"Glutathione: a review on biotechnological production","volume":"66","author":"Li","year":"2004","journal-title":"Appl Microbiol Biotechnol"},{"key":"10.1016\/j.clnu.2009.01.011_bib12","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1091\/mbc.8.9.1699","article-title":"Glutathione synthase is dispensable for growth under both normal and oxidative stress conditions in the yeast Saccharomyces cerevisiae due to an accumulation of the dipeptide gamma-glutamylcysteine","volume":"8","author":"Grant","year":"1997","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.clnu.2009.01.011_bib13","doi-asserted-by":"crossref","first-page":"19387","DOI":"10.1073\/pnas.0708194104","article-title":"Genetic variation in the cysteine biosynthesis pathway causes sensitivity to pharmacological compounds","volume":"104","author":"Kim","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.clnu.2009.01.011_bib14","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1006\/abbi.1993.1474","article-title":"Antioxidant defenses of baker's yeast against free radicals\u00a0and lipid peroxides in rat brain","volume":"306","author":"Santiago","year":"1993","journal-title":"Arch Biochem Biophys"},{"issue":"5 Suppl. 1","key":"10.1016\/j.clnu.2009.01.011_bib15","doi-asserted-by":"crossref","first-page":"1532S","DOI":"10.1093\/jn\/133.5.1532S","article-title":"Multiple regulatory mechanisms maintain zinc homeostasis in Saccharomyces cerevisiae","volume":"133","author":"Eide","year":"2003","journal-title":"J Nutr"},{"key":"10.1016\/j.clnu.2009.01.011_bib16","doi-asserted-by":"crossref","first-page":"8731","DOI":"10.1021\/jf0711901","article-title":"Effect of\u00a0selenium- and glutathione-enriched yeast supplementation on\u00a0a combined atherosclerosis and diabetes hamster model","volume":"55","author":"Agbor","year":"2007","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.clnu.2009.01.011_bib17","doi-asserted-by":"crossref","unstructured":"Lai JT, Fang HL, Lin WL, Lin WC. Protective effect of a fermented substance from Saccharomyces cerevisiae on liver injury in mice caused by acetaminophen. Biosci Biotechnol Biochem 2008;72:2514\u201320.","DOI":"10.1271\/bbb.70681"},{"key":"10.1016\/j.clnu.2009.01.011_bib18","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/0006-2952(88)90169-4","article-title":"Flavonoids are scavengers of superoxide anions","volume":"37","author":"Robak","year":"1998","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.clnu.2009.01.011_bib19","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for lipid peroxide in animal tissue by thiobarbituric acid reaction","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Anal Biochem"},{"key":"10.1016\/j.clnu.2009.01.011_bib20","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J Biol Chem"},{"key":"10.1016\/j.clnu.2009.01.011_bib21","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/0003-2697(76)90326-2","article-title":"A fluorometric method for determination of oxidized and reduced glutathione in tissue","volume":"74","author":"Hssin","year":"1976","journal-title":"Anal Biochem"},{"key":"10.1016\/j.clnu.2009.01.011_bib22","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S0021-9258(19)51149-8","article-title":"The determination of hydroxyproline","volume":"184","author":"Neuman","year":"1950","journal-title":"J Biol Chem"},{"key":"10.1016\/j.clnu.2009.01.011_bib23","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0076-6879(84)05016-3","article-title":"Catalase in vitro","volume":"105","author":"Aebi","year":"1984","journal-title":"Methods Enzymol"},{"key":"10.1016\/j.clnu.2009.01.011_bib24","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/0003-2697(87)90021-2","article-title":"Single-step method of RNA isolation by acid guanidium thiocyanate\u2013phenol\u2013chloroform extraction","volume":"162","author":"Chomczynski","year":"1987","journal-title":"Anal Biochem"},{"key":"10.1016\/j.clnu.2009.01.011_bib25","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1096\/fj.01-0401rev","article-title":"S-adenosylmethionine: a control switch that regulates liver function","volume":"16","author":"Mato","year":"2002","journal-title":"FASEB J"},{"key":"10.1016\/j.clnu.2009.01.011_bib26","doi-asserted-by":"crossref","first-page":"265","DOI":"10.3748\/wjg.v12.i2.265","article-title":"Ameliorative effect of Ganoderma lucidum on carbon tetrachloride-induced liver fibrosis in rats","volume":"14","author":"Lin","year":"2006","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.clnu.2009.01.011_bib27","series-title":"Pharmacotherapy: a pathophysiologic approach","first-page":"785","article-title":"Alcoholic liver disease","author":"Gill","year":"1997"},{"key":"10.1016\/j.clnu.2009.01.011_bib28","series-title":"Hepatology: a textbook of liver disease","first-page":"347","article-title":"Fibrosis: of the liver, representative molecular elements and their emerging role as anti-fibrotic targets","author":"Hanauske-Abel","year":"2003"},{"key":"10.1016\/j.clnu.2009.01.011_bib29","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1016\/S0021-9258(19)75686-5","article-title":"Increased procollagen mRNA levels in carbon tetrachloride-induced liver fibrosis in rats","volume":"262","author":"Pierce","year":"1987","journal-title":"J Biol Chem"},{"key":"10.1016\/j.clnu.2009.01.011_bib30","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1111\/j.1582-4934.2006.tb00292.x","article-title":"Modern pathogenetic concepts of liver fibrosis suggest stellate cells and TGF-\u03b2 as major players and therapeutic targets","volume":"10","author":"Gressner","year":"2006","journal-title":"J cell Mol Med"},{"key":"10.1016\/j.clnu.2009.01.011_bib31","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1079\/BJN19890068","article-title":"Effect of oral glutathione on hepatic glutathione levels in rats and mice","volume":"62","author":"Vina","year":"1989","journal-title":"Br J Nutr"},{"key":"10.1016\/j.clnu.2009.01.011_bib32","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1038\/labinvest.3700332","article-title":"F2-isoprostanes stimulate collagen synthesis in activated hepatic stellate cells: a link with liver fibrosis?","volume":"85","author":"Comporti","year":"2005","journal-title":"Lab Invest"},{"key":"10.1016\/j.clnu.2009.01.011_bib33","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.3748\/wjg.v11.i12.1764","article-title":"Protective effects of 5,4\u2032-dihydroxy-3\u2032-5\u2032-dimethoxy-7-O-beta-D-glucopyranosyloxy-flavone on experimental hepatic injury","volume":"38","author":"Xu","year":"2005","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.clnu.2009.01.011_bib34","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/0885-4505(88)90102-8","article-title":"Hepatic antioxidant enzymes and lipid peroxidation in carbon tetrachloride-induced liver cirrhosis","volume":"40","author":"Nadkarni","year":"1998","journal-title":"Biochem Med Biol"}],"container-title":["Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0261561409000223?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0261561409000223?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,10,2]],"date-time":"2021-10-02T07:40:08Z","timestamp":1633160408000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0261561409000223"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,6]]},"references-count":34,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,6]]}},"alternative-id":["S0261561409000223"],"URL":"https:\/\/doi.org\/10.1016\/j.clnu.2009.01.011","relation":{},"ISSN":["0261-5614"],"issn-type":[{"type":"print","value":"0261-5614"}],"subject":[],"published":{"date-parts":[[2009,6]]}}}