{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T12:25:54Z","timestamp":1792758354581,"version":"4.5.0"},"reference-count":43,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T00:00:00Z","timestamp":1370044800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Nutrition"],"published-print":{"date-parts":[[2013,6]]},"DOI":"10.1016\/j.clnu.2013.02.004","type":"journal-article","created":{"date-parts":[[2013,2,18]],"date-time":"2013-02-18T18:28:30Z","timestamp":1361212110000},"page":"353-360","source":"Crossref","is-referenced-by-count":48,"title":["A systematic review and meta-analysis of probiotics for the management of radiation induced bowel disease"],"prefix":"10.1016","volume":"32","author":[{"given":"Adeel","family":"Hamad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos C.","family":"Fragkos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alastair","family":"Forbes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clnu.2013.02.004_bib1","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1136\/bmj.2.1909.272","article-title":"Deep tissue traumatism from Roentgen ray exposure","volume":"2","author":"Walsh","year":"1897","journal-title":"Br Med J"},{"key":"10.1016\/j.clnu.2013.02.004_bib2","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/S1470-2045(07)70341-8","article-title":"Gastrointestinal symptoms after pelvic radiotherapy: a new understanding to improve management of symptomatic patients","volume":"8","author":"Andreyev","year":"2007","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.clnu.2013.02.004_bib3","doi-asserted-by":"crossref","first-page":"389","DOI":"10.3109\/00365521.2010.545832","article-title":"\u201cPelvic radiation disease\u201d: new understanding and new solutions for a new disease in the era of cancer survivorship","volume":"46","author":"Andreyev","year":"2011","journal-title":"Scand J Gastroenterol"},{"key":"10.1016\/j.clnu.2013.02.004_bib4","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/j.clon.2007.08.011","article-title":"Gastrointestinal problems after pelvic radiotherapy: the past, the present and the future","volume":"19","author":"Andreyev","year":"2007","journal-title":"Clin Oncol (R Coll Radiol)"},{"key":"10.1016\/j.clnu.2013.02.004_bib5","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD003455","article-title":"Non surgical interventions for late radiation proctitis in patients who have received radical radiotherapy to the pelvis","volume":"1","author":"Denton","year":"2002","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.clnu.2013.02.004_bib6","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.ejon.2009.02.007","article-title":"The prevalence of chronic radiation enteritis following radiotherapy for cervical or endometrial cancer and its impact on quality of life","volume":"13","author":"Abayomi","year":"2009","journal-title":"Eur J Oncol Nurs"},{"key":"10.1016\/j.clnu.2013.02.004_bib7","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1016\/j.ijrobp.2004.12.087","article-title":"Gastrointestinal symptoms after pelvic radiotherapy: role for the gastroenterologist?","volume":"62","author":"Andreyev","year":"2005","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.clnu.2013.02.004_bib8","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1111\/j.1365-2036.2007.03405.x","article-title":"The clinical needs of patients with chronic gastrointestinal symptoms after pelvic radiotherapy","volume":"26","author":"Gillespie","year":"2007","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.clnu.2013.02.004_bib9","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1055\/s-2008-1027150","article-title":"Medical prevention and treatment of acute and chronic radiation induced enteritis \u2013 is there any proven therapy? a short review","volume":"46","author":"Zimmerer","year":"2008","journal-title":"Z\u00a0Gastroenterol"},{"key":"10.1016\/j.clnu.2013.02.004_bib10","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1007\/s00520-011-1323-5","article-title":"Gastrointestinal symptoms after pelvic radiotherapy: a national survey of gastroenterologists","volume":"20","author":"Henson","year":"2012","journal-title":"Support Care Cancer"},{"key":"10.1016\/j.clnu.2013.02.004_bib11","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.1038\/sj.bjc.6601868","article-title":"Role of nutritional intervention in patients treated with radiotherapy for pelvic malignancy","volume":"90","author":"McGough","year":"2004","journal-title":"Br J Cancer"},{"key":"10.1016\/j.clnu.2013.02.004_bib12","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1111\/j.1365-2036.2007.03562.x","article-title":"Review article: the role of butyrate on colonic function","volume":"27","author":"Hamer","year":"2008","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.clnu.2013.02.004_bib13","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1097\/00004836-200308000-00004","article-title":"New scientific paradigms for probiotics and prebiotics","volume":"37","author":"Reid","year":"2003","journal-title":"J\u00a0Clin Gastroenterol"},{"key":"10.1016\/j.clnu.2013.02.004_bib14","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1079\/BJN20051428","article-title":"Should yoghurt cultures be considered probiotic?","volume":"93","author":"Guarner","year":"2005","journal-title":"Br J Nutr"},{"key":"10.1016\/j.clnu.2013.02.004_bib15","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1001\/jama.2012.3507","article-title":"Probiotics for the prevention and treatment of antibiotic-associated diarrhea: a systematic review and meta-analysis","volume":"307","author":"Hempel","year":"2012","journal-title":"J\u00a0Am Med Assoc"},{"key":"10.1016\/j.clnu.2013.02.004_bib16","doi-asserted-by":"crossref","first-page":"264","DOI":"10.7326\/0003-4819-151-4-200908180-00135","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"151","author":"Moher","year":"2009","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.clnu.2013.02.004_bib17","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1037\/1082-989X.11.2.193","article-title":"Assessing heterogeneity in meta-analysis: Q statistic or I2 index?","volume":"11","author":"Huedo-Medina","year":"2006","journal-title":"Psychol Methods"},{"key":"10.1016\/j.clnu.2013.02.004_bib18","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1002\/sim.1186","article-title":"Quantifying heterogeneity in a meta-analysis","volume":"21","author":"Higgins","year":"2002","journal-title":"Stat Med"},{"key":"10.1016\/j.clnu.2013.02.004_bib19","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/1471-2288-11-41","article-title":"Quantifying, displaying and accounting for heterogeneity in the meta-analysis of RCTs using standard and generalised Q statistics","volume":"11","author":"Bowden","year":"2011","journal-title":"BMC Med Res Methodol"},{"key":"10.1016\/j.clnu.2013.02.004_bib20","first-page":"511","article-title":"Supplementation with oral probiotic bacteria maintains cutaneous immune homeostasis after UV exposure","volume":"16","author":"Gueniche","year":"2006","journal-title":"Eur J Dermatol"},{"key":"10.1016\/j.clnu.2013.02.004_bib21","first-page":"504","article-title":"Supplementation with oral probiotic bacteria protects human cutaneous immune homeostasis after UV exposure-double blind, randomized, placebo controlled clinical trial","volume":"18","author":"Peguet-Navarro","year":"2008","journal-title":"Eur J Dermatol"},{"key":"10.1016\/j.clnu.2013.02.004_bib22","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1111\/j.1365-2133.2010.09888.x","article-title":"Clinical evidence of benefits of a dietary supplement containing probiotic and carotenoids on ultraviolet-induced skin damage","volume":"163","author":"Bouilly-Gauthier","year":"2010","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.clnu.2013.02.004_bib23","first-page":"1","article-title":"Lipoteichoic acid from Lactobacillus rhamnosus GG as an oral photoprotective agent against UV-induced carcinogenesis","author":"Weill","year":"2012","journal-title":"Br J Nutr"},{"key":"10.1016\/j.clnu.2013.02.004_bib24","first-page":"748","article-title":"The use of therapeutic\/prophylactic dragee \u201choney laminolact\u201d in radiotherapy of uterine tumors","volume":"46","author":"Smirnova","year":"2000","journal-title":"Vopr Onkol"},{"key":"10.1016\/j.clnu.2013.02.004_bib25","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1097\/00042737-200104000-00015","article-title":"Results of a double-blind, randomized study to evaluate the efficacy and safety of antibiophilus in patients with radiation-induced diarrhoea","volume":"13","author":"Urbancsek","year":"2001","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10.1016\/j.clnu.2013.02.004_bib26","doi-asserted-by":"crossref","first-page":"912","DOI":"10.3748\/wjg.v13.i6.912","article-title":"Use of probiotics for prevention of radiation-induced diarrhea","volume":"13","author":"Delia","year":"2007","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.clnu.2013.02.004_bib27","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1016\/j.ijrobp.2007.11.009","article-title":"Effects of probiotic Lactobacillus casei DN-114 001 in prevention of radiation-induced diarrhea: results from multicenter, randomized, placebo-controlled nutritional trial","volume":"71","author":"Giralt","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.clnu.2013.02.004_bib28","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/1748-717X-5-31","article-title":"Randomized controlled trial of live Lactobacillus acidophilus plus Bifidobacterium bifidum in prophylaxis of diarrhea during radiotherapy in cervical cancer patients","volume":"5","author":"Chitapanarux","year":"2010","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.clnu.2013.02.004_bib29","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1017\/S1460396910000087","article-title":"Probiotics as prevention of radiation-induced diarrhoea","volume":"9","author":"Timko","year":"2010","journal-title":"J\u00a0Radiother Pract"},{"key":"10.1016\/j.clnu.2013.02.004_bib30","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/S0009-9260(88)80296-4","article-title":"Preservation of intestinal integrity during radiotherapy using live Lactobacillus acidophilus cultures","volume":"39","author":"Salminen","year":"1988","journal-title":"Clin Radiol"},{"key":"10.1016\/j.clnu.2013.02.004_bib31","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1002\/1097-0142(19930915)72:6<1949::AID-CNCR2820720626>3.0.CO;2-W","article-title":"Effect of LC9018 combined with radiation therapy on carcinoma of the uterine cervix. A phase III, multicenter, randomized, controlled study","volume":"72","author":"Okawa","year":"1993","journal-title":"Cancer"},{"key":"10.1016\/j.clnu.2013.02.004_bib32","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/BF00343926","article-title":"Effects of active addition of bacterial cultures in fermented milk to patients with chronic bowel discomfort following irradiation","volume":"3","author":"Henriksson","year":"1995","journal-title":"Support Care Cancer"},{"key":"10.1016\/j.clnu.2013.02.004_bib33","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/S1744-1161(09)70162-0","article-title":"Effects of probiotic in prevention of radiation-induced diarrhea","volume":"4","author":"Castro","year":"2009","journal-title":"Clin Nutr Suppl"},{"key":"10.1016\/j.clnu.2013.02.004_bib34","doi-asserted-by":"crossref","first-page":"S667","DOI":"10.1016\/j.ijrobp.2011.06.916","article-title":"Phase III study: impact of probiotics on diarrhea in patients treated with pelvic radiation","volume":"81","author":"Germain","year":"2011","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"Suppl. 2","key":"10.1016\/j.clnu.2013.02.004_bib35","doi-asserted-by":"crossref","first-page":"S84","DOI":"10.1016\/S1590-8658(02)80173-6","article-title":"Prophylaxis of diarrhoea in patients submitted to radiotherapeutic treatment on pelvic district: personal experience","volume":"34","author":"Delia","year":"2002","journal-title":"Dig Liver Dis"},{"key":"10.1016\/j.clnu.2013.02.004_bib36","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.1111\/j.1572-0241.2002.05946.x","article-title":"Prevention of radiation-induced diarrhea with the use of VSL#3, a new high-potency probiotic preparation","volume":"97","author":"Delia","year":"2002","journal-title":"Am J Gastroenterol"},{"issue":"Suppl.","key":"10.1016\/j.clnu.2013.02.004_bib37","first-page":"1","article-title":"Use of probiotics for prevention of radiation-induced diarrhea","volume":"93","author":"Delia","year":"2007","journal-title":"Tumori"},{"key":"10.1016\/j.clnu.2013.02.004_bib38","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1002\/bimj.200510175","article-title":"Assessing the amount of heterogeneity in random-effects meta-analysis","volume":"48","author":"Knapp","year":"2006","journal-title":"Biom J"},{"key":"10.1016\/j.clnu.2013.02.004_bib39","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.2174\/138161209788168155","article-title":"Probiotics, immune function, infection and inflammation: a review of the evidence from studies conducted in humans","volume":"15","author":"Lomax","year":"2009","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.clnu.2013.02.004_bib40","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1136\/gutjnl-2011-300367","article-title":"Lactobacillus probiotic protects intestinal epithelium from radiation injury in a TLR-2\/cyclo-oxygenase-2-dependent manner","volume":"61","author":"Ciorba","year":"2012","journal-title":"Gut"},{"key":"10.1016\/j.clnu.2013.02.004_bib41","first-page":"143","article-title":"Experimental radiotherapy-induced enteritis: a probiotic interventional study","volume":"8","author":"Seal","year":"2007","journal-title":"J\u00a0Dig Dis"},{"key":"10.1016\/j.clnu.2013.02.004_bib42","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1136\/gut.52.7.975","article-title":"Double blind, placebo controlled trial of two probiotic strains in interleukin 10 knockout mice and mechanistic link with cytokine balance","volume":"52","author":"McCarthy","year":"2003","journal-title":"Gut"},{"key":"10.1016\/j.clnu.2013.02.004_bib43","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1136\/gut.52.3.370","article-title":"Lactobacillus GG prevents recurrence of colitis in HLA-B27 transgenic rats after antibiotic treatment","volume":"52","author":"Dieleman","year":"2003","journal-title":"Gut"}],"container-title":["Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0261561413000502?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0261561413000502?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,7,9]],"date-time":"2019-07-09T17:19:44Z","timestamp":1562692784000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0261561413000502"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6]]},"references-count":43,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["S0261561413000502"],"URL":"https:\/\/doi.org\/10.1016\/j.clnu.2013.02.004","relation":{},"ISSN":["0261-5614"],"issn-type":[{"value":"0261-5614","type":"print"}],"subject":[],"published":{"date-parts":[[2013,6]]}}}