{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T17:13:36Z","timestamp":1792430016729,"version":"4.5.0"},"reference-count":51,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Nutrition"],"published-print":{"date-parts":[[2012,12]]},"DOI":"10.1016\/j.clnu.2012.04.001","type":"journal-article","created":{"date-parts":[[2012,4,27]],"date-time":"2012-04-27T03:17:49Z","timestamp":1335496669000},"page":"940-945","source":"Crossref","is-referenced-by-count":18,"title":["Changes in adipokines after transjugular intrahepatic porto-systemic shunt indicate an anabolic shift in metabolism"],"prefix":"10.1016","volume":"31","author":[{"given":"Karen Louise","family":"Thomsen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas Damgaard","family":"Sandahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Holland-Fischer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels","family":"Jessen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Frystyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan","family":"Flyvbjerg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henning","family":"Gr\u00f8nb\u00e6k","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hendrik","family":"Vilstrup","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clnu.2012.04.001_bib1","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/1-4020-5688-5_3","article-title":"Obesity, inflammation, and vascular disease: the role of the adipose tissue as an endocrine organ","volume":"42","author":"Calabro","year":"2007","journal-title":"Subcell Biochem"},{"issue":"Suppl. 5","key":"10.1016\/j.clnu.2012.04.001_bib2","doi-asserted-by":"crossref","first-page":"242S","DOI":"10.1038\/oby.2006.317","article-title":"Adipose tissue as an endocrine organ","volume":"14","author":"Ahima","year":"2006","journal-title":"Obesity (Silver Spring)"},{"issue":"11 Suppl. 1","key":"10.1016\/j.clnu.2012.04.001_bib3","doi-asserted-by":"crossref","first-page":"S57","DOI":"10.1210\/jc.2008-1585","article-title":"Role of body fat distribution and the metabolic complications of obesity","volume":"93","author":"Jensen","year":"2008","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.clnu.2012.04.001_bib4","first-page":"26","article-title":"Lipolysis in human adipocytes, effects of cell size, age and of regional differences","volume":"19","author":"Engfeldt","year":"1988","journal-title":"Horm Metab Res Suppl"},{"issue":"5","key":"10.1016\/j.clnu.2012.04.001_bib5","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/nrm2391","article-title":"Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes","volume":"9","author":"Guilherme","year":"2008","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"7","key":"10.1016\/j.clnu.2012.04.001_bib6","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1172\/JCI29126","article-title":"Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome","volume":"116","author":"Kadowaki","year":"2006","journal-title":"J\u00a0Clin Invest"},{"issue":"6","key":"10.1016\/j.clnu.2012.04.001_bib7","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/S0899-9007(01)00521-4","article-title":"Nutrition and survival in patients with liver cirrhosis","volume":"17","author":"Alberino","year":"2001","journal-title":"Nutrition"},{"issue":"6","key":"10.1016\/j.clnu.2012.04.001_bib8","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/S0899-9007(02)01071-7","article-title":"Evaluation of nutritional practice in hospitalized cirrhotic patients: results of a prospective study","volume":"19","author":"Campillo","year":"2003","journal-title":"Nutrition"},{"issue":"6","key":"10.1016\/j.clnu.2012.04.001_bib9","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1093\/ajcn\/69.6.1194","article-title":"Hypermetabolism in clinically stable patients with liver cirrhosis","volume":"69","author":"Muller","year":"1999","journal-title":"Am J Clin Nutr"},{"issue":"5","key":"10.1016\/j.clnu.2012.04.001_bib10","doi-asserted-by":"crossref","first-page":"2136","DOI":"10.1210\/jc.2003-031771","article-title":"Plasma ghrelin concentrations, food intake, and anorexia in liver failure","volume":"89","author":"Marchesini","year":"2004","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"2","key":"10.1016\/j.clnu.2012.04.001_bib11","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.jhep.2003.10.011","article-title":"Weight gain after transjugular intrahepatic portosystemic shunt is associated with improvement in body composition in malnourished patients with cirrhosis and hypermetabolism","volume":"40","author":"Plauth","year":"2004","journal-title":"J\u00a0Hepatol"},{"issue":"2","key":"10.1016\/j.clnu.2012.04.001_bib12","doi-asserted-by":"crossref","first-page":"G486","DOI":"10.1152\/ajpgi.00375.2009","article-title":"Insulin sensitivity and body composition in cirrhosis: changes after TIPS","volume":"299","author":"Holland-Fischer","year":"2010","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"8","key":"10.1016\/j.clnu.2012.04.001_bib13","doi-asserted-by":"crossref","first-page":"2442","DOI":"10.1111\/j.1572-0241.2001.04051.x","article-title":"Effects of ascites resolution after successful TIPS on nutrition in cirrhotic patients with refractory ascites","volume":"96","author":"Allard","year":"2001","journal-title":"Am J Gastroenterol"},{"issue":"2","key":"10.1016\/j.clnu.2012.04.001_bib14","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.diabres.2003.09.010","article-title":"Relationship between serum adiponectin and leptin concentrations and body fat distribution","volume":"63","author":"Park","year":"2004","journal-title":"Diabetes Res Clin Pract"},{"issue":"1","key":"10.1016\/j.clnu.2012.04.001_bib15","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1097\/00041433-200202000-00008","article-title":"Control of energy homeostasis and insulin action by adipocyte hormones: leptin, acylation stimulating protein, and adiponectin","volume":"13","author":"Havel","year":"2002","journal-title":"Curr Opin Lipidol"},{"issue":"24","key":"10.1016\/j.clnu.2012.04.001_bib16","doi-asserted-by":"crossref","first-page":"2552","DOI":"10.1056\/NEJMoa054862","article-title":"Retinol-binding protein 4 and insulin resistance in lean, obese, and diabetic subjects","volume":"354","author":"Graham","year":"2006","journal-title":"N\u00a0Engl J Med"},{"issue":"9","key":"10.1016\/j.clnu.2012.04.001_bib17","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1373\/clinchem.2004.032482","article-title":"Endocrine regulation of energy metabolism: review of pathobiochemical and clinical chemical aspects of leptin, ghrelin, adiponectin, and resistin","volume":"50","author":"Meier","year":"2004","journal-title":"Clin Chem"},{"issue":"3","key":"10.1016\/j.clnu.2012.04.001_bib18","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1530\/eje.0.1480293","article-title":"The role of the novel adipocyte-derived hormone adiponectin in human disease","volume":"148","author":"Diez","year":"2003","journal-title":"Eur J Endocrinol"},{"issue":"3","key":"10.1016\/j.clnu.2012.04.001_bib19","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1056\/NEJM199401203300303","article-title":"The transjugular intrahepatic portosystemic stent-shunt procedure for variceal bleeding","volume":"330","author":"Rossle","year":"1994","journal-title":"N\u00a0Engl J Med"},{"issue":"2","key":"10.1016\/j.clnu.2012.04.001_bib20","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1053\/jhep.2001.22172","article-title":"A\u00a0model to predict survival in patients with end-stage liver disease","volume":"33","author":"Kamath","year":"2001","journal-title":"Hepatology"},{"key":"10.1016\/j.clnu.2012.04.001_bib21","first-page":"118","article-title":"Determination of the hepatic elimination capacity (Lm) of galactose by single injection","volume":"18","author":"Tygstrup","year":"1966","journal-title":"Scand J Clin Lab Invest Suppl"},{"issue":"2","key":"10.1016\/j.clnu.2012.04.001_bib22","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0261-5614(97)80022-2","article-title":"ESPEN guidelines for nutrition in liver disease and transplantation","volume":"16","author":"Plauth","year":"1997","journal-title":"Clin Nutr"},{"issue":"3","key":"10.1016\/j.clnu.2012.04.001_bib23","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1093\/ajcn\/44.3.417","article-title":"Estimation of total body water by bioelectrical impedance analysis","volume":"44","author":"Kushner","year":"1986","journal-title":"Am J Clin Nutr"},{"issue":"6","key":"10.1016\/j.clnu.2012.04.001_bib24","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1007\/BF00210228","article-title":"Protein-calorie malnutrition in liver cirrhosis","volume":"70","author":"Lautz","year":"1992","journal-title":"Clin Investig"},{"issue":"5","key":"10.1016\/j.clnu.2012.04.001_bib25","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1210\/jc.2006-2310","article-title":"Gender differences of oligomers and total adiponectin during puberty: a cross-sectional study of 859 Danish school children","volume":"92","author":"Andersen","year":"2007","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"9","key":"10.1016\/j.clnu.2012.04.001_bib26","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1007\/s00125-005-1850-z","article-title":"Increased serum adiponectin levels in type 1 diabetic patients with microvascular complications","volume":"48","author":"Frystyk","year":"2005","journal-title":"Diabetologia"},{"issue":"3","key":"10.1016\/j.clnu.2012.04.001_bib27","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/ajh.2009.244","article-title":"Leptin, not adiponectin, predicts hypertension in the Copenhagen City Heart Study","volume":"23","author":"Asferg","year":"2010","journal-title":"Am J Hypertens"},{"issue":"7","key":"10.1016\/j.clnu.2012.04.001_bib28","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/BF00280883","article-title":"Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man","volume":"28","author":"Matthews","year":"1985","journal-title":"Diabetologia"},{"issue":"1","key":"10.1016\/j.clnu.2012.04.001_bib29","doi-asserted-by":"crossref","first-page":"E82","DOI":"10.1152\/ajpendo.00494.2003","article-title":"Elevated circulating adiponectin levels in liver cirrhosis are associated with reduced liver function and\u00a0altered hepatic hemodynamics","volume":"287","author":"Tietge","year":"2004","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"5","key":"10.1016\/j.clnu.2012.04.001_bib30","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.2337\/dc06-2323","article-title":"Insulin resistance in liver cirrhosis is not associated with circulating retinol-binding protein 4","volume":"30","author":"Yagmur","year":"2007","journal-title":"Diabetes Care"},{"issue":"6","key":"10.1016\/j.clnu.2012.04.001_bib31","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1002\/hep.510290601","article-title":"Increased circulating leptin in alcoholic cirrhosis: relation to release and disposal","volume":"29","author":"Henriksen","year":"1999","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.clnu.2012.04.001_bib32","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/j.1478-3231.2004.0986.x","article-title":"Elevated plasma adiponectin concentrations in patients with liver cirrhosis correlate with plasma insulin levels","volume":"25","author":"Sohara","year":"2005","journal-title":"Liver Int"},{"issue":"3","key":"10.1016\/j.clnu.2012.04.001_bib33","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1111\/j.1365-2796.2005.01543.x","article-title":"Circulating adiponectin reflects severity of liver disease but not insulin sensitivity in liver cirrhosis","volume":"258","author":"Kaser","year":"2005","journal-title":"J\u00a0Intern Med"},{"issue":"1","key":"10.1016\/j.clnu.2012.04.001_bib34","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1111\/j.1365-2265.2008.03295.x","article-title":"Decreased hepatic RBP4 secretion is correlated with reduced hepatic glucose production but is not associated with insulin resistance in patients with liver cirrhosis","volume":"70","author":"Bahr","year":"2009","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"4","key":"10.1016\/j.clnu.2012.04.001_bib35","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/S0016-5085(98)70267-7","article-title":"Gender-dependent alterations in serum leptin in alcoholic cirrhosis","volume":"115","author":"McCullough","year":"1998","journal-title":"Gastroenterology"},{"issue":"25","key":"10.1016\/j.clnu.2012.04.001_bib36","doi-asserted-by":"crossref","first-page":"16309","DOI":"10.1073\/pnas.222657499","article-title":"Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: acetyl-CoA carboxylase inhibition and AMP-activated protein kinase activation","volume":"99","author":"Tomas","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"issue":"11","key":"10.1016\/j.clnu.2012.04.001_bib37","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1038\/nm788","article-title":"Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase","volume":"8","author":"Yamauchi","year":"2002","journal-title":"Nat Med"},{"issue":"1","key":"10.1016\/j.clnu.2012.04.001_bib38","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.biochi.2004.10.017","article-title":"AMP-activated protein kinase: balancing the scales","volume":"87","author":"Carling","year":"2005","journal-title":"Biochimie"},{"issue":"13","key":"10.1016\/j.clnu.2012.04.001_bib39","doi-asserted-by":"crossref","first-page":"12005","DOI":"10.1074\/jbc.C300557200","article-title":"AMP-activated protein kinase plays a role in the control of food intake","volume":"279","author":"Andersson","year":"2004","journal-title":"J\u00a0Biol Chem"},{"issue":"1","key":"10.1016\/j.clnu.2012.04.001_bib40","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.cmet.2007.06.003","article-title":"Adiponectin stimulates AMP-activated protein kinase in the hypothalamus and increases food intake","volume":"6","author":"Kubota","year":"2007","journal-title":"Cell Metab"},{"issue":"4","key":"10.1016\/j.clnu.2012.04.001_bib41","doi-asserted-by":"crossref","first-page":"389","DOI":"10.2217\/17460875.1.4.389","article-title":"Adiposopathy: why do adiposity and obesity cause metabolic disease?","volume":"1","author":"Bays","year":"2006","journal-title":"Future Lipidol"},{"issue":"7049","key":"10.1016\/j.clnu.2012.04.001_bib42","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/nature03711","article-title":"Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes","volume":"436","author":"Yang","year":"2005","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.clnu.2012.04.001_bib43","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1210\/jc.2006-2712","article-title":"Reduction of elevated serum retinol binding protein in obese children by lifestyle intervention: association with subclinical inflammation","volume":"92","author":"Balagopal","year":"2007","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"1","key":"10.1016\/j.clnu.2012.04.001_bib44","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.cmet.2007.06.002","article-title":"Serum retinol-binding protein is more highly expressed in visceral than in subcutaneous adipose tissue and is a marker of intra-abdominal fat mass","volume":"6","author":"Kloting","year":"2007","journal-title":"Cell Metab"},{"issue":"10","key":"10.1016\/j.clnu.2012.04.001_bib45","doi-asserted-by":"crossref","first-page":"2588","DOI":"10.2337\/dc07-0275","article-title":"Serum levels of adipokine retinol-binding protein-4 in relation to renal function","volume":"30","author":"Ziegelmeier","year":"2007","journal-title":"Diabetes Care"},{"issue":"3","key":"10.1016\/j.clnu.2012.04.001_bib46","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S0002-9343(99)00029-7","article-title":"Long-term renal sodium handling in patients with cirrhosis treated with transjugular intrahepatic portosystemic shunts for refractory ascites","volume":"106","author":"Wong","year":"1999","journal-title":"Am J Med"},{"issue":"2","key":"10.1016\/j.clnu.2012.04.001_bib47","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1002\/hep.510280219","article-title":"Transjugular intrahepatic portosystemic shunt in hepatorenal syndrome:\u00a0effects on renal function and vasoactive systems","volume":"28","author":"Guevara","year":"1998","journal-title":"Hepatology"},{"issue":"5","key":"10.1016\/j.clnu.2012.04.001_bib48","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1046\/j.1365-2281.1998.00129.x","article-title":"Leptin: physiology and pathophysiology","volume":"18","author":"Fruhbeck","year":"1998","journal-title":"Clin Physiol"},{"issue":"2","key":"10.1016\/j.clnu.2012.04.001_bib49","doi-asserted-by":"crossref","first-page":"E190","DOI":"10.1152\/ajpendo.00207.2011","article-title":"Insulin resistance after a 72-h fast is associated with impaired AS160 phosphorylation and accumulation of lipid and glycogen in human skeletal muscle","volume":"302","author":"Vendelbo","year":"2012","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"5","key":"10.1016\/j.clnu.2012.04.001_bib50","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1172\/JCI111142","article-title":"Nature and quantity of fuels consumed in patients with alcoholic cirrhosis","volume":"72","author":"Owen","year":"1983","journal-title":"J\u00a0Clin Invest"},{"issue":"6","key":"10.1016\/j.clnu.2012.04.001_bib51","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1530\/EJE-08-0971","article-title":"The IGF system after insertion of a transjugular intrahepatic porto-systemic shunt in patients with liver cirrhosis","volume":"160","author":"Holland-Fischer","year":"2009","journal-title":"Eur J Endocrinol"}],"container-title":["Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0261561412000738?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0261561412000738?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,28]],"date-time":"2019-06-28T00:51:37Z","timestamp":1561683097000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0261561412000738"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12]]},"references-count":51,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["S0261561412000738"],"URL":"https:\/\/doi.org\/10.1016\/j.clnu.2012.04.001","relation":{},"ISSN":["0261-5614"],"issn-type":[{"value":"0261-5614","type":"print"}],"subject":[],"published":{"date-parts":[[2012,12]]}}}