{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T13:00:01Z","timestamp":1788872401499,"version":"build-2803163510"},"reference-count":46,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100012164","name":"National High-tech Research and Development Program","doi-asserted-by":"publisher","award":["N20080753"],"award-info":[{"award-number":["N20080753"]}],"id":[{"id":"10.13039\/501100012164","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30972464"],"award-info":[{"award-number":["30972464"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002338","name":"Ministry of Education of the People's Republic of China","doi-asserted-by":"publisher","award":["20070335025"],"award-info":[{"award-number":["20070335025"]}],"id":[{"id":"10.13039\/501100002338","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","clinicalnutritionjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Nutrition"],"published-print":{"date-parts":[[2012,8]]},"DOI":"10.1016\/j.clnu.2011.01.003","type":"journal-article","created":{"date-parts":[[2012,5,29]],"date-time":"2012-05-29T14:47:30Z","timestamp":1338302850000},"page":"448-454","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":98,"title":["Meta-analysis of B vitamin supplementation on plasma homocysteine, cardiovascular and all-cause mortality"],"prefix":"10.1016","volume":"31","author":[{"given":"Tao","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark L.","family":"Wahlqvist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duo","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clnu.2011.01.003_bib1","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1096\/fasebj.7.14.7901104","article-title":"Metabolic abnormalities in cobalamin (vitamin B12) and folate deficiency","volume":"7","author":"Allen","year":"1993","journal-title":"FASEB J"},{"key":"10.1016\/j.clnu.2011.01.003_bib2","first-page":"8","article-title":"Cardiovascular pathogenesis in hyperhomocysteinemia","volume":"17","author":"Huang","year":"2008","journal-title":"Asia Pac J Clin Nutr"},{"key":"10.1016\/j.clnu.2011.01.003_bib3","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1146\/annurev.med.49.1.31","article-title":"Homocysteine and cardiovascular disease","volume":"49","author":"Refsum","year":"1998","journal-title":"Annu Rev Med"},{"key":"10.1016\/j.clnu.2011.01.003_bib4","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1136\/bmj.325.7374.1202","article-title":"Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis","volume":"325","author":"Wald","year":"2002","journal-title":"Br Med J"},{"key":"10.1016\/j.clnu.2011.01.003_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/ije\/dyg070","article-title":"'Mendelian randomization': can genetic epidemiology contribute to understanding environmental determinants of disease?","volume":"32","author":"Davey Smith","year":"2003","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.clnu.2011.01.003_bib6","first-page":"35","article-title":"Molecular genetic analysis in mild hyperhomocysteinemia: a common mutation in the methylenetetrahydrofolate reductase gene is a genetic risk factor for cardiovascular disease","volume":"58","author":"Kluijtmans","year":"1996","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.clnu.2011.01.003_bib7","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1093\/ajcn\/82.4.806","article-title":"Dose-dependent effects of folic acid on blood concentrations of homocysteine: a meta-analysis of the randomized trials","volume":"82","year":"2005","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.clnu.2011.01.003_bib8","doi-asserted-by":"crossref","first-page":"215","DOI":"10.3109\/00365518809167487","article-title":"Folic acid\u2013an innocuous means to reduce plasma homocysteine","volume":"48","author":"Brattstrom","year":"1988","journal-title":"Scand J Clin Lab Invest"},{"key":"10.1016\/j.clnu.2011.01.003_bib9","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1136\/bmj.316.7135.894","article-title":"Lowering blood homocysteine with folic acid based supplements: meta-analysis of randomised trials","volume":"316","author":"Brattstrom","year":"1998","journal-title":"Br Med J"},{"key":"10.1016\/j.clnu.2011.01.003_bib10","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1056\/NEJMoa055227","article-title":"Homocysteine lowering and cardiovascular events after acute myocardial infarction","volume":"354","author":"Bonaa","year":"2006","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.clnu.2011.01.003_bib11","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1136\/bmj.326.7404.1419","article-title":"A\u00a0strategy to reduce cardiovascular disease by more than 80%","volume":"326","author":"Wald","year":"2003","journal-title":"BMJ"},{"key":"10.1016\/j.clnu.2011.01.003_bib12","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1161\/hq0102.102190","article-title":"Folates and cardiovascular disease","volume":"22","author":"Verhaar","year":"2002","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.clnu.2011.01.003_bib13","doi-asserted-by":"crossref","first-page":"2720","DOI":"10.1001\/jama.296.22.2720","article-title":"Effect of folic acid supplementation on risk of cardiovascular diseases: a meta-analysis of randomized controlled trials","volume":"296","author":"Bazzano","year":"2006","journal-title":"JAMA"},{"key":"10.1016\/j.clnu.2011.01.003_bib14","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1001\/jama.291.5.565","article-title":"Lowering homocysteine in patients with ischemic stroke to prevent recurrent stroke, myocardial infarction, and death: the Vitamin Intervention for Stroke Prevention (VISP) randomized controlled trial","volume":"291","author":"Toole","year":"2004","journal-title":"JAMA"},{"key":"10.1016\/j.clnu.2011.01.003_bib15","doi-asserted-by":"crossref","first-page":"2404","DOI":"10.1161\/01.STR.0000185929.38534.f3","article-title":"Vitamin Intervention For Stroke Prevention trial: an efficacy analysis","volume":"36","author":"Spence","year":"2005","journal-title":"Stroke"},{"key":"10.1016\/j.clnu.2011.01.003_bib16","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1056\/NEJMoa011364","article-title":"Decreased rate of coronary restenosis after lowering of plasma homocysteine levels","volume":"345","author":"Schnyder","year":"2001","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.clnu.2011.01.003_bib17","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.1056\/NEJMoa032845","article-title":"Folate therapy and in-stent restenosis after coronary stenting","volume":"350","author":"Lange","year":"2004","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.clnu.2011.01.003_bib18","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1001\/jama.299.17.2027","article-title":"Effect of folic acid and B vitamins on risk of cardiovascular events and total mortality among women at high risk for cardiovascular disease: a randomized trial","volume":"299","author":"Albert","year":"2008","journal-title":"JAMA"},{"key":"10.1016\/j.clnu.2011.01.003_bib19","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1161\/STROKEAHA.108.529503","article-title":"Homocysteine-lowering therapy and stroke risk, severity, and disability: additional findings from the HOPE 2 trial","volume":"40","author":"Saposnik","year":"2009","journal-title":"Stroke"},{"key":"10.1016\/j.clnu.2011.01.003_bib20","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1161\/CIRCULATIONAHA.109.904672","article-title":"B\u00a0vitamins and the risk of total mortality and cardiovascular disease in end-stage renal disease: results of a randomized controlled trial","volume":"121","author":"Heinz","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.clnu.2011.01.003_bib21","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1001\/jama.298.10.1163","article-title":"Effect of homocysteine lowering on mortality and vascular disease in advanced chronic kidney disease and end-stage renal disease: a randomized controlled trial","volume":"298","author":"Jamison","year":"2007","journal-title":"JAMA"},{"key":"10.1016\/j.clnu.2011.01.003_bib22","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1016\/S0140-6736(06)68534-6","article-title":"Folate supplementation and cardiovascular disease","volume":"367","author":"Stampfer","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.clnu.2011.01.003_bib23","doi-asserted-by":"crossref","first-page":"133","DOI":"10.7326\/0003-4819-135-2-200107170-00014","article-title":"Power shortage: clinical trials testing the \u201chomocysteine hypothesis\u201d against a background of folic acid-fortified cereal grain flour","volume":"135","author":"Bostom","year":"2001","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.clnu.2011.01.003_bib24","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0197-2456(86)90046-2","article-title":"Meta-analysis in clinical trials","volume":"7","author":"DerSimonian","year":"1986","journal-title":"Control Clin Trials"},{"key":"10.1016\/j.clnu.2011.01.003_bib25","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.2307\/2533446","article-title":"Operating characteristics of a rank correlation test for publication bias","volume":"50","author":"Begg","year":"1994","journal-title":"Biometrics"},{"key":"10.1016\/j.clnu.2011.01.003_bib26","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","article-title":"Bias in meta-analysis detected by a simple, graphical test","volume":"315","author":"Egger","year":"1997","journal-title":"BMJ"},{"key":"10.1016\/j.clnu.2011.01.003_bib27","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1001\/jama.288.8.973","article-title":"Effect of homocysteine-lowering therapy with folic acid, vitamin B12, and vitamin B6 on clinical outcome after percutaneous coronary intervention: the Swiss Heart study: a randomized controlled trial","volume":"288","author":"Schnyder","year":"2002","journal-title":"JAMA"},{"key":"10.1016\/j.clnu.2011.01.003_bib28","first-page":"PI19","article-title":"Effects of folic acid treatment on homocysteine levels and vascular disease in hemodialysis patients","volume":"9","author":"Righetti","year":"2003","journal-title":"Med Sci Monit"},{"key":"10.1016\/j.clnu.2011.01.003_bib29","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.ijcard.2003.02.001","article-title":"Efficacy of folic acid when added to statin therapy in patients with hypercholesterolemia following acute myocardial infarction: a randomised pilot trial","volume":"93","author":"Liem","year":"2004","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.clnu.2011.01.003_bib30","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1097\/01.ASN.0000110181.64655.6C","article-title":"Randomized trial of folic acid for prevention of cardiovascular events in end-stage renal disease","volume":"15","author":"Wrone","year":"2004","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.clnu.2011.01.003_bib31","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1136\/hrt.2004.035030","article-title":"Secondary prevention with folic acid: results of the Goes extension study","volume":"91","author":"Liem","year":"2005","journal-title":"Heart"},{"key":"10.1016\/j.clnu.2011.01.003_bib32","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1056\/NEJMoa060900","article-title":"Homocysteine lowering with folic acid and B vitamins in vascular disease","volume":"354","author":"Lonn","year":"2006","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.clnu.2011.01.003_bib33","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1159\/000093680","article-title":"Homocysteine-lowering vitamin B treatment decreases cardiovascular events in hemodialysis patients","volume":"24","author":"Righetti","year":"2006","journal-title":"Blood Purif"},{"key":"10.1016\/j.clnu.2011.01.003_bib34","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1016\/j.jacc.2005.10.064","article-title":"Cardiovascular morbidity and mortality in the Atherosclerosis and Folic Acid Supplementation Trial (ASFAST) in chronic renal failure: a multicenter, randomized, controlled trial","volume":"47","author":"Zoungas","year":"2006","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.clnu.2011.01.003_bib35","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1001\/jama.300.7.795","article-title":"Mortality and cardiovascular events in patients treated with homocysteine-lowering B vitamins after coronary angiography: a randomized controlled trial","volume":"300","author":"Ebbing","year":"2008","journal-title":"JAMA"},{"key":"10.1016\/j.clnu.2011.01.003_bib36","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/S1474-4422(10)70187-3","article-title":"B\u00a0vitamins in patients with recent transient ischaemic attack or stroke in the VITAmins TO Prevent Stroke (VITATOPS) trial: a randomised, double-blind, parallel, placebo-controlled trial","volume":"9","author":"Hankey","year":"2010","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.clnu.2011.01.003_bib37","doi-asserted-by":"crossref","first-page":"2486","DOI":"10.1001\/jama.2010.840","article-title":"Effects of homocysteine-lowering with folic acid plus vitamin B-12 vs placebo on mortality and major morbidity in myocardial infarction survivors A randomized trial","volume":"303","author":"Armitage","year":"2010","journal-title":"JAMA"},{"key":"10.1016\/j.clnu.2011.01.003_bib38","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1001\/jama.1995.03530130055028","article-title":"A\u00a0quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes","volume":"274","author":"Boushey","year":"1995","journal-title":"JAMA"},{"key":"10.1016\/j.clnu.2011.01.003_bib39","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1097\/00043798-199808000-00004","article-title":"Plasma homocysteine and coronary heart disease: systematic review of published epidemiological studies","volume":"5","author":"Danesh","year":"1998","journal-title":"J\u00a0Cardiovasc Risk"},{"key":"10.1016\/j.clnu.2011.01.003_bib40","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1001\/jama.288.16.2015","article-title":"Homocysteine and risk of ischemic heart disease and stroke \u2013 A meta-analysis","volume":"288","author":"Clarke","year":"2002","journal-title":"JAMA"},{"key":"10.1016\/j.clnu.2011.01.003_bib41","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.nut.2009.05.015","article-title":"Docosahexaenoic acid decreases plasma homocysteine via regulating enzyme activity and mRNA expression involved in methionine metabolism","volume":"26","author":"Huang","year":"2010","journal-title":"Nutrition"},{"key":"10.1016\/j.clnu.2011.01.003_bib42","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.numecd.2010.07.015","article-title":"MAT1A variants modulate the effect of dietary fatty acids on plasma homocysteine concentrations","volume":"22","author":"Huang","year":"2012","journal-title":"Nutr Metab Cardiovas"},{"key":"10.1016\/j.clnu.2011.01.003_bib43","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/S1474-4422(07)70219-3","article-title":"Homocysteine-lowering therapy: a role in stroke prevention?","volume":"6","author":"Spence","year":"2007","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.clnu.2011.01.003_bib44","first-page":"47","article-title":"Rationale, design and baseline characteristics of a large, simple, randomized trial of combined folic acid and vitamins B6 and B12 in high-risk patients: the Heart Outcomes Prevention Evaluation (HOPE)-2 trial","volume":"22","author":"Lonn","year":"2006","journal-title":"Can J Cardiol"},{"key":"10.1016\/j.clnu.2011.01.003_bib45","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1016\/S0140-6736(07)60854-X","article-title":"Efficacy of folic acid supplementation in stroke prevention: a meta-analysis","volume":"369","author":"Wang","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.clnu.2011.01.003_bib46","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.3945\/ajcn.2009.28837","article-title":"Multivitamin use and breast cancer incidence in a prospective cohort of Swedish women","volume":"91","author":"Larsson","year":"2010","journal-title":"Am J Clin Nutr"}],"container-title":["Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0261561411000057?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0261561411000057?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T00:50:35Z","timestamp":1759366235000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0261561411000057"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8]]},"references-count":46,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["S0261561411000057"],"URL":"https:\/\/doi.org\/10.1016\/j.clnu.2011.01.003","relation":{},"ISSN":["0261-5614"],"issn-type":[{"value":"0261-5614","type":"print"}],"subject":[],"published":{"date-parts":[[2012,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Meta-analysis of B vitamin supplementation on plasma homocysteine, cardiovascular and all-cause mortality","name":"articletitle","label":"Article Title"},{"value":"Clinical Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clnu.2011.01.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Crown copyright \u00a9 2012 Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}