{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T13:28:48Z","timestamp":1781530128264,"version":"3.54.1"},"reference-count":30,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2009,6,1]],"date-time":"2009-06-01T00:00:00Z","timestamp":1243814400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Nutrition"],"published-print":{"date-parts":[[2009,6]]},"DOI":"10.1016\/j.clnu.2009.03.005","type":"journal-article","created":{"date-parts":[[2009,4,9]],"date-time":"2009-04-09T04:32:49Z","timestamp":1239251569000},"page":"249-255","source":"Crossref","is-referenced-by-count":62,"title":["Critically ill infants benefit from early administration of protein and energy-enriched formula: A randomized controlled trial"],"prefix":"10.1016","volume":"28","author":[{"given":"Dick A.","family":"van Waardenburg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlijn T.","family":"de Betue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes B. van","family":"Goudoever","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc J.","family":"Zimmermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koen F.","family":"Joosten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clnu.2009.03.005_bib1","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1177\/0148607185009003309","article-title":"Nutritional depletions in critically ill children: associations with physiologic instability and increased quantity of care","volume":"9","author":"Pollack","year":"1985","journal-title":"J Parenter Enteral Nutr"},{"key":"10.1016\/j.clnu.2009.03.005_bib2","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/S0022-3476(88)80185-9","article-title":"Beneficial effects of early hypocaloric enteral feeding on neonatal gastrointestinal function: preliminary report of a randomized trial","volume":"112","author":"Dunn","year":"1988","journal-title":"J Pediatr"},{"key":"10.1016\/j.clnu.2009.03.005_bib3","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1097\/00000658-198010000-00009","article-title":"Beneficial effects of aggressive protein feeding in severely burned children","volume":"192","author":"Alexander","year":"1980","journal-title":"Ann Surg"},{"key":"10.1016\/j.clnu.2009.03.005_bib4","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1177\/0115426595010005177","article-title":"Body composition and nutrition support in pediatrics: what to defend and how soon to begin","volume":"10","author":"Cunningham","year":"1995","journal-title":"Nutr Clin Pract"},{"key":"10.1016\/j.clnu.2009.03.005_bib5","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/S0022-3476(75)80060-6","article-title":"Effects of starvation in infancy (pyloric stenosis) on subsequent learning abilities","volume":"87","author":"Klein","year":"1975","journal-title":"J Pediatr"},{"key":"10.1016\/j.clnu.2009.03.005_bib6","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1097\/01.mco.0000222115.91783.71","article-title":"Causes and consequences of inadequate substrate supply to pediatric ICU patients","volume":"9","author":"Hulst","year":"2006","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"10.1016\/j.clnu.2009.03.005_bib7","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1097\/00003246-198811000-00006","article-title":"Pediatric risk of mortality (PRISM) score","volume":"16","author":"Pollack","year":"1988","journal-title":"Crit Care Med"},{"key":"10.1016\/j.clnu.2009.03.005_bib8","series-title":"Dietary reference intakes for macronutrients","article-title":"Macronutrients","year":"2005"},{"key":"10.1016\/j.clnu.2009.03.005_bib9","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0261-5614(99)80004-1","article-title":"Indirect calorimetry in mechanically ventilated infants and children: accuracy of total daily energy expenditure with 2 hour measurements","volume":"18","author":"Joosten","year":"1999","journal-title":"Clin Nutr"},{"issue":"Suppl. 1","key":"10.1016\/j.clnu.2009.03.005_bib10","first-page":"5","article-title":"Predicting basal metabolic rate, new standards and review of previous work","volume":"39","author":"Schofield","year":"1985","journal-title":"Hum Nutr Clin Nutr"},{"key":"10.1016\/j.clnu.2009.03.005_bib11","series-title":"Physiological measurements of metabolic function in man","first-page":"313","article-title":"The computation of metabolic balances","author":"Consolazio","year":"1963"},{"key":"10.1016\/j.clnu.2009.03.005_bib12","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1006\/abio.1999.4112","article-title":"Determination of amino acid isotope enrichment using liquid chromatography\u2013mass spectrometry","volume":"271","author":"van Eijk","year":"1999","journal-title":"Anal Biochem"},{"key":"10.1016\/j.clnu.2009.03.005_bib13","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/S0022-5223(97)70019-9","article-title":"Nitrogen balance, 3-methylhistidine excretion, and plasma amino acid profile in infants after cardiac operations for congenital heart defects: the effect of early nutritional support","volume":"114","author":"Chaloupecky","year":"1997","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.clnu.2009.03.005_bib14","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.1093\/clinchem\/36.11.1922","article-title":"Diet-related reference values for plasma amino acids in newborns measured by reversed-phase HPLC","volume":"36","author":"Scott","year":"1990","journal-title":"Clin Chem"},{"key":"10.1016\/j.clnu.2009.03.005_bib15","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/j.1365-277X.2006.00689.x","article-title":"Should high-energy infant formula be given at full strength from its first day of usage?","volume":"19","author":"Evans","year":"2006","journal-title":"J Hum Nutr Diet"},{"key":"10.1016\/j.clnu.2009.03.005_bib16","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1111\/j.1365-277X.2007.00805.x","article-title":"Randomized comparison of a nutrient-dense formula with an energy-supplemented formula for infants with faltering growth","volume":"20","author":"Clarke","year":"2007","journal-title":"J Hum Nutr Diet"},{"key":"10.1016\/j.clnu.2009.03.005_bib17","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.jpeds.2005.05.038","article-title":"Amino acid administration to premature infants directly after birth","volume":"147","author":"te Braake","year":"2005","journal-title":"J Pediatr"},{"key":"10.1016\/j.clnu.2009.03.005_bib18","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/S0026-0495(97)90196-7","article-title":"Urea and protein metabolism in burned children: effect of dietary protein intake","volume":"46","author":"Patterson","year":"1997","journal-title":"Metabolism"},{"key":"10.1016\/j.clnu.2009.03.005_bib19","doi-asserted-by":"crossref","first-page":"3219S","DOI":"10.1093\/jn\/131.10.3219S","article-title":"Regulation of muscle protein by amino acids","volume":"132","author":"Wolfe","year":"2002","journal-title":"J Nutr"},{"key":"10.1016\/j.clnu.2009.03.005_bib20","first-page":"E592","article-title":"Amino acids suppress proteolysis independent of insulin throughout the neonatal period","volume":"272","author":"Poindexter","year":"1997","journal-title":"Am J Physiol"},{"key":"10.1016\/j.clnu.2009.03.005_bib21","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/S0022-3476(87)80394-3","article-title":"Indices of protein metabolism in term infants fed either human milk or formulas with reduced protein concentration and various whey\/casein ratios","volume":"110","author":"Janas","year":"1987","journal-title":"J Pediatr"},{"key":"10.1016\/j.clnu.2009.03.005_bib22","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/S0899-9007(99)00081-7","article-title":"Energy expenditure and substrate utilization in mechanically ventilated children","volume":"15","author":"Joosten","year":"1999","journal-title":"Nutrition"},{"key":"10.1016\/j.clnu.2009.03.005_bib23","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1079\/PHN2005790","article-title":"Energy requirements of infants","volume":"8","author":"Butte","year":"2005","journal-title":"Public Health Nutr"},{"key":"10.1016\/j.clnu.2009.03.005_bib24","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/0022-3468(93)90144-A","article-title":"Glucose utilization in the surgical newborn infant receiving total parenteral nutrition","volume":"28","author":"Jones","year":"1993","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.clnu.2009.03.005_bib25","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1177\/0148607198022004212","article-title":"Maximal parenteral glucose oxidation in hypermetabolic young children: a stable isotope study [see comments]","volume":"22","author":"Sheridan","year":"1998","journal-title":"J Parenter Enteral Nutr"},{"key":"10.1016\/j.clnu.2009.03.005_bib26","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1093\/ajcn\/67.1.74","article-title":"Resting energy expenditure in children in a pediatric intensive care unit: comparison of Harris\u2013Benedict and Talbot predictions with indirect calorimetry values","volume":"67","author":"Coss-Bu","year":"1998","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.clnu.2009.03.005_bib27","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.nut.2004.05.020","article-title":"Adequate feeding and the usefulness of the respiratory quotient in critically ill children","volume":"21","author":"Hulst","year":"2005","journal-title":"Nutrition"},{"key":"10.1016\/j.clnu.2009.03.005_bib28","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/S0899-9007(03)00170-9","article-title":"Barriers to adequate nutrition in critically ill children","volume":"19","author":"Rogers","year":"2003","journal-title":"Nutrition"},{"key":"10.1016\/j.clnu.2009.03.005_bib29","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1016\/j.clnu.2004.05.006","article-title":"The effect of cumulative energy and protein deficiency on anthropometric parameters in a pediatric ICU population","volume":"23","author":"Hulst","year":"2004","journal-title":"Clin Nutr"},{"issue":"8","key":"10.1016\/j.clnu.2009.03.005_bib30","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1080\/08035250600724507","article-title":"Postnatal growth, neurodevelopment and altered adiposity after preterm birth\u2014from a clinical nutrition perspective","volume":"95","author":"Yeung","year":"2006","journal-title":"Acta Paedatr"}],"container-title":["Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0261561409000673?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0261561409000673?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,17]],"date-time":"2020-05-17T07:27:38Z","timestamp":1589700458000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0261561409000673"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,6]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,6]]}},"alternative-id":["S0261561409000673"],"URL":"https:\/\/doi.org\/10.1016\/j.clnu.2009.03.005","relation":{},"ISSN":["0261-5614"],"issn-type":[{"value":"0261-5614","type":"print"}],"subject":[],"published":{"date-parts":[[2009,6]]}}}